专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JP2008309799A Label-free high-throughput optical technique for detecting biomolecular interaction 审中-公开
标题翻译：用于检测生物分子相互作用的无标签高分辨率光学技术
公开(公告)号：JP2008309799A
公开(公告)日：2008-12-25
申请号：JP2008208969
申请日：2008-08-14
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/45 , G01N21/47 , G01N33/543 , G01N33/566 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10T436/24
摘要： PROBLEM TO BE SOLVED: To provide a structure and a method for detecting bonding to each bonding partners of ≥1 specific bonding substances. SOLUTION: The method and structure substance are provided for detecting the biomolecular interaction, which are free from using labels. This method can perform high-throughput system. This invention is capable of providing useful optical device as a narrow-frequency band filter. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种结构和方法，用于检测与≥1种特定粘结物质的每个粘合剂的结合。解决方案：提供了用于检测生物分子相互作用的方法和结构物质，其不使用标记。该方法可以执行高吞吐量系统。本发明能够提供有用的光学装置作为窄带滤波器。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2010122227A Guided-mode resonant filter biosensor using linear optical surface structure 有权
标题翻译：使用线性光学表面结构的引导型谐振滤波器生物传感器
公开(公告)号：JP2010122227A
公开(公告)日：2010-06-03
申请号：JP2009270534
申请日：2009-11-27
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , QIU JEAN , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/47 , G01N21/78 , G01N33/543 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10S435/808 , Y10S436/805
摘要： PROBLEM TO BE SOLVED: To provide a method and a formation to detect an interaction between biomolecules. SOLUTION: The detection can be carried out in a high throughput system without using a label. An optical device useful as a narrow band filter is offered. One biosensor comprises a one-dimensional grating layer containing a high refractive index material, a low refractive index material layer supporting the one-dimensional grating layer, and one or more specific binding substance immobilized on the surface of the one-dimensional grating layer at the side opposite to the low refractive index material layer. When the biosensor is irradiated, a resonant grating effect occurs on a reflected emission spectrum. Cross-sectional period of the one-dimensional grating is shorter than the wavelength of the resonant grating effect. Another biosensor comprises a one-dimensional grating surface structure containing a low refractive index material, a high refractive index material layer applied to top of the low refractive index one-dimensional grating layer, and one or more specific binding substance immobilized on the surface of the high refractive index material at the side opposite to the one-dimensional grating surface structure containing a low refractive index material. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供检测生物分子之间的相互作用的方法和形式。
解决方案：可以在高吞吐量系统中进行检测，而不使用标签。提供用作窄带滤波器的光学装置。一个生物传感器包括含有高折射率材料的一维光栅层，支撑一维光栅层的低折射率材料层和固定在一维光栅层的表面上的一种或多种特异性结合物质与低折射率材料层相反的一侧。当照射生物传感器时，在反射发射光谱上产生谐振光栅效应。一维光栅的横截面周期短于谐振光栅效应的波长。另一种生物传感器包括一个包含低折射率材料的一维光栅表面结构，施加到低折射率一维光栅层顶部的高折射率材料层和固定在低折射率一维光栅层的表面上的一种或多种特异性结合物质在与包含低折射率材料的一维光栅表面结构相反的一侧的高折射率材料。版权所有（C）2010，JPO＆INPIT

3. 发明专利

JP2009025312A Label-free high-throughput optical technique for detecting biomolecular interaction 审中-公开
标题翻译：用于检测生物分子相互作用的无标签高分辨率光学技术
公开(公告)号：JP2009025312A
公开(公告)日：2009-02-05
申请号：JP2008208966
申请日：2008-08-14
申请人： Sru Biosystems Inc , エスアールユーバイオシステムズ,インコーポレイテッド
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LIN BO , LI PETER , PIEN HOMER
IPC分类号： G01N21/27 , B01L3/00 , G01N21/25 , G01N21/35 , G01N21/45 , G01N21/47 , G01N33/543 , G01N33/566 , G01N37/00 , G02B5/18
CPC分类号： G01N33/54373 , B01L3/5085 , G01N21/253 , G01N21/4788 , G01N21/7743 , G02B5/1809 , Y10T436/24
摘要： PROBLEM TO BE SOLVED: To provide compositions and methods for detecting a coupling of one or more of specific coupling substances to respective coupling partners. SOLUTION: The present invention discloses the method and the component for detecting biomolecular interactions. The use of labels is not required, and the methods are executed by a high-throughput system. The present invention also provides an optical device which is useful as a narrow band filter. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供用于检测一种或多种特定偶联物质与各个偶合物的偶联的组合物和方法。解决方案：本发明公开了用于检测生物分子相互作用的方法和组分。不需要使用标签，并且该方法由高吞吐量系统执行。本发明还提供一种用作窄带滤波器的光学装置。版权所有（C）2009，JPO＆INPIT

4. 发明申请

WO2005031349A3 LABEL-FREE METHODS FOR PERFORMING ASSAYS USING A COLORIMETRIC RESONANT REFLECTANCE OPTICAL BIOSENSOR 审中-公开
标题翻译：使用比色反射式光学生物传感器进行检测的无标签方法
公开(公告)号：WO2005031349A3
公开(公告)日：2005-06-02
申请号：PCT/US2004030893
申请日：2004-09-22
申请人： SRU BIOSYSTEMS INC , LIN BO , CUNNINGHAM BRIAN T , LI PETER
发明人： LIN BO , CUNNINGHAM BRIAN T , LI PETER
IPC分类号： B01L3/00 , C12Q1/68 , G01N21/25 , G01N21/47 , G01N33/543 , G02B5/18
CPC分类号： B01L3/5085 , C12Q1/6816 , C40B30/04 , C40B30/10 , G01N21/253 , G01N21/255 , G01N21/4788 , G01N21/7743 , G01N33/54366 , G01N33/54373 , G02B5/1809 , Y10S435/808 , Y10S436/805 , Y10S436/809
摘要： The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.
摘要翻译：本发明提供了确定细胞相互作用的组合物和方法，其比常规方法更快并且需要使用比常规方法更少的试剂。

5. 发明申请

WO2008027025A3 PHOTONIC CRYSTAL BIOSENSOR STRUCTURE AND FABRICATION METHOD 审中-公开
标题翻译：光电晶体生物传感器结构与制造方法
公开(公告)号：WO2008027025A3
公开(公告)日：2008-05-08
申请号：PCT/US2006025317
申请日：2006-06-29
申请人： SRU BIOSYSTEMS INC , CUNNINGHAM BRIAN T
发明人： CUNNINGHAM BRIAN T
IPC分类号： G01N21/25 , G01N33/52 , G02B5/18
CPC分类号： G01N21/7743 , B82Y20/00 , C12M23/20 , C12M41/36 , G01N2021/7776 , G02B6/1225
摘要： The invention provides a sensor. The sensor comprises a nanoporous material supported on a substrate and coated on a top surface with a high dielectric constant dielectric coating. The coating and the nanoporous material form a sub-wavelength period grating structure.
摘要翻译：本发明提供一种传感器。传感器包括支撑在基底上的纳米多孔材料，并涂覆在具有高介电常数电介质涂层的顶表面上。涂层和纳米多孔材料形成亚波长周期光栅结构。

6. 发明申请

WO2008008247A2 NEAR ULTRAVIOLET-WAVELENGTH PHOTONIC-CRYSTAL BIOSENSOR WITH ENHANCED SURFACE TO BULK SENSITIVITY RATIO 审中-公开
标题翻译：近紫外线波长光电晶体生物传感器，具有增强的表面，具有较强的灵敏度比
公开(公告)号：WO2008008247A2
公开(公告)日：2008-01-17
申请号：PCT/US2007015448
申请日：2007-07-02
申请人： UNIV ILLINOIS BOARD OF REGENTS , SRU BIOSYSTEMS INC , CUNNINGHAM BRIAN T , BLOCK IAN D , GANESH NIKHIL
发明人： CUNNINGHAM BRIAN T , BLOCK IAN D , GANESH NIKHIL
IPC分类号： G01N21/47 , B01L3/00 , G01N21/25 , G01N33/551 , G01N33/552 , G02B5/18
CPC分类号： G01N21/7743 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B82Y20/00 , G01N21/253 , G01N21/33 , G01N33/54373 , G01N33/551 , G01N33/552 , G02B1/005
摘要： Biosensors are disclosed based on one- or two-dimensional photonic-crystal reflectance filters operating at near-ultraviolet wavelengths. Rigorous Coupled- Wave Analysis simulations predict a more tightly confined resonant electric field at the surface of this biosensor as compared to previously fabricated near-infrared photonic-crystal biosensors. This change in the resonant electric field provides an improvement of over 4.5 times in the surface-sensitivity to bulk-sensitivity ratio, and therefore enables enhanced detection resolution for biomolecules adsorbed on the biosensor surface. These new biosensors can be fabricated in mass by replica molding. They are especially well suited for applications requiring the detection of small molecules or ultra-low analyte concentrations.
摘要翻译：基于在近紫外波长下操作的一维或二维光子晶体反射滤光片来公开生物传感器。与先前制造的近红外光子晶体生物传感器相比，严格的耦合波分析模拟预测了该生物传感器表面更紧密的约束共振电场。谐振电场的这种变化提供了表面灵敏度到体敏感比的4.5倍以上的改进，因此能够增强吸附在生物传感器表面上的生物分子的检测分辨率。这些新的生物传感器可以通过复制成型制成。它们特别适用于需要检测小分子或超低分析物浓度的应用。

7. 发明申请

WO2005102020A3 PHOTONIC CRYSTAL DEFECT CAVITY BIOSENSOR 审中-公开
标题翻译： PHOTONIC CRYSTAL DEFIT CAVITY生物传感器
公开(公告)号：WO2005102020A3
公开(公告)日：2006-02-02
申请号：PCT/US2005000498
申请日：2005-01-06
申请人： SRU BIOSYSTEMS INC , CUNNINGHAM BRIAN T
发明人： CUNNINGHAM BRIAN T
IPC分类号： G01J3/28 , G01N21/03 , G01N21/25 , G01N21/31 , G02B6/00 , G02B6/122
CPC分类号： G01N21/03 , B82Y20/00 , G01J3/2803 , G01J3/2823 , G01N21/253 , G01N21/552 , G01N2021/0346 , G02B6/1225
摘要： A biosensor is described having the form of a photonic crystal having defect cavities formed in a periodic pattern in the device. The invention provides a higher sensitivity and a greater degree of spatial localization of incoupled photons than previously reported photonic crystal biosensor devices.
摘要翻译：描述了具有在装置中以周期性图案形成的缺陷腔的光子晶体的形式的生物传感器。本发明提供了比先前报道的光子晶体生物传感器装置更高的灵敏度和更大程度的离子化光子的空间定位。

8. 发明申请

WO2007019024A2 GRATING-BASED SENSOR COMBINING LABEL-FREE BINDING DETECTION AND FLUORESCENCE AMPLIFICATION AND READOUT SYSTEM FOR SENSOR 审中-公开
标题翻译：基于GRATING的传感器组合无标签绑定检测和荧光放大和读取传感器系统
公开(公告)号：WO2007019024A2
公开(公告)日：2007-02-15
申请号：PCT/US2006028473
申请日：2006-07-20
申请人： SRU BIOSYSTEMS INC , SCHULZ STEPHEN C , CUNNINGHAM BRIAN T , LAING LANCE G , LI PETER Y , BINDER BRANT , JOGIKALMATH GANGADHAR , BORSODY ALEX
发明人： SCHULZ STEPHEN C , CUNNINGHAM BRIAN T , LAING LANCE G , LI PETER Y , BINDER BRANT , JOGIKALMATH GANGADHAR , BORSODY ALEX
IPC分类号： G01N21/55 , G01N21/64
CPC分类号： G01N21/648 , G01N21/552 , G01N21/6428 , G01N21/7743 , Y10S435/808 , Y10S436/805 , Y10T436/143333
摘要： A grating-based sensor is disclosed that has a grating structure constructed and designed for both evanescent resonance (ER) fluorescence detection and label-free detection applications. Some embodiments are disclosed which are optimized for ER detection in an air mode, in which the sample is dry. Other embodiments are optimized for ER detection in liquid mode, in which the sample is suspended in liquid medium such as water. One and two-dimensional gratings are also disclosed, including gratings characterized by unit cells with central posts, central holes, and two-level, two-dimensional gratings. A readout system for such sensors is also disclosed. One embodiment includes a first light source optimized for collecting label -free detection data, a second light source optimized for collecting ER fluorescence amplification data, and at least one detector. In one embodiment, the detector is an imaging system and includes a CCD camera for collecting both ER and label-free data. In other embodiments, the at least one detector takes the form of a spectrometer for collection of label-free data and a photomultiplier for collecting ER data. In other embodiments, a single light source such as a tunable laser or broad band light source is used.
摘要翻译：公开了一种光栅传感器，其具有构造和设计用于ev逝共振（ER）荧光检测和无标签检测应用的光栅结构。公开了一些实施例，其被优化用于空气模式中的ER检测，其中样品是干的。其它实施例针对液体模式中的ER检测进行了优化，其中将样品悬浮在诸如水的液体介质中。还公开了一维和二维光栅，包括以具有中心柱，中心孔和两层二维光栅的单元电池为特征的光栅。还公开了一种用于这种传感器的读出系统。一个实施例包括优化用于收集无标记检测数据的第一光源，为收集ER荧光放大数据而优化的第二光源和至少一个检测器。在一个实施例中，检测器是成像系统，并且包括用于收集ER和无标签数据的CCD照相机。在其他实施例中，至少一个检测器采用用于收集无标签数据的光谱仪的形式和用于收集ER数据的光电倍增管。在其他实施例中，使用诸如可调激光器或宽带光源的单个光源。

9. 发明公开

EP1468291A4 A LABEL-FREE HIGH THROUGHPUT OPTICAL TECHNIQUE FOR DETECTING BIOMOLECULAR INTERACTIONS. 审中-公开
标题翻译：无标记的光学技术高通量识别生物分子相互作用
公开(公告)号：EP1468291A4
公开(公告)日：2010-04-14
申请号：EP03734959
申请日：2003-01-16
申请人： SRU BIOSYSTEMS INC
发明人： CUNNINGHAM BRIAN T , PEPPER JANE , LI PETER , QIU JEAN , PIEN HOMER
IPC分类号： G01N21/77 , G01N33/483 , B01L3/00 , G01N21/25 , G01N21/41 , G01N21/47 , G01N33/53 , G01N33/543 , G01N37/00 , G02B5/18 , G02B6/02
CPC分类号： G01N21/7743 , B01L3/5085 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , G01N21/253 , G01N21/4788 , G01N33/54373 , G02B5/1809 , G02B5/1852 , G02B6/02061 , Y10S436/805
摘要： Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters.

10. 发明专利

CA2539187C LABEL-FREE METHODS FOR PERFORMING ASSAYS USING A COLORIMETRIC RESONANT REFLECTANCE OPTICAL BIOSENSOR 未知
公开(公告)号：CA2539187C
公开(公告)日：2011-05-17
申请号：CA2539187
申请日：2004-09-22
申请人： SRU BIOSYSTEMS INC
发明人： LIN BO , CUNNINGHAM BRIAN T , LI PETER
IPC分类号： G01N33/543 , B01L3/00 , C12Q1/68 , G01N21/25 , G01N21/47 , G02B5/18
摘要： The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式