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1. 发明申请

WO2012071618A1 CONTROLLED RELEASE PRODUCT 审中-公开
标题翻译：控制释放产品
公开(公告)号：WO2012071618A1
公开(公告)日：2012-06-07
申请号：PCT/AU2011/001559
申请日：2011-11-30
申请人： THE UNIVERSITY OF QUEENSLAND , CSBP LIMITED , GILBERT, Robert Goulston , MCKENZIE, Colin , SMITH, Bradley , WARRENDER, Cristy Manala , WARRENDER, Garry William
发明人： GILBERT, Robert Goulston , MCKENZIE, Colin , SMITH, Bradley , WARRENDER, Cristy Manala , WARRENDER, Garry William
IPC分类号： C05G3/00
CPC分类号： C05G3/0041 , C05B7/00 , C05D9/00
摘要： A method for producing controlled release granules containing an agriculturally active ingredient, which method comprises: granulating agriculturally active ingredients with an aqueous slurry of an exfoliated clay in the presence of a binder; and drying the granules.
摘要翻译：一种生产含有农业活性成分的控释颗粒的方法，该方法包括：在粘合剂存在下，用剥落粘土的含水浆料对农业活性成分进行造粒; 并干燥颗粒。

2. 发明申请

WO2007003221A1 WAFER AND METHOD OF PLANARIZING A SURFACE OF A WAFER 审中-公开
标题翻译： WAFER和WAFER表面平面化方法
公开(公告)号：WO2007003221A1
公开(公告)日：2007-01-11
申请号：PCT/EP2005/008204
申请日：2005-06-30
申请人： FREESCALE SEMICONDUCTOR, INC. , SMITH, Bradley
发明人： SMITH, Bradley
IPC分类号： H01L21/3105 , H01L21/321
CPC分类号： H01L21/3212 , H01L21/31053
摘要： A Chemical Mechanical Polishing (CMP) process receives a pretreated wafer (20), the pre-treated wafer (20) having an abrasive-containing sacrificial layer (26) disposed thereon. During polishing using the CMP process, the abrasivecontaining sacrificial layer (26) is broken-down to release abrasive that is used to abrade a surface (22) of the wafer (20).
摘要翻译：化学机械抛光（CMP）工艺接收预处理的晶片（20），预处理的晶片（20）具有设置在其上的含磨料的牺牲层（26）。在使用CMP工艺的抛光期间，含磨料的牺牲层（26）被分解以释放用于磨蚀晶片（20）的表面（22）的磨料。

3. 发明申请

WO2003087761A3 MOLECULAR PROFILING OF DISEASE AND THERAPEUTIC RESPONSE USING PHOSPHO-SPECIFIC ANTIBODIES 审中-公开
公开(公告)号：WO2003087761A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010573
申请日：2003-04-07
申请人： CELL SIGNALING TECHNOLOGY, INC. , CROSBY, Katherine , SMITH, Bradley
发明人： CROSBY, Katherine , SMITH, Bradley
IPC分类号： C07K1/00 , C12Q1/00 , G01N33/53 , A61K39/395
摘要： The present invention provides methods for identifying the most relevant signal transduction pathway biomarkers of disease progression, outcome, or therapeutic responsiveness, using phospho-specific antibodies in cellular assays to identify proteins whose activity is correlated to the relevant outcome (e.g. therapeutic responsiveness). The invention also provides a method for utilizing correlated biomarker(s) to predict patient response to a therapeutic composition having efficacy against a disease involving altered signal transduction by employing one or more phospho-specific antibodies to detect activation status of such biomarker(s) in cellular assays. Kits for carrying out the methods of the invention are also provided.

4. 发明申请

WO2003087760A3 METHODS FOR DETECTING BCR-ABL SIGNALING ACTIVITY IN TISSUES USING PHOSPHO- SPECIFIC ANTIBODIES 审中-公开
公开(公告)号：WO2003087760A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010569
申请日：2003-04-07
申请人： CELL SIGNALING TECHNOLOGY, INC. , CROSBY, Katherine , SMITH, Bradley , GOSS, Valerie, L.
发明人： CROSBY, Katherine , SMITH, Bradley , GOSS, Valerie, L.
IPC分类号： G01N33/53
摘要： The invention provides novel reagents and methods for detecting BCR-ABL or c-Abl kinase activity, and/or Abl signaling pathway activation in a cell or tissue, and discloses novel biomarkers relevant to Abl- mediated disease progression and therapeutic responsiveness, and provides predictive and detection methods based on the same. Phosphorylated BCR-ABL (Tyr245) and/or c-Abl (Tyr245), BCR-ABL (Tyr735) and/or c-Abl (Tyr735), Bcr (Tyr177), CRKL (Tyr207), Gab1 (Tyr627), PYK2 (Tyr402), Tyk2 (Tyrl054/1055), SHP2 (Tyr580), ERK1/2 (Thr202/Tyr2O4) and MEK1/2 (Ser217/221) have now been identified as relevant biomarkers of c-Abl pathway-mediated disease, and phosphospecific antibodies to these targets are provided. Kits for carrying out the methods of the invention are also provided.

5. 发明申请

WO2018116175A1 ROTATIONAL COUPLING DEVICE 审中-公开
公开(公告)号：WO2018116175A1
公开(公告)日：2018-06-28
申请号：PCT/IB2017/058156
申请日：2017-12-19
申请人： SMITH, Bradley
发明人： SMITH, Bradley
IPC分类号： F16M11/18 , B62B1/22
摘要： A rotational coupling device may include a housing which may be coupled to a stationary coupler. The stationary coupler may be used to engage or couple the device to a machinery stand. A motivator shaft may be positioned on one side of the housing and a rotational drive shaft may be positioned on the other side of the housing. The motivator shaft and the rotational drive shaft may be operably connected together with a gear arrangement with rotation of the motivator shaft resulting in rotation of the rotational drive shaft that is of a reduced rate compared to the motivator shaft. The rotational drive shaft may be coupled or connected to the rotational assembly via a rotational coupler thereby allowing rotational motion provided by the motivator shaft to be transferred through the rotational drive shaft to the rotational assembly of the machinery stand to which the device is engaged.

6. 发明申请

WO2011059457A1 HIGH PERFORMANCE LUMINESCENT COMPOUNDS 审中-公开
标题翻译：高性能发光化合物
公开(公告)号：WO2011059457A1
公开(公告)日：2011-05-19
申请号：PCT/US2009/064621
申请日：2009-11-16
申请人： UNIVERSITY OF NOTRE DAME DU LAC , MOLECULAR TARGETING TECHNOLOGIES, INC. , SMITH, Bradley , EASWARAN, Arunkumar
发明人： SMITH, Bradley , EASWARAN, Arunkumar
IPC分类号： C09B62/006 , H01L27/32 , H01L51/54
CPC分类号： C09B57/00 , C09B57/007 , G01N2458/30
摘要： Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.
摘要翻译：实施方案涉及化学和生物化学领域，更具体地涉及光稳定并且耐淬火的新型近红外染料。这些染料属于一种新型的方酸酯轮烷系列，它们特别适用于生物应用。还公开了合成染料的方法和使用染料的方法。

7. 发明申请

WO2006014956A1 HEAT EXCHANO'ER HAVING A DOUBLE BAFFLE 审中-公开
标题翻译：加热双鱼座
公开(公告)号：WO2006014956A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/026491
申请日：2005-07-27
申请人： VALEO, INC. , LORENTZ, Jay , SMITH, Bradley
发明人： LORENTZ, Jay , SMITH, Bradley
IPC分类号： F28F9/02
CPC分类号： F28F9/0212 , F28F2265/16
摘要： There is disclosed a heat exchanger for transferring heat between at least two fluids and a method for forming the heat exchanger. The heat exchanger preferably includes one or more end tanks, one or more inlets and outlets, one or more tubes, one or more fins, and one or more improved baffle combinations including at least one single piece double baffle. The improved single piece double baffles act as part of a baffle system, with advantages over multiple-piece only double baffle systems due to being assembled in one piece.
摘要翻译：公开了一种用于在至少两种流体之间传递热量的热交换器和用于形成热交换器的方法。热交换器优选地包括一个或多个端部罐，一个或多个入口和出口，一个或多个管，一个或多个翅片，以及包括至少一个单件双挡板的一个或多个改进的挡板组合。改进的单件双挡板作为挡板系统的一部分，由于组装成一体而具有超过多件式双挡板系统的优点。

8. 发明申请

WO2003087760A2 METHODS FOR DETECTING BCR-ABL SIGNALING ACTIVITY IN TISSUES USING PHOSPHO- SPECIFIC ANTIBODIES 审中-公开
标题翻译：检测使用磷酸化特异性抗体的组织中BCR-ABL信号活性的方法
公开(公告)号：WO2003087760A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/010569
申请日：2003-04-07
申请人： CELL SIGNALING TECHNOLOGY, INC. , CROSBY, Katherine , SMITH, Bradley , GOSS, Valerie, L.
发明人： CROSBY, Katherine , SMITH, Bradley , GOSS, Valerie, L.
IPC分类号： G01N
CPC分类号： G01N33/57484 , G01N33/5011 , G01N2333/912 , G01N2500/10
摘要： The invention provides novel reagents and methods for detecting BCR-ABL or c-Abl kinase activity, and/or Abl signaling pathway activation in a cell or tissue, and discloses novel biomarkers relevant to Abl- mediated disease progression and therapeutic responsiveness, and provides predictive and detection methods based on the same. Phosphorylated BCR-ABL (Tyr245) and/or c-Abl (Tyr245), BCR-ABL (Tyr735) and/or c-Abl (Tyr735), Bcr (Tyr177), CRKL (Tyr207), Gab1 (Tyr627), PYK2 (Tyr402), Tyk2 (Tyrl054/1055), SHP2 (Tyr580), ERK1/2 (Thr202/Tyr2O4) and MEK1/2 (Ser217/221) have now been identified as relevant biomarkers of c-Abl pathway-mediated disease, and phosphospecific antibodies to these targets are provided. Kits for carrying out the methods of the invention are also provided.
摘要翻译：本发明提供用于检测细胞或组织中的BCR-ABL或c-Abl激酶活性和/或Ab1信号传导途径活化的新型试剂和方法，并公开了与Abl介导的疾病进展和治疗反应性相关的新型生物标志物，并提供预测和基于此的检测方法。磷酸化BCR-ABL（Tyr245）和/或c-Abl（Tyr245），BCR-ABL（Tyr735）和/或c-Abl（Tyr735），Bcr（Tyr177），CRKL（Tyr207），Gab1（Tyr627） Tyr402），Tyk2（Tyrl054 / 1055），SHP2（Tyr580），ERK1 / 2（Thr202 / Tyr2O4）和MEK1 / 2（Ser217 / 221）已经被鉴定为c-Abl途径介导的疾病的相关生物标志物，提供了针对这些靶标的抗体。还提供了用于实施本发明方法的试剂盒。

9. 发明申请

WO2014045060A1 APPARATUS AND METHOD FOR MAKING A FROZEN CONFECTIONARY PRODUCT 审中-公开
标题翻译：制造冷冻食品的装置和方法
公开(公告)号：WO2014045060A1
公开(公告)日：2014-03-27
申请号：PCT/GB2013/052478
申请日：2013-09-23
申请人： SMITH, Bradley
发明人： SMITH, Bradley
IPC分类号： A23G9/10 , A23G9/22 , A23G9/46 , A23G9/06
CPC分类号： A23G9/106 , A23G9/06 , A23G9/20 , A23G9/224 , A23G9/46
摘要： The invention relates to apparatus and method of making a frozen confectionary product such as ice cream or sorbet in which a confectionary mix is churned in a vessel whilst a liquid gas such as liquid nitrogen is added. Existing churning apparatus moves a stirrer through the ice cream mix in an epicyclical motion. This tends to splash liquid nitrogen so that it evaporates without contributing to the freezing of the ice cream. In the improved mixing method, the stirrer is repeatedly drawn against the inside wall(s) of the vessel. This reduces splashing of the liquid nitrogen. The drawing action also removes build up of frozen confectionary product on both the stirrer and the vessel walls and allows unfrozen confectionary mix to move to the edges of the vessel and be preferentially frozen.
摘要翻译：本发明涉及制作冷冻糖食产品如冰淇淋或果汁冰糕的装置和方法，其中将糖果混合物搅拌在容器中，同时加入诸如液氮的液体气体。现有的搅拌装置将搅拌器通过冰淇淋混合物以周期运动方式移动。这倾向于溅出液氮，使其蒸发而不会导致冰淇淋的冻结。在改进的混合方法中，将搅拌器重复地拉到容器的内壁上。这样可以减少液氮飞溅。拉拔动作还消除了在搅拌器和容器壁上的冷冻糖食产品的积聚，并且使未冷冻的糖食混合物移动到容器的边缘并优先冷冻。

10. 发明申请

WO2012068237A1 SPHERICAL PLAIN BEARING AND METHOD FOR ASSEMBLING THE SAME 审中-公开
标题翻译：球形轴承及其装配方法
公开(公告)号：WO2012068237A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/060971
申请日：2011-11-16
申请人： ROLLER BEARING COMPANY OF AMERICA, INC. , VOISINE, James , SMITH, Bradley , CONDON III, Charles E.
发明人： VOISINE, James , SMITH, Bradley , CONDON III, Charles E.
IPC分类号： F16C23/04 , F16C33/74 , F16C43/02
CPC分类号： F16C23/046 , F16C33/74 , F16C43/02
摘要： A spherical plain bearing and method of assembling the same is disclosed. The bearing has an outer ring having a bore, a concave surface, and at least one fracture. The bearing further includes an inner ring having a convex surface. The convex surface is in sliding disposition with the concave surface when the inner ring is disposed in the bore. The bearing has a groove in a face of the outer ring radially outside a first opening of the bore. The bearing further includes a band coupled to a portion of the outer ring defining the groove. The band retains the outer ring around the inner ring when the inner ring is disposed in the bore.
摘要翻译：公开了一种球面滑动轴承及其组装方法。该轴承具有一个具有孔，一个凹面和至少一个断裂的外圈。轴承还包括具有凸面的内圈。当内圈设置在孔中时，凸面与凹面滑动配置。所述轴承在所述孔的第一开口的径向外侧处具有在所述外环的表面中的凹槽。所述轴承还包括连接到限定所述凹槽的所述外圈的一部分的带。当内圈设置在孔中时，带将内圈保持在内圈周围。

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