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    • 1. 发明申请
    • PIPERIDINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS
    • 哌啶衍生物可用作CCR5拮抗剂
    • WO2004056770A3
    • 2004-08-12
    • PCT/US0340619
    • 2003-12-17
    • SCHERING CORP
    • MILLER MICHAEL WSCOTT JACK D
    • A61P31/18A61P37/00C07D401/14A61K31/506
    • C07D401/14
    • The present invention provides a compound of the formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein the various moieties are as defined in the specification. The present invention also provides pharmaceutical compositions containing the compound of this invention, and methods of treatment using the compound of this invention. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
    • 本发明提供了式(I)化合物或其药学上可接受的盐或溶剂化物,其中各种部分如说明书中所定义。 本发明还提供含有本发明化合物的药物组合物和使用本发明化合物的治疗方法。 本发明还涉及本发明化合物和一种或多种可用于治疗人类免疫缺陷病毒(HIV)的抗病毒剂或其他药剂的组合的用途。 本发明进一步涉及本发明化合物单独或与其他药物组合用于治疗实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎性肠病,特应性皮炎,牛皮癣 ,哮喘,过敏或多发性硬化。
    • 4. 发明申请
    • BIPIPERIDINYL DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS
    • 用作趋化因子受体抑制剂的双脒基衍生物
    • WO2005042517A3
    • 2005-07-28
    • PCT/US2004036273
    • 2004-11-01
    • SCHERING CORPMILLER MICHAEL WSCOTT JACK D
    • MILLER MICHAEL WSCOTT JACK D
    • A61K31/445C07D401/14C07D413/14A61P9/02A61P11/06A61P17/06A61P31/18
    • C07D413/14C07D401/14
    • In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
    • 在其许多实施方案中,本发明提供了一类新的双哌啶基化合物作为CCR5受体的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种此类化合物的药物制剂的方法,以及 使用此类化合物或药物组合物治疗,预防,抑制或改善与CCR5相关的一种或多种疾病的方法。 本发明还涉及本发明化合物和一种或多种可用于治疗人类免疫缺陷病毒(HIV)的抗病毒剂或其他药剂的组合的用途。 本发明进一步涉及本发明化合物单独或与其他药物组合用于治疗实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎性肠病,特应性皮炎,牛皮癣 ,哮喘,过敏或多发性硬化。