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1. 发明申请

WO2005042517A3 BIPIPERIDINYL DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS 审中-公开
标题翻译：用作趋化因子受体抑制剂的双脒基衍生物
公开(公告)号：WO2005042517A3
公开(公告)日：2005-07-28
申请号：PCT/US2004036273
申请日：2004-11-01
申请人： SCHERING CORP , MILLER MICHAEL W , SCOTT JACK D
发明人： MILLER MICHAEL W , SCOTT JACK D
IPC分类号： A61K31/445 , C07D401/14 , C07D413/14 , A61P9/02 , A61P11/06 , A61P17/06 , A61P31/18
CPC分类号： C07D413/14 , C07D401/14
摘要： In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
摘要翻译：在其许多实施方案中，本发明提供了一类新的双哌啶基化合物作为CCR5受体的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备包含一种或多种此类化合物的药物制剂的方法，以及使用此类化合物或药物组合物治疗，预防，抑制或改善与CCR5相关的一种或多种疾病的方法。本发明还涉及本发明化合物和一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其他药剂的组合的用途。本发明进一步涉及本发明化合物单独或与其他药物组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化。

2. 发明申请

WO2009005646A3 SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS 审中-公开
标题翻译：取代的PIPERAZINES作为CB1拮抗剂
公开(公告)号：WO2009005646A3
公开(公告)日：2009-03-19
申请号：PCT/US2008007868
申请日：2008-06-25
申请人： SCHERING CORP , GILBERT ERIC J , MILLER MICHAEL W , SCOTT JACK D , DEMONG DUANE EUGENE , STAMFORD ANDREW , GREENLEE WILLIAM J , CELLY CHANDER SHEKHER
发明人： GILBERT ERIC J , MILLER MICHAEL W , SCOTT JACK D , DEMONG DUANE EUGENE , STAMFORD ANDREW , GREENLEE WILLIAM J , CELLY CHANDER SHEKHER
IPC分类号： C07D241/04 , A61K31/496 , A61K31/506 , A61P3/00 , A61P9/10 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14
CPC分类号： C07D241/04 , C07D401/06 , C07D401/14 , C07D403/12 , C07D403/14
摘要： Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物或酯可用于治疗由CB1受体介导的疾病或病症，例如代谢综合征和肥胖症，神经炎症性疾病，认知障碍和精神病，成瘾（例如戒烟），胃肠道疾病和心血管疾病。

3. 发明申请

WO2009005671A2 SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS 审中-公开
标题翻译：取代的哌嗪作为CB1拮抗剂
公开(公告)号：WO2009005671A2
公开(公告)日：2009-01-08
申请号：PCT/US2008007917
申请日：2008-06-25
申请人： SCHERING CORP , GILBERT ERIC J , GREENLEE WILLIAM J , LI SARAH WEI , MILLER MICHAEL W , SCOTT JACK D , STAMFORD ANDREW , CELLY CHANDER SHEKHER
发明人： GILBERT ERIC J , GREENLEE WILLIAM J , LI SARAH WEI , MILLER MICHAEL W , SCOTT JACK D , STAMFORD ANDREW , CELLY CHANDER SHEKHER
IPC分类号： C07D241/04 , A61K31/495 , A61P3/00 , C07D401/06
CPC分类号： C07D401/06 , C07D241/04
摘要： Compounds of Formula (I): or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：式（I）化合物或其药学上可接受的盐，溶剂合物或酯可用于治疗由CB 1受体介导的疾病或病症，所述疾病或病症例如代谢综合征和肥胖症，神经炎性病症，认知障碍和精神病，成瘾（例如吸烟戒烟），胃肠疾病和心血管疾病。

4. 发明申请

WO2007084319A3 DIARYL PIPERIDINES AS CB1 MODULATORS 审中-公开
标题翻译： DIARYL PIPERIDINES作为CB1调节器
公开(公告)号：WO2007084319A3
公开(公告)日：2007-09-20
申请号：PCT/US2007000705
申请日：2007-01-11
申请人： SCHERING CORP , SCOTT JACK D , WEINSTEIN JAY , MILLER MICHAEL W , STAMFORD ANDREW W , GILBERT ERIC J , XIA YAN , GREENLEE WILLIAM J , LI WEI
发明人： SCOTT JACK D , WEINSTEIN JAY , MILLER MICHAEL W , STAMFORD ANDREW W , GILBERT ERIC J , XIA YAN , GREENLEE WILLIAM J , LI WEI
IPC分类号： C07D211/18 , C07D211/26 , C07D211/28 , C07D211/32 , C07D211/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
CPC分类号： C07D211/18 , C07D211/22 , C07D211/26 , C07D211/28 , C07D211/30 , C07D211/32 , C07D211/58 , C07D211/60 , C07D211/76 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D471/10
摘要： A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, or ester thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome (e.g., obesity, waist circumference, lipid profile, and insulin sensitivity), neuroinflammatory disorders, cognitive disorders, psychosis, addictive behavior, gastrointestinal disorders, and cardiovascular conditions.
摘要翻译：具有式（I）的通式结构的化合物或其药学上可接受的盐，溶剂化物或酯可用于治疗疾病，病症或病症如代谢综合征（例如，肥胖，腰围，脂质分布和胰岛素敏感性），神经炎症性疾病，认知障碍，精神病，成瘾行为，胃肠道疾病和心血管疾病。

5. 发明申请

WO2007050375A3 PIPERAZINE DERIVATIVES USEFUL AS CCR5 ANTAGONISTS 审中-公开
标题翻译：哌嗪衍生物作为CCR5拮抗剂有用
公开(公告)号：WO2007050375A3
公开(公告)日：2007-06-14
申请号：PCT/US2006040636
申请日：2006-10-18
申请人： SCHERING CORP , RAMANTHAN RAGULAN , GHOSAL ANIMA , MILLER MICHAEL W , CHOWDHURY SWAPAN K , ALTON KEVIN B
发明人： RAMANTHAN RAGULAN , GHOSAL ANIMA , MILLER MICHAEL W , CHOWDHURY SWAPAN K , ALTON KEVIN B
IPC分类号： C07D401/14 , A61K31/506 , A61P31/18 , A61P37/06 , C07H17/02
CPC分类号： C07D401/14 , C07D401/06 , C07H17/02
摘要： CCR5 antagonists having the following core structure Formula (I) (AA) are claimed, for the treatment of HIV, solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis .
摘要翻译：要求具有以下核心结构式（I）（AA）的CCR5拮抗剂用于治疗HIV，实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎性肠病，特应性皮炎，牛皮癣，哮喘，过敏或多发性硬化。

6. 发明专利

CA2149612A1 INSULATION BLOWER HAVING HANDS-FREE METERED FEEDING 未知
公开(公告)号：CA2149612A1
公开(公告)日：1995-11-19
申请号：CA2149612
申请日：1995-05-17
申请人： MILLER MICHAEL W , MILLER KERRY W
发明人： MILLER MICHAEL W , MILLER KERRY W
IPC分类号： B65G53/46 , B65G53/00
摘要： The thermal insulation blower of the present invention is built around a vertically oriented air lock system. The insulation blower is capable of being configured for high delivery rates suitable for open area blowing and is capable of being reconfigured for lower delivery rates as a through-the- blower system for closed area blowing operations. The insulation blower includes a metering feeder assembly which can be adjusted to control the rate at which a bale of insulation is ripped and fed into the air lock system. The thermal insulation blower of the present invention also includes a bypass system around the air lock which serves to automatically clear impending plugs of insulation material in the delivery hose.

7. 发明专利

CA2149612C INSULATION BLOWER HAVING HANDS-FREE METERED FEEDING 未知
公开(公告)号：CA2149612C
公开(公告)日：2006-08-22
申请号：CA2149612
申请日：1995-05-17
申请人： MILLER KERRY W , MILLER MICHAEL W
发明人： MILLER KERRY W , MILLER MICHAEL W
IPC分类号： B65G53/00 , B65G53/46
摘要： The thermal insulation blower of the present invention is built around a vertically oriented air lock system. The insulation blower is capable of being configured for high delivery rates suitable for open area blowing and is capable of being reconfigured for lower delivery rates as a through-the- blower system for closed area blowing operations. The insulation blower includes a metering feeder assembly which can be adjusted to control the rate at which a bale of insulation is ripped and fed into the air lock system. The thermal insulation blower of the present invention also includes a bypass system around the air lock which serves to automatically clear impending plugs of insulation material in the delivery hose.

8. 发明专利

AU2020407589A1 Inhibitors of ENL/AF9 YEATS 未知
公开(公告)号：AU2020407589A1
公开(公告)日：2022-07-21
申请号：AU2020407589
申请日：2020-12-17
申请人： BRIDGE MEDICINES LLC , FUKASE YOSHIYUKI , HUGGINS DAVID , KHAN TANWEER A , LIVERTON NIGEL , MEINKE PETER , MICHINO MAYAKO , MILLER MICHAEL W , STAMFORD ANDREW W , THE ROCKEFELLER UNIV
发明人： KHAN TANWEER A , LIVERTON NIGEL , FUKASE YOSHIYUKI , MICHINO MAYAKO , STAMFORD ANDREW W , MILLER MICHAEL W , HUGGINS DAVID , MEINKE PETER , ALLIS C DAVID , WAN LILING , VACCA JOSEPH , LADDUWAHETTY TAMMY
IPC分类号： A61K31/409 , A61P35/00 , C07D209/00 , C07D487/04
摘要： Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF

9. 发明申请

WO2005081826A2 OVERRIDE CONTROL CIRCUITS FOR A LAWN AND GARDEN TRACTOR 审中-公开
标题翻译：法律和庭园拖拉机的覆盖控制电路
公开(公告)号：WO2005081826A2
公开(公告)日：2005-09-09
申请号：PCT/US2005004782
申请日：2005-02-16
申请人： MTD PRODUCTS INC , ONDERKO JOSEPH M , MILLER MICHAEL W , BLY SCOTT C
发明人： ONDERKO JOSEPH M , MILLER MICHAEL W , BLY SCOTT C
CPC分类号： A01D34/006 , A01D34/828 , B60K28/10
摘要： Control circuits for a riding lawn mower. The control circuits provide an override condition for selectively allowing the cutting blades of the lawn mower to operate when the vehicle is traveling in reverse. The circuits incorporate an ignition switch, an override switch, a vehicle reverse switch, and an operator presence switch. In one aspect of the invention, the control circuits disable the engine when the vehicle is placed in reverse with the PTO engaged and without the override condition having been established. In another aspect of the invention, an electric PTO clutch is disabled when the vehicle is placed in reverse with the PTO engaged and without the override condition having been established. The override condition is terminated when the vehicle is turned off, or when the operator deactivates the manual override switch.
摘要翻译：骑马割草机的控制电路。控制电路提供超驰条件，用于选择性地允许割草机的切割刀片在车辆相反行进时操作。电路包括点火开关，超控开关，车辆反向开关和操作者存在开关。在本发明的一个方面，当车辆在PTO接合并且没有超驰条件已经建立的情况下，当车辆反向放置时，控制电路禁止发动机。在本发明的另一方面，当PTO接合并且没有超驰条件已被建立时，当车辆反向放置时，电动PTO离合器被禁用。当车辆关闭时，或当操作者停用手动超驰开关时，超驰条件终止。

10. 发明申请

WO2009029488A2 MEDIA-BASED RECOMMENDATIONS 审中-公开
标题翻译：基于媒体的建议
公开(公告)号：WO2009029488A2
公开(公告)日：2009-03-05
申请号：PCT/US2008073883
申请日：2008-08-21
申请人： GOOGLE INC , JEON JOON-HEE , DUREAU VINCENT , BENTING STEVE DALE , LIN ZHENHAI , MILLER MICHAEL W , PATEL MANISH G
发明人： JEON JOON-HEE , DUREAU VINCENT , BENTING STEVE DALE , LIN ZHENHAI , MILLER MICHAEL W , PATEL MANISH G
IPC分类号： G06F17/00 , H04N5/445
CPC分类号： H04N21/4668 , G06F17/30017 , G06F17/30846 , H04N5/44543 , H04N21/251 , H04N21/252 , H04N21/254 , H04N21/25891 , H04N21/431 , H04N21/44222 , H04N21/4532 , H04N21/4667 , H04N21/4756 , H04N21/4826 , H04N21/4828
摘要： A computer-implemented method includes receiving information expressing a user's interest in one or more media programs, obtaining information indicative of popularity for a plurality of media programs responsive to the received information by individuals other than the user, and transmitting one or more recommendations of media programs for display to the user, from the plurality of media programs that relate to the received information.
摘要翻译：一种计算机实现的方法包括：接收表达用户对一个或多个媒体节目的兴趣的信息;响应于除用户之外的个体接收的信息，获得指示多个媒体节目的受欢迎程度的信息;以及发送媒体的一个或多个推荐从与接收到的信息有关的多个媒体节目向用户显示用于显示的节目。

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