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1. 发明专利

DE69519126T2 未知
公开(公告)号：DE69519126T2
公开(公告)日：2001-03-01
申请号：DE69519126
申请日：1995-05-16
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SHIOTA MAKOTO , HANAGATA GORO , TATSUMI KIYOSHI
IPC分类号： C07H1/08 , C07B63/00 , C07G3/00 , C07H15/12
摘要： The present invention relates to glycophospholipids represented by the general formula [I]: The glycophospholipid of the present invention can be obtained by extracting lipid fraction of whey, butter milk, etc. with a mixed solvent of chloroform/methanol and purifying by silica gel chromatography. The glycophospholipid of the present invention is that having a novel structure and existing in milk lipid, and utilized as a biochemical reagent, a starting material for medicine and foodstuff or a surfactant.

2. 发明专利

JPH08238096A PRODUCTION OF SPHINGO GLYCOLIPID 失效
公开(公告)号：JPH08238096A
公开(公告)日：1996-09-17
申请号：JP7076295
申请日：1995-03-03
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SUGURI TOSHIAKI , YANAGIDAIRA SHUICHI , HANAGATA GORO , TATSUMI KIYOSHI
IPC分类号： C12P19/14 , C12P19/44
摘要： PURPOSE: To readily and inexpensively obtain a highly purified sphingo glycolipid for a raw material of a medicine and a reagent, etc., by acting glycosidase to an oligosaccharide higher than a disaccharide or a glycoside and a ceramide and a sugar residue is bonded with the ceramide by a sugar- transfer reaction. CONSTITUTION: An oligosaccharide higher than a disaccharide (e.g. cellobiose) or a glycoside and a ceramide are suspended in a 0.1M acetic acid buffer solution (pH 5.0) containing taurodeoxycholic acid, a glycosidase (e.g. β-glycosidase) is added to the suspension and reacted for 2hr to bind a sugar residue with the ceramide by a sugar-transfer reaction to generate the objective sphingo glycolipid, the reacted solution is subjected to ODS (octadecylsilane) column chromatography and an unreacted substance, a decomposition product and a taurodeoxycholic acid, etc., are removed, and further the resultant solution is purified by subjecting to silica gel column chromatography to readily and inexpensively obtain the objective highly purified sphingo glycolipid useful for a raw material of a medicine and a reagent, etc.

3. 发明专利

JPS63269992A CONCENTRATION PREPARATION OF MILK GANGLIOSIDE 失效
公开(公告)号：JPS63269992A
公开(公告)日：1988-11-08
申请号：JP10311487
申请日：1987-04-28
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , HANAGATA GORO , SHUKKE SAKANORI
IPC分类号： A23C9/142 , A23C9/12 , C07H1/08 , C07H15/04 , C07H15/10 , C12P19/00 , C12P19/26
摘要： PURPOSE:To produce concentrated ganglioside in high efficiency at a low cost, by treating a milky substance containing milk ganglioside with a proteinase. CONSTITUTION:A milky substance containing milk ganglioside (e.g. milk, butter milk or whey) is treated with a proteinase to decompose the proteins. The obtained solution of decomposed protein is treated by ultrafiltration, gel-filtration or dialysis, etc., to obtain concentrated ganglioside.

4. 发明专利

JPH1072355A ADSORPTION INHIBITOR FOR INFLUENZA VIRUS 失效
公开(公告)号：JPH1072355A
公开(公告)日：1998-03-17
申请号：JP24709696
申请日：1996-08-29
申请人： SNOW BRAND MILK PROD CO LTD , SUZUKI YASUO , SUZUKI TAKASHI
发明人： SUZUKI YASUO , SUZUKI TAKASHI , HANAGATA GORO , ODA HIROSHI , TATSUMI KIYOSHI
IPC分类号： C07H15/04 , A61K31/70 , A61K31/7028 , A61P31/12 , A61P43/00
摘要： PROBLEM TO BE SOLVED: To obtain an influenza virus adsorption inhibitor containing a sulfatide of sialoglyco chain-free sulfated glycolipid different from the ganglioside (Gdla of the like) which is known to have the function as influenza virus receptor. SOLUTION: This influenza virus adsorption inhibitor contains a sulfatide as an active ingredient, and is administered orally or parenterally to inhibit the ansorption of influenza virus to tissues and can prevent the infection with influenza virus. The preferable dose is orally about 0.1-1g and intravenously about 10-100mg.

5. 发明专利

JPH05328989A PRODUCTION OF 9-O-ACETYLATED SIALIC ACID BOND COMPOUND 失效
公开(公告)号：JPH05328989A
公开(公告)日：1993-12-14
申请号：JP16221292
申请日：1992-05-28
申请人： SNOW BRAND MILK PROD CO LTD
发明人： MORITA MINORU , YANAGIDAIRA SHUICHI , HANAGATA GORO , MURAKAMI MOTOTAKE , SHUKKE SAKANORI
IPC分类号： C12P19/26
摘要： PURPOSE:To product 9-O-acetylated sialic acid bond compounds with industrial advantage. CONSTITUTION:Lipase is allowed to act on a sialic acid bond compound in the presence of an acetyl group donor to effect acetyl group rearrangement reaction to give 9-O-acetylated sialic acid bond compound. This process enables a large scale production of 9-O-acetylated sialic acid bond compound such as 9-O-acetyl GD3 with industrial advantage. The product is utilized in the fields of medicine, pharmacy and biochemistry as a reagent or the like.

6. 发明专利

JPH0499494A PRODUCTION OF SPHINGOGLYCOLIPID 失效
公开(公告)号：JPH0499494A
公开(公告)日：1992-03-31
申请号：JP21411690
申请日：1990-08-13
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SUGURI TOSHIAKI , YAKABE TAKASHI , MORITA MINORU , KOBAYASHI TOMOKO , HANAGATA GORO
IPC分类号： C12P19/44 , C07H15/10
摘要： PURPOSE:To obtain the subject lipid having biochemical importance with a relatively simple operation in high purity scarcely producing reaction by-products by carrying out the enzymatic reaction of an oligosaccharide with a ceramide using a specific enzyme. CONSTITUTION:The objective lipid is produced by the enzymatic reaction of (A) an oligosaccharide with (B) a ceramide in the presence of (C) an enzyme capable of cutting a glycoside bond between the sugar chain of a glycolipid (glycosphingolipid) and a ceramide to isolate an oligosaccharide. Preferably, the component A is sialyl lactose, the component B is a ceramide originated from bovine brain and the component C is an enzyme originated from a microbial strain belonging to e.g. genus Rhodococcus.

7. 发明专利

JPH0967389A PRODUCTION OF LIPID CONTAINING SACCHARIDE 失效
公开(公告)号：JPH0967389A
公开(公告)日：1997-03-11
申请号：JP24530595
申请日：1995-08-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SHIODA MAKOTO , WATANABE KEIKO , HANAGATA GORO , TATSUMI KIYOSHI
IPC分类号： C07H1/02 , C07H15/04
摘要： PROBLEM TO BE SOLVED: To produce a lipid, capable of readily providing a lipid containing saccharides in an aqueous system and useful as a raw material for medicines, foods and drinks, a surfactant or a biochemical reagent. SOLUTION: A solution prepared by mixing a glucide with a lipid is heated to produce a lipid containing the glucide. A reducing sugar such as maltose or galactose is used as the glucide and a lipid containing a primary amine such as a lysosphingomyelin or phosphatidylethanolamine is used as the lipid. The thermal reaction of aqueous solutions of both is carried out at pH 4.5-7.5 and 90-100 deg.C for several hr in the presence of an emulsifying agent and the lipid containing the saccharide is extracted from the reactional solution. The resultant extract is then concentrated and dried to afford the product.

8. 发明专利

JPH0899987A PRODUCTION OF GANGLIOSIDE 失效
公开(公告)号：JPH0899987A
公开(公告)日：1996-04-16
申请号：JP26196694
申请日：1994-09-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： HANAGATA GORO , MIURA SUSUMU , TATSUMI KIYOSHI
IPC分类号： C07H1/00 , C07H15/04 , C07H15/10
摘要： PURPOSE: To obtain the subject compound useful as a material, etc., for medicines, cosmetics, foods and drinks and feeds, etc., without carrying out the neutralizing or desalting by heat-treating a ganglioside GD3 in a neutral region, then converting the ganglioside GD3 in a raw material containing a lipid into a ganglioside GM3 . CONSTITUTION: A cream containing >=10wt.% lipid based on the solid or a raw material derived from the cream is heat-treated in a neutral region of pH 6-8 at a reactional temperature within the range of 60-140 deg.C to convert a ganglioside GD3 in the raw material into a ganglioside GM3 . The resultant reactional solution is then evaporated to dryness under a reduced pressure and the prepared white powder is treated by an anion exchange chromatography and subsequently by a silica gel chromatography to recover the reactional product. Thereby, the objective ganglioside GM3 which is a receptor for influenza or Newcastle disease virus, having inhibiting actions on proliferation of keratinocytes, suppressing actions on the angiogenesis and differentiating actions on leukocytes and useful as a material for medicines, cosmetics, foods and drinks and feeds, etc., is obtained on an industrial scale.

9. 发明专利

JPH0834793A GLYCOPHOSPHOLIPID AND ITS PREPARATION 失效
公开(公告)号：JPH0834793A
公开(公告)日：1996-02-06
申请号：JP15548494
申请日：1994-06-15
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SHIODA MAKOTO , HANAGATA GORO , TATSUMI KIYOSHI
IPC分类号： C07H1/08 , C07B63/00 , C07G3/00 , C07H15/12
摘要： PURPOSE:To obtain a new glycophospholipid useful as e.g. a biochemical reagent, raw material for medicines or foods, surfactant, by extracting the lipid fraction of cow milk or a dairy product with an organic solvent, etc., followed by purifying the fraction through a silica gel chromatography. CONSTITUTION:This new glycophospholipid of the formula (R1 and R2 are each an aliphatic hydrocarbon; A is an N-glycoside-bound saccharide) useful as e.g. a biochemical reagent, raw material for medicines or foods, and as a surfactant, is obtained by extracting the lipid fraction of cow milk or a dairy product with a chloroform-methanol-(water) mixed liquid followed by purifying the extract-contg. liquid by acetone washing and silica gel chromatography. This glycophospholipid has the following characteristics: decomposable by phospholipase C; manifesting color reaction of phospholipid by Dittmer-Lester test; liberating the saccharide by beta-galactosidase; manifesting saccharide color reaction by orcinol sulfate or a diphenylamine-aniline reagent; developing color by a ninhydrin reagent; and containing in one molecule galactose, ethanolamine, glycerol, phosphate group and a 12-20C fatty acid.

10. 发明专利

JPH02250834A THERAPEUTIC AGENT FOR DEMYELINATING DISEASES 失效
公开(公告)号：JPH02250834A
公开(公告)日：1990-10-08
申请号：JP7246689
申请日：1989-03-24
申请人： SNOW BRAND MILK PROD CO LTD
发明人： WASHIDA NAOHIRO , FUJI KENTARO , YOSHIDA NORIKO , YANAGIDAIRA SHUICHI , HANAGATA GORO , KOBAYASHI TOMOKO
IPC分类号： A61K31/715 , A61P25/00
摘要： PURPOSE:To obtain a therapeutic agent for demyelinating diseases of high safety with no side effect by using lactosyl ceramide as an active ingredient. CONSTITUTION:A compound of the formula (R1 is an aliphatic group which has 9 to 22 carbon atoms in its straight chain moiety and may have one or more double bonds and/or side-chain methyl and/or hydroxyl; R2 is an acyl group derived from a fatty acid which has an alkyl group of 12 to 30 carbon atoms, saturated or having 1 or more unsaturated bonds and/or hydroxyl groups, occurring in animal tissue such as bovine spleen or human tumors or cow milk. The compound is obtained by extraction from milk or chemical synthesis and the effective dose is 0.1 to 4mg/kg/day in injection or oral administration.

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