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1. 发明申请

WO2009062114A3 COCHLEAR STIMULATION DEVICE COMPRISING A FLEXIBLE ELECTRODE ARRAY 审中-公开
标题翻译：包括柔性电极阵列的COCHLEAR刺激装置
公开(公告)号：WO2009062114A3
公开(公告)日：2009-08-27
申请号：PCT/US2008082904
申请日：2008-11-07
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , ZHOU DAVID DAOMIN , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY , WEI JIANING , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON
发明人： GREENBERG ROBERT J , ZHOU DAVID DAOMIN , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY , WEI JIANING , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译：耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。该设备旨在通过适当的电极设计实现最佳的神经刺激，是相对于市售的手工设备的显着改进。

2. 发明申请

WO2009006636A3 RETURN ELECTRODE FOR A FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：返回电极用于柔性电路电极阵列
公开(公告)号：WO2009006636A3
公开(公告)日：2009-02-26
申请号：PCT/US2008069348
申请日：2008-07-07
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , MCCLURE KELLY H , MECH BRIAN V , DAI RONGQING , ZHOU DAVID DAOMIN , NOLAN GAILLARD R
发明人： GREENBERG ROBERT J , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , MCCLURE KELLY H , MECH BRIAN V , DAI RONGQING , ZHOU DAVID DAOMIN , NOLAN GAILLARD R
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large. The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes. The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.
摘要翻译：在视觉假体中，电极刺激视网膜组织以诱导植入假体的使用者对光的感知。假体必须具有返回或常见的电极以与视网膜组织形成完整的电路。为了避免用返回电极刺激组织，如果电极很大，则是有利的。本发明涉及柔性电路电极阵列，其包括聚合物基底层，沉积在所述聚合物基底层上的金属迹线，包括适于刺激沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层的神经组织的电极和分离的回流电极从所述刺激电极。柔性电路电极阵列包括用于接收视觉数据的次级线圈; 电耦合到所述接收线圈的电子封装，以及电耦合到所述电子封装的多个刺激电极。

3. 发明申请

WO2008021524A2 PACKAGE FOR AN IMPLANTABLE NEURAL STIMULATION DEVICE 审中-公开
标题翻译：可植入神经刺激装置的包装
公开(公告)号：WO2008021524A2
公开(公告)日：2008-02-21
申请号：PCT/US2007018315
申请日：2007-08-18
申请人： SECOND SIGHT MEDICAL PROD INC , OK JERRY , GREENBERG ROBERT J , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , DAI RONGQING , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY H
发明人： OK JERRY , GREENBERG ROBERT J , TALBOT NEIL HAMILTON , LITTLE JAMES SINGLETON , DAI RONGQING , NEYSMITH JORDAN MATTHEW , MCCLURE KELLY H
IPC分类号： A61N1/00
CPC分类号： A61N1/36046 , A61F15/001 , A61N1/0529 , A61N1/0543 , A61N1/36125 , A61N1/375 , H01L23/055 , H01L23/06 , H01L23/08 , H01L23/10 , H01L24/16 , H01L24/48 , H01L25/18 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48106 , H01L2224/48225 , H01L2924/00014 , H01L2924/00 , H01L2224/0401
摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device comprises an electrically non-conductive substrate; a plurality of electrically conductive vias through said electrically non-conductive substrate; a flip-chip circuit attached to said electrically non-conductive substrate using conductive bumps and electrically connected to a first subset of said plurality of electrically conductive vias, wherein said flip-chip circuit contains one or more stacks or a folded stack; a wire bonded circuit attached to said electrically non-conductive substrate and electrically connected to a second subset of said electrically conductive vias; and a cover bonded to said electrically non-conductive substrate, said cover, said electrically non-conductive substrate and said electrically conductive vias forming a hermetic package.
摘要翻译：本发明是用于植入人体的改进的密封包装。可植入装置包括非导电基底; 通过所述非导电衬底的多个导电通孔; 使用导电凸块连接到所述非导电衬底并电连接到所述多个导电通孔的第一子集的倒装芯片电路，其中所述倒装芯片电路包含一个或多个堆叠或折叠堆叠; 连接到所述非导电衬底并电连接到所述导电通孔的第二子集的引线键合电路; 以及盖，其结合到所述非导电衬底，所述盖，所述非导电衬底和所述导电通孔形成气密封装。

4. 发明申请

WO2008101225A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH WIRE OR FILM SUPPORT 审中-公开
标题翻译：柔性电路阵列，电线或电影支持
公开(公告)号：WO2008101225A2
公开(公告)日：2008-08-21
申请号：PCT/US2008054181
申请日：2008-02-15
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
发明人： GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
摘要翻译：本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连垫连接的折叠柔性电路电缆。本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆至少一次将电极阵列与互连衬垫连接在一起。

5. 发明申请

WO2008109862A9 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：WO2008109862A9
公开(公告)日：2008-11-13
申请号：PCT/US2008056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
发明人： AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 以及金属迹线区域的中央开口。柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 和填充附着点的软聚合物。柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 和避免触摸柔性电极阵列和视神经的驼峰。

6. 发明申请

WO2008109862A3 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
公开(公告)号：WO2008109862A3
公开(公告)日：2008-12-24
申请号：PCT/US2008056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
发明人： AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

7. 发明专利

AU2007284422A1 Package for an implantable neural stimulation device 未知
公开(公告)号：AU2007284422A1
公开(公告)日：2008-02-21
申请号：AU2007284422
申请日：2007-08-18
申请人： SECOND SIGHT MEDICAL PROD INC
发明人： DAI RONGQING , GREENBERG ROBERT J , OK JERRY , LITTLE JAMES SINGLETON , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW
IPC分类号： A61N1/00
摘要： An implantable device, comprising a rigid substrate having an electrically non-conductive portion; a plurality of electrically conductive vias through said electrically non-conductive portion, said vias and electrically non-conductive portion forming said rigid substrate; metal traces on said rigid substrate electrically connected to said conductive vias; a circuit attached to said metal traces; a braze stop trace surrounding said metal traces; a cover bonded to said rigid substrate with a braze, said cover and said rigid substrate forming a hermetic package; wherein said braze stop trace prevents said braze from contacting said metal traces.

8. 发明专利

AU2008268154A1 Flexible circuit electrode array 未知
公开(公告)号：AU2008268154A1
公开(公告)日：2008-12-31
申请号：AU2008268154
申请日：2008-06-27
申请人： SECOND SIGHT MEDICAL PROD INC
发明人： ZHOU DAVID DAOMIN , NEYSMITH JORDAN MATTHEW , GREENBERG ROBERT J , NG BOON-KHAI , LITTLE JAMES SINGLETON
IPC分类号： A61N1/05
摘要： A flexible circuit electrode array, which comprises: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a partial or entire coating of the base and top layer by a soft polymer.

9. 发明专利

AU2008216010A1 Flexible circuit electrode array with wire or film support 未知
公开(公告)号：AU2008216010A1
公开(公告)日：2008-08-21
申请号：AU2008216010
申请日：2008-02-15
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST
发明人： NEYSMITH JORDAN MATTHEW , MCCLURE KELLY H , MECH BRIAN V , HUMAYUN MARK S , LITTLE JAMES SINGLETON , JUAN EUGENE DE , GREENBERG ROBERT J , TALBOT NEIL HAMILTON , KHALDI MOHAMED
IPC分类号： A61N1/05

10. 发明专利

AU2008272808A1 Return electrode for a flexible circuit electrode array 未知
公开(公告)号：AU2008272808A1
公开(公告)日：2009-01-08
申请号：AU2008272808
申请日：2008-07-07
申请人： SECOND SIGHT MEDICAL PROD INC
发明人： DAI RONGQING , TALBOT NEIL HAMILTON , GREENBERG ROBERT J , ZHOU DAVID DAOMIN , MECH BRIAN V , NOLAN GAILLARD R , LITTLE JAMES SINGLETON , MCCLURE KELLY H , NEYSMITH JORDAN MATTHEW
IPC分类号： A61N1/36 , A61N1/05
摘要： In a visual prosthesis electrodes stimulate retinal tissue to induce the perception of light to a user implanted with the prosthesis. The prosthesis must have a return, or common, electrode to make a complete circuit with the retinal tissue. To avoid stimulating tissue with the return electrode, it is advantageous if the electrode is large. The invention involver a flexible circuit electrode array comprising a polymer base layer, metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue a polymer top layer deposited on said polymer base layer and said metal traces, and a return electrode separate from said stimulating electrodes. The flexible circuit electrode array comprises a secondary coil for receiving visual data; an electronics package electrically coupled to said receiving coil, and a plurality of stimulating electrode electrically coupled to said electronics package.

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