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2. 发明专利

FR2879600A1 NOUVEAUX DERIVES CINNAMATES DE BENZO[B]PYRANO[3,2-H]ACRIDIN-7-ONE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 未知
公开(公告)号：FR2879600A1
公开(公告)日：2006-06-23
申请号：FR0413682
申请日：2004-12-22
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , PFEIFFER BRUNO , KRAUS BERTHIER LAURENCE
IPC分类号： C07D491/04 , C07D491/052 , A61K31/436 , A61K31/4741 , A61P35/00 , C07D219/06 , C07D309/10
摘要： dans laquelle :. X et Y représentent chacun un groupement choisi parmi hydrogène, halogène, alkoxy, nitro, cyano, alkyle, alkényle, polyhalogénoalkyle, et -NRaRb dans lequel Ra et Rb sont tels que définis dans la description,. Z représente un atome d'oxygène ou NRc dans lequel Rc, est tel que défini dans la description,. Ar représente aryle ou hétéroaryle,. R1 représente un atome d'hydrogène ou un groupement alkyle,. R2 représente un groupement choisi parmi atome d'hydrogène, alkyle, -ORa ; NRaRb dans lesquels Ra et Rb sont tels que définis dans la description,. R3, R4 représentent un atome d'hydrogène ou un groupement alkyle,. R5 représente atome d'hydrogène ou un groupement de formule ORc, NRcRd, W1-C(W2)-U-V, W1-C(W2)-W3-T1, Z-CO-CH=CHAr dans lesquels Rc, Rd, W1, W2, W3, U, V, T, Z et Ar sont tels que définis dans la description,leurs isomères, ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable.Médicaments.

3. 发明专利

FR2859208B1 NOUVEAUX DERIVES DE 9-AMINO-PODOPHYLLOTOXINE, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT 未知
公开(公告)号：FR2859208B1
公开(公告)日：2006-01-21
申请号：FR0310367
申请日：2003-09-02
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT
发明人： MONNERET CLAUDE , DAUZONNE DANIEL , HICKMAN JOHN , PIERRE ALAIN , KRAUS BERTHIER LAURENCE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00 , C07D307/33 , C07D317/50
摘要： Composés de formule (I) :dans laquelle :R1 représente un groupement choisi parmi hydrogène, alkyle, aryle, arylalkyle, hétéroaryle, hétéroarylalkyle, alkylcarbonyle, arylcarbonyle, arylalkylcarbonyle, alkoxycarbonyle, aryloxycarbonyle, arylalkoxycarbonyle, hétérocycloalkoxycarbonyle, alkylsulfonyle, arylsulfonyle, arylalkylsulfonyle, phosphonique et Si(Ra)2Rb,Y représente un groupement choisi parmi HN-NH et N-R2,R3 représente un atome d'hydrogène, un groupement alkyle, cycloalkyle, aryle, arylalkyle,R4 représente un atome d'hydrogène ou un groupement alkyle,leurs énantiomères, diastéréoisomères ainsi que leurs sels d'addition à un acide ou à une base pharmaceutiquement acceptable.

4. 发明专利

FR2859208A1 未知
公开(公告)号：FR2859208A1
公开(公告)日：2005-03-04
申请号：FR0310367
申请日：2003-09-02
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT
发明人： MONNERET CLAUDE , DAUZONNE DANIEL , HICKMAN JOHN , PIERRE ALAIN , KRAUS BERTHIER LAURENCE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： A61P35/00 , C07D493/04 , A61K31/36

5. 发明专利

DE602005003315D1 未知
公开(公告)号：DE602005003315D1
公开(公告)日：2007-12-27
申请号：DE602005003315
申请日：2005-12-21
申请人： CENTRE NAT RECH SCIENT , SERVIER LAB , UNIV PARIS DESCARTES
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , PFEIFFER BRUNO , KRAUS-BERTHIER LAURENCE
IPC分类号： A61K31/4741 , C07D491/04 , A61K31/436 , A61P35/00
摘要： Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds of formula (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. X, Y 1H, halo, OH, (1-6C) alkoxy, nitro, CN, (1-6C) alkyl (optionally substituted by one or more OH or halo), (2-6C) alkenyl or -NRaRb; either R-a, R-b : H or (1-6C) alkyl; or N-R-aR-b : a monocyclic or 5-7-membered heterocycle optionally having a second heteroatom of O or N in the cyclic system; Z : O or NR-c; R-c : H, (1-6C) alkyl, aryl or aryl-(1-6C)alkyl; Ar : (hetero)aryl; R 1, R 3, R 4H or (1-6C) alkyl; R 2H, (1-6C) alkyl, OR-a or NR-aR-b; R 5OR-c, NR-cR-d, W 1-C(W 2)-U 1-V 1, W-a-C(W 2)-W 3-T 1 or -Z-CO-CH=CHAr; W-a, W 3O or NR-c; W 2O; U 1(1-8C) alkylene or (2-8C) alkenylene; V 1H, (hetero) aryl, OR, CO 2R-c, COR-c, CON-aaR-bb, NR-aaR-bb, N(R-c)-CO 2R-cc or N(R-c)COR-cc; R-cc : R-c; either R-aa, R-bb : R-a, R-b or aryl-(1-6C)alkyl; or N-R-aaR-bb : N-R-aR-b; and T 1H, (1-6C) alkyl or (2-6C) alkenyl, aryl or aryl-(1-6C) alkyl (all optionally substituted by OR-c or NR-aaR-bb). where the aryl is phenyl or naphthyl optionally substituted by one or more substituents of (1-6C) alkyl (optionally substituted by one or more OH or halo), OH, halo, carboxy, NO 2, NH 2, or mono- or di-(1-6C) alkylamino, where the alkyl moiety is (1-6C) alkoxy, (1-6C) acyl or (1-6C) alkylcarbonyloxy; and the heteroaryl is 5-12-membered (monocyclic, aromatic or bicyclic with aromatic ring(s)), and has 1, 2 or 3 heteroatoms of O, N or S, and optionally substituted by one or more groups of halo, (1-6C) alkyl optionally substituted by one or more OH, halo, (1-6C) alkoxy or NH 2 optionally substituted by one or two (1-6C)alkyl. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.

6. 发明专利

AT378050T 未知
公开(公告)号：AT378050T
公开(公告)日：2007-11-15
申请号：AT05292744
申请日：2005-12-21
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE , PFEIFFER BRUNO , KRAUS-BERTHIER LAURENCE
IPC分类号： A61K31/4741 , C07D491/04 , A61K31/436 , A61P35/00
摘要： Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds of formula (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. X, Y 1H, halo, OH, (1-6C) alkoxy, nitro, CN, (1-6C) alkyl (optionally substituted by one or more OH or halo), (2-6C) alkenyl or -NRaRb; either R-a, R-b : H or (1-6C) alkyl; or N-R-aR-b : a monocyclic or 5-7-membered heterocycle optionally having a second heteroatom of O or N in the cyclic system; Z : O or NR-c; R-c : H, (1-6C) alkyl, aryl or aryl-(1-6C)alkyl; Ar : (hetero)aryl; R 1, R 3, R 4H or (1-6C) alkyl; R 2H, (1-6C) alkyl, OR-a or NR-aR-b; R 5OR-c, NR-cR-d, W 1-C(W 2)-U 1-V 1, W-a-C(W 2)-W 3-T 1 or -Z-CO-CH=CHAr; W-a, W 3O or NR-c; W 2O; U 1(1-8C) alkylene or (2-8C) alkenylene; V 1H, (hetero) aryl, OR, CO 2R-c, COR-c, CON-aaR-bb, NR-aaR-bb, N(R-c)-CO 2R-cc or N(R-c)COR-cc; R-cc : R-c; either R-aa, R-bb : R-a, R-b or aryl-(1-6C)alkyl; or N-R-aaR-bb : N-R-aR-b; and T 1H, (1-6C) alkyl or (2-6C) alkenyl, aryl or aryl-(1-6C) alkyl (all optionally substituted by OR-c or NR-aaR-bb). where the aryl is phenyl or naphthyl optionally substituted by one or more substituents of (1-6C) alkyl (optionally substituted by one or more OH or halo), OH, halo, carboxy, NO 2, NH 2, or mono- or di-(1-6C) alkylamino, where the alkyl moiety is (1-6C) alkoxy, (1-6C) acyl or (1-6C) alkylcarbonyloxy; and the heteroaryl is 5-12-membered (monocyclic, aromatic or bicyclic with aromatic ring(s)), and has 1, 2 or 3 heteroatoms of O, N or S, and optionally substituted by one or more groups of halo, (1-6C) alkyl optionally substituted by one or more OH, halo, (1-6C) alkoxy or NH 2 optionally substituted by one or two (1-6C)alkyl. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.

7. 发明专利

DE602004003719T2 未知
公开(公告)号：DE602004003719T2
公开(公告)日：2007-10-18
申请号：DE602004003719
申请日：2004-09-01
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT
发明人： MONNERET CLAUDE , DAUZONNE DANIEL , HICKMAN JOHN , PIERRE ALAIN , KRAUS-BERTHIER LAURENCE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00

8. 发明专利

DE602004003719D1 未知
公开(公告)号：DE602004003719D1
公开(公告)日：2007-01-25
申请号：DE602004003719
申请日：2004-09-01
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT
发明人： MONNERET CLAUDE , DAUZONNE DANIEL , HICKMAN JOHN , PIERRE ALAIN , KRAUS-BERTHIER LAURENCE , PFEIFFER BRUNO , RENARD PIERRE
IPC分类号： C07D493/04 , A61K31/36 , A61P35/00

9. 发明专利

HRP20070524T3 CINNAMATES OF BENZO[b]PYRANO[3,2-h]ACRIDIN-7-ONE, PROCESS FOR PREPARATION THEREOF AND THEIR PHARMACEUTICAL COMPOSITION 未知
公开(公告)号：HRP20070524T3
公开(公告)日：2008-07-31
申请号：HRP20070524
申请日：2007-11-15
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES
发明人： KOCH MICHEL , TILLEQUIN FRANÇOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STUPHANE , PFEIFFER BRUNO , KRAUS-BERTHIER LAURENCE
IPC分类号： A61K31/4741 , C07D491/04 , A61K31/436 , A61P35/00
摘要： Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. Benzo pyarano[3,2-h]acridin-7-one cinnamate compounds of formula (I) and their enantiomers, diastereoisomers, hydrates, solvates, acids, bases or addition salts are new. X, Y 1H, halo, OH, (1-6C) alkoxy, nitro, CN, (1-6C) alkyl (optionally substituted by one or more OH or halo), (2-6C) alkenyl or -NRaRb; either R-a, R-b : H or (1-6C) alkyl; or N-R-aR-b : a monocyclic or 5-7-membered heterocycle optionally having a second heteroatom of O or N in the cyclic system; Z : O or NR-c; R-c : H, (1-6C) alkyl, aryl or aryl-(1-6C)alkyl; Ar : (hetero)aryl; R 1, R 3, R 4H or (1-6C) alkyl; R 2H, (1-6C) alkyl, OR-a or NR-aR-b; R 5OR-c, NR-cR-d, W 1-C(W 2)-U 1-V 1, W-a-C(W 2)-W 3-T 1 or -Z-CO-CH=CHAr; W-a, W 3O or NR-c; W 2O; U 1(1-8C) alkylene or (2-8C) alkenylene; V 1H, (hetero) aryl, OR, CO 2R-c, COR-c, CON-aaR-bb, NR-aaR-bb, N(R-c)-CO 2R-cc or N(R-c)COR-cc; R-cc : R-c; either R-aa, R-bb : R-a, R-b or aryl-(1-6C)alkyl; or N-R-aaR-bb : N-R-aR-b; and T 1H, (1-6C) alkyl or (2-6C) alkenyl, aryl or aryl-(1-6C) alkyl (all optionally substituted by OR-c or NR-aaR-bb). where the aryl is phenyl or naphthyl optionally substituted by one or more substituents of (1-6C) alkyl (optionally substituted by one or more OH or halo), OH, halo, carboxy, NO 2, NH 2, or mono- or di-(1-6C) alkylamino, where the alkyl moiety is (1-6C) alkoxy, (1-6C) acyl or (1-6C) alkylcarbonyloxy; and the heteroaryl is 5-12-membered (monocyclic, aromatic or bicyclic with aromatic ring(s)), and has 1, 2 or 3 heteroatoms of O, N or S, and optionally substituted by one or more groups of halo, (1-6C) alkyl optionally substituted by one or more OH, halo, (1-6C) alkoxy or NH 2 optionally substituted by one or two (1-6C)alkyl. [Image] ACTIVITY : Cytostatic. MECHANISM OF ACTION : None given.

10. 发明专利

ES2297648T3 DERIVADOS CINAMATO DE BENZO(B)PIRAN(3,2-H)ACRIDIN-7ONA, SU PROCEDIMIENTO DE PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN. 未知
公开(公告)号：ES2297648T3
公开(公告)日：2008-05-01
申请号：ES05292744
申请日：2005-12-21
申请人： SERVIER LAB , CENTRE NAT RECH SCIENT , UNIV PARIS DESCARTES
发明人： KOCH MICHEL , TILLEQUIN FRANCOIS , MICHEL SYLVIE , HICKMAN JOHN , PIERRE ALAIN , LEONCE STEPHANE
IPC分类号： A61K31/4741 , C07D491/04 , A61K31/436 , A61P35/00
摘要： Compuestos de fórmula (I): en la cual: * X e Y, idénticos o diferentes, independientemente uno del otro, representan cada uno un grupo seleccionado entre: * un átomo de hidrógeno, de halógeno, * un grupo hidroxilo, alcoxi(C1-C6) lineal o ramificado, nitro, ciano, alquilo(C1-C6) lineal o ramificado eventualmente sustituido con uno o varios grupos seleccionados de entre hidroxilo y halógeno, y alquenilo(C2-C6) lineal o ramificado, o * un grupo de fórmula -NRaRb en el cual: Ra y Rb, idénticos o diferentes, independientemente uno del otro, representan cada uno un grupo seleccionado de entre un átomo de hidrógeno o un grupo alquilo(C1-C6) lineal o ramificado, o Ra y Rb forman, junto con el átomo de nitrógeno que los porta, un heterociclo de 5 a 7 eslabones monocíclico, el cual eventualmente contiene en el seno del sistema cíclico un segundo heteroátomo seleccionado de entre oxígeno y nitrógeno, entendiéndose que los sustituyentes X e Y pueden estar presentes, independientemente uno delotro, en uno u otro de los dos ciclos bencénicos adyacentes.

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