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1. 发明申请

WO2007149291A3 A METHOD FOR ELECTRICAL STIMULATION OF HUMAN RETINA USING PULSE TRAINS 审中-公开
标题翻译：一种使用脉冲火车电刺激人类血红蛋白的方法
公开(公告)号：WO2007149291A3
公开(公告)日：2008-02-14
申请号：PCT/US2007013918
申请日：2007-06-14
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , HORSAGER ALAN MATTHEW , GREENWALD SCOTT H , HUMAYUN MARK S , MCMAHON MATTHEW J , FINE IONE , GREENBERG ROBERT J , BOYNTON GEOFFREY M
发明人： HORSAGER ALAN MATTHEW , GREENWALD SCOTT H , HUMAYUN MARK S , MCMAHON MATTHEW J , FINE IONE , GREENBERG ROBERT J , BOYNTON GEOFFREY M
IPC分类号： A61N1/36
CPC分类号： A61N1/36046
摘要： An apparatus and method for retinal stimulation are shown. The apparatus comprises an implantable and external portion, and the method comprises varied parameters, including frequency, pulse width, and pattern of pulse trains to determine a stimulation pattern and visual perception threshold.
摘要翻译：显示视网膜刺激的装置和方法。该装置包括可植入和外部部分，该方法包括变化的参数，包括脉冲序列的频率，脉冲宽度和模式，以确定刺激模式和视觉感知阈值。

2. 发明申请

WO2007064916A9 FITTING A NEURAL PROSTHESIS USING IMPEDANCE AND ELECTRODE HEIGHT 审中-公开
标题翻译：使用阻抗和电极高度配置神经前体
公开(公告)号：WO2007064916A9
公开(公告)日：2008-05-22
申请号：PCT/US2006046042
申请日：2006-12-01
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
发明人： GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
IPC分类号： A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

3. 发明申请

WO2007064916A3 FITTING A NEURAL PROSTHESIS USING IMPEDANCE AND ELECTRODE HEIGHT 审中-公开
标题翻译：使用阻抗和电极高度配置神经前体
公开(公告)号：WO2007064916A3
公开(公告)日：2007-08-09
申请号：PCT/US2006046042
申请日：2006-12-01
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
发明人： GREENBERG ROBERT J , ROY ARUP , MCMAHON MATTHEW J , HUMAYUN MARK S , WEILAND JAMES DAVID , HORSAGER ALAN MATTHEW , ZHOU DAO MIN , HINES AMY , YADAV SUMIT , DAI RONGQING , FINE IONE
IPC分类号： A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。可以使用阻抗测量来预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极放置。

4. 发明申请

WO2008109771A3 SALIENCY-BASED APPARATUS AND METHODS FOR VISUAL PROSTHESES 审中-公开
标题翻译：基于SALIENCY的设备和视觉展示的方法
公开(公告)号：WO2008109771A3
公开(公告)日：2009-01-15
申请号：PCT/US2008056089
申请日：2008-03-06
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , HORSAGER ALAN MATTHEW , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J , MEILSTRUP PETER , PARIKH NEHA JAGDISH , ROY ARUP , WEILAND JAMES D , ZHOU CHUNHONG
发明人： GREENBERG ROBERT J , HORSAGER ALAN MATTHEW , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J , MEILSTRUP PETER , PARIKH NEHA JAGDISH , ROY ARUP , WEILAND JAMES D , ZHOU CHUNHONG
IPC分类号： A61N1/36 , G06T7/00
CPC分类号： A61N1/36046 , A61F9/08 , G06K9/4604 , G06K9/4628 , G06K9/605 , G09B21/008
摘要： Saliency-based apparatus and methods for visual prostheses are disclosed. A saliency-based component processes video data output by a digital signal processor before the video data are input to the retinal stimulator. In a saliency-based method, an intensity stream is extracted from an input image, feature maps based on the intensity stream are developed, plural most salient regions of the input image are detected and one of the regions is selected as a highest saliency region.
摘要翻译：公开了用于视觉假体的基于显着性的装置和方法。基于显眼的组件在将视频数据输入到视网膜刺激器之前处理由数字信号处理器输出的视频数据。在基于显着性的方法中，从输入图像中提取强度流，基于强度流形成特征图，检测输入图像的多个最显着区域，并选择其中一个区域作为最高显着区域。

5. 发明申请

WO2008051869A3 VISUAL PROSTHESIS 审中-公开
标题翻译：视觉假体
公开(公告)号：WO2008051869A3
公开(公告)日：2008-06-19
申请号：PCT/US2007082004
申请日：2007-10-19
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J
发明人： GREENBERG ROBERT J , HUMAYUN MARK S , MCCLURE KELLY H , MCMAHON MATTHEW J
IPC分类号： A61N1/36 , A61F2/14 , A61F9/08 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/37247
摘要： A method for stimulating a subject's retina. The method comprising selecting at least a first and a second electrode each configured to apply current to a subject's retina, determining impedance for the at least first electrode and second electrode, and applying current to the subject's retina through the at least first and second electrode, wherein current to be applied by the first electrode and the second electrode is configured to be higher for the first electrode when the first electrode has an impedance lower than a second electrode's impedance.
摘要翻译：一种刺激受试者视网膜的方法。该方法包括选择至少第一和第二电极，每个电极被配置为将电流施加到对象的视网膜，确定至少第一电极和第二电极的阻抗，并且通过至少第一和第二电极向对象的视网膜施加电流，其中当所述第一电极具有比第二电极的阻抗低的阻抗时，由所述第一电极和所述第二电极施加的电流被配置为对于所述第一电极更高。

6. 发明申请

WO2008109862A3 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
公开(公告)号：WO2008109862A3
公开(公告)日：2008-12-24
申请号：PCT/US2008056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
发明人： AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.

7. 发明申请

WO2008109862A9 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：WO2008109862A9
公开(公告)日：2008-11-13
申请号：PCT/US2008056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
发明人： AGRAWAL RAJAT , GREENBERG ROBERT J , HUMAYUN MARK S , LITTLE JAMES SINGLETON , MECH BRIAN V , NEYSMITH JORDAN MATTHEW , TALBOT NEIL HAMILTON , ZHOU DAO MIN
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 以及金属迹线区域的中央开口。柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 和填充附着点的软聚合物。柔性电路电极阵列，包括：聚合物基底层; 沉积在所述聚合物基层上的金属迹线，包括适于刺激神经组织的电极; 沉积在所述聚合物基层和所述金属迹线上的聚合物顶层; 和避免触摸柔性电极阵列和视神经的驼峰。

8. 发明申请

WO2008064269A8 METHOD OF IMPROVING ELECTRODE TISSUE INTERFACE 审中-公开
标题翻译：改善电极组织界面的方法
公开(公告)号：WO2008064269A8
公开(公告)日：2008-09-18
申请号：PCT/US2007085306
申请日：2007-11-20
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , SHAH SAMIP , HINES AMY CHU PEISHUAN , ZHOU DAO MIN , GREENBERG ROBERT J , HUMAYUN MARK S , WEILAND JAMES D
发明人： SHAH SAMIP , HINES AMY CHU PEISHUAN , ZHOU DAO MIN , GREENBERG ROBERT J , HUMAYUN MARK S , WEILAND JAMES D
IPC分类号： A61N1/05
CPC分类号： A61N1/0543

9. 发明申请

WO2008101225A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH WIRE OR FILM SUPPORT 审中-公开
标题翻译：柔性电路阵列，电线或电影支持
公开(公告)号：WO2008101225A2
公开(公告)日：2008-08-21
申请号：PCT/US2008054181
申请日：2008-02-15
申请人： SECOND SIGHT MEDICAL PROD INC , DOHENY EYE INST , GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
发明人： GREENBERG ROBERT J , DE JUAN EUGENE , HUMAYUN MARK S , MCCLURE KELLY H , TALBOT NEIL HAMILTON , NEYSMITH JORDAN MATTHEW , MECH BRIAN V , LITTLE JAMES SINGLETON , KHALDI MOHAMED
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/05 , A61N1/0541 , H05K1/0393 , H05K1/118
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.
摘要翻译：本发明涉及柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及嵌入在所述阵列中的至少一个支撑。本发明还涉及一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及将电极阵列与互连垫连接的折叠柔性电路电缆。本公开还涉及一种制造柔性电路电极阵列的方法，包括：沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 将所述柔性电路电极阵列加热到模具中以在所述柔性电路电极阵列中形成三维形状，至少在基层，顶层或基底与顶层之间嵌入支撑件，和/或折叠柔性电路电缆至少一次将电极阵列与互连衬垫连接在一起。

10. 发明申请

WO2007035361A3 TRANS-RETINAL FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译： TRANS -RETINAL柔性电路电极阵列
公开(公告)号：WO2007035361A3
公开(公告)日：2007-07-05
申请号：PCT/US2006035674
申请日：2006-09-13
申请人： SECOND SIGHT MEDICAL PROD INC , GREENBERG ROBERT J , HUMAYUN MARK S
发明人： GREENBERG ROBERT J , HUMAYUN MARK S
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/118
摘要： Applicant has proposed a combination of the subretinal and epiretinal methods by placing the electronics external to the eye, entering the eye through the pars plana and the piercing the retina (retinotomy) from inside the eye to stimulate subreintally. The present invention is an improved electrode array for subretinal stimulation. A hard polymer such as polyimide is biocompatible and strong for supporting an electrode array and supporting traces in a thin flex circuit array. In the present invention applicant takes advantage of the sharp nature of thin polyimide making a point on the end of the electrode array. This allows the flexible circuit electrode array to be both electrode array and surgical tool to cut the retinal and slide the array under the retina in a single action.
摘要翻译：申请人已经提出了视网膜下和视网膜前方法的组合，通过将电子器件放置在眼睛外部，通过睫状体平坦部进入眼睛并且从眼内刺入视网膜（视网膜切开术）以进行子宫内刺激。本发明是一种用于视网膜下刺激的改进的电极阵列。诸如聚酰亚胺之类的硬质聚合物具有生物相容性和强度，可用于支撑电极阵列和薄柔性电路阵列中的支撑迹线。在本发明中，申请人利用在电极阵列的端部上形成一点的薄聚酰亚胺的尖锐特性。这允许柔性电路电极阵列既是电极阵列又是手术工具以切割视网膜并在单一动作下在视网膜下滑动阵列。

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