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1. 发明申请

WO0047580A3 PHENYL UREA AND PHENYL THIOUREA DERIVATIVES 审中-公开
标题翻译：苯乙酸和苯乙酸衍生物
公开(公告)号：WO0047580A3
公开(公告)日：2000-12-21
申请号：PCT/EP0001142
申请日：2000-02-10
申请人： SMITHKLINE BEECHAM PLC , COULTON STEVEN , JOHNS AMANDA , PORTER RODERICK ALAN
发明人： COULTON STEVEN , JOHNS AMANDA , PORTER RODERICK ALAN
IPC分类号： A61K31/4375 , A61K31/4725 , A61P1/04 , A61P1/08 , A61P3/04 , A61P3/10 , A61P5/06 , A61P5/10 , A61P5/14 , A61P9/00 , A61P9/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/12 , A61P15/08 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P37/08 , A61P43/00 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds of formula (I) in which: one of X and Y is N and the other is CH; Z represents oxygen or sulfur; and R to R represent various substituent groups; and pharmaceutically acceptable salts thereof.
摘要翻译：式（I）化合物，其中：X和Y之一是N，另一个是CH; Z表示氧或硫; R 1〜R 7表示各种取代基; 及其药学上可接受的盐。

2. 发明申请

WO0008020A8 TRICYCLIC CARBOXAMIDES 审中-公开
标题翻译：三氯碳酰胺
公开(公告)号：WO0008020A8
公开(公告)日：2001-04-26
申请号：PCT/EP9905584
申请日：1999-08-03
申请人： SMITHKLINE BEECHAM PLC , COULTON STEVEN , NOVELLI RICCARDO , PORTER RODERICK ALAN , THOMPSON MERVYN , WARD ROBERT WILLIAM
发明人： COULTON STEVEN , NOVELLI RICCARDO , PORTER RODERICK ALAN , THOMPSON MERVYN , WARD ROBERT WILLIAM
IPC分类号： A61K31/4375 , A61K31/4745 , A61K31/55 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D455/03 , C07D471/04 , C07D471/14 , C07D487/04 , A61K31/437 , C07D455/04
CPC分类号： C07D455/00 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Compounds of formula (I) or salt thereof or solvate thereof, in which: m is 1 or 2; n is 1 or 2; X is CH or N; Y is selected from hydrogen, halogen, cyano, CF3, alkyl or alkoxy; R , which may be at any position within the saturated ring system, is hydrogen or up to two substituents which may be the same or different and each of which is selected from fluoro and C1-6 alkyl; R is hydrogen or up to four substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6-alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, oxazolyl, (C1-4alkyl)NHCO-, CONH2; or R CONH- or -NR R , wherein R is hydrogen or C1-4 alkyl; and R is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R groups are linked together form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O are indicated to be useful in the treatment and pophylaxis of epilepsy, migraine, and other disorders.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中：m为1或2; n为1或2; X是CH或N; Y选自氢，卤素，氰基，CF 3，烷基或烷氧基; 可以在饱和环体系内的任何位置的R 1是氢或最多两个可以相同或不同的取代基，其各自选自氟和C 1-6烷基; R 2是氢或至多四个选自卤素，NO 2，CN，N 3，CF 3 O-，CF 3 S-，CF 3 CO-，C 1-6烷基，C 1-6烯基，C 1-6炔基，C 1-6全氟烷基，C 3-6环烷基， C 3-6烷基-C 1-4烷基 - ，C 1-6烷基O - ，C 1-6 - 烷基CO-，C 3-6环烷基O - ，C 3-6环烷基CO-，C 3-6环烷基-C 1-4烷基O - ，C 3-6环烷基-C 1-4烷基CO-，苯基，苯氧基，苄氧基，苯甲酰基，苯基-C 1-4烷基 - ，C 1-6烷基-S-，C 1-6烷基SO 2 - ，（C 1-4烷基）2NSO 2 - ，（C 1-4烷基）NHSO 2 - ，（C 1-4烷基）2 CO-，恶唑基，（C 1-4烷基）NHCO-，CONH 2; 或R 4 CONH-或-NR 4 R 5，其中R 4是氢或C 1-4烷基; 和R 5是氢，C 1-4烷基，甲酰基，-CO 2 C 1-4烷基或-COC 1-4烷基; 或两个R 2连接在一起形成饱和或不饱和且未被取代或被-OH或= O取代的碳环或杂环，可用于治疗和预防癫痫，偏头痛和其他疾病。

3. 发明申请

WO0008020A3 TRICYCLIC CARBOXAMIDES 审中-公开
标题翻译：三氯碳酰胺
公开(公告)号：WO0008020A3
公开(公告)日：2000-07-13
申请号：PCT/EP9905584
申请日：1999-08-03
申请人： SMITHKLINE BEECHAM PLC , COULTON STEVEN , NOVELLI RICCARDO , PORTER RODERICK ALAN , THOMPSON MERVYN , WARD ROBERT WILLIAM
发明人： COULTON STEVEN , NOVELLI RICCARDO , PORTER RODERICK ALAN , THOMPSON MERVYN , WARD ROBERT WILLIAM
IPC分类号： A61K31/4375 , A61K31/4745 , A61K31/55 , A61P9/10 , A61P25/00 , A61P25/02 , A61P25/08 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , C07D455/03 , C07D471/04 , C07D471/14 , C07D487/04 , A61K31/437 , C07D455/04
CPC分类号： C07D455/00 , C07D471/04 , C07D471/14 , C07D487/04
摘要： Compounds of formula (I) or salt thereof or solvate thereof, in which: m is 1 or 2; n is 1 or 2; X is CH or N; Y is selected from hydrogen, halogen, cyano, CF3, alkyl or alkoxy; R , which may be at any position within the saturated ring system, is hydrogen or up to two substituents which may be the same or different and each of which is selected from fluoro and C1-6 alkyl; R is hydrogen or up to four substituents selected from halogen, NO2, CN, N3, CF3O-, CF3S-, CF3CO-, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6perfluoroalkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl-, C1-6alkylO-, C1-6-alkylCO-, C3-6cycloalkylO-, C3-6cycloalkylCO-, C3-6cycloalkyl-C1-4alkylO-, C3-6cycloalkyl-C1-4alkylCO-, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C1-4alkyl-, C1-6alkylS-, C1-6alkylSO2-, (C1-4alkyl)2NSO2-, (C1-4alkyl)NHSO2-, (C1-4alkyl)2NCO-, oxazolyl, (C1-4alkyl)NHCO-, CONH2; or R CONH- or -NR R , wherein R is hydrogen or C1-4 alkyl; and R is hydrogen, C1-4alkyl, formyl, -CO2C1-4alkyl or -COC1-4alkyl; or two R groups are linked together form a carbocyclic or heterocyclic ring that is saturated or unsaturated and unsubstituted or substituted by -OH or =O are indicated to be useful in the treatment and pophylaxis of epilepsy, migraine, and other disorders.
摘要翻译：式（I）化合物或其盐或其溶剂合物，其中：m为1或2; n为1或2; X是CH或N; Y选自氢，卤素，氰基，CF 3，烷基或烷氧基; 可以在饱和环体系内的任何位置的R 1是氢或最多两个可以相同或不同的取代基，其各自选自氟和C 1-6烷基; R 2是氢或至多四个选自卤素，NO 2，CN，N 3，CF 3 O-，CF 3 S-，CF 3 CO-，C 1-6烷基，C 1-6烯基，C 1-6炔基，C 1-6全氟烷基，C 3-6环烷基， C 3-6烷基-C 1-4烷基 - ，C 1-6烷基O - ，C 1-6 - 烷基CO-，C 3-6环烷基O - ，C 3-6环烷基CO-，C 3-6环烷基-C 1-4烷基O - ，C 3-6环烷基-C 1-4烷基CO-，苯基，苯氧基，苄氧基，苯甲酰基，苯基-C 1-4烷基 - ，C 1-6烷基-S-，C 1-6烷基SO 2 - ，（C 1-4烷基）2NSO 2 - ，（C 1-4烷基）NHSO 2 - ，（C 1-4烷基）2 CO-，恶唑基，（C 1-4烷基）NHCO-，CONH 2; 或R 4 CONH-或-NR 4 R 5，其中R 4是氢或C 1-4烷基; 和R 5是氢，C 1-4烷基，甲酰基，-CO 2 C 1-4烷基或-COC 1-4烷基; 或两个R 2连接在一起形成饱和或不饱和且未被取代或被-OH或= O取代的碳环或杂环，可用于治疗和预防癫痫，偏头痛和其他疾病。

4. 发明申请

WO03002559A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO03002559A2
公开(公告)日：2003-01-09
申请号：PCT/EP0207007
申请日：2002-06-25
申请人： SMITHKLINE BEECHAM PLC , CHAN WAI NGOR , JOHNS AMANDA , JOHNSON CHRISTOPHER NORBERT , NOVELLI RICCARDO , PORTER RODERICK ALAN
发明人： CHAN WAI NGOR , JOHNS AMANDA , JOHNSON CHRISTOPHER NORBERT , NOVELLI RICCARDO , PORTER RODERICK ALAN
IPC分类号： A61K31/427 , A61K31/4375 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/10 , A61P5/12 , A61P9/00 , A61P11/00 , A61P15/10 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P43/00 , C07D401/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , A61K31/4545
CPC分类号： C07D413/14 , C07D401/14 , C07D413/06 , C07D417/04 , C07D417/14 , C07D471/04
摘要： This invention relates to N-aroyl cyclic amine derivatives and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译：本发明涉及N-芳酰基环胺衍生物及其作为药物的用途，特别是作为食欲素受体拮抗剂。

5. 发明申请

WO2007113309A3 COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF 审中-公开
标题翻译：抑制甘油运输机及其用途的化合物
公开(公告)号：WO2007113309A3
公开(公告)日：2008-09-12
申请号：PCT/EP2007053275
申请日：2007-04-03
申请人： GLAXO GROUP LTD , COULTON STEVEN , GILPIN MARTIN , PORTER RODERICK ALAN
发明人： COULTON STEVEN , GILPIN MARTIN , PORTER RODERICK ALAN
IPC分类号： C07C211/27 , A61K31/166 , A61K31/40 , A61K31/445 , A61P25/28 , C07C233/78 , C07D213/40 , C07D295/13
CPC分类号： C07C211/27 , C07C233/78 , C07D213/40 , C07D295/13
摘要： Compounds of formula (I) and salts and solvates are provided wherein R 2 is selected from phenyl substituted with n R 1 groups, and pyridyl substituted with n R 1 groups; n = 0, 1 or 2; each R 1 is independently selected from the group consisting of halo, C 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy and cyano; R 3 is selected from hydrogen and C 1-2 alkyl; R 4 is selected from the group consisting of ethyl, n- propyl, i-propyl, n-butyl, i-butyl and t-butyl; or R 3 and R 4 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic ring optionally substituted with one or more groups X; each X is independently selected from the group consisting of C 1-4 alkyl, and haloC 1-4 alkyl; R 12 is selected from the group consisting of hydrogen, fluoro, chloro, bromo, methyl and methylthio; R 13 is selected from hydrogen, chloro and trifluoromethyl; R 14 is selected from hydrogen, trifluoromethyl and chloro; R 15 is selected from hydrogen, chloro and trifluoromethyl; R 16 is selected from hydrogen, methyl, fluoro and chloro; R 12 , R 13 , R 14 , R 15 and R 16 not all simultaneously being hydrogen. Processes for the preparation and uses of the compounds as medicaments for treating disorders such as psychoses, dementia or attention deficit disorder are also disclosed.
摘要翻译：提供式（I）化合物及其盐和溶剂合物，其中R 2选自被n R 1基团取代的苯基，和被n R 1取代的吡啶基组 n = 0,1或2; 每个R 1独立地选自卤素，C 1-4烷基，C 1-4烷氧基，卤代C 1 -C 4烷基， 1-4个C 1-4烷基，卤代C 1-4烷氧基和氰基; R 3选自氢和C 1-12烷基; R 4选自乙基，正丙基，异丙基，正丁基，异丁基和叔丁基; 或R 3和R 4与它们所连接的氮原子一起形成任选被一个或多个基团X取代的饱和5或6元杂环; 每个X独立地选自C 1-4烷基和卤代C 1-4烷基; R 12选自氢，氟，氯，溴，甲基和甲硫基; R 13选自氢，氯和三氟甲基; R 14选自氢，三氟甲基和氯; R 15选自氢，氯和三氟甲基; R 16选自氢，甲基，氟和氯; R 12，R 13，R 14，R 15和R 16不是全部同时为氢。还公开了用于制备和使用化合物作为治疗诸如精神病，痴呆或注意力缺陷障碍之类疾病的药物的方法。

6. 发明申请

WO2006067414A3 GLYCINE TRANSPORT INHIBITORS 审中-公开
标题翻译：甘氨酸运输抑制剂
公开(公告)号：WO2006067414A3
公开(公告)日：2006-09-08
申请号：PCT/GB2005004937
申请日：2005-12-21
申请人： GLAXO GROUP LTD , BOZZOLI ANDREA , BRADLEY DANIEL MARCUS , COULTON STEVEN , GILPIN MARTIN LEONARD , MACRITCHIE JACQUELINE ANNE , PORTER RODERICK ALAN , THEWLIS KEVIN MICHAEL
发明人： BOZZOLI ANDREA , BRADLEY DANIEL MARCUS , COULTON STEVEN , GILPIN MARTIN LEONARD , MACRITCHIE JACQUELINE ANNE , PORTER RODERICK ALAN , THEWLIS KEVIN MICHAEL
IPC分类号： C07C233/78 , A61K31/166 , A61K31/381 , A61K31/47 , C07C211/29 , C07C211/36 , C07D215/50 , C07D333/20 , C07D409/12
CPC分类号： C07C211/36 , C07C211/29 , C07C229/34 , C07C233/78 , C07C271/22 , C07C2601/08 , C07D215/50 , C07D295/13 , C07D333/20 , C07D409/12
摘要： The present invention relates to compounds of formula (I), or salts or solvates thereof, their use in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder. The invention further comprises processes to make these compounds and pharmaceutical formulations thereof.
摘要翻译：本发明涉及式（I）化合物或其盐或溶剂合物，其用于制备用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物。本发明还包括制备这些化合物及其药物制剂的方法。

7. 发明申请

WO2007147839A9 GLYCINE TRANSPORTER INHIBITING COMPOUNDS AND USES IN MEDICINE 审中-公开
标题翻译：甘氨酸转运蛋白抑制化合物和药物用途
公开(公告)号：WO2007147839A9
公开(公告)日：2008-11-13
申请号：PCT/EP2007056120
申请日：2007-06-20
申请人： GLAXO GROUP LTD , COULTON STEVEN , GILPIN MARTIN LEONARD , PORTER RODERICK ALAN
发明人： COULTON STEVEN , GILPIN MARTIN LEONARD , PORTER RODERICK ALAN
IPC分类号： C07C235/50 , A61K31/166 , C07C235/60 , C07D295/12
CPC分类号： C07C235/60 , C07D295/13
摘要： Compounds of formula (I) and salts and solvates thereof are provided: wherein R1 and R2 are both methyl, or R1 and R2 form a pyrrolidinyl group. Uses in the manufacture of medicaments for treating neurological and neuropsychiatric disorders, such as psychoses, dementia or attention deficit disorder, and processes to make these compounds and pharmaceutical formulations thereof are also disclosed.
摘要翻译：提供式（I）化合物及其盐和溶剂合物：其中R1和R2均为甲基，或R1和R2形成吡咯烷基。还公开了用于治疗神经和神经精神障碍的药物的用途，例如精神病，痴呆或注意力缺陷障碍，以及制备这些化合物及其药物制剂的方法。

8. 发明专利

JP2010132662A Benzamide derivative as antagonist of orexin receptor 审中-公开
标题翻译：苯甲酸衍生物作为OREXIN受体的拮抗剂
公开(公告)号：JP2010132662A
公开(公告)日：2010-06-17
申请号：JP2009295790
申请日：2009-12-25
申请人： Smithkline Beecham Plc , スミスクラインビーチャムピーエルシー
发明人： CHAN WAI NGOR , JOHNS AMANDA , PORTER RODERICK ALAN , STEAD RACHEL ELIZABETH ANNE , VIMAL MYTHILY
IPC分类号： C07C235/60 , A61K31/166 , A61K31/235 , A61K31/277 , A61K31/343 , A61K31/36 , A61K31/415 , A61K31/4192 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/47 , A61K31/472 , A61P3/00 , A61P3/04 , A61P3/10 , A61P5/00 , A61P5/02 , A61P5/06 , A61P5/10 , A61P5/38 , A61P7/00 , A61P7/04 , A61P9/00 , A61P9/10 , A61P11/00 , A61P15/08 , A61P15/10 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P35/00 , A61P43/00 , C07C231/02 , C07C233/23 , C07C233/73 , C07C233/76 , C07C233/77 , C07C233/78 , C07C233/87 , C07C235/46 , C07C235/48 , C07C235/84 , C07C255/50 , C07C255/57 , C07C255/63 , C07C315/04 , C07C317/14 , C07C317/44 , C07D215/48 , C07D215/50 , C07D217/26 , C07D231/14 , C07D249/06 , C07D271/06 , C07D271/12 , C07D277/20 , C07D277/56 , C07D277/62 , C07D285/14 , C07D307/79 , C07D317/50 , C07D317/68
CPC分类号： C07D271/06 , C07C233/73 , C07C233/77 , C07C233/87 , C07C235/46 , C07C235/84 , C07C255/57 , C07C2603/18 , C07D215/48 , C07D215/50 , C07D217/26 , C07D231/14 , C07D249/06 , C07D277/56 , C07D307/79 , C07D317/68
摘要： PROBLEM TO BE SOLVED: To provide a specific benzamide derivative, and to provide a method for using the same as a medicine. SOLUTION: There is provided a compound, for example, represented by the formula (wherein, Ar is phenyl, naphthyl, or the like) of figure or its pharmaceutically acceptable salt or solvate. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供特定的苯甲酰胺衍生物，并提供使用该药物的方法。解决方案：提供了一种化合物，例如由式（其中Ar是苯基，萘基等）或其药学上可接受的盐或溶剂化物所表示的化合物。版权所有（C）2010，JPO＆INPIT

9. 发明申请

WO2010018213A2 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO2010018213A2
公开(公告)日：2010-02-18
申请号：PCT/EP2009060514
申请日：2009-08-13
申请人： GLAXO GROUP LTD , PORTER RODERICK ALAN
发明人： PORTER RODERICK ALAN
CPC分类号： C07D231/20
摘要： The present invention relates to compounds, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in the treatment of a condition wherein inhibition of GIyT1 would be beneficial, including neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder.
摘要翻译：本发明涉及化合物，其制备方法，药物组合物和含有它们的药物及其用于治疗其中抑制GlyT1将是有益的病症，包括神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷紊乱。

10. 发明申请

WO2008092877A3 8-OXA-1, 4-DIAZASPIRO [4,5] DEC-3-EN-1-YL AND 1,4, 8-TRIAZASPIRO [4,5] DEC- 3-EN-1-YL ACETAMIDES AS GLYTI TRANSPORTER INHIBITORS IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译： 8-OXA-1,4-DIAZASPIRO [4,5] DEC-3-EN-1-YL和1,4,8-三氮唑[4,5] DEC-3-EN-1-YL乙酰胺作为GLYTI运输机抑制剂治疗神经病学和神经功能障碍
公开(公告)号：WO2008092877A3
公开(公告)日：2008-10-02
申请号：PCT/EP2008051083
申请日：2008-01-30
申请人： GLAXO GROUP LTD , UNIV NOTTINGHAM , AHMAD NADIA MAMOONA , LAI JUSTINE YEUN QUAI , MARSHALL HOWARD ROBERT , NASH DAVID JOHN , PORTER RODERICK ALAN
发明人： AHMAD NADIA MAMOONA , LAI JUSTINE YEUN QUAI , MARSHALL HOWARD ROBERT , NASH DAVID JOHN , PORTER RODERICK ALAN
IPC分类号： C07D471/10 , A61K31/4188 , A61K31/438 , A61P25/18 , A61P25/28 , C07D491/10
CPC分类号： C07D471/10 , C07D491/10
摘要： Compounds of formula (I) or a salt thereof are provided wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 9 , R 10 , X, n, p and m are as defined in the description. Uses of the compounds as medicaments, and in the manufacture of medicament for treating neurological and neuropsychiatric disorders, in particular psychoses, dementia or attention deficit disorder are also disclosed. The invention further discloses pharmaceutical compositions and combinations comprising the compounds.
摘要翻译：提供式（I）化合物或其盐，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7，R 9，R 10， SUP>，X，n，p和m如说明书中所定义。还公开了化合物作为药物的用途，以及用于治疗神经和神经精神障碍，特别是精神病，痴呆或注意力缺陷障碍的药物的制备。本发明还公开了包含该化合物的药物组合物和组合。

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