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1. 发明专利

IL280473D0 1h-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (tlr7) agonists and methods and uses therefor 未知
公开(公告)号：IL280473D0
公开(公告)日：2021-03-01
申请号：IL28047321
申请日：2021-01-28
申请人： SQUIBB BRISTOL MYERS CO , TARBY CHRISTINE M , HE LIQI , GANGWAR SANJEEV , SIVAPRAKASAM PRASANNA , POUDEL YAM B , BROEKEMA MATTHIAS , CHOWDARI NAIDU S , COX MATTHEW , ZHANG QIAN
发明人： TARBY CHRISTINE M , HE LIQI , GANGWAR SANJEEV , SIVAPRAKASAM PRASANNA , POUDEL YAM B , BROEKEMA MATTHIAS , CHOWDARI NAIDU S , COX MATTHEW , ZHANG QIAN
IPC分类号： A61K31/519 , A61K39/395 , A61K47/60 , A61P35/00
摘要： Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

2. 发明专利

IL272626D0 6-amino-7,9-dihydro-8h-purin-8-one derivatives as immunostimulant toll-like receptor 7 (tlr7) agonists 未知
公开(公告)号：IL272626D0
公开(公告)日：2020-03-31
申请号：IL27262620
申请日：2020-02-12
申请人： SQUIBB BRISTOL MYERS CO , POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , SIVAPRAKASAM PRASANNA
发明人： POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , SIVAPRAKASAM PRASANNA
IPC分类号： C07D20060101
摘要： where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

3. 发明专利

IL272632D0 6-amino-7,9-dihydro-8h-purin-8-one derivatives as immunostimulant toll-like receptor 7 (tlr7) agonists 未知
公开(公告)号：IL272632D0
公开(公告)日：2020-03-31
申请号：IL27263220
申请日：2020-02-12
申请人： SQUIBB BRISTOL MYERS CO , POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , POSY SHOSHANA L , SIVAPRAKASAM PRASANNA
发明人： POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , POSY SHOSHANA L , SIVAPRAKASAM PRASANNA
IPC分类号： C07D20060101
摘要： where R1, R2, and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

4. 发明专利

IL272631D0 6-amino-7,9-dihydro-8h-purin-8-one derivatives as toll-like receptor 7 (tlr7) agonists as immunostimulants 未知
公开(公告)号：IL272631D0
公开(公告)日：2020-03-31
申请号：IL27263120
申请日：2020-02-12
申请人： SQUIBB BRISTOL MYERS CO , POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , POSY SHOSHANA L , SIVAPRAKASAM PRASANNA
发明人： POUDEL YAM B , HE LIQI , GANGWAR SANJEEV , POSY SHOSHANA L , SIVAPRAKASAM PRASANNA
IPC分类号： C07D20060101
摘要： where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

5. 发明申请

WO2006084017A2 PHENYL-SUBSTITUTED PYRIMIDINE COMPOUNDS USEFUL AS KINASE INHIBITORS 审中-公开
标题翻译：苯基取代的吡咯烷酮化合物作为激酶抑制剂有用
公开(公告)号：WO2006084017A2
公开(公告)日：2006-08-10
申请号：PCT/US2006003659
申请日：2006-02-02
申请人： SQUIBB BRISTOL MYERS CO , WROBELSKI STEPHEN T , LIN SHUQUN , LEFTHERIS KATERINA , HE LIQI , SEITZ STEVEN P , LIN TAI-AN , VACCARO WAYNE
发明人： WROBELSKI STEPHEN T , LIN SHUQUN , LEFTHERIS KATERINA , HE LIQI , SEITZ STEVEN P , LIN TAI-AN , VACCARO WAYNE
IPC分类号： C07D417/04 , A61P29/00 , A61P35/00 , C07D401/04 , C07D417/14
CPC分类号： C07D417/14 , C07D401/04 , C07D413/04 , C07D417/04
摘要： Compounds having the formula (I), and pharmaceutically acceptable salts, and solvates thereof, are useful as kinase inhibitors, wherein: two of X 1 , X 2 , and X 3 are N, and the remaining one of X 1 , X 2 , and X 3 is -CR 1 ; R 1 is hydrogen or -CN; and N, G, Z, R 2 , R 3 , R 4 , R 5 , and R 6 are described in the specification. Also disclosed are pharmaceutical compositions containing compounds of formula (I), and methods of treating conditions associated with the activity of p38 kinase and/or conditions associated with the activity of LIM kinase.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐及其溶剂化物可用作激酶抑制剂，其中：X 1，X 2和X 2中的两个， SUB> 3 是N，X 1，X 2和X 3中的剩余的一个是-CR _{1 ; R 1是氢或-CN; 和N，G，Z，R 2，R 3，R 4，R 5和R 5， SUB> 6 在说明书中描述。还公开了含有式（I）化合物的药物组合物，以及治疗与p38激酶活性相关的病症和/或与LIM激酶活性相关的病症的方法。}

6. 发明专利

AR112689A1 AGONISTAS DEL RECEPTOR TIPO TOLL 7 (TLR7) QUE TIENEN PORCIONES AROMÁTICAS LIGADAS AL HETEROÁTOMO, CONJUGADOS DE ESTOS Y MÉTODOS Y USOS DE ESTOS 未知
公开(公告)号：AR112689A1
公开(公告)日：2019-11-27
申请号：ARP180102341
申请日：2018-08-15
申请人： SQUIBB BRISTOL MYERS CO
发明人： SIVAPRAKASAM PRASANNA , POUDEL YAM B , GANGWAR SANJEEV , HE LIQI
IPC分类号： C07D473/18 , A61K31/52 , A61P31/14 , A61P37/04
摘要： Estos compuestos son agonistas del receptor tipo toll 7 (TLR7) y se pueden usar como adyuvantes para estimular el sistema inmunitario. Algunos de estos compuestos se pueden usar en conjugados para la administración dirigida a un órgano o tejido de la acción prevista. Reivindicación 1: Un compuesto caracterizado por la fórmula (1) ó (2), en donde R¹ es (C₁₋₅ alquil)O, (C₁₋₂ alquil)O(CH₂)₂₋₃O, (C₁₋₅ alquil)C(=O)O, (C₁₋₅ alquil)NH, (C₁₋₂ alquil)O(CH₂)₂₋₃NH o (C₁₋₅ alquil)C(=O)NH; R² es, independientemente de cada caso, H, C₁₋₃ alquilo, halo, O(C₁₋₃ alquilo), CN o NO₂; X es, independientemente de cada caso, CR² o N; R³ es O, S, NH o N(C₁₋₃ alquilo); Ar es un compuesto del grupo de fórmulas (3), en donde uno de Y, Y e Y se selecciona de -O-, -S-, -NH- y -N(C₁₋₃ alquil)-, y los otros dos de Y, Y e Y se seleccionan de =N- y =CR²-; R⁴ es H, C₁₋₃ alquilo, halo, O(C₁₋₃ alquilo), CN, NO₂ o (CH₂)ˣR⁵, en donde el subíndice x es 1, 2, 3 ó 4; y R⁵ es H, halo, OH, CN, NH₂, NH(C₁₋₅ alquilo), N(C₁₋₅ alquilo)₂, NH(C₃₋₆ cicloalquilo), NH(C₄₋₈ bicicloalquilo), NH(C₆₋₁₀ espirocicloalquilo), N(C₃₋₆ cicloalquilo)₂, NH(CH₂)₁₋₃(arilo), N((CH₂)₁₋₃(arilo))₂, una porción amina cíclica que tiene la estructura de fórmula (4), una porción aromática o heteroaromática de 6 miembros o una porción heteroaromática de 5 miembros; en donde una porción alquilo, cicloalquilo, bicicloalquilo, espirocicloalquilo, amina cíclica, aromática o heteroaromática de 6 miembros o heteroaromática de 5 miembros se sustituye opcionalmente con uno o más sustituyentes seleccionados de OH, halo, CN, (C₁₋₃ alquilo), O(C₁₋₃ alquilo), C(=O)(Me), SO₂(C₁₋₃ alquilo), C(=O)(Et), NH₂, NH(Me), N(Me)₂, NH(Et), N(Et)₂ y N(C₁₋₃ alquilo)₂; y una porción cicloalquilo, bicicloalquilo, espiroalquilo o amina cíclica puede tener un grupo CH₂ reemplazado por O, S, NH, N(C₁₋₃ alquilo) o N(Boc).

7. 发明专利

CA3073013A1 6-AMINO-7,9-DIHYDRO-8H-PURIN-8-ONE DERIVATIVES AS IMMUNOSTIMULANT TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS 未知
公开(公告)号：CA3073013A1
公开(公告)日：2019-02-21
申请号：CA3073013
申请日：2018-08-16
申请人： SQUIBB BRISTOL MYERS CO
发明人： HE LIQI , GANGWAR SANJEEV , POUDEL YAM B , SIVAPRAKASAM PRASANNA
IPC分类号： C07D473/18 , A61K31/522 , A61P37/04
摘要： Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

9. 发明专利

PE20150332A1 IMIDAZOTRIAZINCARBONITRILOS UTILES COMO INHIBIDORES DE CINASA 未知
公开(公告)号：PE20150332A1
公开(公告)日：2015-02-28
申请号：PE2015000038
申请日：2013-07-12
申请人： SQUIBB BRISTOL MYERS CO
发明人： PURANDARE ASHOK VINAYAK , FINK BRIAN E , JOHNSON WALTER LEWIS , HART AMY C , HE LIQI , HUYNH TRAM N , INGHRIM JENNIFER , MASTALERZ HAROLD , SANG XIAOPENG , TARBY CHRISTINE M , WAN HONGHE , VACCARO WAYNE , ZHANG GUIFEN , ZHAO YUFEN , ZIMMERMANN KURT , ZHANG YONG , CHEN LIBING , CHEN BIN , TOKARSKI JOHN S , GAVAL ASHVINIKUMAR V
IPC分类号： C07D487/04 , A61K31/53 , A61P17/08 , A61P19/02 , A61P35/00
摘要： La invencion se refiere a compuestos de la Formula (I), y sales de los mismos farmaceuticamente aceptables. Las imidazotriazinas de la Formula (I) inhiben la actividad de la proteina cinasa, lo cual las vuelve utiles como agentes anticancerigenos

10. 发明专利

PE03322015A1 IMIDAZOTRIAZINCARBONITRILOS UTILES COMO INHIBIDORES DE CINASA 未知
公开(公告)号：PE03322015A1
公开(公告)日：2015-02-28
申请号：PE0000382015
申请日：2013-07-12
申请人： SQUIBB BRISTOL MYERS CO
发明人： PURANDARE ASHOK VINAYAK , FINK BRIAN E , JOHNSON WALTER LEWIS , HART AMY C , HE LIQI , HUYNH TRAM N , INGHRIM JENNIFER , MASTALERZ HAROLD , SANG XIAOPENG , TARBY CHRISTINE M , WAN HONGHE , VACCARO WAYNE , ZHANG GUIFEN , ZHAO YUFEN , ZIMMERMANN KURT , ZHANG YONG , CHEN LIBING , CHEN BIN , TOKARSKI JOHN S , GAVAL ASHVINIKUMAR V
IPC分类号： C07D487/04 , A61K31/53 , A61P17/08 , A61P19/02 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/551 , A61K31/675 , A61K45/06 , C07D471/10 , C07D487/08 , C07D487/10 , C07D487/22 , C07D498/04 , C07D519/00 , C07F7/1804 , C07F9/65213 , C07F9/6561 , C07F9/65616
摘要： La invencion se refiere a compuestos de la Formula (I), y sales de los mismos farmaceuticamente aceptables. Las imidazotriazinas de la Formula (I) inhiben la actividad de la proteina cinasa, lo cual las vuelve utiles como agentes anticancerigenos

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