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1. 发明专利

IL260448A Spiroheptane salicylamides and related compounds as inhibitors of rock 未知
公开(公告)号：IL260448A
公开(公告)日：2020-09-30
申请号：IL26044818
申请日：2018-07-05
申请人： SQUIBB BRISTOL MYERS CO , SMITH II LEON M , LADZIATA VLADIMIR , DELUCCA INDAWATI , PINTO DONALD J P , ORWAT MICHAEL J , DILGER ANDREW K , PABBISETTY KUMAR BALASHANMUGA , YANG WU , SHAW SCOTT A , GLUNZ PETER W , PANDA MANORANJAN
发明人： DILGER ANDREW K , PABBISETTY KUMAR BALASHANMUGA , YANG WU , SHAW SCOTT A , SMITH II LEON M , LADZIATA VLADIMIR , DELUCCA INDAWATI , PINTO DONALD J P , ORWAT MICHAEL J , GLUNZ PETER W , PANDA MANORANJAN
IPC分类号： A61K31/437 , A61K31/4427
摘要： The present invention provides compounds of Formula (I):or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

2. 发明申请

WO2007050425A2 LXR MODULATORS 审中-公开
标题翻译： LXR调制器
公开(公告)号：WO2007050425A2
公开(公告)日：2007-05-03
申请号：PCT/US2006040882
申请日：2006-10-19
申请人： SQUIBB BRISTOL MYERS CO , CHAO HANNGUANG J , TUERDI HUJI , KICK ELLEN K , YANG WU
发明人： CHAO HANNGUANG J , TUERDI HUJI , KICK ELLEN K , YANG WU
CPC分类号： C07D417/06 , C07D279/16 , C07D281/10
摘要： A compound of formula I,wherein A, X, q, R 1 , R 2a , R 2b , R 2c , R 3a , and R 3b are defined herein.
摘要翻译：式I的化合物，其中A，X，q，R 1，R 2a，R 2b，R 2c， R 3a，R 3a和R 3b在本文中定义。

3. 发明申请

WO2004069793A3 NOVEL 2-SUBSTITUTED CYCLIC AMINES AS CALCIUM SENSING RECEPTOR MODULATORS 审中-公开
标题翻译：新型2-取代的循环胺作为钙感测受体调节剂
公开(公告)号：WO2004069793A3
公开(公告)日：2005-01-20
申请号：PCT/US2004002296
申请日：2004-01-27
申请人： SQUIBB BRISTOL MYERS CO , GAVAI ASHVINIKUMAR V , VAZ ROY J , DICKSON JOHN K JR , ROBERGE JACQUES Y , YANG WU , GUNGOR TIMUR , CORTE JAMES R , ROTELLA DAVID P , WANG YUFENG
发明人： GAVAI ASHVINIKUMAR V , VAZ ROY J , DICKSON JOHN K JR , ROBERGE JACQUES Y , YANG WU , GUNGOR TIMUR , CORTE JAMES R , ROTELLA DAVID P , WANG YUFENG
IPC分类号： A61K31/517 , C07D20060101 , C07D205/04 , C07D207/09 , C07D207/34 , C07D207/48 , C07D211/26 , C07D215/20 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/14
CPC分类号： C07D409/06 , C07D205/04 , C07D207/09 , C07D207/34 , C07D207/48 , C07D211/26 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/06 , C07D417/14
摘要： The present invention relates to modulators of the calcium sensing receptor having the formula I (I) wherein Ar , X, n, R , R , R , and Q are as defined herein.
摘要翻译：本发明涉及具有式I（I）的钙感应受体的调节剂，其中Ar 1，X，n，R 1，R 2，R 3和Q如本文所定义。

4. 发明申请

WO2004106295A3 SUBSTITUTED PIPERODINES AND PYRROLIDINES AS CALCIUM SENSING RECEPTOR MODULATORS AND METHOD 审中-公开
标题翻译：作为钙感测受体调节剂和方法的取代的哌嗪和吡咯烷
公开(公告)号：WO2004106295A3
公开(公告)日：2005-12-29
申请号：PCT/US2004016712
申请日：2004-05-27
申请人： SQUIBB BRISTOL MYERS CO , DICKSON JOHN K , LAWRENCE R MICHAEL , ROBERGE JACQUES Y , ROTELLA DAVID P , YANG WU
发明人： DICKSON JOHN K , LAWRENCE R MICHAEL , ROBERGE JACQUES Y , ROTELLA DAVID P , YANG WU
IPC分类号： A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/454 , A61K31/55 , C07D20060101 , C07D207/04 , C07D409/06
CPC分类号： C07D207/06 , C07D207/08 , C07D207/10 , C07D211/18 , C07D211/22 , C07D333/28
摘要： Compounds are provided which are antagonists of the calcium sensing receptor, and have the general formula (I) wherein m is 0, 1, 2, 3 or 4; each X is independently selected from the group consisting of hydrogen, halo, cyano, nitro, OCF3, hydroxy, amino, carboxyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, haloalkyl, alkoxy, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkylalkyl, R O, R R N, R OCO, R CO, R R NCO, R R NCONR , R OCONR , R CONR , R S, R SO, R SO2, R R NSO2, R R NSO2NR , and R SO2NR ; R is alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R and R are the same or different and are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; n is 1, 2, or 3; W is O or H,R ; R is hydrogen or hydroxyl; Ar is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; Q is hydrogen, F, or hydroxyl. In addition, a method for using these compounds to treat diseases associated with abnormal or mineral homeostasis is also provided.
摘要翻译：提供化合物，其是钙感应受体的拮抗剂，并具有通式（I），其中m为0,1,2,3或4; 每个X独立地选自氢，卤素，氰基，硝基，OCF 3，羟基，氨基，羧基，烷基，烯基，炔基，环烷基，环杂烷基，卤代烷基，烷氧基，烷氧基羰基烷基，羟基羰基烷基，芳基，芳基烷基，杂芳基，杂芳基烷基，环烷基烷基，R 1 O，R 1 R 2 N，R 1 OCO，R 1 CO，R 1 R 2 NCO，R 1 R 2， NCONR 2a，R 1 OCONR 2a，R 1 CONR 2a，R 1 S，R 1 SO，R 1 SO 2，R 1 R 2 NSO 2 R 1 R 2 NSO 2 NR 2a和R 1 SO 2 NR 2a; R 1是烷基，烯基，炔基，环烷基，环杂烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; R 2和R 2a相同或不同并且独立地选自氢，烷基，烯基，炔基，环烷基，环杂烷基，芳基，杂芳基，芳基烷基或杂芳基烷基; n为1,2或3; W是O或H，R 3; R 3是氢或羟基; Ar是取代或未取代的芳基或取代或未取代的杂芳基; Q是氢，F或羟基。此外，还提供了使用这些化合物治疗与异常或矿物质内稳态相关疾病的方法。

5. 发明申请

WO2004106296A3 TRISUBSTITUTED HETEROAROMATIC COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS 审中-公开
标题翻译：作为钙感测受体调节剂的三唑酮异构化合物
公开(公告)号：WO2004106296A3
公开(公告)日：2005-12-22
申请号：PCT/US2004016713
申请日：2004-05-27
申请人： SQUIBB BRISTOL MYERS CO , YANG WU , DICKSON JOHN K , COOPER CHRISTOPHER B , DODD DHARMPAL S , RUAN ZHEMING , SCHNUR DORA M
发明人： YANG WU , DICKSON JOHN K , COOPER CHRISTOPHER B , DODD DHARMPAL S , RUAN ZHEMING , SCHNUR DORA M
IPC分类号： A61K31/4418 , A61K31/444 , A61K31/505 , A61K31/506 , C07D20060101 , C07D213/36 , C07D239/42 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14
CPC分类号： C07D239/42 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14
摘要： Trisubstituted heteroaromatic compounds having the structure Formula (I) are provided, wherein X is C or N; A and B are each independently CH or N, with the proviso that A and B cannot both be CH; R is Ar-L-; R is hydrogen or alkyl; or R and R can be joined together to form a 4- to 7-membered cycloheteroalkyl ring; R to R , Ar and L are as defined herein. A method for using these compounds to treat diseases associated with abnormal bone or mineral homeostasis is also provided.
摘要翻译：提供具有结构式（I）的三取代杂芳族化合物，其中X是C或N; A和B各自独立地为CH或N，条件是A和B不能都是CH; R 1是Ar-L-; R 2是氢或烷基; 或R 1和R 2可以连接在一起形成4-至7-元环杂烷基环; R 3至R 8中，Ar和L如本文所定义。还提供了使用这些化合物治疗与异常骨或矿物质内稳态相关疾病的方法。

6. 发明申请

WO2007062314A3 HETEROCYCLIC CETP INHIBITORS 审中-公开
标题翻译：杂环类CETP抑制剂
公开(公告)号：WO2007062314A3
公开(公告)日：2007-11-22
申请号：PCT/US2006060978
申请日：2006-11-16
申请人： SQUIBB BRISTOL MYERS CO , SALVATI MARK E , FINLAY HEATHER , HARIKRISHNAN LALGUDI S , JIANG JI , JOHNSON JAMES A , KAMAU MUTHONI G , LAWRENCE R MICHAEL , MILLER MICHAEL M , QIAO JENNIFER X , WANG TAMMY C , WANG YUFENG , YANG WU
发明人： SALVATI MARK E , FINLAY HEATHER , HARIKRISHNAN LALGUDI S , JIANG JI , JOHNSON JAMES A , KAMAU MUTHONI G , LAWRENCE R MICHAEL , MILLER MICHAEL M , QIAO JENNIFER X , WANG TAMMY C , WANG YUFENG , YANG WU
IPC分类号： C07D213/40 , A61K31/435 , A61P3/00 , A61P9/00 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/06 , C07D417/12
CPC分类号： C07D417/06 , C07D213/40 , C07D213/61 , C07D277/28 , C07D401/04 , C07D401/12 , C07D405/06 , C07D405/12 , C07D417/12
摘要： Compounds of formula Ia and Ib wherein A, B, C and R 1 are described herein.
摘要翻译：其中A，B，C和R 1'的式Ia和Ib化合物在本文中描述。

8. 发明专利

IL263499D0 Biarylmethyl heterocycles 未知
公开(公告)号：IL263499D0
公开(公告)日：2019-01-31
申请号：IL26349918
申请日：2018-12-04
申请人： SQUIBB BRISTOL MYERS CO , UNIV MONTREAL , YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
发明人： YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
IPC分类号： C07D20060101
摘要： wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

9. 发明专利

IL263499B Biarylmethyl heterocycles 未知
公开(公告)号：IL263499B
公开(公告)日：2022-04-01
申请号：IL26349918
申请日：2018-12-04
申请人： UNIV MONTREAL , SQUIBB BRISTOL MYERS CO , YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
发明人： YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
摘要： The present invention provides compounds of Formula (I):wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

10. 发明专利

IL263499A Biarylmethyl heterocycles 未知
公开(公告)号：IL263499A
公开(公告)日：2022-04-01
申请号：IL26349918
申请日：2018-12-04
申请人： UNIV MONTREAL , SQUIBB BRISTOL MYERS CO , YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
发明人： YANG WU , JIANG WEN , ZHANG XIAOJUN , RICHTER JEREMY , PRIESTLEY ELDON SCOTT , REZNIK SAMUEL KAYE , RUEDIGER EDWARD H , GILLARD JAMES R , HALPERN OZ SCOTT , RUEL REJEAN , TRIPATHY SASMITA
摘要： wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or β-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

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