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1. 发明申请

WO2009018065A2 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 审中-公开
标题翻译：新型葡糖激酶激活剂及其使用方法
公开(公告)号：WO2009018065A2
公开(公告)日：2009-02-05
申请号：PCT/US2008070962
申请日：2008-07-24
申请人： SQUIBB BRISTOL MYERS CO , SHI YAN , CHENG PETER T W , WANG YING , RYONO DENIS E
发明人： SHI YAN , CHENG PETER T W , WANG YING , RYONO DENIS E
IPC分类号： C07D213/81 , A61K31/4164 , A61K31/4196 , A61K31/426 , A61P3/00 , C07C237/22 , C07D231/14 , C07D233/90 , C07D241/24 , C07D249/10 , C07D277/56 , C07D277/68 , C07D471/04 , C07D513/04
CPC分类号： C07D277/56 , C07C317/22 , C07D213/81 , C07D231/14 , C07D233/90 , C07D241/24 , C07D249/10 , C07D277/68 , C07D471/04 , C07D513/04
摘要： Compounds are provided which are activators of the enzyme glucokinase and thus are useful in treating diabetes and related diseases, which compounds have the structure Formula: (I); where Q is Formula: (II); or Formula: (III); and R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了作为酶葡糖激酶活化剂的化合物，因此可用于治疗糖尿病和相关疾病，所述化合物具有结构式：（I）; 其中Q是式（II）; 或式（III）; 且R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

2. 发明申请

WO2008006043A2 SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTI-ATHEROSCLEROTIC, ANTI-DYSLIPIDEMIC, ANTI-DIABETIC AND ANTI-OBESITY AGENTS AND METHOD 审中-公开
标题翻译：取代的酸衍生物有助于抗甲状腺激素，抗血糖，抗糖尿病和抗胆碱药物和方法
公开(公告)号：WO2008006043A2
公开(公告)日：2008-01-10
申请号：PCT/US2007072891
申请日：2007-07-06
申请人： SQUIBB BRISTOL MYERS CO , TINO JOSEPH A , CHENG PETER T W , SHI YAN , LI JUN , MUKHERJEE RANJAN
发明人： TINO JOSEPH A , CHENG PETER T W , SHI YAN , LI JUN , MUKHERJEE RANJAN
IPC分类号： C07D263/32 , A61K31/421 , A61P3/00
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R1 is halogen; and X is hydrogen or halogen, and salts thereof, which compounds are useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic, and anti-obesity agents.
摘要翻译：提供具有式（I）结构的化合物：其中R1是卤素; X是氢或卤素，及其盐，该化合物可用作抗动脉粥样硬化，抗血脂异常，抗糖尿病和抗肥胖剂。

3. 发明申请

WO2008005964A3 PHOSPHONATE AND PHOSPHINATE COMPOUNDS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译：磷酸酯和磷酸酯化合物作为GLUCOKINASE激活剂
公开(公告)号：WO2008005964A3
公开(公告)日：2008-03-06
申请号：PCT/US2007072708
申请日：2007-07-03
申请人： SQUIBB BRISTOL MYERS CO , RYONO DENNIS E , CHENG PETER T W , BOLTON SCOTT A , CHEN SEAN S , SHI YAN , MENG WEI , TINO JOSEPH A , ZHANG HAO , SULSKY RICHARD B
发明人： RYONO DENNIS E , CHENG PETER T W , BOLTON SCOTT A , CHEN SEAN S , SHI YAN , MENG WEI , TINO JOSEPH A , ZHANG HAO , SULSKY RICHARD B
IPC分类号： C07F9/32 , A61K31/675 , A61P3/00 , C07F9/40
CPC分类号： C07F9/6539 , C07F9/582 , C07F9/587 , C07F9/65032 , C07F9/650964 , C07F9/650982 , C07F9/65181
摘要： Compounds are provided which are phosphonate and phosphinate activators and thus are useful in treating diabetes and related diseases and have the structure of Formula (I), wherein Formula (II) is a heteroaryl ring; R 4 is -(CH 2 ) n -Z-(CH 2 ) m -PO(OR 7 )(OR 8 ), -(CH 2 ) n Z-(CH 2 ) m -PO(OR 7 )R 9 , -(CH 2 ) n -Z-(CH 2 ) m -OPO(OR 7 )R 9 , -(CH 2 ) n Z-(CH 2 ) m -OPO(R 9 )(R 10 ), or -(CH 2 ) n Z-(CH 2 ) m -PO(R 9 )(R 10 ); R 5 and R 6 are independently selected from H, alkyl and halogen; Y is R 7 (CH 2 ) s or is absent; and X, n, Z, m, R 4 , R 5 , R 6 , R 7 , and s are as defined herein; or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供了膦酸酯和次膦酸酯活化剂的化合物，因此可用于治疗糖尿病和相关疾病，并具有式（I）的结构，其中式（II）是杂芳基环; R 4是 - （CH 2 CH 2）n - （Z）（CH 2）n - （OR 7）（OR 8）， - （CH 2 CH 2）n - Z - （ CH 2 OR 2（OR 7）R 9， - （CH 2 CH 2） SUB>）_{名词 -Z-（CH _{2 ）_{米 -OPO（OR _{7 ）R _{9 - （CH 2）n - Z - （CH 2）2 - （O） - （CH 2）n - （R 10），或 - （CH 2）n - Z - （CH 2） 2 ）_{米 -PO（R _{9 ）（R _{10 ）; R 5和R 6独立地选自H，烷基和卤素; Y是R 7（CH 2）2，或不存在; 和X，n，Z，m，R 4，R 5，R 6，R 7，和 s如本文所定义; 或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。}}}}}}}}

4. 发明申请

WO2008006044A3 SUBSTITUTED ACID DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：替代的酸衍生物作为抗真菌剂和抗菌药物和方法有用
公开(公告)号：WO2008006044A3
公开(公告)日：2008-04-10
申请号：PCT/US2007072897
申请日：2007-07-06
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , QIAN XINHUA , DESHPANDE RAJENDRA P , TANG ERQING
发明人： CHENG PETER T W , CHEN SEAN , QIAN XINHUA , DESHPANDE RAJENDRA P , TANG ERQING
IPC分类号： C07D263/32 , A61K31/421
CPC分类号： C07D263/32
摘要： Compounds are provided which have the structure of Formula (I): wherein R is hydrogen or C1-C4 alkyl; and each of R1 and R2 is independently hydrogen, C1-C4 alkyl, halo or C1-C4 alkoxy, and salts thereof, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.
摘要翻译：提供具有式（I）结构的化合物：其中R是氢或C 1 -C 4烷基; 并且R 1和R 2各自独立地为氢，C 1 -C 4烷基，卤素或C 1 -C 4烷氧基及其盐，所述化合物可用作抗糖尿病，降血脂药和抗肥胖剂。

5. 发明申请

WO2008005914A3 NOVEL GLUCOKINASE ACTIVATORS AND METHODS OF USING SAME 审中-公开
标题翻译：新型GLUCOKINASE激活剂及其使用方法
公开(公告)号：WO2008005914A3
公开(公告)日：2009-04-02
申请号：PCT/US2007072633
申请日：2007-07-02
申请人： SQUIBB BRISTOL MYERS CO , CHEN SEAN , CHENG PETER T W , SMIRK REBECCA A
发明人： CHEN SEAN , CHENG PETER T W , SMIRK REBECCA A
IPC分类号： C07D277/46 , A61K31/426 , A61K31/427 , A61K31/4427 , A61K31/506 , A61P3/10 , C07D417/12 , C07D417/14
CPC分类号： C07D417/14 , C07D277/46 , C07D417/12
摘要： Compounds are provided which axe gl?cokinasß activators and thus are useful in treating diabetes and related diseases and have the structure Formula (I), wherein in the ring represents one or two double bonds; R1 is aryl or heteroaryl; R2 is cycloalkyl, heterocyclyl, aryl, or heteroaryl; R5 is as defined herein; Z is O, S, S(O), S(O)2, or NR5a; X is S, O, N, NR3, or CR3; Y is NCR4 or NR4; R3, R4, and R5 are as defined herein; ' R8 is aryl or heteroaryl; R6 and R7 are independently H, halogen, or alkyl; m is 0 or 1; and n is 0 to 3, or a pharmaceutically acceptable salt thereof. A method for treating diabetes and related diseases employing the above compounds is also provided.
摘要翻译：提供化合物，其可用于治疗糖尿病和相关疾病，并具有结构式（I），其中环表示一个或两个双键; R1是芳基或杂芳基; R 2是环烷基，杂环基，芳基或杂芳基; R5如本文所定义; Z是O，S，S（O），S（O）2或NR5a; X是S，O，N，NR 3或CR 3; Y是NCR4或NR4; R3，R4和R5如本文所定义; R8是芳基或杂芳基; R6和R7独立地是H，卤素或烷基; m为0或1; 和n为0至3，或其药学上可接受的盐。还提供了使用上述化合物治疗糖尿病和相关疾病的方法。

6. 发明申请

WO2004004665A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：用作抗糖尿病药和抗衰老药的取代的杂环衍生物和方法
公开(公告)号：WO2004004665A2
公开(公告)日：2004-01-15
申请号：PCT/US0322149
申请日：2003-07-02
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
发明人： CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
IPC分类号： A61K31/155 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/397 , A61K31/401 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/06 , C07D403/08 , C07D403/10 , C07D403/14 , C07D413/12 , C07D413/14 , A61K
CPC分类号： C07D413/12 , C07D413/14
摘要： Formula, wherein Z is (CH2)q or C=O; Z is (CH2)p or C=O; D is -CH= or C=O or (CH2)m where m is 0, 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2; q = 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x , where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C. R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino, substituted amino or cyano; and R , E, Z and Y are as defined herein.
摘要翻译：式，其中Z 1是（CH 2）q或C = O; Z 2是（CH 2）p或C = O; D是-CH =或C = O或（CH 2）m，其中m是0,1,2或3; n = 0,1或2; p = 1或2; q = 0,1或2; Q是C或N; A是（CH 2）x，其中x是1至5，或A是（CH 2）x 1，其中x 1是1至5且链中任何位置嵌入烯基键或炔基键，或A是 - （CH 2）x 2 -O-（CH 2）x 3 - 其中x 2为0至5且x 3为0至5，条件是x 2和x中的至少一个 <3>不是0; B是键或是（CH 2）x 4，其中x 4是1至5; X是CH或N; X2是C，N，O或S; X3是C，N，O或S; X4是C，N，O或S; X5是C，N，O或S; X6是C，N，O或S; 条件是X2，X3，X4，X5和X6中的至少一个是N; 并且X 2，X 3，X 4，X 5和X 6中的至少一个是C.R 1是H或烷基; R 2是H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; R 2a，R 2b和R 2c可以相同或不同，并且选自H，烷基，烷氧基，卤素，氨基，取代的氨基或氰基; 并且R 3，E，Z和Y如本文所定义。

7. 发明申请

WO2004004655A2 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译：作为抗真菌剂和抗菌剂和方法有用的取代的杂环衍生物
公开(公告)号：WO2004004655A2
公开(公告)日：2004-01-15
申请号：PCT/US0321331
申请日：2003-07-08
申请人： SQUIBB BRISTOL MYERS CO , CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
发明人： CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
IPC分类号： A61K31/41 , A61K31/42 , A61K31/435 , A61K31/50 , A61K31/52 , C07D233/54 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12 , A61K
CPC分类号： C07D233/64 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12
摘要： Compounds are provided which are useful as antidiabetic agents and antiobesity agents and have the structure (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; Q is C or N; A is (CH2)x where x is 1 to 5, or A is (CH2)x1 where x is 1 to 5 with an alkenyl bond or an alkynyl bond embedded anywhere in the chain, or A is -(CH2)x -O-(CH2)x - where x is 0 to 5 and x is 0 to 5, provided that at least one of x and x is other than 0; B is a bond or is (CH2)x where x is 1 to 5; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4, X5 and X6 is C, and specifically excluding the structure (II) where X2 = N, X3 = C, X4 = O or S, Z = o or a bond; R is H or alkyl; R is H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; R , R and R may be the same or different and are selected from H, alkyl, alkoxy, halogen, amino or substituted amino or cyano; and R and Y are as defined herein, which compounds are useful in treating diabetes and obesity.
摘要翻译：提供可用作抗糖尿病药和抗肥胖剂的化合物，并具有其中m为0,1或2的结构（I）; n为0,1或2; Q是C或N; A是（CH 2）x，其中x是1至5，或A是（CH 2）x1，其中x 1是1至5，链烯基或炔基键嵌入链中的任何位置，或A是 - （CH 2） x 2 -O-（CH 2）x 3 - 其中x 2为0至5且x 3为0至5，条件是x 2和x 3中的至少一个为 0以外; B是键或是（CH 2）x 4，其中x 4是1至5; X是CH或N; X2是C，N，O或S; X3为C，N，O或S; X4为C，N，O或S; X5为C，N，O或S; X6为C，N，O或S; 条件是X 2，X 3，X 4 X 5和X 6中的至少一个为N; X2，X3，X4，X5和X6中的至少一个为C，并且具体排除其中X2 = N，X3 = C，X4 = O或S，Z = o或键的结构（II） R 1是H或烷基; R 2是H，烷基，烷氧基，卤素，氨基或取代的氨基或氰基; R 2a，R 2b和R 2c可以相同或不同，并且选自H，烷基，烷氧基，卤素，氨基或取代的氨基或氰基; R 3和Y如本文所定义，该化合物可用于治疗糖尿病和肥胖症。

8. 发明申请

WO2014159794A3 BICYCLO [2.2.1] ACID GPR120 MODULATORS 审中-公开
标题翻译： BICYCLO [2.2.1]酸GPR120调节剂
公开(公告)号：WO2014159794A3
公开(公告)日：2014-12-11
申请号：PCT/US2014025153
申请日：2014-03-13
申请人： SQUIBB BRISTOL MYERS CO
发明人： SHI YAN , CHENG PETER T W , WANG YING , WU SHUNG C , HAO ZHANG
IPC分类号： C07C59/86
CPC分类号： C07C59/13 , A61K31/192 , A61K31/343 , A61K31/381 , A61K31/397 , A61K31/415 , A61K31/4245 , A61K31/505 , A61K45/06 , C07C43/192 , C07C43/196 , C07C47/277 , C07C59/215 , C07C59/72 , C07C62/34 , C07C69/675 , C07C69/708 , C07C69/732 , C07C69/734 , C07C69/736 , C07C69/757 , C07C69/76 , C07C205/34 , C07C235/26 , C07C237/22 , C07C311/51 , C07C323/19 , C07C2601/02 , C07C2602/08 , C07C2602/42 , C07D205/04 , C07D231/12 , C07D239/38 , C07D271/06 , C07D307/79 , C07D333/16 , C07D333/28 , C07D333/56
摘要： The present invention provides compounds of Formula (I): (I) or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.
摘要翻译：本发明提供式（I）化合物或其立体异构体或药学上可接受的盐，其中所有变量如本文所定义。这些化合物是可以用作药物的GPR120G蛋白偶联受体调节剂。

9. 发明公开

EP1656368A4 SUBSTITUTED HERTOCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 审中-公开
标题翻译： AS抗糖尿病和手段对抗肥胖合适的取代的杂环衍生物方法
公开(公告)号：EP1656368A4
公开(公告)日：2009-08-26
申请号：EP03763485
申请日：2003-07-02
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHENG PETER T W , CHEN SEAN , DEVASTHALE PRATIK , DING CHARLES Z , HERPIN TIMOTHY F , WU SHUNG , ZHANG HAO , WANG WEI , YE XIANG-YANG
IPC分类号： C07D403/06 , A61K31/155 , A61K31/216 , A61K31/22 , A61K31/365 , A61K31/366 , A61K31/397 , A61K31/401 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/616 , A61K31/64 , A61K38/28 , A61K45/00 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/10 , A61P17/06 , A61P19/10 , A61P29/00 , A61P35/00 , A61P43/00 , C07D403/08 , C07D403/10 , C07D403/14 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12 , C07D413/14

10. 发明公开

EP1531810A4 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD 有权
标题翻译：取代的杂环衍生物作为预防糖尿病剂和肥胖程序
公开(公告)号：EP1531810A4
公开(公告)日：2008-05-28
申请号：EP03763345
申请日：2003-07-08
申请人： SQUIBB BRISTOL MYERS CO
发明人： CHENG PETER T W , CHEN SEAN , DING CHARLES Z , HERPIN TIMOTHY F
IPC分类号： A61K31/41 , A61K31/42 , A61K31/435 , A61K31/50 , A61K31/52 , C07D233/54 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12
CPC分类号： C07D233/64 , C07D249/06 , C07D263/32 , C07D271/06 , C07D413/12

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