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1. 发明申请

WO2012009397A3 SHARING AND DECONFLICTING DATA CHANGES IN A MULTIMASTER DATABASE SYSTEM 审中-公开
标题翻译：在多重数据库系统中共享和分解数据更改
公开(公告)号：WO2012009397A3
公开(公告)日：2012-04-26
申请号：PCT/US2011043794
申请日：2011-07-13
申请人： PALANTIR TECHNOLOGIES INC , GARROD JOHN KENNETH , CARRINO JOHN ANTONIO , BRAINARD KATHERINE , SCOTT JACOB , CHANG ALLEN
发明人： GARROD JOHN KENNETH , CARRINO JOHN ANTONIO , BRAINARD KATHERINE , SCOTT JACOB , CHANG ALLEN
IPC分类号： G06F15/16 , G06F17/40
CPC分类号： G06F17/30578 , G06F17/30356
摘要： A computer-based method and system for sharing and deconflicting data changes amongst a plurality of replication sites. In a particular embodiment, data changes at sites to data objects are tracked by each site on a per-data object basis using per-data object version vectors. In another particular embodiment, data changes at sites to links connecting two data objects are tracked by each site on a per-link set basis using per-link set version vectors. In another particular embodiment, per-object version vectors are used to detect a conflict resulting from concurrent changes at two or more sites in which one of the concurrent changes includes an object resolution change.
摘要翻译：一种用于在多个复制站点之间共享和解除数据变化的基于计算机的方法和系统。在特定实施例中，使用每数据对象版本向量，在每个数据对象的基础上，每个站点跟踪站点到数据对象的数据更改。在另一特定实施例中，使用每链路集版本向量，每个站点在每个链路集合的基础上跟踪站点处数据到连接两个数据对象的链路的变化。在另一个具体实施例中，每个对象版本向量用于检测由两个或更多个站点中的并发改变导致的冲突，其中一个并发更改包括对象分辨率改变。

2. 发明申请

WO1993024656A1 LIGASE CHAIN REACTION STARTING WITH RNA SEQUENCES 审中-公开
标题翻译：使用RNA序列启动链反应
公开(公告)号：WO1993024656A1
公开(公告)日：1993-12-09
申请号：PCT/US1993004863
申请日：1993-05-24
申请人： ABBOTT LABORATORIES , MARSHALL, Ronald, L. , CARRINO, John, J. , SUSTACHEK, Joann, C.
发明人： ABBOTT LABORATORIES
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6862 , Y10S435/81 , C12Q2525/186 , C12Q2537/157 , C12Q2533/101 , C12Q2527/137
摘要： The present invention involves a method of amplifying RNA by producing complementary DNA (cDNA) by reverse transcription of RNA, and amplification of the cDNA sequences. The analysis of the amplified material facilitates the detection of pathogens and disease states associated with the presence of particular nucleic acid sequences, so the present invention is important in medical diagnostic procedures. A method of producing cDNA of predetermined length is also disclosed.
摘要翻译：本发明涉及通过逆转录RNA产生互补DNA（cDNA）和cDNA序列扩增来扩增RNA的方法。扩增物质的分析有助于检测与特定核酸序列存在相关的病原体和疾病状态，因此本发明在医学诊断程序中是重要的。还公开了一种产生预定长度的cDNA的方法。

3. 发明申请

WO2012012527A8 METHOD FOR LINKING POINT OF CARE RAPID DIAGNOSTIC TESTING RESULTS TO LABORATORY-BASED METHODS 审中-公开
标题翻译：将紧急点诊断测试结果点连接到基于实验室的方法
公开(公告)号：WO2012012527A8
公开(公告)日：2013-03-14
申请号：PCT/US2011044674
申请日：2011-07-20
申请人： BECTON DICKINSON CO , CARRINO JOHN J , FAN JAMES
发明人： CARRINO JOHN J , FAN JAMES
IPC分类号： C12Q1/24 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/56983 , C12Q1/6806 , C12Q1/70 , C12Q2527/125
摘要： A method for using a single sample suspected of containing a microorganism for both a local rapid test immunoassay and a remote laboratory test. The sample is collected from a patient at a physician's office or from the environment to be tested. The sample is collected using a swab or other implement, combined with a rapid test processing reagent and a portion of the processed sample is used for the local rapid test. The rapid test processing reagent typically consists of a buffer, a salt, and a detergent and is compatible with the local rapid test immunoassay. Only a portion of the processed sample is used for the local rapid test, leaving a remaining portion of the processed sample to be used in a remote laboratory assay. At least some of the remaining portion of the processed sample is combined with a stabilization agent that preserves at least the nucleic acid in the processed sample for the remote laboratory assay.
摘要翻译：使用怀疑含有微生物的单个样品用于局部快速测试免疫测定和远程实验室测试的方法。样本是从医生办公室的患者或被检测的环境中收集的。使用拭子或其他工具收集样品，并与快速测试处理试剂结合，并将一部分经处理的样品用于本地快速测试。快速测试处理试剂通常由缓冲液，盐和洗涤剂组成，并且与本地快速测试免疫测定相兼容。只有一部分经处理的样品用于本地快速测试，留下待处理样品的剩余部分用于远程实验室测定。经处理样品的至少一部分剩余部分与至少保留经处理样品中的核酸的稳定剂组合用于远程实验室测定。

4. 发明申请

WO2005113812A2 COLLECTIONS OF MATCHED BIOLOGICAL REAGENTS AND METHODS FOR IDENTIFYING MATCHED REAGENTS 审中-公开
标题翻译：匹配生物试剂的收集和鉴定匹配试剂的方法
公开(公告)号：WO2005113812A2
公开(公告)日：2005-12-01
申请号：PCT/US2005/013914
申请日：2005-04-22
申请人： INVITROGEN CORPORATION , CARRINO, John , LIANG, Feng , BAHARLOO, Siamek , SCHWEITZER, Barry, I.
发明人： CARRINO, John , LIANG, Feng , BAHARLOO, Siamek , SCHWEITZER, Barry, I.
IPC分类号： C12Q1/68
CPC分类号： G01N33/6842 , C12Q1/6837 , G06F19/28 , Y02A90/22 , Y02A90/24

5. 发明申请

WO2005113812A8 COLLECTIONS OF MATCHED BIOLOGICAL REAGENTS AND METHODS FOR IDENTIFYING MATCHED REAGENTS 审中-公开
标题翻译：匹配生物试剂的收集和鉴定匹配试剂的方法
公开(公告)号：WO2005113812A8
公开(公告)日：2006-02-02
申请号：PCT/US2005013914
申请日：2005-04-22
申请人： INVITROGEN CORP , CARRINO JOHN , LIANG FENG , BAHARLOO SIAMEK , SCHWEITZER BARRY I
发明人： CARRINO JOHN , LIANG FENG , BAHARLOO SIAMEK , SCHWEITZER BARRY I
IPC分类号： C12Q1/68 , G06F19/00 , G06F19/28
CPC分类号： G01N33/6842 , C12Q1/6837 , G06F19/28 , Y02A90/22 , Y02A90/24
摘要： Provided herein are collections of matched biological reagents selected from a larger collection of biological reagents, wherein the collection of matched biological reagents relate to a biological element. Also provided are methods for selling an isolated biomolecule or biological research reagent in a collection of matched biological reagents, and methods for selecting an isolated biomolecule or biological research reagent from a collection of biological reagents.
摘要翻译：本文提供了选自更大量的生物试剂的匹配生物试剂的集合，其中匹配的生物试剂的收集涉及生物学元件。还提供了在匹配的生物试剂的集合中销售分离的生物分子或生物研究试剂的方法，以及从生物试剂的集合中选择分离的生物分子或生物研究试剂的方法。

6. 发明申请

WO0062036A9 AMPLIFICATION AND SEPARATION OF NUCLEIC ACID SEQUENCES USING STRAND DISPLACEMENT AMPLIFICATION AND BIOELECTRONIC MICROCHIP TECHNOLOGY 审中-公开
标题翻译：使用带状位移扩增和生物电子微波技术的核酸序列的扩增和分离
公开(公告)号：WO0062036A9
公开(公告)日：2002-02-21
申请号：PCT/US0009711
申请日：2000-04-11
申请人： NANOGEN BECTON DICKINSON PARTN , NERENBERG MICHAEL I , EDMAN CARL F , SPARGO CATHERINE A , WALKER GEORGE T , CARRINO JOHN J , GERRUE LOUIS O , DIVER JONATHAN M
发明人： NERENBERG MICHAEL I , EDMAN CARL F , SPARGO CATHERINE A , WALKER GEORGE T , CARRINO JOHN J , GERRUE LOUIS O , DIVER JONATHAN M
IPC分类号： G01N33/53 , C12Q1/68 , G01N1/28 , G01N21/78 , G01N37/00 , G01N15/06 , C12P19/34
CPC分类号： C12Q1/6844 , C12P19/34 , C12Q1/6825 , C12Q1/6837 , C12Q2537/143 , C12Q2531/119 , C12Q2565/501 , C12Q2565/607
摘要： Described and disclosed are devices, methods, and compositions of matter for the multiplex amplification and analysis of nucleic acid sequences in a sample using novel strand displacement amplification technologies in combination with bioelectronic microchip technology. Specifically, a nucleic acid in a sample is amplified to form amplicons, the amplicons are addressed to specified electronically addressable capture sites of the bioelelectronic microchip, the addressed amplicons are captured and labeled, and then the capture sites are analyzed for the presence of label. Samples may be amplified using strand displacement amplification. The invention is also amenable to other amplification methodologies well known by those skilled in the art. The capture and label steps may be by a method of universal capture with sequence specific reporter, or by a method of sequence specific capture with universal reporter. The label may be detected by fluorescence, chemiluminescence, electrochemiluminescence, or any other technique as are well known by those skilled in the art. This invention further allows for analyzing multiple nucleic acid targets on a single diagnostic platform wherein the nucleic acids may be amplified while either in direct contact with microchip components or in solution above the microchip array.
摘要翻译：描述和公开的是使用新颖的链置换扩增技术结合生物电子微芯片技术在样品中多重扩增和分析核酸序列的物质的装置，方法和组成。具体地说，样品中的核酸被扩增以形成扩增子，扩增子被寻址到生物电子微芯片的指定的可电子寻址的捕获位点，被寻址的扩增子被捕获和标记，然后分析捕获位点的标记物的存在。可以使用链置换扩增来扩增样品。本发明还适用于本领域技术人员熟知的其它扩增方法。捕获和标记步骤可以通过使用序列特异性报告物通用捕获的方法，或通过使用通用报告物的序列特异性捕获的方法。可以通过荧光，化学发光，电化学发光或本领域技术人员公知的任何其它技术来检测标记。本发明还允许在单个诊断平台上分析多个核酸靶标，其中核酸可以在与微芯片部件直接接触或在微芯片阵列上方的溶液中被放大。

7. 发明申请

WO2012012527A3 METHOD FOR LINKING POINT OF CARE RAPID DIAGNOSTIC TESTING RESULTS TO LABORATORY-BASED METHODS 审中-公开
公开(公告)号：WO2012012527A3
公开(公告)日：2012-01-26
申请号：PCT/US2011/044674
申请日：2011-07-20
申请人： BECTON, DICKINSON AND COMPANY , CARRINO, John, J. , FAN, James
发明人： CARRINO, John, J. , FAN, James
IPC分类号： C12Q1/24 , G01N33/53 , C12Q1/68
摘要： A method for using a single sample suspected of containing a microorganism for both a local rapid test immunoassay and a remote laboratory test. The sample is collected from a patient at a physician's office or from the environment to be tested. The sample is collected using a swab or other implement, combined with a rapid test processing reagent and a portion of the processed sample is used for the local rapid test. The rapid test processing reagent typically consists of a buffer, a salt, and a detergent and is compatible with the local rapid test immunoassay. Only a portion of the processed sample is used for the local rapid test, leaving a remaining portion of the processed sample to be used in a remote laboratory assay. At least some of the remaining portion of the processed sample is combined with a stabilization agent that preserves at least the nucleic acid in the processed sample for the remote laboratory assay.

8. 发明申请

WO2007106541A2 CITIZEN COMMUNICATION CENTER 审中-公开
标题翻译：公民通讯中心
公开(公告)号：WO2007106541A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006507
申请日：2007-03-14
申请人： CARRINO, John
发明人： CARRINO, John
IPC分类号： G08B23/00 , G08B29/00 , G08B1/00
CPC分类号： G08B27/00 , G06F17/3087 , G06Q10/10 , G08B25/14
摘要： A versatile Citizen Alert System is connected to Internet and private databases to acquire real time information useful for subscribed users. During registration, users are required to provide multimedia contact information, including telephone numbers, cell phone numbers, pager information, Blackberry or PDA information, e-mail address, and physical address, along with user defined sensitivities to alerts, including sensitivities to natural emergencies, man made emergencies and professional requirements. The system has a local or remote administrator that constantly analyzes the acquired data in accordance with requirements of each and every user, orders the data to generate alert information specific to a user, and communicates the alert to each and every user using multiple delivery platforms. A user specific, secured web page providing details of alert and hyperlinks constitutes an additional information source.
摘要翻译：多功能公民警报系统连接到互联网和私人数据库，以获取对订阅用户有用的实时信息。在注册期间，用户需要提供多媒体联系信息，包括电话号码，手机号码，寻呼机信息，黑莓或PDA信息，电子邮件地址和物理地址，以及用户定义的敏感信息，包括对自然紧急情况的敏感性，人为紧急情况和专业要求。该系统具有本地或远程管理员，其根据每个用户的要求不断分析所获取的数据，订购数据以生成特定于用户的警报信息，并且使用多个传送平台将警报传达给每个用户。提供警报和超链接详细信息的用户特定的安全网页构成了附加信息源。

9. 发明申请

WO2012012527A2 METHOD FOR LINKING POINT OF CARE RAPID DIAGNOSTIC TESTING RESULTS TO LABORATORY-BASED METHODS 审中-公开
标题翻译：将紧急点诊断测试结果点连接到基于实验室的方法
公开(公告)号：WO2012012527A2
公开(公告)日：2012-01-26
申请号：PCT/US2011044674
申请日：2011-07-20
申请人： BECTON DICKINSON CO , CARRINO JOHN J , FAN JAMES
发明人： CARRINO JOHN J , FAN JAMES
IPC分类号： C12Q1/24 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/56983 , C12Q1/6806 , C12Q1/70 , C12Q2527/125
摘要： A method for using a single sample suspected of containing a microorganism for both a local rapid test immunoassay and a remote laboratory test. The sample is collected from a patient at a physician's office or from the environment to be tested. The sample is collected using a swab or other implement, combined with a rapid test processing reagent and a portion of the processed sample is used for the local rapid test. The rapid test processing reagent typically consists of a buffer, a salt, and a detergent and is compatible with the local rapid test immunoassay. Only a portion of the processed sample is used for the local rapid test, leaving a remaining portion of the processed sample to be used in a remote laboratory assay. At least some of the remaining portion of the processed sample is combined with a stabilization agent that preserves at least the nucleic acid in the processed sample for the remote laboratory assay.
摘要翻译：使用怀疑含有微生物的单个样品用于局部快速测试免疫测定和远程实验室测试的方法。样本是从医生办公室的患者或被检测的环境中收集的。使用拭子或其他工具收集样品，并与快速测试处理试剂结合，并且将一部分经处理的样品用于本地快速测试。快速测试处理试剂通常由缓冲液，盐和洗涤剂组成，并且与本地快速测试免疫测定相兼容。只有一部分经处理的样品用于本地快速测试，留下待处理样品的剩余部分用于远程实验室测定。经处理样品的至少一部分剩余部分与至少保留经处理样品中的核酸的稳定剂组合用于远程实验室测定。

10. 发明申请

WO2012009397A2 SHARING AND DECONFLICTING DATA CHANGES IN A MULTIMASTER DATABASE SYSTEM 审中-公开
标题翻译：在多数据库系统中共享和响应数据更改
公开(公告)号：WO2012009397A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/043794
申请日：2011-07-13
申请人： PALANTIR TECHNOLOGIES, INC. , GARROD, John Kenneth , CARRINO, John Antonio , BRAINARD, Katherine , SCOTT, Jacob , CHANG, Allen
发明人： GARROD, John Kenneth , CARRINO, John Antonio , BRAINARD, Katherine , SCOTT, Jacob , CHANG, Allen
IPC分类号： G06F15/16 , G06F17/40
CPC分类号： G06F17/30578 , G06F17/30356
摘要： A computer-based method and system for sharing and deconflicting data changes amongst a plurality of replication sites. In a particular embodiment, data changes at sites to data objects are tracked by each site on a per-data object basis using per-data object version vectors. In another particular embodiment, data changes at sites to links connecting two data objects are tracked by each site on a per-link set basis using per-link set version vectors. In another particular embodiment, per-object version vectors are used to detect a conflict resulting from concurrent changes at two or more sites in which one of the concurrent changes includes an object resolution change.
摘要翻译：用于在多个复制站点之间共享和解除冲突数据改变的基于计算机的方法和系统。在特定实施例中，每个站点在每个数据对象的基础上使用每个数据对象版本向量来跟踪站点到数据对象的数据更改。在另一个特定实施例中，使用每链路集合版本矢量，每个站点在每个链路集合的基础上跟踪站点处到连接两个数据对象的链路的数据变化。在另一特定实施例中，每个对象版本矢量被用于检测由两个或更多个站点处的并发变化引起的冲突，其中并发变化中的一个包括对象分辨率变化。

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