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    • 1. 发明申请
    • FLEXIBLE CIRCUIT ELECTRODE ARRAY
    • 柔性电路阵列
    • WO2006116765A2
    • 2006-11-02
    • PCT/US2006016655
    • 2006-04-28
    • SECOND SIGHT MEDICAL PROD INCGREENBERG ROBERT JAYTALBOT NEILNEYSMITH JORDANLITTLE JAMES SMECH BRIAN VHUMAYAN MARKGUVEN DILEKRIPLEY ANN MARIE DE MERLIER
    • GREENBERG ROBERT JAYTALBOT NEILNEYSMITH JORDANLITTLE JAMES SMECH BRIAN VHUMAYAN MARKGUVEN DILEKRIPLEY ANN MARIE DE MERLIER
    • A61N1/05
    • H05K3/0011A61N1/0541A61N1/0543A61N1/36036A61N1/36046Y10T29/49124
    • Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
    • 聚合物材料可用作神经刺激的电极阵列体。 它们对视网膜刺激特别有用,用于创建人造视觉,人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。 通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。 太小的压力会导致电阻增加以及电场分散。 太大的压力可能会阻止血液流动。 通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。 由于神经组织几乎从不平坦,平面阵列必然会施加不均匀的压力。 此外,柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。 通过将适量的热应用于完整的阵列,可以引起曲线。 对于热塑性聚合物,可以进一步有利的是在多个模具中反复加热柔性电路,每个模具具有减小的半径。 此外,沿着边缘添加材料是有利的。 在柔性电路阵列中提供折叠或扭曲是更有利的。 可以在折叠内部和外部添加附加材料以促进与组织的良好密封。
    • 8. 发明申请
    • FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH WIRE OR FILM SUPPORT
    • 柔性电路阵列,电线或电影支持
    • WO2008101225A2
    • 2008-08-21
    • PCT/US2008054181
    • 2008-02-15
    • SECOND SIGHT MEDICAL PROD INCDOHENY EYE INSTGREENBERG ROBERT JDE JUAN EUGENEHUMAYUN MARK SMCCLURE KELLY HTALBOT NEIL HAMILTONNEYSMITH JORDAN MATTHEWMECH BRIAN VLITTLE JAMES SINGLETONKHALDI MOHAMED
    • GREENBERG ROBERT JDE JUAN EUGENEHUMAYUN MARK SMCCLURE KELLY HTALBOT NEIL HAMILTONNEYSMITH JORDAN MATTHEWMECH BRIAN VLITTLE JAMES SINGLETONKHALDI MOHAMED
    • A61N1/05
    • A61N1/0543A61N1/05A61N1/0541H05K1/0393H05K1/118
    • The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
    • 本发明涉及柔性电路电极阵列,包括:聚合物基层; 沉积在所述聚合物基层上的金属痕迹,包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。 本发明还涉及一种柔性电路电极阵列,包括:聚合物基层; 沉积在所述聚合物基层上的金属痕迹,包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连垫连接的折叠柔性电路电缆。 本公开还涉及一种制造柔性电路电极阵列的方法,包括:沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状,至少在基层,顶层或基底与顶层之间嵌入支撑件,和/或折叠柔性电路电缆 至少一次将电极阵列与互连衬垫连接在一起。
    • 10. 发明申请
    • ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME
    • 具有增加的稳定性的电极及其制造方法
    • WO2007149465A2
    • 2007-12-27
    • PCT/US2007014332
    • 2007-06-19
    • SECOND SIGHT MEDICAL PROD INCZHOU DAO MINOK JERRYTALBOT NEIL HAMILTONMECH BRIAN VLITTLE JAMESGREENBERG ROBERT J
    • ZHOU DAO MINOK JERRYTALBOT NEIL HAMILTONMECH BRIAN VLITTLE JAMESGREENBERG ROBERT J
    • A61N1/0543A61N1/36046
    • The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer
    • 本发明提供具有增加的稳定性的可植入电极,其具有聚集结构,其中电极的表面被包括填充有棒或柱的开口的材料覆盖。 本发明提供了具有增加的稳定性的可植入电极,其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。 本发明提供一种具有增加的稳定性的电极的制造方法,包括:在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。 本发明提供了一种制造具有增加的稳定性的电极的方法,包括:在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层