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1. 发明专利

RS51146B NOVI DIFENIL-AZETIDINON SA POBOLJŠANIM FIZIOLOŠKIM OSOBINAMA POSTUPAK ZA NJEGOVU PROIZVODNJU,LEKOVI KOJI SADRŽE OVO JEDINJENJE I NJIHOVA UPOTREBA 未知
公开(公告)号：RS51146B
公开(公告)日：2010-10-31
申请号：YUP20050719
申请日：2004-03-16
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： LINDENSCHMIDT ANDREAS , JAEHNE GERHARD , FRICK WENDELIN , GLOMBIK HEINER , KRAMER WERNER , HEUER HUBERT , FLOHR STEFANIE , SCHAEFER HANS-LUDWIG , GALIA ERIC
IPC分类号： A61K31/397 , C07D205/08 , A61P3/06 , C07C233/18
摘要： Jedinjenje formule I,kao i njegove farmaceutski prihvatljive soli.Prijava sadrži još 13 patentnih zahteva.

2. 发明专利

AT478842T 未知
公开(公告)号：AT478842T
公开(公告)日：2010-09-15
申请号：AT03760591
申请日：2003-06-04
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： JAEHNE GERHARD , FRICK WENDELIN , FLOHR STEFANIE , LINDENSCHMIDT ANDREAS , GLOMBIK HEINER , KRAMER WERNER , HEUER HUBERT , SCHAEFER HANS-LUDWIG
IPC分类号： C07D205/08 , A61K31/137 , A61K31/195 , A61K31/397 , A61K31/426 , A61K31/48 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/64 , A61K38/27 , A61K38/28 , A61K45/00 , A61K45/06 , A61P3/06 , A61P5/50 , A61P9/10 , C07D403/12 , C07D453/02 , C07D471/08 , C07D487/08

4. 发明专利

AU2005238144B2 Imidazole derivatives used as TAFIa inhibitors 未知
公开(公告)号：AU2005238144B2
公开(公告)日：2010-08-26
申请号：AU2005238144
申请日：2005-04-07
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： HEITSCH HOLGER , GRUENEBERG SVEN , LINDENSCHMIDT ANDREAS , KALLUS CHRISTOPHER
IPC分类号： C07D401/06 , A61K31/41 , A61K31/435 , C07D401/14 , C07D409/14 , C07D417/06
摘要： Imidazolyl-acetic acid derivatives (I) are new. Imidazolylacetic acid derivatives of formula (I) and their stereoisomers, mixtures and/or salts are new. U = H, 1-6C alkyl, 3-6C cycloalkyl, F, OCF 3 or CF 3; X = (A 1) m-A 2; Y = CH[6-14C aryl] 2, A 3-(A 4) o-(A 5) p, lactam of formula (a), CR 16R 17(CR 18R 19) x-C(O)NR 12R 13 or CR 26R 27(CR 28R 29) x-SO 2NR 24R 25; Z = H, 1-6C alkyl, 1-6C hydroxyalkyl, 3-6C cycloalkyl(0-4C alkyl), (1-10C alkylene)-OC(O)OR 1 or (CH 2) n-(6-14C aryl) or (CH 2) n-Het (both optionally substituted by 1-3 R 1); A 1 = (CH 2) n or O(CH 2) n; m = 0 or 1; n = 1-3; x = 0-3; y = 1-5; A 2 = 4-15 membered heterocyclic ring containing at least one N and substituted by amino, (optionally further substituted by 1-3 1-3C alkyl, halo, CF 3 or OCF 3), 1-6C aminoalkyl or 3-8C aminocycloalkyl; either (a) A 3 = 3-8C cycloalkyl or 2-6C alkynylene (optionally substituted (os) by 1-3 OR 10 or R 1), A4 = N(R 2) 2, A 5 is absent and o = 0 or 1; or (b) A 3 = 3-8C cycloalkyl (os by 1-3 OR 10 or R 1), A 4 = NR 2, A 5 = C(O)R 3, C(O)NR 4R 5, SO 2R 6 or C(O)OR 7, o and p =1; (c) A 3 = 3-8 membered cyclic amine (os by 1-3 R 1), A 4 and A 5 are as in (b) with A 5 bonded to the N atom of A 3, o = 0 and p = 0 or 1; (d) A 3 = (CH 2) q(6-14C aryl) optionally ring-substituted by 1-3 R 1, A 4 and A 5 are as in (b), o = 0 or 1, p = 1 and q = 1-3; (e) A 3 = (CH 2) r-Het1, A 4 and A 5 are as in (b), o = 0 or 1, p = 1 and r = 1-3; or (f) A 3 = (CH 2) q(6-14C aryl) optionally ring-substituted by 1-3 R 1, A 4 = O, A 5 = 6-14C aryl (os by 1-3 R 1), o, p = 1 and q =1-3; Het1 = 4-15 membered heterocycle os by 1-3 oxo or R 1; R 1 = 6-14C aryl (os by 1-3 1-6C alkyl, 3-8C cycloalkyl(0-4C alkyl), CF 3, O, OCF 3 or halo), 4-15 membered heterocycle, 1-6C alkyl, 3-8C cycloalkyl(0-4C)alkyl, CF 3, OCF 3 or halo; R 2 = 6-14C aryl, 1-6C alkyl or 3-8C cycloalkyl (all os by 1-3 R 1), CF 3 or H; R 3, R 6-R 8 = 1-6C alkyl, 6-14C aryl, 4-15 membered heterocycle or 3-8C cycloalkyl (all os by 1-3 R 1) or H; R 4, R 5 = 1-6C alkyl, 2-10C alkenyl, 6-14C aryl, 4-15 membered heterocycle or 3-8C cycloalkyl (all os by 1-3 R 1) or H; or R 4+R 5 complete a 3-8 membered ring optionally including 1 or 2 additional O, S or N; R 12 = 1-6C alkyl or Q-(0-3C alkyl) (all os by 1-3 R 1) and R 13 = 6-14C aryl(0-3C alkyl) or Het(0-3C alkyl) (both os by 1-3 R 1); or R 12 = H, 1-6C alkyl, 0-3C alkyl(6-14C aryl) or 0-3C alkyl(Het) (all os by 1-3 R1) and R 13 = CHR 8R 9; Q = 3-6C cycloalkyl, 6-14C aryl or heterocycle; R 8, R 9 = 6-14C aryl or heterocycle (both os by 1-3 1-4C alkoxy or R 1); R 16-R 19 = H, 1-6C alkyl (os by 1 or 2 R 1), halo, OH, amino, 0-3C alkyl(6-14C aryl) or 0-3C alkyl-Het (all os by 1-3 R 1); or R 16+R 17 or R 18+R 19 = 3-6 membered ring; R 24, R 25 = H, 1-6C alkyl (os by 1-2 R 1), 0-3C alkyl(6-14C aryl or Het), os by 1-3 R 1, or 0-3C alkyl(3-6C cycloalkyl); or R 24+R 25 complete a 3-8 membered ring that may contain 1 or 2 additional O, S or N; R 26-R 29 = H, 1-6C alkyl (os by 1 or 2 R 1), halo, OH, amino, or (0-3C alkyl)-6-14C aryl or -Het (all os by 1-3 R 1); or R 26+R 27 or R 28+R 29 = 3-6 membered ring. An independent claim is also included for preparation of (I). [Image] [Image] ACTIVITY : Thrombolytic; Anticoagulant; Cardiant; Antianginal; Cerebroprotective; Antiarteriosclerotic; Antidiabetic; Cytostatic; Ophthalmological; Vulnerary. MECHANISM OF ACTION : TAFIa inhibitor (activated thrombin-activatable fibrinolysis inhibitor). 3-(6-Aminopyridin-3-yl)-2-(1-cyclohexyl-1H-imidazol-1-yl)propionic acid, when tested using Actichrome Plasma TAFI Activity kit, had IC 50 against TAFIa of 0.03 mu M.

5. 发明专利

RS50539B POSTUPAK PROIZVODNJE DERIVATA 1,4-DIFENIL-AZETIDINONA 未知
公开(公告)号：RS50539B
公开(公告)日：2010-05-07
申请号：RSP20070483
申请日：2005-05-20
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： LINDENSCHMIDT ANDREAS , WILL DAVID , JAEHNE GERHARD , WOLLMANN THEODOR , FRICK WENDELIN , JUNKER BERND , RIGAL DAVID , BILLEN GUENTER , JENDRALLA HEINER
IPC分类号： C07D205/08 , A61K31/33

6. 发明专利

PL1862455T3 Kwas 11-((4R,6R)-4,5,6-trihydroksy-3-(R)-hydroksy-2-(S)-hydroksy-heksylokarbamoilo)-undekanowy 未知
公开(公告)号：PL1862455T3
公开(公告)日：2009-07-31
申请号：PL07016889
申请日：2004-03-16
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： JAEHNE GERHARD , FRICK WENDELIN , LINDENSCHMIDT ANDREAS , FLOHR STEFANIE , HEUER HUBERT , SCHAEFER HANS-LUDWIG , KRAMER WERNER , GALIA ERIC , GLOMBIK HEINER
IPC分类号： A61K31/397 , C07D205/08 , A61P3/06 , C07C233/18 , C07C235/74

7. 发明专利

NO20091746L 未知
公开(公告)号：NO20091746L
公开(公告)日：2009-07-21
申请号：NO20091746
申请日：2009-05-04
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： FRICK WENDELIN , HEUER HUBERT , SCHAEFER HANS-LUDWIG , LINDENSCHMIDT ANDREAS , JAEHNE GERHARD , KRAMER WERNER , GRAF CLAUS-DIETER , SCHMIDER WOLFGANG
IPC分类号： C07D205/08
摘要： The invention therefore relates to the compound of the formula I or a pharmaceutically acceptable salt thereof, its pharmaceutically composition and uses.

8. 发明专利

PT1862455E ÁCIDO 11-((4R,6R)-4,5,6-TRI-HIDROXI-3-(R)-HIDROXI-2-(S)- HIDROXI-HEXILCARBAMOIL)-UNDECANÓICO 未知
公开(公告)号：PT1862455E
公开(公告)日：2009-04-23
申请号：PT07016889
申请日：2004-03-16
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： GALIA ERIC , JAEHNE GERHARD , FRICK WENDELIN , LINDENSCHMIDT ANDREAS , FLOHR STEFANIE , HEUER HUBERT , SCHAEFER HANS-LUDWIG , KRAMER WERNER , GLOMBIK HEINER
IPC分类号： C07D205/08 , A61K31/397 , A61P3/06 , C07C233/18 , C07C235/74

9. 发明专利

DE50310161D1 未知
公开(公告)号：DE50310161D1
公开(公告)日：2008-08-28
申请号：DE50310161
申请日：2003-06-04
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： JAEHNE GERHARD , FRICK WENDELIN , FLOHR STEFANIE , LINDENSCHMIDT ANDREAS , GLOMBIK HEINER , KRAMER WERNER , HEUER HUBERT , SCHAEFER HANS-LUDWIG
IPC分类号： C07D205/08 , A61K31/397 , A61K31/4025 , A61K31/4985 , A61K31/5377 , A61P3/06 , A61P3/10 , A61P9/10 , C07D487/08
摘要： The invention relates to compounds of formula (I), in which R1, R2, R3, R4, R5 and R6 are defined as cited, in addition to their physiologically compatible salts. The compounds are suitable for use e.g. as hypolipidaemics.

10. 发明专利

PL1740569T3 Pochodne imidazolu jako inhibitory TAFIA 未知
公开(公告)号：PL1740569T3
公开(公告)日：2008-07-31
申请号：PL05731221
申请日：2005-04-07
申请人： SANOFI AVENTIS DEUTSCHLAND
发明人： KALLUS CHRISTOPHER , HEITSCH HOLGER , LINDENSCHMIDT ANDREAS , GRUENEBERG SVEN , SZILLAT HAUKE
IPC分类号： C07D401/06 , A61K31/41 , A61K31/435 , A61P7/00 , C07D401/14 , C07D409/14 , C07D417/06

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