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1. 发明专利

JP2002275072A LIPID METABOLISM AMELIORANT 失效
公开(公告)号：JP2002275072A
公开(公告)日：2002-09-25
申请号：JP2001080810
申请日：2001-03-21
申请人： SNOW BRAND MILK PROD CO LTD
发明人： TOBA YASUHIRO , IKEUCHI YOSHIHIRO , SUNAKAWA TADAHIRO , TANAKA MIYAKO , YANAGIDAIRA SHUICHI , KAWAKAMI HIROSHI
IPC分类号： A23L2/38 , A23L1/30 , A23L2/52 , A61K31/7028 , A61K31/7032 , A61P1/16 , A61P3/04 , A61P3/06 , A61P9/10 , C07H15/04
摘要： PROBLEM TO BE SOLVED: To obtain an orally ingestible lipid metabolism ameliorant having effects with a relatively small amount without any problem in flavor or preservation stability. SOLUTION: This lipid metabolism ameliorant or food and drink for ameliorating the lipid metabolism comprises a neutral sphingoglycolipid such as lactosylceramide or glucosylceramide as an active ingredient.

2. 发明专利

JP2000279091A OIL AND FAT-CONTAINING FOOD 失效
公开(公告)号：JP2000279091A
公开(公告)日：2000-10-10
申请号：JP9301599
申请日：1999-03-31
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IKEUCHI YOSHIHIRO , SASAKI ATSUSHI , SHIOTANI TOSHIAKI , YANAGIDAIRA SHUICHI
IPC分类号： A23L3/3562 , A23D7/06 , A23L27/60 , A23L29/20 , A23L1/05
摘要： PROBLEM TO BE SOLVED: To obtain an oil and fat-containing food having controlled deterioration of oils and fats. SOLUTION: This oil and fat-containing comprises a low-molecular weight xanthan gum which has 100,000-960,000 molecular weight and >=3% pyruvic acid of intramolecular side chain so as to control the deterioration of oils and fats.

3. 发明专利

JPH1029945A ENTERIC METABOLISM-IMPROVING AGENT 失效
公开(公告)号：JPH1029945A
公开(公告)日：1998-02-03
申请号：JP20653796
申请日：1996-07-17
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , IKEUCHI YOSHIHIRO , YABE KYOKO , TOMIZAWA AKIRA , ISHIKAWA HIDETOSHI
IPC分类号： A23C9/123 , A23L1/30 , A61K31/70 , A61K31/7012 , A61P1/12 , C07H7/027
摘要： PROBLEM TO BE SOLVED: To obtain a medicine and a food or beverage capable of improving enteric metabolism by lowering pH in the intestine. SOLUTION: This enteric metabolism-improving agent or this food or beverage contains sialyllactose or its salt as an active ingredient and lowers pH in intestine. It can be expected to enhance an organic acid amount in the intestines, lower pH and promote intestine-control action and decrease enteric bacterium producing carcinogen and prevent occurrence of cancer by orally administering the enteric metabolism-improving agent.

4. 发明专利

JPH09301874A IMPROVING AGENT FOR CEREBRAL FUNCTION 失效
公开(公告)号：JPH09301874A
公开(公告)日：1997-11-25
申请号：JP14678696
申请日：1996-05-16
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , YABE KYOKO , MORITA MINORU
IPC分类号： A23L1/30 , A61K31/70 , A61K31/7008 , A61P25/28 , C07H5/06
摘要： PROBLEM TO BE SOLVED: To obtain a cerebral function improving agent containing N- acetylneuraminic acid bonded oligosaccharides promoting the metabolism of cerebral phospholipid and gangliosides. SOLUTION: This agent contains the N-acetylneuraminic acid bonded oligosaccharides expressed by the formula (Gal)n-Neu5Ac (Gal is galactose residue; Neu5Ac is N-acetylneuraminic acid residue; (n) is 1 or 2), as the active ingredient. Other suitable conventional ingredients are blended and can be prepared in conventional method. This compound can be used in food and drink such as yogurt, cheese, bread, drinkable beverage, etc. The adult's dosage of the N-acetylneuraminic acid bonded oligosaccharides is at least 10mg/kg per day, preferably 30 to 100mg/kg per day. The N-acetylneuraminic acid bonded oligosaccharides is an oligosaccharides in which galactose is bonded with N- acetylneuraminic acid, obtained by glycosyltransfer reaction of β-galactosidase using lactose and N-acetylneuraminic acid or its salt as the raw material.

5. 发明专利

JPH08238096A PRODUCTION OF SPHINGO GLYCOLIPID 失效
公开(公告)号：JPH08238096A
公开(公告)日：1996-09-17
申请号：JP7076295
申请日：1995-03-03
申请人： SNOW BRAND MILK PROD CO LTD
发明人： SUGURI TOSHIAKI , YANAGIDAIRA SHUICHI , HANAGATA GORO , TATSUMI KIYOSHI
IPC分类号： C12P19/14 , C12P19/44
摘要： PURPOSE: To readily and inexpensively obtain a highly purified sphingo glycolipid for a raw material of a medicine and a reagent, etc., by acting glycosidase to an oligosaccharide higher than a disaccharide or a glycoside and a ceramide and a sugar residue is bonded with the ceramide by a sugar- transfer reaction. CONSTITUTION: An oligosaccharide higher than a disaccharide (e.g. cellobiose) or a glycoside and a ceramide are suspended in a 0.1M acetic acid buffer solution (pH 5.0) containing taurodeoxycholic acid, a glycosidase (e.g. β-glycosidase) is added to the suspension and reacted for 2hr to bind a sugar residue with the ceramide by a sugar-transfer reaction to generate the objective sphingo glycolipid, the reacted solution is subjected to ODS (octadecylsilane) column chromatography and an unreacted substance, a decomposition product and a taurodeoxycholic acid, etc., are removed, and further the resultant solution is purified by subjecting to silica gel column chromatography to readily and inexpensively obtain the objective highly purified sphingo glycolipid useful for a raw material of a medicine and a reagent, etc.

6. 发明专利

JPH06205654A MINERAL SORPTION PROMOTOR CONTAINING BRANCHED GALACTOOLIGOSACCHARIDE AS ACTIVE INGREDIENT 失效
公开(公告)号：JPH06205654A
公开(公告)日：1994-07-26
申请号：JP1685793
申请日：1993-01-08
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , TAKADA YUKIHIRO , AOE SEIICHIRO , MORITA MINORU , KOBAYASHI TOMOKO , MATSUYAMA HIROAKI
IPC分类号： A23L33/16 , A61K31/70 , A61K31/702 , A61P3/00 , A61P3/02 , C07H3/06 , A23L1/30 , A23L1/304
摘要： PURPOSE:To obtain a mineral sorption promotor containing a branched galactooligosaccharide as an active ingredient. CONSTITUTION:This mineral sorption promotor contains a branched galactooligosaccharide expressed by the general formula Gal(Gal)-X (Gal is galactose residue and X is glucose residue or sorbitol residue) as an active ingredient. The promotor is useful in prevention and treatment of osteoporosis and other bone diseases, because the promotor can enhance sorption of the minerals by oral administration.

7. 发明专利

JP2001158736A AGENT FOR PREVENTING AND IMPROVING OSTEOARTHROPATHY 失效
公开(公告)号：JP2001158736A
公开(公告)日：2001-06-12
申请号：JP34021199
申请日：1999-11-30
申请人： SNOW BRAND MILK PROD CO LTD
发明人： TAKADA YUKIHIRO , MATSUBARA NORIYOSHI , YANAGIDAIRA SHUICHI , KAWAKAMI HIROSHI , AOE SEIICHIRO
IPC分类号： A23L1/30 , A61K31/164 , A61K31/688 , A61K31/7032 , A61P19/00 , A61P19/10
摘要： PROBLEM TO BE SOLVED: To provide an agent for preventing and improving osteoarthropathy such as osteoporosis, fracture, lumbago and rheumatism, and to provide a drink, food or feed to which an effect for preventing and improving the osteoarthropathy is imparted. SOLUTION: This agent for preventing or improving the osteoarthropathy, containing a sphingosine skeleton-having compound such as ceramide, sphingomyelin, a sphingoglycolipid or ganglioside as an active ingredient, or containing the sphingosine skeleton-having compound and further suitably one or more substances selected from calcium agents, vitamin D and vitamin K.

8. 发明专利

JPH11246586A RADIOACTIVE RAY-LABELED OLIGOSACCHARIDE 失效
公开(公告)号：JPH11246586A
公开(公告)日：1999-09-14
申请号：JP5221698
申请日：1998-03-04
申请人： SNOW BRAND MILK PROD CO LTD
发明人： IKEUCHI YOSHIHIRO , MATSUBARA NORINOBU , YANAGIDAIRA SHUICHI
IPC分类号： C12P19/26 , A61K51/00 , C07H3/06 , C07H5/04 , C07H7/027
摘要： PROBLEM TO BE SOLVED: To safely and simply obtain various radioactive ray-labeled oligosaccharides and a method for producing the oligosaccharide. SOLUTION: This radioactive ray-labeled oligosaccharide is obtained by reacting a glycolipid, whose sugar chain part is labeled by radiation, with an enzyme having a property specifically cleaving the binding of lipid part of glycolipid to sugar chain to cleave the biding between the lipid part of glycolipid and sugar chain part and separating and recovering the sugar chain part.

9. 发明专利

JPH09315981A SUPPRESSANT FOR REDUCTION IN CEREBRAL GANGLIOSIDE CONTENT 失效
公开(公告)号：JPH09315981A
公开(公告)日：1997-12-09
申请号：JP16065496
申请日：1996-05-31
申请人： SNOW BRAND MILK PROD CO LTD
发明人： MATSUBARA NORINOBU , YANAGIDAIRA SHUICHI , IKEUCHI YOSHIHIRO , YABE KYOKO , AOE SEIICHIRO
IPC分类号： A23L1/30 , A61K31/70 , A61K31/7032 , A61P25/28 , A61P43/00 , C07H7/027
摘要： PROBLEM TO BE SOLVED: To prepare the subject suppressant, comprising a sialyllactose (salt) as an active ingredient and useful for improving cerebropathy, etc., caused by a reduction in an intracerebral ganglioside content in the aged due to its ability to suppress the reduction in the intracerebral ganglioside content and improve the cerebral function. SOLUTION: This suppressant for a reduction in intracerebral ganglioside content comprises a sialyllactose or its salt as an active ingredient. A sialyllactose derived from a milk is preferred as the sialyllactose. The sialyllactose is obtained by treating a whey discharged when producing, e.g. a cheese with an ultrafiltration membrane, removing proteins, then treating the resultant whey with a simulated moving bed type chromatographic separator, providing a fraction containing about 5wt.% silalyllactose, subsequently concentrating the prepared fraction, then treating the concentrate with an anion exchange resin, further desalting the treated concentrate according to an electrodialysis, concentrating the resultant substance under a reduced pressure and subsequently freeze-drying the obtained concentrate. The ob jective suppressant is preferably perorally administered. The sialyllactose in a daily dose of 30-100mg/kg body weight for an adult is preferably ingested in order to manifest the suppressing effects on the reduction in the intracerebral ganglioside content.

10. 发明专利

JPH06228181A NEW OLIGOSACCHARIDE COMPRISING GLUCURONIC ACID, ITS PRODUCTION AND UTILIZATION 失效
公开(公告)号：JPH06228181A
公开(公告)日：1994-08-16
申请号：JP20258793
申请日：1993-07-23
申请人： SNOW BRAND MILK PROD CO LTD
发明人： YANAGIDAIRA SHUICHI , KOBAYASHI TOMOKO , AOE SEIICHIRO , SHUKKE SAKANORI , TAKADA YUKIHIRO
IPC分类号： A23L33/12 , A61K31/70 , A61K31/7012 , A61P3/00 , A61P3/14 , C07H7/033 , C12P19/14 , A23K1/16 , A23L1/30
摘要： PURPOSE:To obtain a new compound, capable of enhancing the mineral absorbability by the oral administration and useful for preventing or treating osteoporosis or other osteopathies and maintaining and controlling the human or animal health. CONSTITUTION:This oligosaccharide comprises glucuronic acid and is expressed by the formula (Gal)m-GlcUA [Ga1 is galactose; GlcUA is glucuronic acid; (n) is an integer of 1-3]. Furthermore, a medicine, a food and a drink comprise the oligosaccharide and have enhanced mineral absorbability. The oligosaccharide can be produced by reacting lactic acid with glucuronic acid and a beta-galactosidase or a beta-glucosidase and carrying out the galactose transfer reaction.

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