专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2007084595A2 BENZENESULFONYL-CHROMANE, THIOCHROMANE, TETRAHYDRONAPHTHALENE AND RELATED GAMMA SECRETASE INHIBITORS 审中-公开
标题翻译：苯并呋喃酮，噻吗啉，四氢萘酮和相关的游离氨基酸酶抑制剂
公开(公告)号：WO2007084595A2
公开(公告)日：2007-07-26
申请号：PCT/US2007/001302
申请日：2007-01-18
申请人： SCHERING CORPORATION , ASBEROM, Theodros , BARA, Thomas , BENNETT, Chad, E. , BURNETT, Duane, A. , CAPLEN, Mary Ann , CLADER, John, W. , COLE, David, J. , DOMALSKI, Martin, S. , JOSIEN, Hubert, B. , KNUTSON, Chad, E. , LI, Hongmei , MCBRIAR, Mark, D. , PISSARNITSKI, Dmitri, A. , QIANG, Li , RAJAGOPALAN, Murali , SASIKUMAR, Thavalakulamgar, K. , SU, Jing , TANG, Haiqun , WU, Wen-Lian , XU, Ruo , ZHAO, Zhiqiang
发明人： ASBEROM, Theodros , BARA, Thomas , BENNETT, Chad, E. , BURNETT, Duane, A. , CAPLEN, Mary Ann , CLADER, John, W. , COLE, David, J. , DOMALSKI, Martin, S. , JOSIEN, Hubert, B. , KNUTSON, Chad, E. , LI, Hongmei , MCBRIAR, Mark, D. , PISSARNITSKI, Dmitri, A. , QIANG, Li , RAJAGOPALAN, Murali , SASIKUMAR, Thavalakulamgar, K. , SU, Jing , TANG, Haiqun , WU, Wen-Lian , XU, Ruo , ZHAO, Zhiqiang
IPC分类号： C07D311/22 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06
CPC分类号： C07D311/22 , C07C317/14 , C07C317/20 , C07C317/44 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D311/80 , C07D311/92 , C07D311/94 , C07D313/08 , C07D335/06 , C07D405/12 , C07D409/12 , C07D491/04 , C07D493/04
摘要： This invention discloses novel gamma secretase inhibitors of the formula: R 2 and R 3 , or R 2 and R 4 , or R 3 and R 4 , together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substituents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.
摘要翻译：本发明公开了下式的新型γ分泌酶抑制剂：R 2和R 3，或R 2和R 4 O / >或R 3和R 4与它们所连接的原子一起可以形成稠合的环烷基或稠合的杂环烷基环。环烷基环或杂环烷基环可任选被一个或多个取代基取代。一种或多种式（I）化合物或包含这些化合物的制剂可以是有用的，例如，治疗阿尔茨海默病。

2. 发明申请

WO2005097768A2 NOVEL GAMMA SECRETASE INHIBITORS 审中-公开
标题翻译：新的GAMMA秘密抑制剂
公开(公告)号：WO2005097768A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/011456
申请日：2005-04-04
申请人： SCHERING CORPORATION , ASBEROM, Theodros , CLADER, John, W. , JOSIEN, Hubert, B. , PISSARNITSKI, Dmitri, A. , ZHAO, Zhiqiang , MCBRIAR, Mark, D.
发明人： ASBEROM, Theodros , CLADER, John, W. , JOSIEN, Hubert, B. , PISSARNITSKI, Dmitri, A. , ZHAO, Zhiqiang , MCBRIAR, Mark, D.
IPC分类号： C07D295/00
CPC分类号： C07D451/04 , C07D211/96 , C07D401/06 , C07D401/12 , C07D413/06 , C07D413/14 , C07D451/06 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/08
摘要： Gamma-secretase inhibitors of the formula: Chemical formula should be inserted here as it appears on the abstract in paper form. are useful in treating various neurodegenerative diseases, wherein, for example: R1 includes unsubstituted or substituted aryl or heteroaryl groups; R2 includes -C(O)-Y, alkylene-C(O)-Y, alkylene-cycloalkylene-C(O)-Y, cycloalkylene-alkylene-C(O)-Y, alkylene cycloalkylene-alkylene-C(O)-Y, cycloalkylene-C(O)-Y, -S(O)-Y, alkylene-S(O)-Y, alkylene-cycloalkylene-S(O)-Y, cycloalkylene-alkylene-S(O)-Y, alkylene cycloalkylene-alkylene-S(O)-Y, cycloalkylene-S(O)-Y, -S(O2)-Y, alkylene-S(O2)-Y, alkylene cycloalkylene S(O2)-Y, cycloalkylene alkylene S(O2)-Y, alkylene cycloalkylene-alkylene-S(O2)-Y, and cycloalkylene-S(O2)-Y, wherein Y is as defined herein, and each of said alkylene or cycloalkylene may be unsubstituted or substituted as provided herein; each R3 is independently includes H, alkyl, O alkyl, OH, N(R9)2, acyl, and aroyl; or the moiety (R3)2, together with the ring carbon atom to which it is shown attached in formula I, defines a carbonyl group, -C(O)-; each R3A and R3B independently includes H, or alkyl; R11 includes aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. One or more of the compounds of formula I, or pharmaceutically acceptable salts, solvates, and/or esters, or compositions comprised thereof, may be used to treat, e.g., Alzheimer's Disease.
摘要翻译： Gamma-secretase抑制剂的配方：化学式应该插在这里，它以纸质形式出现在抽象上。可用于治疗各种神经变性疾病，其中例如：R 1包括未取代或取代的芳基或杂芳基; R 2包括-C（O）-Y，亚烷基-C（O）-Y，亚烷基 - 亚环烷基-C（O）-Y，亚环烷基亚烷基-C（O）-Y，亚烷基亚环烷基 - 亚烷基-C（O） -Y，亚环烷基-C（O）-Y，-S（O）-Y，亚烷基-S（O）-Y，亚烷基 - 亚环烷基-S（O）-Y，亚环烷基 - 亚烷基-S（O）亚烷基亚环烷基亚烷基-S（O）-Y，亚环烷基-S（O）-Y，-S（O 2）-Y，亚烷基-S（O 2）-Y，亚烷基亚环烷基S（O 2） S（O 2）-Y，亚烷基亚烷基亚烷基 - 亚烷基-S（O 2）-Y和亚环烷基-S（O 2）-Y，其中Y如本文所定义，并且所述亚烷基或亚环烷基中的每一个可以是未取代的或如所提供的取代本文; 每个R 3独立地包括H，烷基，O烷基，OH，N（R 9）2，酰基和芳酰基; 或（R3）2部分与式I中所示的环碳原子一起定义为羰基-C（O） - ; 每个R3A和R3B独立地包括H或烷基; R11包括芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基或烷氧基烷基。一种或多种式I化合物或其药学上可接受的盐，溶剂化物和/或酯或其组合物可用于治疗，例如阿尔茨海默氏病。

3. 发明申请

WO2010054078A1 GAMMA SECRETASE MODULATORS 审中-公开
标题翻译： GAMMA秘密调节器
公开(公告)号：WO2010054078A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063396
申请日：2009-11-05
申请人： SCHERING CORPORATION , ZHU, Zhaoning , GREENLEE, William, J. , COLE, David, James , PISSARNITSKI, Dmitri, A. , GALLO, Gioconda, V. , LI, Hongmei , JOSIEN, Hubert, B. , QIN, Jun , KNUTSON, Chad, E. , MANDAL, Mihirbaran , VICAREL, Monica, L. , RAJAGOPALAN, Murali , DHONDI, Pawan, Kumar , XU, Ruo , SUN, Zhong-Yue , BARA, Thomas, A. , HUANG, Xianhai , ZHU, Xiaohong , ZHAO, Zhiqiang , CLADER, John, W. , PALANI, Anandan , ASBEROM, Theodros , MCCRACKEN, Troy , BENNETT, Chad, E.
发明人： ZHU, Zhaoning , GREENLEE, William, J. , COLE, David, James , PISSARNITSKI, Dmitri, A. , GALLO, Gioconda, V. , LI, Hongmei , JOSIEN, Hubert, B. , QIN, Jun , KNUTSON, Chad, E. , MANDAL, Mihirbaran , VICAREL, Monica, L. , RAJAGOPALAN, Murali , DHONDI, Pawan, Kumar , XU, Ruo , SUN, Zhong-Yue , BARA, Thomas, A. , HUANG, Xianhai , ZHU, Xiaohong , ZHAO, Zhiqiang , CLADER, John, W. , PALANI, Anandan , ASBEROM, Theodros , MCCRACKEN, Troy , BENNETT, Chad, E.
IPC分类号： C07D413/10 , C07D471/04 , C07D498/04 , C07D498/20 , A61K31/4245 , A61K31/4162 , A61P25/28
CPC分类号： C07D471/04 , C07D413/10 , C07D498/04 , C07D498/20 , C07F7/0812
摘要： In its many embodiments, the present invention provides novel heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了作为γ-分泌酶的调节剂的新型杂环化合物，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，使用这种化合物或药物组合物预防，抑制或改善与中枢神经系统相关的一种或多种疾病。

4. 发明申请

WO2010054067A1 GAMMA SECRETASE MODULATORS 审中-公开
公开(公告)号：WO2010054067A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063385
申请日：2009-11-05
申请人： SCHERING CORPORATION , ZHU, Zhaoning , GREENLEE, William, J. , COLE, David, James , PISSARNITSKI, Dmitri, A. , GALLO, Gioconda, V. , LI, Hongmei , JOSIEN, Hubert, B. , QIN, Jun , KNUTSON, Chad, E. , MANDAL, Mihirbaran , VICAREL, Monica, L. , RAJAGOPALAN, Murali , DHONDI, Pawan, Kumar , XU, Ruo , SUN, Zhong-Yue , BARA, Thomas, A. , HUANG, Xianhai , ZHU, Xiaohong , ZHAO, Zhiqiang , CLADER, John, W. , PALANI, Anandan , ASBEROM, Theodros , MCCRACKEN, Troy , BENNETT, Chad, E.
发明人： ZHU, Zhaoning , GREENLEE, William, J. , COLE, David, James , PISSARNITSKI, Dmitri, A. , GALLO, Gioconda, V. , LI, Hongmei , JOSIEN, Hubert, B. , QIN, Jun , KNUTSON, Chad, E. , MANDAL, Mihirbaran , VICAREL, Monica, L. , RAJAGOPALAN, Murali , DHONDI, Pawan, Kumar , XU, Ruo , SUN, Zhong-Yue , BARA, Thomas, A. , HUANG, Xianhai , ZHU, Xiaohong , ZHAO, Zhiqiang , CLADER, John, W. , PALANI, Anandan , ASBEROM, Theodros , MCCRACKEN, Troy , BENNETT, Chad, E.
IPC分类号： C07D403/10 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/20 , C07D498/04 , C07D498/20 , C07D513/04 , C07F7/10 , A61K31/53 , A61P25/28
CPC分类号： C07D471/04 , C07D413/10 , C07D498/04 , C07D498/20 , C07F7/0812
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds of the formula: as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新的下式杂环化合物：作为γ分泌酶的调节剂，制备这些化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病的方法。

5. 发明申请

WO2005028440A1 NOVEL GAMMA SECRETASE INHIBITORS 审中-公开
标题翻译：新的GAMMA秘密抑制剂
公开(公告)号：WO2005028440A1
公开(公告)日：2005-03-31
申请号：PCT/US2004/030191
申请日：2004-09-15
申请人： SCHERING CORPORATION , PHARMACOPEIA DRUG DISCOVERY, INC. , PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , SMITH, Elizabeth, M. , CLADER, John, W. , ASBEROM, Theodros , GUO, Tao , HOBBS, Douglas, W.
发明人： PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , SMITH, Elizabeth, M. , CLADER, John, W. , ASBEROM, Theodros , GUO, Tao , HOBBS, Douglas, W.
IPC分类号： C07D211/96
CPC分类号： C07D401/14 , C07D207/08 , C07D211/96 , C07D401/12 , C07D403/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D451/06 , C07D471/04 , C07D471/10 , C07D491/10
摘要： This invention discloses novel gamma secretase inhibitors of the formula: wherein: R 1 is a substituted aryl or substituted heteroaryl group; R 2 is an R 1 group, alkyl, -XC(O)Y, alkylene-XC(O)Y, cycloalkylene-X-C(O)-Y, -CH-X-C(O)-NR 3 -Y or -CH-X-C(O)-Y, wherein X and Y are as defined herein; each R 3 and each R 3A are independently H, or alkyl; R 11 is aryl, heteroaryl, alkyl, cycloalkyl, arylalkyl, arylcycloalkyl, heteroarylalkyl, heteroarylcycloalkyl, arylheterocycloalkyl, or alkoxyalkyl. Also disclosed is a method of treating Alzheimer's Disease using one or more compounds of the invention.
摘要翻译：本发明公开了下式的新型γ分泌酶抑制剂：其中：R 1是取代的芳基或取代的杂芳基; R 2是R 1基团，烷基，-XC（O）Y，亚烷基-XC（O）Y，亚环烷基-XC（O）-Y，-CH-XC（O）-NR 3 -Y或-CH-XC（O）-Y，其中X和Y如本文所定义; 每个R 3和每个R 3A独立地是H或烷基; R 11是芳基，杂芳基，烷基，环烷基，芳基烷基，芳基环烷基，杂芳基烷基，杂芳基环烷基，芳基杂环烷基或烷氧基烷基。还公开了使用一种或多种本发明化合物治疗阿尔茨海默病的方法。

6. 发明申请

WO2010075203A1 GAMMA SECRETASE MODULATORS 审中-公开
标题翻译： GAMMA秘密调节器
公开(公告)号：WO2010075203A1
公开(公告)日：2010-07-01
申请号：PCT/US2009/068684
申请日：2009-12-18
申请人： SCHERING CORPORATION , ASBEROM, Theodros , HUANG, Xianhai , ZHU, Zhaoning , CLADER, John, W. , PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , LI, Hongmei
发明人： ASBEROM, Theodros , HUANG, Xianhai , ZHU, Zhaoning , CLADER, John, W. , PISSARNITSKI, Dmitri, A. , JOSIEN, Hubert, B. , LI, Hongmei
IPC分类号： C07D498/04 , A61K31/4245 , A61P25/00 , A61P25/28
CPC分类号： C07D498/04
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (Chemical formula should be inserted here as it appears on abstract in paper form). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。这些化合物具有式（化学式应该插在这里，如纸上所示）。还公开了使用式（I）化合物调节γ-分泌酶活性和治疗阿尔茨海默病的方法的方法。

7. 发明申请

WO2008137139A1 GAMMA SECRETASE MODULATORS 审中-公开
标题翻译： GAMMA秘密调节器
公开(公告)号：WO2008137139A1
公开(公告)日：2008-11-13
申请号：PCT/US2008/005777
申请日：2008-05-05
申请人： SCHERING CORPORATION , VOIGT, Johannes, H. , ZHU, Zhaoning , GREENLEE, William, J. , SUN, Zhong-yue , GALLO, Gioconda , ASBEROM, Theodros , HUANG, Xianhai , ZHU, Xiaohong , MCBRIAR, Mark, D. , PISSARNITSKI, Dmitri, A. , ZHAO, Zhiqiang , XU, Ruo , LI, Hongmei , PALANI, Anandan , MAZZOLA, Robert, D., Jr. , CLADER, John , JOSIEN, Hubert , QIN, Jun
发明人： ZHU, Zhaoning , GREENLEE, William, J. , SUN, Zhong-yue , GALLO, Gioconda , ASBEROM, Theodros , HUANG, Xianhai , ZHU, Xiaohong , MCBRIAR, Mark, D. , PISSARNITSKI, Dmitri, A. , ZHAO, Zhiqiang , XU, Ruo , LI, Hongmei , PALANI, Anandan , MAZZOLA, Robert, D., Jr. , CLADER, John , JOSIEN, Hubert , QIN, Jun
IPC分类号： C07D413/10 , C07D413/14 , C07D498/04 , C07D498/10 , C07D498/20 , A61K31/4245 , A61P25/00 , A61P25/28
CPC分类号： C07D413/10 , C07D413/14 , C07D498/04 , C07D498/10 , C07D498/20
摘要： In its many embodiments, the present invention provides a novel class of heterocyclic compounds as modulators of gamma secretase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the central nervous system using such compounds or pharmaceutical compositions.
摘要翻译：在其许多实施方案中，本发明提供了一类新颖的杂环化合物作为γ-分泌酶的调节剂，制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种这类化合物的药物制剂的方法和方法使用这些化合物或药物组合物治疗，预防，抑制或改善与中枢神经系统相关的一种或多种疾病。

8. 发明申请

WO2009008980A3 TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS 审中-公开
公开(公告)号：WO2009008980A3
公开(公告)日：2009-01-15
申请号：PCT/US2008/008192
申请日：2008-07-01
申请人： SCHERING CORPORATION , WU, Wen-lian , BARA, Thomas, A. , BURNETT, Duane, A. , CLADER, John, W. , DOMALSKI, Martin S. , JIN, Yan , JOSIEN, Hubert, B. , LI, Hongmei , LIANG, Xian , PISSARNITSKI, Dmitri, A. , SASIKUMAR, Thavalakulamgara, K. , WONG, Jesse, K. , XU, Ruo , ZHAO, Zhiqiang , MCNAMARA, Paul
发明人： WU, Wen-lian , BARA, Thomas, A. , BURNETT, Duane, A. , CLADER, John, W. , DOMALSKI, Martin S. , JIN, Yan , JOSIEN, Hubert, B. , LI, Hongmei , LIANG, Xian , PISSARNITSKI, Dmitri, A. , SASIKUMAR, Thavalakulamgara, K. , WONG, Jesse, K. , XU, Ruo , ZHAO, Zhiqiang , MCNAMARA, Paul
IPC分类号： C07D311/78 , C07D407/12 , C07D493/04 , A61K31/35 , A61K31/352 , A61P25/28
摘要： Disclosed are novel gamma secretase inhibitors of the formula. Also disclosed are methods of inhibiting gamma-secretase, methods of treating neurodegenerative diseases, and methods of treating Alzheimer's Disease. Also disclosed are processes for preparing alkenes in one reaction step using a mixture of an aldehyde (or ketone) and an alkyl substituted with two electron withdrawing groups, and reacting the mixture with: (a) a sulfonyl halide (e.g., a sulfonyl chloride) and a basic tertiary amine, or, (b) a sulfonyl anhydride and a basic amine, or (c) an aryl-C(O)-halide and a basic tertiary amine, or (d) an aryl-C(O)-O-C(O)-aryl and a basic tertiary amine, or (e) an heteroaryl-C(O)-halide and a basic tertiary amine, or (f) a heteroaryl-C(O)-O-C(O)-heteroaryl and a basic tertiary amine.

9. 发明申请

WO2012078448A1 TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译：作为DIPEPTIDYL PEPTIDASE-IV抑制剂有用的三聚异戊二烯
公开(公告)号：WO2012078448A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/062868
申请日：2011-12-01
申请人： SCHERING CORPORATION , BURNETT, Duane, A. , ZHAO, Zhiqiang , COLE, David , JOSIEN, Hubert , PISSARNITSKI, Dmitri, A. , SASIKUMAR, Thavalakulamgar , WU, Wen-Lian , DOMALSKI, Martin
发明人： BURNETT, Duane, A. , ZHAO, Zhiqiang , COLE, David , JOSIEN, Hubert , PISSARNITSKI, Dmitri, A. , SASIKUMAR, Thavalakulamgar , WU, Wen-Lian , DOMALSKI, Martin
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/519 , C07D487/14
摘要： The present invention is directed to novel tricyclic heterocycles of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. I
摘要翻译：本发明涉及结构式I的新型三环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。一世

10. 发明申请

WO2009108766A1 GAMMA SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER ' S DISEASE 审中-公开
标题翻译：用于治疗阿尔茨海默病的GAMMA秘密调节剂
公开(公告)号：WO2009108766A1
公开(公告)日：2009-09-03
申请号：PCT/US2009/035266
申请日：2009-02-26
申请人： SCHERING CORPORATION , HUANG, Xianhai , PALANI, Anandan , ASLANIAN, Robert, G. , ZHU, Zhaoning , PISSARNITSKI, Dmitri, A. , LI, Hongmei , GREENLEE, William, J. , ZHAO, Zhiqiang , MAZZOLA, JR., Robert, D. , QIN, Jun , DHONDI, Pawan
发明人： HUANG, Xianhai , PALANI, Anandan , ASLANIAN, Robert, G. , ZHU, Zhaoning , PISSARNITSKI, Dmitri, A. , LI, Hongmei , GREENLEE, William, J. , ZHAO, Zhiqiang , MAZZOLA, JR., Robert, D. , QIN, Jun , DHONDI, Pawan
IPC分类号： C07D401/12 , C07D498/20 , A61K31/445 , A61P25/28
CPC分类号： C07D401/12 , C07D498/20
摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula: Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
摘要翻译：本发明提供了作为γ分泌酶调节剂的新型化合物。化合物具有下式：还公开了使用式（I）化合物调节γ-分泌酶活性的方法和治疗阿尔茨海默氏病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式