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1. 发明申请

WO2006074269A3 PREPARATION OF PHARMACEUTICAL SALTS OF PIPERAZINE COMPOUNDS 审中-公开
标题翻译：哌嗪化合物的药用盐的制备
公开(公告)号：WO2006074269A3
公开(公告)日：2006-09-14
申请号：PCT/US2006000261
申请日：2006-01-05
申请人： SCHERING CORP , WU WENXUE , TRAN LOC THANH , D SA BOSCO , LIANG FENG , LEONG WILLIAM , LEE HONG-CHANG , KLOPFER KEVIN , SABESEN VIJAY
发明人： WU WENXUE , TRAN LOC THANH , D SA BOSCO , LIANG FENG , LEONG WILLIAM , LEE HONG-CHANG , KLOPFER KEVIN , SABESEN VIJAY
IPC分类号： C07D401/06
CPC分类号： C07D401/14
摘要： The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
摘要翻译：本发明一般涉及通过创造性地选择酸和溶剂介质来直接制备相对于选择的碱性化合物的旋转异构酸盐富集的药学上可接受的盐的方法。该方法在制备旋转异构体所需优势的药学上有用的盐的特定旋转异构体时特别有用。

2. 发明申请

WO2006074270A2 SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS 审中-公开
标题翻译： CCR5受体拮抗剂的合成
公开(公告)号：WO2006074270A2
公开(公告)日：2006-07-13
申请号：PCT/US2006000262
申请日：2006-01-05
申请人： SCHERING CORP , WU WENXUE , D SA BOSCO , LIANG FENG , TRAN LOC THANH , LEONG WILLIAM , DAHANUKAR VILAS , ZAVIALOV ILIA A , ORR CECILIA , ZHAO SHANNON , LEE HONG-CHANG , LIU YI , NGUYEN HOA N , SHIH XIONGWEI , ZHU MAN
发明人： WU WENXUE , D SA BOSCO , LIANG FENG , TRAN LOC THANH , LEONG WILLIAM , DAHANUKAR VILAS , ZAVIALOV ILIA A , ORR CECILIA , ZHAO SHANNON , LEE HONG-CHANG , LIU YI , NGUYEN HOA N , SHIH XIONGWEI , ZHU MAN
IPC分类号： C07D401/14 , C07D211/26
CPC分类号： C07D211/96 , C07D211/26 , C07D401/14
摘要： The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
摘要翻译：本发明涉及4- [4 - [（R） - [1- [环丙基磺酰基] -4-哌啶基]（3-氟苯基）甲基] -3（S） - 甲基-1-哌嗪基] 1 - [（4,6-二甲基-5-嘧啶基）羰基] -4-甲基哌啶]，以及通过新途径从容易获得的起始原料中间产物。

3. 发明申请

WO2004031153A3 ENANTIOSELECTIVE ALKYLATION OF TRICYCLIC COMPOUNDS 审中-公开
标题翻译：三聚体化合物的选择性烷基化
公开(公告)号：WO2004031153A3
公开(公告)日：2004-07-15
申请号：PCT/US0331102
申请日：2003-10-01
申请人： SCHERING CORP , CHEN FRANK X , WONG YEE-SHING , ECKERT JEFFREY M , ZOU NANFEI , LIANG FENG , KIM-MEADE AGNES S , POIRIER MARC , THIRUVENGADAM TIRUVETTIPURAM K , WU GEORGE G
发明人： CHEN FRANK X , WONG YEE-SHING , ECKERT JEFFREY M , ZOU NANFEI , LIANG FENG , KIM-MEADE AGNES S , POIRIER MARC , THIRUVENGADAM TIRUVETTIPURAM K , WU GEORGE G
IPC分类号： C07D221/16 , C07D401/14
CPC分类号： C07D401/14 , C07D221/16
摘要： An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula (I), is disclosed.
摘要翻译：公开了用于制备可用于制备式（I）的手性三环化合物的中间体的对映选择性方法。

4. 发明申请

WO2012078578A3 POLYMERIC PUMP PARTS 审中-公开
标题翻译：聚合物泵零件
公开(公告)号：WO2012078578A3
公开(公告)日：2012-08-30
申请号：PCT/US2011063432
申请日：2011-12-06
申请人： HALLIBURTON ENERGY SERV INC , SAINI RAJESH KUMAR , LIANG FENG , STRIBLING DAVID MARK
发明人： SAINI RAJESH KUMAR , LIANG FENG , STRIBLING DAVID MARK
IPC分类号： F04B53/02 , B29C44/34 , C08G18/10 , C08G18/76 , C08K3/00 , F04B53/10 , F16J15/44 , F16J15/56 , F16K15/02
CPC分类号： F04B53/02 , C08G18/10 , C08G18/7678 , C08K3/013 , F04B53/1025 , F05C2225/00 , C08G18/3206
摘要： Polymeric and polymeric composite parts for pumps and a method of manufacturing same are disclosed. More specifically, a valve insert comprising a polymeric seal sized to fit on an outside diameter of a valve closure member for a plunger pump; a pressure packing element ring for a plunger on a plunger pump; and a pressure packing element ring for a push rod on plunger of a plunger pump, each of said articles being formed from a naphthalene-1, 5-diisocyanate (NDI) based polyurethane component and an extender.
摘要翻译：公开了用于泵的聚合物和聚合物复合部件及其制造方法。更具体地说，一种包括聚合物密封件的阀插入件，该聚合物密封件的尺寸被设计成配合柱塞泵的阀关闭件的外径; 用于柱塞泵上的柱塞的压力填充元件环; 以及用于柱塞泵的柱塞上的推杆的压力填充元件环，所述制品中的每一个由基于萘-1,5-二异氰酸酯（NDI）的聚氨酯组分和增量剂形成。

5. 发明申请

WO2005113812A8 COLLECTIONS OF MATCHED BIOLOGICAL REAGENTS AND METHODS FOR IDENTIFYING MATCHED REAGENTS 审中-公开
标题翻译：匹配生物试剂的收集和鉴定匹配试剂的方法
公开(公告)号：WO2005113812A8
公开(公告)日：2006-02-02
申请号：PCT/US2005013914
申请日：2005-04-22
申请人： INVITROGEN CORP , CARRINO JOHN , LIANG FENG , BAHARLOO SIAMEK , SCHWEITZER BARRY I
发明人： CARRINO JOHN , LIANG FENG , BAHARLOO SIAMEK , SCHWEITZER BARRY I
IPC分类号： C12Q1/68 , G06F19/00 , G06F19/28
CPC分类号： G01N33/6842 , C12Q1/6837 , G06F19/28 , Y02A90/22 , Y02A90/24
摘要： Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.
摘要翻译：本文提供了选自更大量的生物试剂的匹配生物试剂的集合，其中匹配的生物试剂的收集涉及生物学元件。还提供了在匹配的生物试剂的集合中销售分离的生物分子或生物研究试剂的方法，以及从生物试剂的集合中选择分离的生物分子或生物研究试剂的方法。

6. 发明申请

WO2008063779A9 CELLS EXPRESSING ALPHA-SYNUCLEIN AND USES THEREFOR 审中-公开
标题翻译：细胞表达α-SYNUCLEIN并用于此
公开(公告)号：WO2008063779A9
公开(公告)日：2008-07-17
申请号：PCT/US2007081227
申请日：2007-10-12
申请人： FOLDRX PHARMACEUTICALS INC , LIANG FENG
发明人： LIANG FENG
IPC分类号： C12N5/08
CPC分类号： G01N33/5008 , A61K38/1709 , C12N15/635
摘要： Disclosed are mammalian neuronal cells expressing alpha synuclein as well as methods of screening to identify compounds that decrease toxicity induced by alpha synuclein expression. Compounds identified by such screens can be used to treat or prevent synucleinopathies such as Parkinson's disease, familial Parkinson's disease, Lewy body disease, the Lewy body variant of Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, or the Parkinsonism-dementia complex of Guam.
摘要翻译：公开了表达α突触核蛋白的哺乳动物神经元细胞以及筛选以鉴定减少由α突触核蛋白表达诱导的毒性的化合物的方法。通过这种筛选鉴定的化合物可用于治疗或预防突触核蛋白病，例如帕金森病，家族性帕金森病，路易体病，阿尔茨海默氏病的路易体变体，路易体痴呆，多系统萎缩或帕金森综合征痴呆综合征关岛。

7. 发明申请

WO2008063779A2 CELLS EXPRESSING ALPHA-SYNUCLEIN AND USES THEREFOR 审中-公开
公开(公告)号：WO2008063779A2
公开(公告)日：2008-05-29
申请号：PCT/US2007081227
申请日：2007-10-12
申请人： FOLDRX PHARMACEUTICALS INC , LIANG FENG
发明人： LIANG FENG
IPC分类号： C12N5/08
CPC分类号： G01N33/5008 , A61K38/1709 , C12N15/635
摘要： Disclosed are mammalian neuronal cells expressing alpha synuclein as well as methods of screening to identify compounds that decrease toxicity induced by alpha synuclein expression. Compounds identified by such screens can be used to treat or prevent synucleinopathies such as Parkinson's disease, familial Parkinson's disease, Lewy body disease, the Lewy body variant of Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, or the Parkinsonism-dementia complex of Guam.

8. 发明申请

WO2007126841A3 INHIBITION OF ALPHA-SYNUCLEIN TOXICITY 审中-公开
标题翻译：抑制ALPHA-SYNUCLEIN毒性
公开(公告)号：WO2007126841A3
公开(公告)日：2008-11-06
申请号：PCT/US2007007607
申请日：2007-03-29
申请人： FOLDRX PHARMACEUTICALS INC , WHITEHEAD BIOMEDICAL INST , LINDQUIST SUSAN L , OUTEIRO TIAGO , LABAUDINIERE RICHARD , FLEMING JAMES , BULAWA CHRISTINE ELLEN , WEIGEL CHARLOTTE , LIANG FENG , GUPTA SANDEEP , RIPKA AMY
发明人： LINDQUIST SUSAN L , OUTEIRO TIAGO , LABAUDINIERE RICHARD , FLEMING JAMES , BULAWA CHRISTINE ELLEN , WEIGEL CHARLOTTE , LIANG FENG , GUPTA SANDEEP , RIPKA AMY
IPC分类号： A61K31/33
CPC分类号： A61K31/4178 , A61K31/27 , A61K31/445 , A61K31/473 , A61K31/55 , A61K45/06 , A61K2300/00
摘要： Compounds and compositions are provided for treatment or amelioration of one or more symptoms of a-synuclein toxicity, a-synuclein mediated diseases or diseases in which a-synuclein fibrils are a symptom or cause of the disease.
摘要翻译：提供化合物和组合物用于治疗或改善一种或多种α-突触核蛋白毒性，α-突触核蛋白介导的疾病或其中α-突触核蛋白原纤维是疾病症状或原因的疾病症状。

9. 发明申请

WO2005090233A3 REDUCTIVE FUNCTIONALIZATION OF CARBON NANOTUBES 审中-公开
标题翻译：碳纳米管的还原功能化
公开(公告)号：WO2005090233A3
公开(公告)日：2008-03-20
申请号：PCT/US2005008303
申请日：2005-03-11
申请人： UNIV RICE WILLIAM M , BILLUPS W EDWARD , SADANA ANIL K , LIANG FENG , HAUGE ROBERT H
发明人： BILLUPS W EDWARD , SADANA ANIL K , LIANG FENG , HAUGE ROBERT H
IPC分类号： C01B31/02
CPC分类号： B82Y40/00 , B82Y30/00 , C01B32/05 , C01B32/152 , C01B32/174 , C01B2202/02 , C01B2202/36 , C01P2002/82 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/13
摘要： The present invention is directed to novel processes for the functionalization (derivatization) of carbon nanotubes and, as an extension, to fullerenes and other carbon surfaces. Generally, such processes involve reductive pathways. In some embodiments, carbon nanotubes are reacted with alkali metal and organic halides in anhydrous liquid ammonia. In other embodiments, polymers are grown from carbon nanotube sidewalls by reacting carbon nanotubes with alkali metal and monomer species in anhydrous liquid ammonia.
摘要翻译：本发明涉及用于碳纳米管的功能化（衍生化）和作为对富勒烯和其它碳表面的延伸的新方法。通常，这些方法涉及还原途径。在一些实施方案中，碳纳米管与碱金属和有机卤化物在无水液态氨中反应。在其它实施方案中，通过使碳纳米管与碱金属和单体物质在无水液态氨中反应，从碳纳米管侧壁生长聚合物。

10. 发明申请

US20130298314A1 UNDERWEAR FOR MEN 审中-公开
标题翻译：男人内衣
公开(公告)号：US20130298314A1
公开(公告)日：2013-11-14
申请号：US13466199
申请日：2012-05-08
申请人： LIANG FENG
发明人： LIANG FENG
IPC分类号： A41B9/02
CPC分类号： A41B9/02 , A41B2400/20
摘要： An underwear for a male with mesh strips or a hole to ease air flows around wearer's scrotum and groin regions to lower temperature and humidity. Apart from traditional men's underwears, there are mesh strips covering or crossing on wearer's groin, buttock channel and scrotum. When wearer in a standing or walking or running position with loose outerwear, the air around scrotum can flow naturally to lower the temperature and humidity of scrotum, and then increase the productivity of spermatogenesis and sex hormones.
摘要翻译：男性内裤为网带或孔，用于缓解佩戴者阴囊和腹股沟区域周围的空气流动，以降低温度和湿度。除了传统男士内衣外，还有穿着者腹股沟，臀部通道和阴囊的网带。当穿着者穿着松散的外衣的站立或步行或跑步位置时，阴囊周围的空气可以自然流动，以降低阴囊的温度和湿度，从而提高精子发生和性激素的生产力。

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