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1. 发明申请

WO2005030333A3 NOVEL DERIVATIVES OF 4A,5,9,10,11,12-HEXAHYDROBENZOFURO[3A,3,2] [2]- BENZAZEPINE, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF IN THE PRODUCTION OF MEDICAMENTS 审中-公开
标题翻译：图4A的新衍生物，5,9,10,11,12-HEXAHYDROBENZOFURO [3A，3.2] [2] - 苯并氮杂，生产和及其使用方法为药物的制造
公开(公告)号：WO2005030333A3
公开(公告)日：2005-06-23
申请号：PCT/AT2004000309
申请日：2004-09-09
申请人： SANOCHEMIA PHARMAZEUTIKA AG , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN , FRANTSITS WERNER J , JORDIS ULRICH , FROEHLICH JOHANNES
发明人： CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN , FRANTSITS WERNER J , JORDIS ULRICH , FROEHLICH JOHANNES
IPC分类号： A61K31/55 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , C07D491/10
CPC分类号： A61K31/55 , C07D491/10
摘要： The invention relates to novel derivatives of 4a,5,9,10,11,12-hexahydro-benzofuro[3a,3,2] [2]benzazepine of general formulae 1a, 1b and 1c. Compounds 1a, 1b and 1c can be produced in an efficient manner on an industrial scale with the desired optical purity and are suitable for the production of medicaments for the treatment of a diverse range of symptoms, particularly diseases of the central nervous system (CNS), on account of the pharmacological effect thereof.
摘要翻译：本发明涉及4a的新的衍生物，5,9,10,11,12六氢苯并呋喃并[3a中，3,2] [2]与上述通式1a，1b和1c的苯并吖庚因。化合物1a，1b和1c中，不仅可以在与在工业规模生产所期望的光学纯度以有效的方式，但是它们适于的，因为它们的药理作用和用于药物的特别是中枢神经系统的疾病的各种疾病的治疗，制备（CNS ）。

2. 发明申请

WO03080623A8 METHODS FOR PRODUCING NORGALANTHAMINE, AS WELL AS ISOMERS, SALTS AND HYDRATES THEREOF 审中-公开
标题翻译：用于生产norgalanthamine它们的异构体，盐和水合物
公开(公告)号：WO03080623A8
公开(公告)日：2004-02-19
申请号：PCT/AT0300007
申请日：2003-01-09
申请人： SANOCHEMIA PHARMAZEUTIKA AG , JORDIS ULRICH , TREU MATTHIAS , HIRNSCHALL MANFRED , FROEHLICH JOHANNES , CZOLLNER LASZLO , KAELZ BEATE , KAELZ THOMAS , KUEHNHACKL PETER
发明人： JORDIS ULRICH , TREU MATTHIAS , HIRNSCHALL MANFRED , FROEHLICH JOHANNES , CZOLLNER LASZLO , KAELZ BEATE , KAELZ THOMAS , KUEHNHACKL PETER
IPC分类号： C07D491/06
CPC分类号： C07D491/06
摘要： The invention relates to industrial scale-executable methods for producing norgalanthamine, norgalanthamine derivatives and their isomers of general formula (A) as well as their salts or hydrates of general formula (B). An oxidative demethylation and a catalytic demethylation of the corresponding galanthamine compounds serve as methods for producing the compounds of general formula (A) or (B).
摘要翻译：本发明涉及在工业规模上可行的方法为norgalanthamine，Norgalanthaminderivaten和它们的异构体的通式中A和它们的或通式（B）作为用于制备具有通式（A）或化合物的方法的水合物的盐的制备（B）氧化去甲基化和相应的Galanthaminverbindungen的催化脱甲基指定。

3. 发明专利

CZ300160B6 Deriváty galanthaminu, zpusob výroby techto derivátu, lécivo, které tyto deriváty obsahuje, použitítechto derivátu pro výrobu léciva, zpusob výroby tohoto léciva a zpusob separace (+)- a (-)-izomeruuvedených derivátu 未知
公开(公告)号：CZ300160B6
公开(公告)日：2009-02-25
申请号：CZ20014178
申请日：2001-03-22
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KOLZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , C07D491/10 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/107 , C40B40/04
摘要： Vynález se týká derivátu galanthaminu obecného vzorce I, zpusobu výroby techto derivátu, léciv, která tyto deriváty obsahují, použití techto derivátupro výrobu léciv, zpusobu výroby techto léciv a zpusobu separace (+)- a (-)-izomeru uvedených derivátu. Uvedená léciva jsou urcena pro lécení zejménaAlzheimerovy a Parkinsonovy choroby.

4. 发明专利

DE50307080D1 未知
公开(公告)号：DE50307080D1
公开(公告)日：2007-05-31
申请号：DE50307080
申请日：2003-01-09
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： TREU MATTHIAS , HIRNSCHALL MANFRED , FROEHLICH JOHANNES , CZOLLNER LASZLO , KAELZ BEATE , KAELZ THOMAS , KUEHNHACKL PETER , JORDIS ULRICH
IPC分类号： C07D491/06
摘要： Preparation of norgalanthamine (I) (or its derivatives, isomers, salts or hydrates) involves demethylation of the corresponding galanthamine compounds (II). Preparation of norgalanthamine of formula (I) (or its derivatives, isomers, salts or hydrates) involves demethylation of the corresponding galanthamine compounds of formula (II). [Image].

5. 发明专利

DK1181294T3 未知
公开(公告)号：DK1181294T3
公开(公告)日：2004-08-02
申请号：DK01914813
申请日：2001-03-22
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： JORDIS ULRICH , FROEHLICH JOHANNES , TREU MATTHIAS , HIRNSCHALL MANFRED , CZOLLNER LASZLO , KAELZ BEATE , WELZIG STEFAN
IPC分类号： C07D487/04 , A61K20060101 , A61K31/343 , A61K31/35 , A61K31/443 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61P20060101 , A61P3/10 , A61P9/10 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/28 , A61P43/00 , C07D20060101 , C07D307/94 , C07D413/02 , C07D417/02 , C07D491/10 , C07D491/107 , C40B40/04
摘要： New compounds of general formula I

6. 发明专利

PL184590B1 METHOD OF OBTAINING DERIVATIVES OF 4A,5,9,10,11,12-HEXAHYDRO-6H-BENZOFURO(3A,3,2-EF)(2)BENZODIAZEPIN 未知
公开(公告)号：PL184590B1
公开(公告)日：2002-11-29
申请号：PL31975495
申请日：1995-10-23
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07B53/00 , C07B57/00 , C07D491/048 , C07C217/58 , C07D223/00 , C07D307/00 , C07D491/00 , C07D491/06 , C07D491/10 , C07D491/153 , C07D491/20
摘要： The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.

7. 发明专利

NO313234B1 未知
公开(公告)号：NO313234B1
公开(公告)日：2002-09-02
申请号：NO971645
申请日：1997-04-10
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07B53/00 , C07B57/00 , C07C217/58 , C07D491/048 , C07D223/00 , C07D307/00 , C07D491/00 , C07D491/06 , C07D491/10 , C07D491/153 , C07D491/20
摘要： The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.

8. 发明专利

DE59507585D1 未知
公开(公告)号：DE59507585D1
公开(公告)日：2000-02-10
申请号：DE59507585
申请日：1995-10-23
申请人： SANOCHEMIA PHARMAZEUTIKA AG WI
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D491/048 , C07B53/00 , C07B57/00 , C07C217/58 , C07D223/00 , C07D307/00 , C07D491/00 , C07D491/06 , C07D491/10 , C07D491/153 , C07D491/20
摘要： The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.

9. 发明专利

AT188460T 未知
公开(公告)号：AT188460T
公开(公告)日：2000-01-15
申请号：AT95944807
申请日：1995-10-23
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D491/048 , C07B53/00 , C07B57/00 , C07C217/58 , C07D223/00 , C07D307/00 , C07D491/00 , C07D491/06 , C07D491/10 , C07D491/153 , C07D491/20
摘要： The invention relates to processes for the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine, or derivatives thereof. Furthermore, the invention also relates to the compounds formed during the preparation of 4a,5,9,10,11,12-hexahydro-6H-benzofuro(3a,3,2-ef)(2)benzazepine.

10. 发明专利

PL190032B1 NEW BENZAZEPINE DERIVATIVES, MEDICAMENTS CONTAINING THE SAME AND THEIR USE TO PREPARE MEDICAMENTS 未知
公开(公告)号：PL190032B1
公开(公告)日：2005-10-31
申请号：PL36169797
申请日：1997-04-21
申请人： SANOCHEMIA PHARMAZEUTIKA AG
发明人： CZOLLNER LASZLO , FROEHLICH JOHANNES , JORDIS ULRICH , KUEENBURG BERNHARD
IPC分类号： C07D471/08 , C07D487/08 , C07D491/056 , C07D491/10 , C07D491/107 , C07D491/20 , C07D519/00 , C07D223/16 , C07D491/14 , A61K31/55 , A61P25/28
摘要： Benzofuro[3a,3,2,ef][2]benzazepines (I), their ring-opened form (II) and diazabicycloalkanes (III) as well as their enantiomers and addition salts are new: Z = N; or N+ if both R6 and R7 are present and if R7 = O-; R1, R2 = H; F; Cl; Br; I; CN; NC; OH; SH; NO2; SO3H; NH2; NH2; CF3; 1-6C (sic) optionally substituted (ar)alkyl or (ar)alkoxy; NH2 optionally mono- or disubstituted by 1-6C (Ar)alkyl, (Ar)alkylcarbonyl or (Ar)alkoxycarbonyl; COOH; COO(Ar)alkyl; CONH; CON(Ar)alkyl; -(CH2)n-Q; n = 1-3; Q = Cl; Br; OH; COOH; CN; or NC; or R1+R2 = -CH=CH-CH=CH- or -O-(CH2)n-O-; R3 = R1, especially OH or OMe; or R2+R3 = -O-(CH2)n-O-; R4, R5 = either both H; or, alternatively, each combination of H, (ar)alkyl, (ar)alkenyl or (ar)alkynyl with the following: SR8; SOR8; SO2R8; OH (optionally with a protecting group, e.g. TMS, TBDMS); OCSNR8; OCONR9; OCOR8, especially of formula (a): or, when R4 or R5 is other than H, the other may be OH; or R4+R5 = a group of formula =N-NH-R10; =N-NR10R11; or =N-O-R11; or a N-NH-C(=Y1)-Q1; L = -CH2-COOBn; -CH2-SMe; or Ph; R8 = H or 1-10C optionally substituted (ar)alkyl; R9 = -CO-NH-C*(H)(Me)-Ph (where * indicates an optically active centre, the Me being depicted in alpha or beta configurations); R10 = H; 1-6C optionally substituted (ar)alkyl, (ar)alkylcarbonyl or (ar)alkylcarbonyloxy; or a sulphonic acid group, e.g. tosyl or mesyl; R11 = R10 except (Ar)alkylcarbonyloxy; Q1 = Y2 or COOR8; Y1, Y2 = O; S; NH; or NR10 (any spare valencies = H); G1, G2 = -C(R13R14)- or G1+G2 = 3-9C cycloalkan-(1,2)-diyl; R13, R14 = H; OH; lower optionally substituted (ar)alkyl, aryl, (ar)alkoxy or aryloxy or R13+R14 = a 3-7C spiro ring; m = 1-7; G3 = CH2 or CO; R6 = -(G4)p-(G5)q-G6; p, q = 0 or 1; G4 = (CH2)r, C(R15R16)-(CH2)r, O, NR15, or a group of formula (f), (g) or (h): r = 1-6; R15, R16 = H; or lower optionally substituted (ar)alkyl, cycloalkyl or aryl; s = 1-4; t = 0-4; G7 = NR15, O or S; G5 = G4; or S when p = 1; G6 = CHO; COOR17; CONHR17; lower optionally substituted (Ar)alkyl, (Ar)alkenyl, (Ar)alkynyl, cycloalkyl or aryl; OR17; NR17R18; phthalimido; CN; NC; or a group of formula (i)-(k): R17-R20 = H; lower optionally substituted (Ar)alkyl, cycloalkyl or aryl; or R17+R18 or R19+R20 = a 3-8 ring C cycloalkyl; G8 = O; S; NH; NR21; or -(CH2)n-; R21 = CHO; COOR17; aryl or heteroaryl (preferably 2- or 4-pyridyl or 2-pyrimidinyl) optionally substituted by 1 or more F, Cl, Br, I, NO2, NH2, OH, alkyl, alkoxy, CN, NC, CF3, CHO, COOH, COOalkyl, SO3H, SH or S-alkyl; or methyl mono-, di- or trisubstituted by Ph (optionally substituted by 1 or more F, Cl, Br, I, NO2, NH2, alkyl, alkoxy, CN, NC or CF3); R7 = R6 or O- or free electron pair; or R6+R7 = a 3-8 membered ring; R22 = (hetero)aryl optionally with the same substituents as the heteroaryl group R21; or methyl disubstituted by phenyl (optionally with the same substituents as the heteroaryl group R21); R23 = -(G5)q-(G4)p-G9; G9 = H; F; Cl; Br; I; OH; OTs; OMs; O-triflate; COOH; COCl; CHO; OR17; NR17R18; phthalimido; CN; NC; or a group suitable for nucleophilic substitutions or addition or condensation reactions, etc.; X = (if present) inorganic or organic acid ion.

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