专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2018153588A1 SINGLE-MOLECULE SEQUENCE AND HIGH SENSITIVITY METHYLATION ANALYSIS FOR TISSUE-SPECIFIC ANALYSIS 审中-公开
公开(公告)号：WO2018153588A1
公开(公告)日：2018-08-30
申请号：PCT/EP2018/051502
申请日：2018-01-23
申请人： SIEMENS HEALTHCARE GMBH
发明人： DIETRICH, Carsten , POSCH, Andreas Emanuel
IPC分类号： C12Q1/68
摘要： The present invention relates to methods of determining one or more modification(s) of the nucleic acid sequence of at least one nucleic acid and at least one epigenetic alteration of said at least one nucleic acid in a sample of a subject, wherein the sample is derived from a body fluid of the subject, in order to link the one or more modification to a specific cell type.

2. 发明申请

WO2022238472A1 METHOD AND A DEVICE FOR DETERMINING ONSET OF SEPSIS 审中-公开
公开(公告)号：WO2022238472A1
公开(公告)日：2022-11-17
申请号：PCT/EP2022/062760
申请日：2022-05-11
申请人： SIEMENS HEALTHCARE GMBH
发明人： GUPTA, Ankit , DIETRICH, Carsten , G, Saravanan , VALLINES, Lisa
IPC分类号： G16H50/20 , G16H50/30 , A61B5/00 , G16H10/40 , G16H10/60 , A61B5/346 , G06N3/08 , A61B5/412 , A61B5/4842 , A61B5/7267 , G06N3/044
摘要： A method (200), and a device (100) for determining onset of sepsis is provided. In one aspect, the method (200) includes receiving at least one medical dataset associated with the patient, wherein the medical dataset comprises a plurality of features. Further, the method (200) includes extracting one or more features from the medical dataset, wherein the one or more features comprises parameters associated with the patient which are indicators of sepsis. Additionally, the method (200) includes imputing at least one missing value in the medical dataset, wherein the missing value is associated with the features in the medical dataset. The method (200) also includes determining an output parameter indicative of the onset of sepsis in the patient by using the one or more features and the at least one missing value in the medical dataset as an input for one or more trained machine learning model (700). Furthermore, the method (200) includes generating an alert (ALT) indicating the onset of sepsis in the patient if the output parameter fulfills a pre-defined criterion associated with sepsis.

3. 发明申请

WO2022069162A1 BESTIMMEN VON VERGLEICHSPATIENTEN BASIEREND AUF ONTOLOGIEN 审中-公开
公开(公告)号：WO2022069162A1
公开(公告)日：2022-04-07
申请号：PCT/EP2021/074567
申请日：2021-09-07
申请人： SIEMENS HEALTHCARE GMBH
发明人： DIETRICH, Carsten , FRINGS, Oliver , JOBLIN, Mitchell , SIEBERT, Matthias , WEISS, Maximilian
IPC分类号： G16H50/20 , G16H50/70
摘要： Die Erfindung betrifft ein computerimplementiertes Verfahren zum Bestimmen eines Ähnlichkeitsmaßes, wobei das Ähnlichkeitsmaß eine Ähnlichkeit eines ersten Patienten und eines zweiten Patienten beschreibt. Das Verfahren basiert darauf, dass ein erster Patientendatensatz und ein zweiter Patientendatensatz empfangen werden, wobei der erste Patientendatensatz dem ersten Patienten zugeordnet ist, und wobei der zweite Patientendatensatz dem zweiten Patienten zugeordnet ist. Weiterhin erfolgt ein Empfangen oder Bestimmen einer medizinischen Ontologie. Hierbei ist die medizinische Ontologie unabhängig vom ersten Patientendatensatz und vom zweiten Patientendatensatz. Weiterhin wird eine Patientenontologie basierend auf der medizinischen Ontologie bestimmt, weiterhin basierend auf dem ersten Patientendatensatz und/oder dem zweiten Patientendatensatz. Weiterhin erfolgt ein Bestimmen eines Ähnlichkeitsmaßes basierend auf der Patientenontologie. Optional erfolgt weiterhin ein Bereitstellen des Ähnlichkeitsmaßes, wobei das Bereitstellen ein Speichern, ein Übermitteln und/oder ein Darstellen des Ähnlichkeitsmaßes umfassen kann. Die Erfindung betrifft weiterhin ein Bestimmungssystem, ein Computerprogrammprodukt sowie ein computerlesbares Speichermedium zum Bestimmen eines Ähnlichkeitsmaßes, wobei das Ähnlichkeitsmaß eine Ähnlichkeit eines ersten Patienten und eines zweiten Patienten beschreibt.

4. 发明申请

WO2021032441A1 MOLECULAR PREDICTORS OF PATIENT RESPONSE TO RADIOTHERAPY TREATMENT 审中-公开
公开(公告)号：WO2021032441A1
公开(公告)日：2021-02-25
申请号：PCT/EP2020/071658
申请日：2020-07-31
申请人： SIEMENS HEALTHCARE GMBH , THE CLEVELAND CLINIC FOUNDATION
发明人： DIETRICH, Carsten , SIEBERT, Matthias , ABAZEED, Mohamed , GEORGI, Jens-Christoph , WEHNER, Heike , KAPPEL, Andreas , MATZAS, Mark , POSCH, Andreas Emanuel
IPC分类号： C12Q1/6886
摘要： The present invention relates to methods of predicting a radiotherapy success in a method of treating a lung cancer of a patient, the use of specific markers for predicting a radiotherapy success in a method of treating a lung cancer of a patient, a database comprising the markers, and a computer program product for use in such a method.

5. 发明申请

WO2020094457A1 LIQUID SAMPLE WORKFLOW FOR NANOPORE SEQUENCING 审中-公开
公开(公告)号：WO2020094457A1
公开(公告)日：2020-05-14
申请号：PCT/EP2019/079479
申请日：2019-10-29
申请人： SIEMENS HEALTHCARE GMBH
发明人： HUANG, Yiwei , DIETRICH, Carsten , MACH, Tivadar , PRAUSE, Stefan , WÜRSTLE, Maximilian
IPC分类号： C12Q1/6827
摘要： The present invention relates to a method of characterizing a target DNA polynucleotide using rolling circle amplification (RCA) and a synthetic single guide RNA (sgRNA) to identify and cleave the WT version of the target DNA polynucleotide. Also provided are characterization steps based on the use of a transmembrane pore and a DNA translocase enzyme controlling the movement of the DNA polynucleotide through the transmembrane pore. Further envisaged is a kit comprising one or more oligonucleotides specific for at least a portion of the target DNA polynucleotide, an sgRNA specific for the WT version of the target DNA polynucleotide and an sgRNA-guided nucleic acid-binding protein.

6. 发明申请

WO2018114243A1 AMPLIFICATION-INTEGRATED GENETIC MATERIAL DEPLETION OF NON-TARGET ORGANISMS USING DIFFERENTIALLY ABUNDANT K-MERS 审中-公开
公开(公告)号：WO2018114243A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/080666
申请日：2017-11-28
申请人： SIEMENS HEALTHCARE GMBH
发明人： DIETRICH, Carsten , HUANG, Yiwei , MATZAS, Mark , POSCH, Andreas Emanuel
IPC分类号： C12Q1/68 , C12Q1/70 , G06F19/22
摘要： The present invention relates to a method of selectively amplifying at least one nucleic acid sequence of at least one microorganism and/or virus in a sample of a subject, wherein k-mers (3) are applied that show a difference in frequency and/or context in the genome (2) of the at least one microorganism and/or virus compared to the genome of the subject (1).

7. 发明公开

EP3877544A1 LIQUID SAMPLE WORKFLOW FOR NANOPORE SEQUENCING 审中-公开
公开(公告)号：EP3877544A1
公开(公告)日：2021-09-15
申请号：EP19801711.3
申请日：2019-10-29
申请人： Siemens Healthcare GmbH
发明人： HUANG, Yiwei , DIETRICH, Carsten , MACH, Tivadar , PRAUSE, Stefan , WÜRSTLE, Maximilian
IPC分类号： C12Q1/6827

8. 发明公开

EP4338171A1 METHOD AND A DEVICE FOR DETERMINING ONSET OF SEPSIS 审中-公开
公开(公告)号：EP4338171A1
公开(公告)日：2024-03-20
申请号：EP22727188.9
申请日：2022-05-11
申请人： Siemens Healthcare GmbH
发明人： GUPTA, Ankit , DIETRICH, Carsten , G, Saravanan , VALLINES, Lisa
IPC分类号： G16H50/20 , G16H50/30 , A61B5/00 , G16H10/40 , G16H10/60 , A61B5/346 , G06N3/08

9. 发明公开

EP4095267A1 METHOD AND SYSTEM FOR DETERMINING EFFICACY OF CANCER THERAPY 审中-公开
公开(公告)号：EP4095267A1
公开(公告)日：2022-11-30
申请号：EP21175843.8
申请日：2021-05-26
申请人： Siemens Healthcare GmbH
发明人： DIETRICH, Carsten , GEORGI, Jens-Christoph , KHANDIGE, Divya , KOLLEGAL, Manohar G , MITRA, Nivedita , RAMYA, V M
IPC分类号： C12Q1/6886
摘要： A method (200) and a system (100) for determining efficacy of a cancer therapy in a patient is disclosed. In one aspect, the method (200) includes determining a first amount of circulating tumor nucleic acid present in the patient before initiating at least one instance of the cancer therapy. The method (200) further includes determining a second amount of circulating tumor nucleic acid present in the patient after the at least one instance of the cancer therapy. Additionally, the method (200) includes computing a difference between the first amount of circulating tumor nucleic acid and the second amount of circulating tumor nucleic acid. Furthermore, the method (200) includes determining the efficacy of the cancer therapy based on the computed difference.

10. 发明公开

EP4089687A1 METHOD AND A DEVICE FOR DETERMINING ONSET OF SEPSIS 审中-公开
公开(公告)号：EP4089687A1
公开(公告)日：2022-11-16
申请号：EP21173588.1
申请日：2021-05-12
申请人： Siemens Healthcare GmbH
发明人： GUPTA, Ankit , DIETRICH, Carsten , G, Saravanan , VALLINES, Lisa
IPC分类号： G16H50/20 , G16H50/30 , A61B5/00 , G16H10/40 , G16H10/60 , A61B5/346 , G06N3/08
摘要： A method (200), and a device (100) for determining onset of sepsis is provided. In one aspect, the method (200) includes receiving at least one medical dataset associated with the patient, wherein the medical dataset comprises a plurality of features. Further, the method (200) includes extracting one or more features from the medical dataset, wherein the one or more features comprises parameters associated with the patient which are indicators of sepsis. Additionally, the method (200) includes imputing at least one missing value in the medical dataset, wherein the missing value is associated with the features in the medical dataset. The method (200) also includes determining an output parameter indicative of the onset of sepsis in the patient by using the one or more features and the at least one missing value in the medical dataset as an input for one or more trained machine learning model (700). Furthermore, the method (200) includes generating an alert (ALT) indicating the onset of sepsis in the patient if the output parameter fulfills a predefined criterion associated with sepsis.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式