专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007113309A3 COMPOUNDS WHICH INHIBIT THE GLYCINE TRANSPORTER AND USES THEREOF 审中-公开
标题翻译：抑制甘油运输机及其用途的化合物
公开(公告)号：WO2007113309A3
公开(公告)日：2008-09-12
申请号：PCT/EP2007053275
申请日：2007-04-03
申请人： GLAXO GROUP LTD , COULTON STEVEN , GILPIN MARTIN , PORTER RODERICK ALAN
发明人： COULTON STEVEN , GILPIN MARTIN , PORTER RODERICK ALAN
IPC分类号： C07C211/27 , A61K31/166 , A61K31/40 , A61K31/445 , A61P25/28 , C07C233/78 , C07D213/40 , C07D295/13
CPC分类号： C07C211/27 , C07C233/78 , C07D213/40 , C07D295/13
摘要： Compounds of formula (I) and salts and solvates are provided wherein R 2 is selected from phenyl substituted with n R 1 groups, and pyridyl substituted with n R 1 groups; n = 0, 1 or 2; each R 1 is independently selected from the group consisting of halo, C 1-4 alkyl, C 1-4 alkoxy, haloC 1-4 alkyl, haloC 1-4 alkoxy and cyano; R 3 is selected from hydrogen and C 1-2 alkyl; R 4 is selected from the group consisting of ethyl, n- propyl, i-propyl, n-butyl, i-butyl and t-butyl; or R 3 and R 4 together with the nitrogen atom to which they are attached form a saturated 5- or 6-membered heterocyclic ring optionally substituted with one or more groups X; each X is independently selected from the group consisting of C 1-4 alkyl, and haloC 1-4 alkyl; R 12 is selected from the group consisting of hydrogen, fluoro, chloro, bromo, methyl and methylthio; R 13 is selected from hydrogen, chloro and trifluoromethyl; R 14 is selected from hydrogen, trifluoromethyl and chloro; R 15 is selected from hydrogen, chloro and trifluoromethyl; R 16 is selected from hydrogen, methyl, fluoro and chloro; R 12 , R 13 , R 14 , R 15 and R 16 not all simultaneously being hydrogen. Processes for the preparation and uses of the compounds as medicaments for treating disorders such as psychoses, dementia or attention deficit disorder are also disclosed.
摘要翻译：提供式（I）化合物及其盐和溶剂合物，其中R 2选自被n R 1基团取代的苯基，和被n R 1取代的吡啶基组 n = 0,1或2; 每个R 1独立地选自卤素，C 1-4烷基，C 1-4烷氧基，卤代C 1 -C 4烷基， 1-4个C 1-4烷基，卤代C 1-4烷氧基和氰基; R 3选自氢和C 1-12烷基; R 4选自乙基，正丙基，异丙基，正丁基，异丁基和叔丁基; 或R 3和R 4与它们所连接的氮原子一起形成任选被一个或多个基团X取代的饱和5或6元杂环; 每个X独立地选自C 1-4烷基和卤代C 1-4烷基; R 12选自氢，氟，氯，溴，甲基和甲硫基; R 13选自氢，氯和三氟甲基; R 14选自氢，三氟甲基和氯; R 15选自氢，氯和三氟甲基; R 16选自氢，甲基，氟和氯; R 12，R 13，R 14，R 15和R 16不是全部同时为氢。还公开了用于制备和使用化合物作为治疗诸如精神病，痴呆或注意力缺陷障碍之类疾病的药物的方法。

IPRDB

热门服务

关于我们

友情链接

联系方式