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    • 1. 发明申请
    • BIPIPERIDINYL DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS
    • 用作趋化因子受体抑制剂的双脒基衍生物
    • WO2005042517A3
    • 2005-07-28
    • PCT/US2004036273
    • 2004-11-01
    • SCHERING CORPMILLER MICHAEL WSCOTT JACK D
    • MILLER MICHAEL WSCOTT JACK D
    • A61K31/445C07D401/14C07D413/14A61P9/02A61P11/06A61P17/06A61P31/18
    • C07D413/14C07D401/14
    • In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.
    • 在其许多实施方案中,本发明提供了一类新的双哌啶基化合物作为CCR5受体的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备包含一种或多种此类化合物的药物制剂的方法,以及 使用此类化合物或药物组合物治疗,预防,抑制或改善与CCR5相关的一种或多种疾病的方法。 本发明还涉及本发明化合物和一种或多种可用于治疗人类免疫缺陷病毒(HIV)的抗病毒剂或其他药剂的组合的用途。 本发明进一步涉及本发明化合物单独或与其他药物组合用于治疗实体器官移植排斥,移植物抗宿主病,关节炎,类风湿性关节炎,炎性肠病,特应性皮炎,牛皮癣 ,哮喘,过敏或多发性硬化。
    • 9. 发明申请
    • OVERRIDE CONTROL CIRCUITS FOR A LAWN AND GARDEN TRACTOR
    • 法律和庭园拖拉机的覆盖控制电路
    • WO2005081826A2
    • 2005-09-09
    • PCT/US2005004782
    • 2005-02-16
    • MTD PRODUCTS INCONDERKO JOSEPH MMILLER MICHAEL WBLY SCOTT C
    • ONDERKO JOSEPH MMILLER MICHAEL WBLY SCOTT C
    • A01D34/006A01D34/828B60K28/10
    • Control circuits for a riding lawn mower. The control circuits provide an override condition for selectively allowing the cutting blades of the lawn mower to operate when the vehicle is traveling in reverse. The circuits incorporate an ignition switch, an override switch, a vehicle reverse switch, and an operator presence switch. In one aspect of the invention, the control circuits disable the engine when the vehicle is placed in reverse with the PTO engaged and without the override condition having been established. In another aspect of the invention, an electric PTO clutch is disabled when the vehicle is placed in reverse with the PTO engaged and without the override condition having been established. The override condition is terminated when the vehicle is turned off, or when the operator deactivates the manual override switch.
    • 骑马割草机的控制电路。 控制电路提供超驰条件,用于选择性地允许割草机的切割刀片在车辆相反行进时操作。 电路包括点火开关,超控开关,车辆反向开关和操作者存在开关。 在本发明的一个方面,当车辆在PTO接合并且没有超驰条件已经建立的情况下,当车辆反向放置时,控制电路禁止发动机。 在本发明的另一方面,当PTO接合并且没有超驰条件已被建立时,当车辆反向放置时,电动PTO离合器被禁用。 当车辆关闭时,或当操作者停用手动超驰开关时,超驰条件终止。