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1. 发明申请

WO2004094593A3 EXPANDING THE EUKARYOTIC GENETIC CODE 审中-公开
标题翻译：扩展“原始遗传代码”
公开(公告)号：WO2004094593A3
公开(公告)日：2007-12-21
申请号：PCT/US2004011786
申请日：2004-04-16
申请人： SCRIPPS RESEARCH INST , CHIN JASON W , CROPP ASHTON T , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
发明人： CHIN JASON W , CROPP ASHTON T , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
IPC分类号： C12N9/10 , C07H21/04 , C12N20060101 , C12N9/16 , C12N9/22 , C12N15/00 , C12N15/10 , C12N15/12 , C12N15/54 , C12P21/00 , C12P21/06 , C12Q1/68
CPC分类号： C12N15/81 , A61K38/1709 , C12N9/93 , C12N15/67 , C12Y601/01 , C12Y601/01001 , C12Y601/0102 , Y10S435/81 , Y10S435/975
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译：本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。组分包括正交tRNA，正交氨酰-tRNA合成酶，正交对tRNA /合成酶和非天然氨基酸。还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

2. 发明申请

WO2005003294A3 UNNATURAL REACTIVE AMINO ACID GENETIC CODE ADDITIONS 审中-公开
标题翻译：联合反应性氨基酸基因代码补充
公开(公告)号：WO2005003294A3
公开(公告)日：2007-11-29
申请号：PCT/US2004011833
申请日：2004-04-16
申请人： SCRIPPS RESEARCH INST , DEITERS ALEXANDER , CROPP ASHTON T , CHIN JASON W , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
发明人： DEITERS ALEXANDER , CROPP ASHTON T , CHIN JASON W , ANDERSON CHRISTOPHER J , SCHULTZ PETER G
IPC分类号： G01N33/53 , C07H21/02 , C07K1/00 , C12N20060101 , C12N1/20 , C12N9/16 , C12N15/00 , C12P21/06
CPC分类号： G01N33/583 , C07C227/22 , C07C229/36 , C07C269/06 , C07C311/41 , C07K1/1072 , C07K1/13 , C07K14/001 , C07K16/18 , C09B11/08 , C09B57/00 , C12N9/93 , C12N15/67 , C12N2510/02 , C12P17/04 , C12P21/02 , G01N33/532 , G01N33/582 , C07C271/22
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNAsynthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
摘要翻译：本发明提供用于产生扩增真核细胞中遗传编码氨基酸数目的翻译组分的组合物和方法。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸对。还提供了在真核细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

3. 发明申请

WO2005007624A3 COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL TRNA SYNTHETASE PAIRS AND USES THEREOF 审中-公开
标题翻译：正交谷氨酰-tRNA和氨基酸TRNA合成酶对的组成及其用途
公开(公告)号：WO2005007624A3
公开(公告)日：2006-03-30
申请号：PCT/US2004021813
申请日：2004-07-07
申请人： SCRIPPS RESEARCH INST , ANDERSON CHRISTOPHER J , SCHULTZ PETER G , SANTORO STEPHEN
发明人： ANDERSON CHRISTOPHER J , SCHULTZ PETER G , SANTORO STEPHEN
IPC分类号： C07D20060101 , C12N9/00 , C12N9/10 , C12N15/12 , C12N15/54 , C12P21/00
CPC分类号： C12N9/93
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include glutamyl orthogonal tRNAs, glutamyl orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of glutamyl tRNAs/synthetases are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins using these orthogonal pairs.
摘要翻译：提供了包括谷氨酰正交tRNA，谷氨酰正交氨酰-tRNA合成酶和正戊基谷氨酰tRNA /合成酶对蛋白质生物合成机理成分的组合物和方法。还提供用于鉴定这些正交对的方法以及使用这些正交对产生蛋白质的方法。

4. 发明申请

WO2009055616A2 GENETIC INCORPORATION OF 3-AMINOTYROSINE INTO REDUCTASES 审中-公开
标题翻译：将氨基苯甲酸的遗传转化为降低成分
公开(公告)号：WO2009055616A2
公开(公告)日：2009-04-30
申请号：PCT/US2008081024
申请日：2008-10-23
申请人： SCRIPPS RESEARCH INST , MASSACHUSETTS INST TECHNOLOGY , SEYEDSAYAMDOST MOHAMMAD R , XIE JIANMING , CHAN CLEMENT TSZ , ALFONTA LITAL , SCHULTZ PETER G , STUBBE JOANNE
发明人： SEYEDSAYAMDOST MOHAMMAD R , XIE JIANMING , CHAN CLEMENT TSZ , ALFONTA LITAL , SCHULTZ PETER G , STUBBE JOANNE
CPC分类号： C12N9/0093 , C12Q1/26 , G01N2333/9029
摘要： This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino acid residues in reductases as molecular probes for probing reductases function, structure and activity.
摘要翻译：本发明提供了包含NH2Y非天然氨基酸残基的还原酶蛋白，用于将NH2Y并入还原酶的正交元件的系统和在还原酶中使用NH 2 Y氨基酸残基作为探针还原酶功能，结构和活性的分子探针的方法。

5. 发明申请

WO2007103490A3 SYSTEM FOR THE EXPRESSION OF ORTHOGONAL TRANSLATION COMPONENTS IN EUBACTERIAL HOST CELLS 审中-公开
标题翻译：用于表达EUBACTERIAL HOST细胞中正交翻译组分的系统
公开(公告)号：WO2007103490A3
公开(公告)日：2008-06-12
申请号：PCT/US2007005914
申请日：2007-03-07
申请人： SCRIPPS RESEARCH INST , RYU YOUNGHA , SCHULTZ PETER G
发明人： RYU YOUNGHA , SCHULTZ PETER G
IPC分类号： C12N15/74
CPC分类号： C07K14/245 , C12N15/70 , C12P21/02
摘要： The invention relates to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural amino acids at genetically-programmed positions.
摘要翻译：本发明涉及用于体内产生包含一种或多种非天然氨基酸的多肽的组合物和方法。具体地，本发明提供了用于在遗传编程的位置上有效地表达包含一个或多个非天然氨基酸的多肽的多肽的质粒系统。

6. 发明申请

WO2006116503A3 METHODS AND COMPOSITIONS FOR MODULATING WNT SIGNALING PATHWAY 审中-公开
标题翻译：用于调制WNT信号通路的方法和组合
公开(公告)号：WO2006116503A3
公开(公告)日：2007-07-05
申请号：PCT/US2006015821
申请日：2006-04-26
申请人： IRM LLC , SCRIPPS RESEARCH INST , ZHANG QISHENG , DING SHENG , SCHULTZ PETER G
发明人： ZHANG QISHENG , DING SHENG , SCHULTZ PETER G
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6897 , G01N33/5023
摘要： This invention provides novel Wnt signaling pathway regulators. The invention also provides methods of using the Wnt signaling pathway regulators to screen for compounds that modulate Wnt signaling pathway. The methods comprise first screening test compounds for modulators of a Wnt signaling pathway regulator disclosed herein, and then further screening the identified modulating agents for ability to modulate Wnt signaling pathway. The invention further provides methods for modulating Wnt signaling pathway and pharmaceutical compositions for treating diseases and conditions (e.g., tumors) associated with abnormal Wnt signaling activities.
摘要翻译：本发明提供了新的Wnt信号通路调节剂。本发明还提供使用Wnt信号通路调节剂筛选调节Wnt信号通路的化合物的方法。所述方法包括首先筛选本文公开的Wnt信号通路调节剂的调节剂的测试化合物，然后进一步筛选鉴定的调节剂调节Wnt信号通路的能力。本发明还提供了用于调节Wnt信号通路和用于治疗与异常Wnt信号传导活性相关的疾病和病症（例如肿瘤）的药物组合物的方法。

7. 发明申请

WO2004035743A8 SITE SPECIFIC INCORPORATION OF KETO AMINO ACIDS INTO PROTEINS 审中-公开
标题翻译： KETO氨基酸在蛋白质中的位点特异性引入
公开(公告)号：WO2004035743A8
公开(公告)日：2005-06-09
申请号：PCT/US0332576
申请日：2003-10-15
申请人： SCRIPPS RESEARCH INST , SCHULTZ PETER G , WANG LEI
发明人： SCHULTZ PETER G , WANG LEI
IPC分类号： C07K14/47 , C12N9/00 , C12N15/10 , C12N15/67 , C12P21/00 , C12N
CPC分类号： C12N15/67 , C12N9/93 , C12N15/10 , C12P21/005
摘要： Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with keto amino acids using these orthogonal pairs.
摘要翻译：提供了生产蛋白质生物合成机器组分的组合物和方法，所述组合物包括正交tRNA，正交氨酰-tRNA合成酶和正交配对的tRNA /合成酶，其将酮氨基酸掺入蛋白质中。还提供了用于鉴定这些正交配对的方法以及使用这些正交配对产生具有酮基氨基酸的蛋白质的方法。

8. 发明申请

WO2010059401A3 COMPOUNDS THAT EXPAND HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译：扩增造血干细胞的化合物
公开(公告)号：WO2010059401A3
公开(公告)日：2010-09-23
申请号：PCT/US2009062646
申请日：2009-10-29
申请人： IRM LLC , SCRIPPS RESEARCH INST , BOITANO ANTHONY , COOKE MICHAEL , PAN SHIFENG , SCHULTZ PETER G , TELLEW JOHN , WAN YONGQIN , WANG XING
发明人： BOITANO ANTHONY , COOKE MICHAEL , PAN SHIFENG , SCHULTZ PETER G , TELLEW JOHN , WAN YONGQIN , WANG XING
IPC分类号： A61K31/519 , A61K31/52 , A61P37/00 , C07D473/34 , C07D487/04
CPC分类号： A61K35/28 , A61K9/0019 , A61K31/52 , A61K38/00 , A61K2035/124 , C07D473/16 , C07D473/34 , C07D487/04 , C07D495/04 , C12N5/0647 , C12N2501/38 , C12N2501/60
摘要： The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
摘要翻译：本发明涉及用于扩增用于移植的CD34 +细胞数量的化合物和组合物。本发明还涉及包含扩增的造血干细胞（HSC）的细胞群及其在自体或同种异体移植中的用途，用于治疗患有遗传性免疫缺陷和自身免疫疾病以及不同造血障碍的患者，以重建造血细胞谱系和免疫系统防御。

9. 发明申请

WO2005081632A3 ENZYMES, CELLS AND METHODS FOR SITE SPECIFIC RECOMBINATION AT ASYMMETRIC SITES 审中-公开
标题翻译：不对称站点特异性重组的酶，细胞和方法
公开(公告)号：WO2005081632A3
公开(公告)日：2009-09-03
申请号：PCT/IL2005000230
申请日：2005-02-24
申请人： ISRAEL STATE , SCRIPPS RESEARCH INST , CARMI NIR , EYAL YORAM , GIDONI DAVID , SCHULTZ PETER G , SANTORO STEPHEN W
发明人： CARMI NIR , EYAL YORAM , GIDONI DAVID , SCHULTZ PETER G , SANTORO STEPHEN W
IPC分类号： C12N9/22
CPC分类号： C12N9/00 , C12N15/902 , C12N2800/30
摘要： The present invention relates to enzymes, compositions and methods for catalyzing asymmetric recombination of non-palindromic recombination sites in a cell free system, in isolated cells or in living organisms. The enzymes and methods of the invention are suitable for mediating specific recombinations between DNA sequences comprising specific recombination sites without being limited to strict palindromic symmetry within each recombination site.
摘要翻译：本发明涉及在无细胞系统，分离的细胞或活生物体中催化非回归重组位点的不对称重组的酶，组合物和方法。本发明的酶和方法适用于介导包含特异性重组位点的DNA序列之间的特异性重组，而不限于每个重组位点内严格的回文对称性。

10. 发明申请

WO2009059056A3 A GENETICALLY ENCODED BORONATE AMINO ACID 审中-公开
标题翻译：一种基因编码的二硼酸氨基酸
公开(公告)号：WO2009059056A3
公开(公告)日：2009-08-20
申请号：PCT/US2008081868
申请日：2008-10-30
申请人： SCRIPPS RESEARCH INST , BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
发明人： BRUSTAD ERIC , BUSHEY MARK L , SCHULTZ PETER G
IPC分类号： C12N9/00
CPC分类号： C12P13/222 , C07K17/06 , C12N9/93 , C12N15/67 , C12P21/02
摘要： Provided are compositions comprising an aminoacyl tRNA synthetase that selectively recognizes a boronic amino acid. Methods of incorporating a boronic amino acid into a target polypeptides and target polypeptides produced by the methods are also provided. Methods of producing a protein, which methods comprise site-specifically encoding a boronic amino acid residue into a mutant protein and selectively converting the boronic amino acid residue into a natural amino acid residue are provided. Also provided are compositions comprising a solid phase matrix covalently bound to a polypeptide through a boronic amino acid residue. In addition, compositions comprising a purified population of polypeptide molecules that each comprise a borono amino acid at a selected site are provided.
摘要翻译：提供了包含选择性识别硼酸氨基酸的氨酰基tRNA合成酶的组合物。还提供了将硼酸氨基酸掺入靶多肽和通过该方法产生的靶多肽的方法。提供了产生蛋白质的方法，该方法包括将硼酸氨基酸残基特异性编码到突变蛋白中并选择性地将硼酸氨基酸残基转化成天然氨基酸残基。还提供了包含通过硼酸氨基酸残基与多肽共价结合的固相基质的组合物。此外，提供了包含纯化的多肽分子群的组合物，其各自包含选定位点的硼氢氨基酸。

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