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1. 发明专利

ES2404312T3 Derivados de 1, 2, 4-triazol-1-il-bisfenilo para uso en el tratamiento de tumores endocrino-dependientes 未知
公开(公告)号：ES2404312T3
公开(公告)日：2013-05-27
申请号：ES06820490
申请日：2006-12-12
申请人： STERIX LTD
发明人： WOO LOK , JACKSON TOBY , PUROHIT ATUL , REED MICHAEL , POTTER BARRY
IPC分类号： C07D249/08 , A61K31/4196 , A61P35/00 , C07D405/10
摘要： Compuesto de fórmula II Fórmula II en la que al menos uno de R3, R4, R5, R6 y R7 es -CH2-1H-1,2,4-triazol, y al menos uno de R3, R4, R5, R6 y R7 es -YR8en el que R8 se selecciona de ciano (-CN), nitro (-NO2), aceptores de puente de H y halógenos; en la que Y es un grupo de unión opcional; en la que el anillo A está opcionalmente sustituido de manera adicional; y en la que R9 se selecciona de H, -OH y -OSO2NR1R2, en el que R1 y R2 se seleccionan independientemente de H ehidrocarbilo.

2. 发明专利

ES2258174T3 COMPUESTOS ESTEROIDEOS PARA LA INHIBICION DE LA SULFATASA ESTEROIDEA. 未知
公开(公告)号：ES2258174T3
公开(公告)日：2006-08-16
申请号：ES02801418
申请日：2002-10-17
申请人： STERIX LTD
发明人： POTTER BARRY , REED MICHAEL J , WOO LOK WAI L
IPC分类号： A61K45/00 , A61K31/58 , A61P15/00 , A61P25/28 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07J1/00 , C07J63/00 , C07J73/00 , A61K31/56
摘要： Compuesto de Fórmula XII: (Ver fórmula) en la que R1 es un grupo sulfamato de fórmula (R4)(R5)NSO2-O-; R4 y R5 se seleccionan independientemente de entre hidrógeno, alquilo, cicloalquilo, alquenilo y arilo o combinaciones de éstos, o que representan conjuntamente alquileno, en la que el o cada alquilo o cicloalquilo o alquenilo contienen opcionalmente uno o más heteroátomos o grupos; G es H o un sustituyente seleccionado de entre OH o un grupo hidrocarbilo; en la que el sistema de anillo está opcionalmente sustituido presión con uno o más sustituyentes seleccionados de entre hidrógeno, alquilo, alcoxi, alquinilo y halógeno.

3. 发明专利

AT308556T 未知
公开(公告)号：AT308556T
公开(公告)日：2005-11-15
申请号：AT00985490
申请日：2000-12-07
申请人： STERIX LTD
发明人： REED MICHAEL , POTTER BARRY , HEJAZ HATEM
IPC分类号： A61K31/566 , A61P1/02 , A61P1/04 , A61P1/14 , A61P3/10 , A61P5/44 , A61P7/00 , A61P7/02 , A61P7/04 , A61P9/00 , A61P9/04 , A61P9/10 , A61P11/02 , A61P11/06 , A61P15/00 , A61P17/00 , A61P17/02 , A61P17/04 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/18 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P31/18 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07J41/00 , C12Q1/34 , A61K31/565 , A61P5/32
摘要： A compound is described. The compound has the formula (Ia) as presented in the FIG. 1; wherein: X is a ring having at least 4 atoms in the ring; K is hydrocarbyl group; Rh1 is an optional halo group; Rh2 is an optional halo group; at least one of Rh1 and Rh2 is present; Rs is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group. The compound is capable of inhibiting steroid sulphatase (STS) activity.

4. 发明专利

ES2394204T3 Compuestos de éster de ácido sulfámico útiles en la inhibición de la actividad esteroide sulfatasa y la actividad aromatasa 未知
公开(公告)号：ES2394204T3
公开(公告)日：2013-01-23
申请号：ES05744488
申请日：2005-05-19
申请人： STERIX LTD
发明人： POTTER BARRY , REED MICHAEL , WOO LOK , PUROHIT ATUL , BURBERT CHRISTIAN , WOOD PAUL , SUTCLIFFE OLIVER
IPC分类号： C07D249/08 , A61K31/4196
摘要： Compuesto de fórmula **Fórmula**

5. 发明专利

CA2519956C COMPOUND 未知
公开(公告)号：CA2519956C
公开(公告)日：2012-12-18
申请号：CA2519956
申请日：2004-03-22
申请人： STERIX LTD
发明人： VICKER NIGEL , LAWRENCE HARSHANI , ALLAN GILLIAN , BUBERT CHRISTIAN , FISCHER DELPHINE , PUROHIT ATUL , REED MICHAEL , POTTER BARRY
IPC分类号： C07J71/00 , A61K31/56 , A61K31/566 , C07J20060101 , C07J41/00
摘要： There is provided a compound of Formula (I) wherein (I) R1 is a selected from (i) an alkyloxyalkyl group (ii) a nitrile group, and wherein R2 is capable of forming a hydrogen bond (iii) alkylaryl group, wherein the aryl group is substituted by other than a C1-10 group (iv) alkenylaryl group wherein the aryl group is substituted (v) alkyiheteroaryl group, wherein when heteroaryl group comprises only C and N in the ring, the aryl group is substituted by other than a methyl group (vi) alkenylheteroaryl group, (vii) =N-O-alkyl or =N-O-H group (viii) branched alkenyl (ix) alkyl-alcohol group (x) amide or alkylamide wherein (a) the alkyl of the alkylamide is - CH2- or -CH2CH2-, (b) the amide is di-substituted and/or (c) the amide is substituted with at least one of a I kyl heterocycle group, al ke nyl heterocycle group, alkylheteroaryl group, alkenylheteroaryl group, heteroaryl group, alkylamine group, alkyloxyalkyl group, alkylaryl group, straight or branched alkyl group, (xi) -CHO so that R, together with R3 provide the enol tautomer (a); OR R1 together with R3 form (xii) a pyrazole wherein (a) R4 is =N-0-alkyl or =N-0-H group, (b) the pyrazole is substituted with one of alkyl-OH group, alkyl ester group, alkyloxyalkyl. group, branched alkyl group, and an amide and/or (c) the 2 position is substituted with a group selected from -OH and -0-hydrocarbyl (xiii) a heteroaryl ring to provide a compound of the formula (b); (II) R2is selected from groups capable of forming a hydrogen bond, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group and a sulphonamide group; and (III) R3 is selected from -OH, =O, or a -C(=O)-mimetic.

6. 发明专利

AT485258T 未知
公开(公告)号：AT485258T
公开(公告)日：2010-11-15
申请号：AT02704938
申请日：2002-03-07
申请人： STERIX LTD
发明人： POTTER BARRY , PUROHIT ATUL , REED MICHAEL , VICKER NIGEL
IPC分类号： C07C62/32 , A61K31/19 , A61K31/57 , A61P5/38 , A61P5/44 , A61P5/46 , C07C62/34 , C07C62/38 , C07C69/753 , C07C235/40 , C07D213/40 , C07D295/13 , C07D295/182 , C07J7/00 , C07J9/00 , C07J51/00

7. 发明专利

AT451107T 未知
公开(公告)号：AT451107T
公开(公告)日：2009-12-15
申请号：AT98957034
申请日：1998-12-03
申请人： STERIX LTD
发明人： REED MICHAEL , POTTER BARRY
IPC分类号： A61K31/565 , A61P5/32 , A61P35/00 , A61P43/00 , C07J41/00

8. 发明专利

AT450516T 未知
公开(公告)号：AT450516T
公开(公告)日：2009-12-15
申请号：AT05747149
申请日：2005-06-03
申请人： STERIX LTD
发明人： WOO LOK , JACKSON TOBY , BUBERT CHRISTIAN , PUROHIT ATUL , REED MICHAEL , POTTER BARRY
IPC分类号： C07D249/08 , A61K31/4196 , A61P35/00
摘要： There is provided a compound of Formula I wherein X, Y and Z are each independently of each other an optional linker group; R1 is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (-CN), nitro (-NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.

9. 发明专利

AT401896T 未知
公开(公告)号：AT401896T
公开(公告)日：2008-08-15
申请号：AT99955428
申请日：1999-06-10
申请人： STERIX LTD
发明人： REED MICHAEL , POTTER BARRY
IPC分类号： A61K31/565 , A61K38/22 , A61K31/566 , A61K38/00 , A61K38/19 , A61P35/00 , A61P43/00
摘要： A composition is described. The composition comprises i) a compound comprising a sulphamate group ("a sulphamate compound"); and ii) a biological response modifier.

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