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1. 发明申请

WO2006032885A3 2-SUBSTITUTED ESTROGEN SULPHAMATES FOR INHIBITION OF STEROID SULPHATASE 审中-公开
标题翻译： 2-取代的雌激素用于抑制甾体硫酸酯酶
公开(公告)号：WO2006032885A3
公开(公告)日：2006-08-24
申请号：PCT/GB2005003641
申请日：2005-09-21
申请人： STERIX LTD , LEESE MATHEW , PUROHIT ALAN , REED MICHAEL JOHN , JOURDAN FABRICE , POTTER BARRY VICTOR LLOYD , BURBERT CHRISTIAN
发明人： LEESE MATHEW , PUROHIT ALAN , REED MICHAEL JOHN , JOURDAN FABRICE , POTTER BARRY VICTOR LLOYD , BURBERT CHRISTIAN
IPC分类号： C07J41/00 , A61K31/565 , A61K31/566 , A61K31/57 , A61K31/58 , A61P5/32 , C07J3/00 , C07J7/00 , C07J31/00 , C07J43/00
CPC分类号： C07J43/003 , C07J3/00 , C07J7/0005 , C07J31/006 , C07J41/0005 , C07J41/0072
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R 1 selected from any one of -OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the A ring of the steroidal ring system is optionally substituted at position 2 or 4 with a group R 4 which may be a suitable subtituent wherein the D ring of the steroidal ring system is substituted by a group R 2 of the formula -L-R 3 , wherein L is an optional linker group and R 3 is selected from groups which are or which comprise one of (i) -S0 2 R 5 , wherein R 5 is H, a hydrocarbyl group or a bond or group attached to the D ring; (ii) -NO 2 ; (iii) -SOR 6 , wherein R 6 is H or a hydrocarbyl group; (iv) -R 7 , wherein R 7 is a halogen; (v) - alkyl; (vi) -C(=O)R 8 , wherein R 8 is H or hydrocarbyl; (vii) -C=CR 9 , wherein R 9 is H or hydrocarbyl; (viii) -OC(=O)NR 10 R 11 wherein R 10 and R 11 are independently selected from H and hydrocarbyl; (ix), (x), (xi), (xii) and (xiii) are formulae wherein when R 3 is -alkyl, R 4 is present as a hydrocarbon group, when R 3 is -NO 2 R 4 is present and/or R 1 is present as a sulphamate group, and when R 3 is -C(=O)R 8 R 4 is present and R 1 is present as a sulphamate group.
摘要翻译：本发明提供了包含选自-OH，氨基磺酸酯基，膦酸酯基，硫代膦酸酯基，磺酸酯基或磺酰胺中的任何一种的甾体环系和任选的基团R 1的化合物组; 其中所述甾族环系统的A环任选在位置2或4处被基团R 4取代，所述基团R 4可以是合适的取代基，其中所述甾族环系统的D环被基团R 其中L是任选的连接基团，R 3选自以下基团：其中R 1，R 2，R 3，（i）-S 0 2 R 5，其中R 5是H，连接到D环的烃基或键或基团; （ii）-NO 2 2; （iii）-SOR 6，其中R 6是H或烃基; （iv）-R 7，其中R 7为卤素; （ⅴ） - 烷基; （vi）-C（= O）R 8，其中R 8为H或烃基; （vii）-C = CR 9，其中R 9是H或烃基; （viii）-OC（= O）NR 10 R 11，其中R 10和R 11独立地选自由H和烃基组成; （ix），（x），（xi），（xii）和（xiii）是其中当R 3为 - 烷基时，R 4为烃，当R 3为-NO 2 R 4存在时，和/或R 1存在作为并且当R 3为-C（= O）时，存在R 8 R 4和R 4，并且R 1〜 >作为氨基磺酸盐基团存在。

2. 发明申请

WO2005115996B1 SULFAMIC ACID ESTER COMPOUNDS USEFUL IN THE INHIBITION OF SEROID SULPHATASE ACTIVITY AND AROMATASE ACTIVITY 审中-公开
标题翻译：用于抑制血清型硫酸酯酶活性和芳香酶活性的硫酸酯化合物
公开(公告)号：WO2005115996B1
公开(公告)日：2006-02-02
申请号：PCT/GB2005001985
申请日：2005-05-19
申请人： STERIX LTD , POTTER BARRY VICTOR LLOYD , REED MICHAEL JOHN , WOO LOK WAI LAWRENCE , PUROHIT ATUL , BURBERT CHRISTIAN , WOOD MICHAEL PAUL , SUTCLIFFE OLIVER BROOK
发明人： POTTER BARRY VICTOR LLOYD , REED MICHAEL JOHN , WOO LOK WAI LAWRENCE , PUROHIT ATUL , BURBERT CHRISTIAN , WOOD MICHAEL PAUL , SUTCLIFFE OLIVER BROOK
IPC分类号： A61K31/4196 , C07D249/08
CPC分类号： C07D249/08
摘要： There is provided a compound of Formula (III) or Formula (IV), wherein A is selected from H, OH, halogen and hydrocarbyl D, E and F are each independently of each other an optional linker group; P, Q and R are independently of each other a ring system, wherein R 4 and R 5 are independently selected from H, alkyl, cycloalkyl, alkenyl, acyl and aryl, or combinations thereof, or together represent alkylene, wherein the or each alkyl or cycloalkyl or alkenyl or optionally contain one or more hetero atoms or groups.
摘要翻译：提供式（III）或式（IV）的化合物，其中A选自H，OH，卤素和烃基D，E和F各自独立地为任选的连接基团; P，Q和R彼此独立地为环系，其中R 4和R 5独立地选自H，烷基，环烷基，烯基，酰基和芳基，或其组合，或一起表示亚烷基，其中所述或每个烷基或环烷基或烯基或任选地含有一个或多个杂原子或基团。

3. 发明专利

CA2576614A1 2-SUBSTITUTED ESTROGEN SULPHAMATES FOR INHIBITION OF STEROIDSULPHATASE 未知
公开(公告)号：CA2576614A1
公开(公告)日：2006-03-30
申请号：CA2576614
申请日：2005-09-21
申请人： STERIX LTD
发明人： JOURDAN FABRICE , REED MICHAEL JOHN , PUROHIT ALAN , LEESE MATHEW , POTTER BARRY VICTOR LLOYD , BURBERT CHRISTIAN
IPC分类号： C07J41/00 , A61K31/565 , A61K31/566 , A61K31/57 , A61K31/58 , A61P5/32 , C07J3/00 , C07J7/00 , C07J31/00 , C07J43/00
摘要： The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of -OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the A ring of the steroidal ring system is optionally substituted at position 2 or 4 with a group R 4 which may be a suitable subtituent, wherein the D ring of the steroidal ring system is substituted by a group R 2 of the formula -L-R 3 , wherein L is an optional linker group and R 3 is selected from groups which are or which comprise one of (i) -SO 2 R 5 , wherein R 5 is H, a hydrocarbyl group or a bond or group attached to the D ring; (ii) -NO 2 ; (iii) -SOR 6 , wherein R 6 is H or a hydrocarbyl group; (iv) -R 7 , wherein R 7 is a halogen; (v) -alkyl; (vi) -C(-O)R 3 , wherein R 3 is H or hydrocarbyl; (vii) -C≡CR 9 , wherein R 9 is H or hydrocarbyl; (viii) -OC(-O)NR 10 R 11 wherein R 10 and R 11 are independently selected from H and hydrocarbyl; (ix), (x), (xi), (xii) and (xiii) are formulae wherein when R 3 is -alkyl, R 4 is present as a hydrocarbon group, when R 3 is -NO 2 R 4 is present and/or R 1 is present as a sulphamate group, and when R 3 is -C(-O)R 3 R 4 is present and R 1 is present as a sulphamate group.

4. 发明专利

ES2394204T3 Compuestos de éster de ácido sulfámico útiles en la inhibición de la actividad esteroide sulfatasa y la actividad aromatasa 未知
公开(公告)号：ES2394204T3
公开(公告)日：2013-01-23
申请号：ES05744488
申请日：2005-05-19
申请人： STERIX LTD
发明人： POTTER BARRY , REED MICHAEL , WOO LOK , PUROHIT ATUL , BURBERT CHRISTIAN , WOOD PAUL , SUTCLIFFE OLIVER
IPC分类号： C07D249/08 , A61K31/4196
摘要： Compuesto de fórmula **Fórmula**

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