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1. 发明申请

WO1998001436A1 HETEROAROMATIC PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION 审中-公开
标题翻译：作为骨骼受体抑制剂的异氟醚酸衍生物
公开(公告)号：WO1998001436A1
公开(公告)日：1998-01-15
申请号：PCT/EP1997003709
申请日：1997-07-07
申请人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , FARINA, Carlo , GAGLIARDI, Stefania , NADLER, Guy, Marguerite, Marie, Gerard , MARTIN, Michel, Jean, Roger
发明人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07D307/80
CPC分类号： C07D405/06 , C07D215/12 , C07D307/80 , C07D333/60 , C07D409/06
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: R1 represents an alkyl group or a substituted or unsubstituted aryl group; R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R5 and R6 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R5 and R6 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; and Y represents O or S and Z represents CH, CH=CH or N; or Y represents NR7 wherein R7 represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl and Z represents CH=CH or N; a pharmaceutical composition containing such a compound, a process for preparing such a compound and the use of such a compound in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中：R1表示烷基或取代或未取代的芳基; R2，R3和R4各自独立地表示氢，烷基，芳基或取代的芳基; R5和R6各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R5和R6一起代表亚甲二氧基，羰基二氧基或羰基二氨基; X表示羟基或烷氧基，其中烷基可以是取代或未取代的或X表示基团NRsRt，其中R 5和R 5各自独立地表示氢，烷基，取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂环基或任选取代的杂环基烷基，或R 5和R 5与它们所连接的氮一起形成杂环基; Y表示O或S，Z表示CH，CH = CH或N; 或Y表示NR7，其中R7表示氢，羟基，烷酰基，烷基，氨基烷基，羟基烷基，羧基烷基，碳烷氧基烷基，氨基甲酰基或氨基磺酰基，Z表示CH = CH或N; 含有这种化合物的药物组合物，这种化合物的制备方法和这种化合物在医药中的应用。

2. 发明申请

WO1998001423A1 5-INDOLYL-2,4-PENTADIENOIC ACID DERIVATIVES USEFUL AS INHIBITORS OF BONE RESORPTION 审中-公开
标题翻译：有用作骨骼吸收抑制剂的5-吲哚基-2,4-二戊二酸衍生物
公开(公告)号：WO1998001423A1
公开(公告)日：1998-01-15
申请号：PCT/EP1997003710
申请日：1997-07-07
申请人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , FARINA, Carlo , GAGLIARDI, Stefania , CONSOLANDI, Emanuela , NADLER, Guy, Marguerite, Marie, Gérard , SENECI, Pierfausto
发明人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07D209/18
CPC分类号： C07D401/06 , C07D209/18
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: R1 represents hydrogen, C1-6 alkyl, halo, azido, C1-6 alkylthio, phnylthio, benzylthio, alkoxyalkyloxy or a group NHR8 wherein R8 represents -CO-R9 or -(CH2)nR11, or R1 represents a group -NR12R13 wherein R12 and R13 each independently represent hydrogen, alkyl or aryl; R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R5 and R6 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R5 and R6 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; X represents a hydroxy or an alkoxy group wherein the alkyl group may be substituted or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substitued alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; R7 represents hydrogen, hydroxy, alkanoyl, alkylaminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl; R9 represents R10 or OR10 wherein R10 is C1-6 alkyl, phenyl or benzyl; and R11 represents NR12R13, wherein R12 and R13 are as defined above, or R11 is hydroxy or C1-6 alkoxy; and n represents an integer 1, 2 or 3; a pharmaceutical composition containing such a compound, a process for preparing such a compound and the use of such a compound in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂化物，其中：R1表示氢，C1-6烷基，卤代，叠氮基，C1-6烷硫基，苯硫基，苄硫基，烷氧基烷氧基或基团NHR8，其中R8表示 - CO-R 9或 - （CH 2）n R 11，或R 1表示-NR 12 R 13基团，其中R 12和R 13各自独立地表示氢，烷基或芳基; R2，R3和R4各自独立地表示氢，烷基，芳基或取代的芳基; R5和R6各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R5和R6一起代表亚甲二氧基，羰基二氧基或羰基二氨基; X表示羟基或烷氧基，其中烷基可以是取代或未取代的或X表示NRsRt基团，其中R 5和R 5各自独立地表示氢，烷基，取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂环基或任选取代的杂环基烷基，或R 5和R 5与它们所连接的氮一起形成杂环基; R 7表示氢，羟基，烷酰基，烷基氨基烷基，羟基烷基，羧基烷基，碳烷氧基烷基，氨基甲酰基或氨基磺酰基; R 9表示R 10或OR 10，其中R 10为C 1-6烷基，苯基或苄基; R 11表示NR 12 R 13，其中R 12和R 13如上所定义，或R 11为羟基或C 1-6烷氧基; 并且n表示整数1,2或3; 含有这种化合物的药物组合物，这种化合物的制备方法和这种化合物在医药中的应用。

3. 发明申请

WO1998001443A1 INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：用于治疗OSTEOPOSOSIS的单独的衍生物
公开(公告)号：WO1998001443A1
公开(公告)日：1998-01-15
申请号：PCT/EP1997003577
申请日：1997-07-03
申请人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , FARINA, Carlo , GAGLIARDI, Stefania , NADLER, Guy, Marguerite, Marie, Gérard
发明人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07D401/12
CPC分类号： C07D451/02 , C07D209/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D451/04 , C07D455/02 , C07D471/04 , C07D471/08
摘要： A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ra represents a group R5 which is hydrogen, alkyl or optionally substituted aryl and Rb represents a moiety of formula (a), wherein X represents a hydroxy or an alkoxy group wherein the alkyl group may be substitued or unsubstituted or X represents a group NRsRt wherein Rs and Rt each independently represent hydrogen, alkyl, substituted alkyl, optionally substituted alkenyl, optionally substituted aryl, optionally substituted arylalkyl, an optionally substituted heterocyclic group or an optionally substituted heterocyclylalkyl group, or Rs and Rt together with the nitrogen to which they are attached form a heterocyclic group; R1 represents an alkyl or a substituted or unsubstituted aryl group; and R2, R3 and R4 each independently represent hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represent hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R6 and R7 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; and R8 represents hydrogen, hydroxy, alkynoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalky, carbalkoxyalkyl, carbamoyl or aminosulphonyl; a process for preparing such a compound, a pharmaceutical composition containing such a compound and the use of such a compound in medecine.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中R a表示氢，烷基或任选取代的芳基的R 5，R b表示式（a）的部分，其中X表示羟基或烷氧基，其中烷基可以被取代或未取代，或X表示基团NRsRt，其中R 5和R 5各自独立地表示氢，烷基，取代的烷基，任选取代的烯基，任选取代的芳基，任选取代的芳基烷基，任选取代的杂环基或任选取代的杂环基烷基，或R 5和R 5与它们所连接的氮一起形成杂环基; R1表示烷基或取代或未取代的芳基; 并且R 2，R 3和R 4各自独立地表示氢，烷基，芳基或取代的芳基; R6和R7各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R6和R7一起表示亚甲二氧基，羰基二氧基或羰基二氨基; R8代表氢，羟基，炔酰基，烷基，氨基烷基，羟基烷基，羧基，烷氧基烷基，氨基甲酰基或氨基磺酰基; 制备这种化合物的方法，含有这种化合物的药物组合物和这种化合物在药物中的用途。

4. 发明申请

WO1998001445A1 INDOLE DERIVATIVES FOR THE TREATMENT OF OSTEOPOROSIS 审中-公开
标题翻译：用于治疗OSTEOPOSOSIS的单独的衍生物
公开(公告)号：WO1998001445A1
公开(公告)日：1998-01-15
申请号：PCT/EP1997003711
申请日：1997-07-07
申请人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , FARINA, Carlo , NADLER, Guy, Marguerite, Marie, Gérard , SENECI, Pierfausto
发明人： SMITHKLINE BEECHAM S.P.A. , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07D405/06
CPC分类号： C07D403/06 , C07D405/06 , C07D417/06
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein: R2, R3 and R4 each independently represents hydrogen, alkyl, aryl or substituted aryl; R5 represents hydrogen, alkyl, aryl or substituted aryl; R6 and R7 each independently represents hydrogen, hydroxy, amino, alkoxy, optionally substituted aryloxy, optionally substituted benzyloxy, alkylamino, dialkylamino, halo, trifluoromethyl, trifluoromethoxy, nitro, alkyl, carboxy, carbalkoxy, carbamoyl, alkylcarbamoyl, or R6 and R7 together represent methylenedioxy, carbonyldioxy or carbonyldiamino; R8 represents hydrogen, hydroxy, alkanoyl, alkyl, aminoalkyl, hydroxyalkyl, carboxyalkyl, carbalkoxyalkyl, carbamoyl or aminosulphonyl; and Z1 and Z2 together with the carbon atom to which they are attached represent a heterocyclic group; a pharmaceutical composition comprising such a compound, a process for preparing such a compound and the use of such compound in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂化物，其中：R 2，R 3和R 4各自独立地表示氢，烷基，芳基或取代的芳基; R5代表氢，烷基，芳基或取代的芳基; R6和R7各自独立地表示氢，羟基，氨基，烷氧基，任选取代的芳氧基，任选取代的苄氧基，烷基氨基，二烷基氨基，卤素，三氟甲基，三氟甲氧基，硝基，烷基，羧基，烷氧基，氨基甲酰基，烷基氨基甲酰基或R6和R7一起表示亚甲二氧基，羰基二氧基或羰基二氨基; R8代表氢，羟基，烷酰基，烷基，氨基烷基，羟基烷基，羧基烷基，碳烷氧基烷基，氨基甲酰基或氨基磺酰基; Z1和Z2与它们所连接的碳原子一起表示杂环基; 包含这种化合物的药物组合物，制备这种化合物的方法以及这种化合物在医药中的用途。

5. 发明申请

WO1996013479A1 NITRO-BENZAMIDES USEFUL AS ANTI-ARRHYTHMIC AGENTS 审中-公开
标题翻译：硝基苯甲酮有效用作抗神经药物
公开(公告)号：WO1996013479A1
公开(公告)日：1996-05-09
申请号：PCT/EP1995004203
申请日：1995-10-24
申请人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , NADLER, Guy, Marguerite, Marie, Gérard , MARTIN, Michel, Jean, Roger
发明人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07C233/78
CPC分类号： C07C233/78
摘要： A compound of formula (I), or a salt thereof, or a solvate thereof, wherein Ar represents substituted or unsubstituted aryl, wherein the optional substituents are selected from alkyl, hydroxy or alkoxy or, if attached to adjacent carbon atoms any two substituents together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; A represents a C1-4n-alkylene group wherein each carbon is optionally substituted by 1 or 2 C1-6alkyl groups; R1 represents hydrogen, alkyl, alkenyl or cycloalkyl; one or two of the group of R2, R3 and R4 represents nitro the remaining members of the group of R2, R3 and R4 represent hydrogen; X represents a -CO-NH- moiety; and Z represents C2-4n-alkylene group wherein each carbon is optionally substituted 1 or 2 C1-6alkyl groups; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中Ar表示取代或未取代的芳基，其中任选的取代基选自烷基，羟基或烷氧基，或者如果连接到相邻的碳原子上，则任意两个取代基在一起与它们所连接的碳原子可以形成五至六个原子的稠合杂环，其中一个，两个或三个所述原子是氧或氮; A表示C 1-4亚烷基，其中每个碳任选被1或2个C 1-6烷基取代; R1代表氢，烷基，烯基或环烷基; R 2，R 3和R 4中的一个或两个表示硝基，R 2，R 3和R 4中的剩余成员表示氢; X表示-CO-NH-部分; Z表示C2-4n亚烷基，其中每个碳任选被1或2个C 1-6烷基取代; 制备这种化合物的方法，包含这些化合物的药物组合物和这些化合物在医药中的用途。

6. 发明申请

WO1995007884A1 ALKANEDIAMINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF ARRHYTHMIC AND ISCHAEMIC RHYTHM DISORDERS 审中-公开
标题翻译：阿卡蜜胺衍生物及其在治疗ARHHTHTHMIC和ISCHEMY RHYTHM病症中的应用
公开(公告)号：WO1995007884A1
公开(公告)日：1995-03-23
申请号：PCT/EP1994002959
申请日：1994-09-05
申请人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , NADLER, Guy, Marguerite, Marie, Gérard , MARTIN, Michel, Jean, Roger
发明人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07C311/08
CPC分类号： C07D231/12 , C07C217/84 , C07C237/42 , C07C311/08 , C07C311/44 , C07D233/56 , C07D249/08
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein A and B each independently represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by a C1-6 alkyl group; D represents CO, SO2, NH-CO or CH2CO; T represents hydrogen, alkyl, alkenyl or cycloalkyl; Z represents a bond, CH2, (CH2)2 or X-CH2-CH2 wherein X represents O or S; R1, R2 and R3 each independently represents H, alkyl, OH or alkoxy or, if attached to adjacent carbon atoms, any two of R1, R2 and R3 together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; R4 represents alkylsulphonamido, alkylamido or imidazo; and Ar represents substituted or unsubstituted aryl, wherein the optional substituents are the above defined R1, R2 and R3; a composition containing such a compound, a process for the preparation of such a compound and the use of such a compound in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂化物，其中A和B各自独立地表示碳原子数为1〜6的亚烷基，其中各碳任选被C 1-6烷基取代; D表示CO，SO 2，NH-CO或CH 2 CO; T代表氢，烷基，烯基或环烷基; Z表示键，CH 2，（CH 2）2或X-CH 2 -CH 2，其中X表示O或S; R 1，R 2和R 3各自独立地表示H，烷基，OH或烷氧基，或者如果连接到相邻的碳原子上，R 1，R 2和R 3中的任何两个与它们所连接的碳原子一起可以形成五个稠合杂环至六个原子，其中一个，两个或三个所述原子是氧或氮; R4代表烷基磺酰氨基，烷基酰氨基或咪唑; 并且Ar表示取代或未取代的芳基，其中任选的取代基是上述定义的R 1，R 2和R 3; 含有这种化合物的组合物，制备这种化合物的方法和这种化合物在医药中的用途。

7. 发明申请

WO1994027971A1 ANTI-ARRHYTHMIC N-SUBSTITUTED 3-BENZAZEPINES OR ISOQUINOLINES 审中-公开
标题翻译：抗坏血酸N-取代的3-苯并嗪或异喹啉
公开(公告)号：WO1994027971A1
公开(公告)日：1994-12-08
申请号：PCT/EP1994001705
申请日：1994-05-24
申请人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , NADLER, Guy, Marguerite, Marie, Gérard , MARTIN, Michel, Jean, Roger
发明人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： C07D223/16
CPC分类号： C07D223/16 , C07D217/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07F9/6558
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein A represents CH2, (CH2)2, CO, COCH2, CH2CO, CSCH2 or CH=CH; B represents CH2 or CO; Z represents a bond, CH2, (CH2)2 or X-CH2-CH2 wherein X represents O or S; D represents CO, SO2, NH-CO, NH-SO2, CH=CH or P(O)OR6 wherein R6 is C1-6 alkyl; Q represents aryl, aralkyl, aralkenyl or aralkynyl, wherein the aryl moiety may be substituted or unsubstituted with 1 to 5 substituents selected from the list consisting of nitro, halogen, alkylsulfonamide, amino, 1-imidazo, alkyl or haloalkyl, or Q represents substituted or unsubstituted: furanyl, pyranyl, thienyl, thiazolyl, imidazolyl, triazolyl or the benzo fused equivalents of furanyl, pyranyl, thienyl, thiazolyl, imidazolyl or triazolyl, indolyl, oxoindolyl, indenyl, isoindenyl, indazolyl, indolizinyl or pyridinyl or cycloalkyl optionally fused to an aryl group; R1, R2, R3, R4 and R5 each independently represent H, alkyl, OH or alkoxy or, if attached to adjacent carbon atoms, any two of R1, R2, R3, R4 and R5 together with the carbon atoms to which they are attached may form a fused heterocyclic ring of four to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; and E represents C2-4 n-alkylene group wherein each carbon is optionally substituted by R6; a process for preparing such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其盐或其溶剂化物，其中A表示CH 2，（CH 2）2，CO，COCH 2，CH 2 CO，CSCH 2或CH = CH; B表示CH 2或CO; Z表示键，CH 2，（CH 2）2或X-CH 2 -CH 2，其中X表示O或S; D表示CO，SO 2，NH-CO，NH-SO 2，CH = CH或P（O）OR 6，其中R 6是C 1-6烷基; Q表示芳基，芳烷基，芳烯基或芳炔基，其中芳基部分可以被1至5个选自硝基，卤素，烷基磺酰胺，氨基，1-咪唑基，烷基或卤代烷基的取代基取代或未取代，或Q表示取代的或未取代的：呋喃基，吡喃基，噻吩基，噻唑基，咪唑基，三唑基或呋喃基，吡喃基，噻吩基，噻唑基，咪唑基或三唑基的苯并稠合当量，吲哚基，氧代吲哚基，茚基，异茚基，吲唑基，中氮茚基或吡啶基或环烷基，芳基; R 1，R 2，R 3，R 4和R 5各自独立地表示H，烷基，OH或烷氧基，或者如果连接到相邻碳原子上，则R 1，R 2，R 3，R 4和R 5中的任何两个与它们所连接的碳原子一起可以形成四至六个原子的稠合杂环，其中一个，两个或三个所述原子是氧或氮; 并且E表示其中每个碳任选被R 6取代的C 2-4的亚烷基; 制备这种化合物的方法，包含这些化合物的药物组合物和这些化合物在医药中的用途。

8. 发明申请

WO1995026726A1 PHARMACEUTICAL COMPOSITION CONTAINING A CLASS III ANTIARRHYTHMIC AGENT AND A CLASS IV ANTIARRHYTHMIC AGENT 审中-公开
标题翻译：含有III类抗真菌剂和IV类抗生素的药物组合物
公开(公告)号：WO1995026726A1
公开(公告)日：1995-10-12
申请号：PCT/EP1995001165
申请日：1995-03-28
申请人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , BRIL, Antoine, Michel, Alain , FAIVRE, Jean-François, Simon, Pierre , GOUT, Bernard, Emile, Joseph , FOREST, Marie-Claire
发明人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： A61K31/445
CPC分类号： A61K31/275 , A61K31/44 , A61K31/445 , A61K31/18 , A61K2300/00
摘要： A pharmaceutical composition, which composition comprises a class III antiarrhythmic agent and a class IV antiarrhythmic agent, providing that the composition is not a combination of 10 mu g/kg E4031 and 0.1mg/kg verapamil, and optionally a pharmaceutically acceptable carrier therefor and in particular a pharmaceutical composition which composition comprises a class III and a class IV antiarrhythmic agent, characterised in that the class III reagent is present in an antiarrhythmic effective amount and the class IV antiarrhythmic agent is present in an amount lower than that which provides a substantial calcium blocking effect, and optionally a pharmaceutically acceptable carrier therefor; a process and medical use for such a composition.
摘要翻译：药物组合物，其组合物包含III类抗心律失常药和IV类抗心律失常药，条件是该组合物不是10μg/ kg E4031和0.1mg / kg维拉帕米以及任选的药用载体，特别是一种药物组合物，其组合物包含III类和IV类抗心律失常药，其特征在于III类试剂以抗心律失常有效量存在，并且IV类抗心律不齐剂的存在量低于提供实质性钙阻断效应，以及任选的药学上可接受的载体; 这种组合物的过程和医疗用途。

9. 发明申请

WO1996027595A1 HETEROCYCLYCARBOXAMIDES AND OTHER COMPOUNDS FOR THE TREATMENT OF THE CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：环孢菌素和其他化合物治疗心脏病
公开(公告)号：WO1996027595A1
公开(公告)日：1996-09-12
申请号：PCT/EP1995000872
申请日：1995-03-08
申请人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
发明人： SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , NADLER, Guy, Marguerite, Marie, Gérard
IPC分类号： C07D333/42
CPC分类号： C07C217/84 , C07D271/12 , C07D307/73 , C07D333/42
摘要： A compound of formula (I) or a salt thereof, or a solvate thereof, wherein A and B each independently represents a C1-4 n-alkylene group wherein each carbon is optionally substituted by a C1-6 alkyl group; D represents CO, SO2, NH-CO or CH2CO; T represents hydrogen, alkyl, alkene, or cycloalkyl; and Het represents substituted or unsubstituted: furanyl, pyranyl, thienyl, thiazolyl, imidazolyl, triazolyl or the benzo fused equivalents of furanyl, pyranyl, thienyl, thiazolyl, imidazolyl or triazolyl, indolyl, oxoindolyl, indenyl, isoindenyl, indazolyl, indolizinyl, or benzofurazanyl; optional substituents for the moiety Het include 1 to 5 substituents selected from the list consisting of nitro, halogen, alkylsulfonamido, alkylamido, 1H-imidazolyl, alkyl and haloalkyl; R1, R2 and R3 each independently represent H, alkyl, OH or alkoxy or, if attached to adjacent carbon atoms, any two of R1, R2 or R3 together with the carbon atoms to which they are attached may form a fused heterocyclic ring of five to six atoms wherein one, two or three of the said atoms are oxygen or nitrogen; Z represents a bond, CH2, (CH2)2 or X-CH2-CH2 wherein X represents O or S; and Ar represents substituted or unsubstituted aryl, wherein the optional substituents are the above defined R1, R2 and R3; a composition containing such compound, a process for the preparation of such a compound and the use of such a compound in the treatment of and/or prophylaxis of arrhythmia.
摘要翻译：式（I）化合物或其盐或其溶剂化物，其中A和B各自独立地表示碳原子数为1〜6的亚烷基，其中各碳任选被C 1-6烷基取代; D表示CO，SO 2，NH-CO或CH 2 CO; T代表氢，烷基，烯烃或环烷基; 呋喃基，吡喃基，噻唑基，噻唑基，咪唑基，三唑基或呋喃基，吡喃基，噻吩基，噻唑基，咪唑基或三唑基的苯并稠合当量，吲哚基，氧代吲哚基，茚基，异茚基，吲唑基，吲嗪基或苯并呋咱基 ; Het部分的任选取代基包括1至5个选自硝基，卤素，烷基磺酰胺基，烷基酰氨基，1H-咪唑基，烷基和卤代烷基的取代基。 R 1，R 2和R 3各自独立地表示H，烷基，OH或烷氧基，或者如果连接到相邻的碳原子上，R 1，R 2或R 3中的任何两个与它们所连接的碳原子一起可以形成五个稠合杂环至六个原子，其中一个，两个或三个所述原子是氧或氮; Z表示键，CH 2，（CH 2）2或X-CH 2 -CH 2，其中X表示O或S; 并且Ar表示取代或未取代的芳基，其中任选的取代基是上述定义的R 1，R 2和R 3; 含有这种化合物的组合物，制备这种化合物的方法以及这种化合物在治疗和/或预防心律失常中的用途。

10. 发明申请

WO1993019754A1 PHENOL AND PYRIDINOL DERIVATIVES AS LUSITROPIC AGENTS 审中-公开
标题翻译：苯酚和吡啶衍生物作为助听剂
公开(公告)号：WO1993019754A1
公开(公告)日：1993-10-14
申请号：PCT/GB1993000615
申请日：1993-03-25
申请人： SMITHKLINE BEECHAM PLC , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES , MURRAY, Kenneth, John , PORTER, Roderick, Alan , WARRINGTON, Brian, Herbert , LAHOURATATE, Philippe
发明人： SMITHKLINE BEECHAM PLC , SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES
IPC分类号： A61K31/44
CPC分类号： A61K31/675 , A61K31/44
摘要： Fused aryl derivatives are described as lusitropic agents for use in the treatment of cardiovascular disease where there is a component of diastolic failure.

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