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1. 发明申请

WO2008101225A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH WIRE OR FILM SUPPORT 审中-公开
标题翻译：柔性电路阵列，电线或电影支持
公开(公告)号：WO2008101225A2
公开(公告)日：2008-08-21
申请号：PCT/US2008054181
申请日：2008-02-15
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
发明人： GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
摘要翻译：本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连垫连接的折叠柔性电路电缆。本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆至少一次将电极阵列与互连衬垫连接在一起。

2. 发明申请

WO2009006636A3 RETURN ELECTRODE FOR A FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：返回电极用于柔性电路电极阵列
公开(公告)号：WO2009006636A3
公开(公告)日：2009-02-26
申请号：PCT/US2008069348
申请日：2008-07-07
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , MCCLURE KELLY H , MECH BRIAN V , DAI RONGQING , ZHOU DAVID DAOMIN , NOLAN GAILLARD R
发明人： GREENBERG ROBERT J , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , MCCLURE KELLY H , MECH BRIAN V , DAI RONGQING , ZHOU DAVID DAOMIN , NOLAN GAILLARD R
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large. The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes. The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
摘要翻译：在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。为了避免用返回电极刺激组织，如果电极很大，则是有利的。本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极从所述刺激电极。柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

3. 发明申请

WO2008021524A2 PACKAGE FOR AN IMPLANTABLE NEURAL STIMULATION DEVICE 审中-公开
标题翻译：可植入神经刺激装置的包装
公开(公告)号：WO2008021524A2
公开(公告)日：2008-02-21
申请号：PCT/US2007018315
申请日：2007-08-18
申请人： SECOND SIGHT MEDICAL PROD INC , OK JERRY , GREENBERG ROBERT J , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , DAI RONGQING , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY H
发明人： OK JERRY , GREENBERG ROBERT J , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , DAI RONGQING , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY H
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61F15/001 , A61N1/0529 , A61N1/0543 , A61N1/36125 , A61N1/375 , H01L23/055 , H01L23/06 , H01L23/08 , H01L23/10 , H01L24/16 , H01L24/48 , H01L25/18 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48106 , H01L2224/48225 , H01L2924/00014 , H01L2924/00 , H01L2224/0401
摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device comprises an electrically non-conductive substrate; a plurality of electrically conductive vias through said electrically non-conductive substrate; a flip-chip circuit attached to said electrically non-conductive substrate using conductive bumps and electrically connected to a first subset of said plurality of electrically conductive vias, wherein said flip-chip circuit contains one or more stacks or a folded stack; a wire bonded circuit attached to said electrically non-conductive substrate and electrically connected to a second subset of said electrically conductive vias; and a cover bonded to said electrically non-conductive substrate, said cover, said electrically non-conductive substrate and said electrically conductive vias forming a hermetic package.
摘要翻译：本发明是用于植入人体的改进的密封包装。可植入装置包括非导电基底; 通过所述非导电衬底的多个导电通孔; 使用导电凸块连接到所述非导电衬底并电连接到所述多个导电通孔的第一子集的倒装芯片电路，其中所述倒装芯片电路包含一个或多个堆叠或折叠堆叠; 连接到所述非导电衬底并电连接到所述导电通孔的第二子集的引线键合电路; 以及盖，其结合到所述非导电衬底，所述盖，所述非导电衬底和所述导电通孔形成气密封装。

4. 发明申请

WO2008051869A3 VISUAL PROSTHESIS 审中-公开
标题翻译：视觉假体
公开(公告)号：WO2008051869A3
公开(公告)日：2008-06-19
申请号：PCT/US2007082004
申请日：2007-10-19
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J
发明人： GREENBERG ROBERT J , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J
IPC分类号： A61N1/36 , A61F2/14 , A61F9/08 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：一种刺激受试者视网膜的方法。该方法包括选择至少第一和第二电极，每个电极被配置为将电流施加到对象的视网膜，确定至少第一电极和第二电极的阻抗，并且通过至少第一和第二电极向对象的视网膜施加电流，其中当所述第一电极具有比第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为对于所述第一电极更高。

5. 发明申请

WO2008109771A3 SALIENCY-BASED APPARATUS AND METHODS FOR VISUAL PROSTHESES 审中-公开
标题翻译：基于SALIENCY的设备和视觉展示的方法
公开(公告)号：WO2008109771A3
公开(公告)日：2009-01-15
申请号：PCT/US2008056089
申请日：2008-03-06
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , HORSAGER ALAN MATTHEW , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J , MEILSTRUP PETER , PARIKH NEHA JAGDISH , ROY ARUP , WEILAND JAMES D , ZHOU CHUNHONG
发明人： GREENBERG ROBERT J , HORSAGER ALAN MATTHEW , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J , MEILSTRUP PETER , PARIKH NEHA JAGDISH , ROY ARUP , WEILAND JAMES D , ZHOU CHUNHONG
IPC分类号： A61N1/36 , G06T7/00
CPC分类号： A61N1/36046 , A61F9/08 , G06K9/4604 , G06K9/4628 , G06K9/605 , G09B21/008
摘要： Saliency-based apparatus and methods for visual prostheses are disclosed. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.
摘要翻译：公开了用于视觉假体的基于显着性的装置和方法。基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

6. 发明申请

WO2009018172A3 IMPLANTABLE DEVICE FOR THE BRAIN 审中-公开
标题翻译：可植入脑的装置
公开(公告)号：WO2009018172A3
公开(公告)日：2009-05-14
申请号：PCT/US2008071260
申请日：2008-07-25
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , MECH BRIAN V , MCCLURE KELLY H
发明人： GREENBERG ROBERT J , MECH BRIAN V , MCCLURE KELLY H
IPC分类号： A61N1/36 , A61N1/05 , A61N1/375
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36082 , A61N1/37229 , A61N1/375 , A61N1/3758 , A61N1/3787 , H05K1/028 , H05K1/111 , H05K1/141 , H05K1/147 , H05K3/284
摘要： The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium or on the dura, or on or in the brain.
摘要翻译：本发明由具有至少一个封装的可植入装置组成，所述封装容纳电子装置，所述电子装置通过连接到所述至少一个封装的至少一个线圈从外部系统接收输入数据或信号以及可选的电源，处理输入数据并传送通过连接到至少一个封装的多个电极的至少一个阵列将电脉冲施加到神经组织。本发明或其组件旨在被安装在头部中，头骨上或头顶上或硬脑膜上，或脑上或脑中。

7. 发明申请

WO2008051800A3 VISUAL PROSTHESIS 审中-公开
标题翻译：视觉假体
公开(公告)号：WO2008051800A3
公开(公告)日：2008-06-19
申请号：PCT/US2007081811
申请日：2007-10-18
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , MCCLURE KELLY H , ROY ARUP
发明人： GREENBERG ROBERT J , MCCLURE KELLY H , ROY ARUP
IPC分类号： A61N1/36
CPC分类号： A61F9/08 , A61N1/36046 , A61N1/37276 , A61N1/3787 , G02C11/10 , H04N5/2254
摘要： A visual prosthesis apparatus and a method for limiting power consumption in a visual prosthesis apparatus. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit associated with the camera, the video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured to stop stimulating neural tissue in a subject's eye based on the stimulation patterns when an error is detected in a forward telemetry received from the video processing unit.
摘要翻译：一种视觉假体装置和一种用于限制视觉假体装置中的功耗的方法。视觉假体设备包括用于捕获视频图像的相机，与相机相关联的视频处理单元，配置为将视频图像转换为刺激图案的视频处理单元，以及配置成停止刺激对象的神经组织的视网膜刺激系统基于在从视频处理单元接收的前向遥测中检测到错误时的刺激模式来生成眼睛。

8. 发明申请

WO2010033728A3 TECHNIQUES AND FUNCTIONAL ELECTRICAL STIMULATION TO ELIMINATE DISCOMFORT DURING ELECTRICAL STIMULATION OF THE RETINA 审中-公开
标题翻译：技术和功能性电刺激消除电刺激下的不舒适
公开(公告)号：WO2010033728A3
公开(公告)日：2010-05-14
申请号：PCT/US2009057357
申请日：2009-09-17
申请人： SECOND SIGHT MEDICAL PROD INC , ZHOU CHUNHONG , CASPI AVRAHAM I , MCCLURE KELLY H , MCMAHON MATTHEW J , ROY ARUP , GREENBERG ROBERT J
发明人： ZHOU CHUNHONG , CASPI AVRAHAM I , MCCLURE KELLY H , MCMAHON MATTHEW J , ROY ARUP , GREENBERG ROBERT J
IPC分类号： A61N1/36 , A61N1/05 , A61N1/08 , A61N1/372 , G06T7/00
CPC分类号： A61N1/36046 , A61N1/0543
摘要： Techniques and functional electrical stimulation to eliminate discomfort during electrical stimulation of the retina are provided. According to a first technique, discomfort is eliminated through control of timing group assignment. According to a second technique, discomfort is eliminated through an edge detection method. According to a third technique, brightness clipping is used to eliminate discomfort. According to a fourth technique, direct reduction of current is obtained by scaling it down by a factor which is dependent on the sum of current in all electrodes. According to a fifth technique, the current being fed to each electrode is adjusted, by dividing it by a weighted sum of currents fed to the surrounding electrodes. According to a sixth technique, a method based on the current summation effect is used. According to a seventh technique, a large return electrode is used. According to an eighth technique, the return electrode is used for a pseudo-multi-polar stimulation.
摘要翻译：提供了在电刺激视网膜期间消除不适的技术和功能性电刺激。根据第一种技术，通过控制定时组分配来消除不适。根据第二种技术，通过边缘检测方法消除不适。根据第三种技术，亮度削减用于消除不适。根据第四种技术，通过按比例缩小电流来直接减小电流，该因数取决于所有电极中电流的总和。根据第五种技术，通过将供给每个电极的电流除以供给周围电极的电流的加权和来调整。根据第六种技术，使用基于当前求和效应的方法。根据第七种技术，使用大的返回电极。根据第八种技术，返回电极用于伪多极刺激。

9. 发明申请

WO2008011096A3 APPARATUS AND METHOD FOR VISUAL STIMULATION INDICATION 审中-公开
标题翻译：用于视觉刺激指示的装置和方法
公开(公告)号：WO2008011096A3
公开(公告)日：2008-04-17
申请号：PCT/US2007016360
申请日：2007-07-19
申请人： SECOND SIGHT MEDICAL PROD INC , VYAS NEHA , WEBBER DONALD A , REINHOLD JOHN R , ROY ARUP , CASTRO RICHARD AGUSTIN , MCCLURE KELLY H , GREENBERG ROBERT J
发明人： VYAS NEHA , WEBBER DONALD A , REINHOLD JOHN R , ROY ARUP , CASTRO RICHARD AGUSTIN , MCCLURE KELLY H , GREENBERG ROBERT J
IPC分类号： A61N1/36 , A61F9/08 , G09B21/00
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37241 , A61N1/37247 , G09B21/00 , G09B23/28
摘要： Methods and devices for verifying that proper visual stimulation is applied to the visual prostheses are described. In one of the methods, a retinal stimulation system implanted on a subject is simulated externally. An external testing device is also discussed.
摘要翻译：描述了用于验证适当的视觉刺激应用于视觉假体的方法和装置。在其中一种方法中，植入到对象上的视网膜刺激系统在外部被模拟。还讨论了外部测试设备。

10. 发明申请

WO2007035743A2 DOWNLOADABLE FILTERS FOR A VISUAL PROSTHESIS 审中-公开
标题翻译：可视化过滤器可视化前景
公开(公告)号：WO2007035743A2
公开(公告)日：2007-03-29
申请号：PCT/US2006036501
申请日：2006-09-18
申请人： SECOND SIGHT MEDICAL PROD INC , MCCLURE KELLY H , ROY ARUP , YADAV SUMIT , MAKSY PISHOY , MELISTRUP PETER
发明人： MCCLURE KELLY H , ROY ARUP , YADAV SUMIT , MAKSY PISHOY , MELISTRUP PETER
IPC分类号： A61N1/36 , A61F2/14 , A61F9/08 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543
摘要： The present invention is a method of neural stimulation and more specifically an improved method of providing flexible video/image possessing in a visual prosthesis by providing downloadable video filters. In a visual prosthesis, the input video image will, for the foreseeable future, be higher resolution than the output stimulation of the retina, optic nerve or visual cortex. This is due to limits of electrode array technology and the rapid advancement of video camera technology. It is therefore, advantageous to apply video processing algorithms (filters) to help provide the most useful information to the lower resolution electrode array. Different filters are more effective in different environments and for different subjects. Furthermore, filters will continue to improve over time. Examples of situation dependent filters include reverse image, contrast increasing, edge detection, segmentation using chromatic information and motion detection. Filters loaded in the video processing unit may be selected dynamically to suit the situation or the user's preference. It is therefore advantageous to provide flexibility in applying filters. However, it is also important to maintain the security necessary for a medical device. The present invention provides for an external (not implanted) video processing unit with downloadable video filters.
摘要翻译：本发明是神经刺激的方法，更具体地，提供了一种通过提供可下载的视频滤波器来提供在视觉假体中拥有的灵活视频/图像的改进方法。在视觉假体中，在可预见的将来，输入视频图像将比视网膜，视神经或视觉皮质的输出刺激更高的分辨率。这是由于电极阵列技术的局限性和摄像机技术的飞速发展。因此，应用视频处理算法（滤波器）有助于向较低分辨率电极阵列提供最有用的信息。不同的过滤器在不同的环境和不同的科目中更有效。此外，过滤器将随着时间的推移而持续改善。情况相关滤波器的示例包括反向图像，对比度增加，边缘检测，使用色彩信息和运动检测的分割。可以动态地选择加载在视频处理单元中的滤波器以适应情况或用户的偏好。因此，提供应用过滤器的灵活性是有利的。然而，保持医疗设备所需的安全性也是重要的。本发明提供具有可下载的视频滤波器的外部（未植入）视频处理单元。

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