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1. 发明授权

US07363071B2 Computer guided ablation of tissue using integrated ablative/temperature sensing devices 有权
标题翻译：使用集成烧蚀/温度感测装置的计算机引导消融组织
公开(公告)号：US07363071B2
公开(公告)日：2008-04-22
申请号：US10700326
申请日：2003-11-03
申请人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
发明人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
IPC分类号： A61B5/05
CPC分类号： A61B18/02 , A61B8/08 , A61B34/10 , A61B90/11 , A61B90/37 , A61B2017/00084 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2090/378
摘要： The system for providing computer guided ablation of tissue of a patient includes an imaging device, an ablative surgical computer system, and a set of surgical devices. The imaging device receives imaging data from a treatment region of a patient, processes the imaging data and provides imaging output data and imaging signals. The imaging output data is available to an operator. The ablative surgical computer system includes a guidance module for processing the imaging signals and providing a treatment guidance plan to the operator; and, a treatment module for acquiring and processing surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. The set of surgical devices includes at least one integrated ablative/temperature sensing device including at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal. The temperature sensing device output signal is a portion of the surgical device output data. The treatment guidance plan is utilized for placing the integrated ablative/temperature sensing device into the treatment region.
摘要翻译：用于提供患者组织的计算机引导消融的系统包括成像装置，烧蚀外科手术计算机系统和一组手术装置。成像装置从患者的治疗区域接收成像数据，处理成像数据并提供成像输出数据和成像信号。成像输出数据可供操作员使用。烧蚀手术计算机系统包括用于处理成像信号并向操作者提供治疗指导计划的引导模块; 以及用于获取和处理手术装置输出数据的治疗模块，用于根据治疗指导计划最佳地控制治疗参数并向操作者提供反馈信息。该组手术装置包括至少一个集成的烧蚀/温度感测装置，其包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个用于从处理区域获取温度数据并提供温度感测装置输出信号的温度感测装置。温度感测装置输出信号是手术装置输出数据的一部分。治疗指导计划用于将整合的烧蚀/温度感测装置放置在治疗区域中。

2. 发明申请

US20080154253A1 SYSTEM FOR PROVIDING COMPUTER GUIDED ABLATION OF TISSUE 有权
标题翻译：用于提供计算机指导组织消除的系统
公开(公告)号：US20080154253A1
公开(公告)日：2008-06-26
申请号：US12025619
申请日：2008-02-04
申请人： SANFORD D. DAMASCO , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
发明人： SANFORD D. DAMASCO , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B8/08 , A61B34/10 , A61B90/11 , A61B90/37 , A61B2017/00084 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2090/378
摘要： The system for providing computer guided ablation of tissue of a patient includes an ablative surgical computer system and a set of surgical devices. The ablative surgical computer system includes a guidance module for providing a treatment guidance plan to an operator; and, a treatment module for acquiring and processing surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. The set of surgical devices includes at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal. The temperature sensing device output signal is a portion of the surgical device output data. The treatment guidance plan is utilized for placing the ablative device and the temperature sensing device into the treatment region.
摘要翻译：用于提供患者的组织的计算机引导消融的系统包括烧蚀性外科手术计算机系统和一组手术装置。烧蚀外科计算机系统包括用于向操作者提供治疗指导计划的引导模块; 以及用于获取和处理手术装置输出数据的治疗模块，用于根据治疗指导计划最佳地控制治疗参数并向操作者提供反馈信息。该组手术装置包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个用于从处理区域获取温度数据并提供温度感测装置输出信号的温度感测装置。温度感测装置输出信号是手术装置输出数据的一部分。治疗指导计划用于将消融装置和温度感测装置放置在治疗区域中。

3. 发明授权

US09326808B2 System for providing computer guided ablation of tissue 有权
标题翻译：用于提供计算机引导消融组织的系统
公开(公告)号：US09326808B2
公开(公告)日：2016-05-03
申请号：US12025619
申请日：2008-02-04
申请人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , Paul W. Mikus , Jay J. Eum
发明人： Sanford D. Damasco , Thach Duong , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
IPC分类号： A61B18/02 , A61B8/08 , A61B17/00 , A61B17/34 , A61B18/00
CPC分类号： A61B18/02 , A61B8/08 , A61B34/10 , A61B90/11 , A61B90/37 , A61B2017/00084 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2090/378
摘要： The system for providing computer guided ablation of tissue of a patient includes an ablative surgical computer system and a set of surgical devices. The ablative surgical computer system includes a guidance module for providing a treatment guidance plan to an operator; and, a treatment module for acquiring and processing surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. The set of surgical devices includes at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal. The temperature sensing device output signal is a portion of the surgical device output data. The treatment guidance plan is utilized for placing the ablative device and the temperature sensing device into the treatment region.
摘要翻译：用于提供患者的组织的计算机引导消融的系统包括烧蚀性外科手术计算机系统和一组手术装置。烧蚀外科计算机系统包括用于向操作者提供治疗指导计划的引导模块; 以及用于获取和处理手术装置输出数据的治疗模块，用于根据治疗指导计划最佳地控制治疗参数并向操作者提供反馈信息。该组手术装置包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个用于从处理区域获取温度数据并提供温度感测装置输出信号的温度感测装置。温度感测装置输出信号是手术装置输出数据的一部分。治疗指导计划用于将消融装置和温度感测装置放置在治疗区域中。

4. 发明授权

US06643535B2 System for providing computer guided ablation of tissue 有权
标题翻译：用于提供计算机引导消融组织的系统
公开(公告)号：US06643535B2
公开(公告)日：2003-11-04
申请号：US10307036
申请日：2002-11-27
申请人： Sanford D. Damasco , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
发明人： Sanford D. Damasco , Jawahar M. Ali , David J. Battles , Paul W. Mikus , Jay J. Eum
IPC分类号： A61B505
CPC分类号： A61B18/02 , A61B8/08 , A61B34/10 , A61B90/11 , A61B90/37 , A61B2017/00084 , A61B2017/00274 , A61B2017/3411 , A61B2018/00547 , A61B2090/378
摘要： An imaging device receives imaging data from a treatment region of a patient, processes the imaging data and provides imaging output data and imaging signals. A computer system includes a guidance module for processing the imaging signals and providing treatment guidance plan to an operator. A treatment module acquires and processes surgical device output data, for optimally controlling treatment parameters and providing feedback information to the operator based on the treatment guidance plan. A set of surgical devices includes at least one ablative device for providing ablation of the treatment region based on the treatment parameters and operator input; and, at least one temperature sensing device for acquiring temperature data from the treatment region and providing a temperature sensing device output signal which is a portion of the surgical device output data. The treatment guidance plan is utilized for appropriately placing the ablative device and the temperature-sensing device.
摘要翻译：成像装置从患者的治疗区域接收成像数据，处理成像数据并提供成像输出数据和成像信号。计算机系统包括用于处理成像信号并向操作者提供治疗指导计划的引导模块。治疗模块基于治疗指导计划获取并处理手术装置输出数据，以最佳地控制治疗参数并向操作者提供反馈信息。一组手术装置包括至少一个消融装置，用于基于治疗参数和操作员输入提供治疗区域的消融; 以及至少一个温度感测装置，用于从治疗区域获取温度数据，并提供作为手术装置输出数据的一部分的温度感测装置输出信号。治疗指导计划用于适当放置烧蚀装置和温度感测装置。

5. 发明授权

US07510554B2 Detachable cryosurgical probe 有权
公开(公告)号：US07510554B2
公开(公告)日：2009-03-31
申请号：US11738653
申请日：2007-04-23
申请人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey D. Kurtzer
发明人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey D. Kurtzer
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/0046 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： A cryosurgical probe system includes a fluid supply line connectable at an inlet section to a source of cryogenic fluid; a fluid connector assembly securely connected to an outlet section of the fluid supply line for receiving fluid from the outlet section of the fluid supply line; and, a detachable cryosurgical probe detachably connectable to the fluid connector assembly. The cryosurgical probe system includes the capability of providing return fluid flow.

6. 发明授权

US07207985B2 Detachable cryosurgical probe 有权
公开(公告)号：US07207985B2
公开(公告)日：2007-04-24
申请号：US10603883
申请日：2003-06-25
申请人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey Kurtzer
发明人： Thach Duong , Sanford D. Damasco , David J. Battles , Paul W. Mikus , Jeffrey Kurtzer
IPC分类号： A61B18/02 , A61B18/08
CPC分类号： A61B18/02 , A61B2017/0046 , A61B2018/00041 , A61B2018/0262 , A61B2018/0293
摘要： A cryosurgical probe system includes a fluid supply line connectable at an inlet section to a source of cryogenic fluid; a fluid connector assembly securely connected to an outlet section of the fluid supply line for receiving fluid from the outlet section of the fluid supply line; and, a detachable cryosurgical probe detachably connectable to the fluid connector assembly. The cryosurgical probe system includes the capability of providing return fluid flow.

7. 发明授权

US6162231A Stent insertion device 失效
标题翻译：支架插入装置
公开(公告)号：US6162231A
公开(公告)日：2000-12-19
申请号：US336974
申请日：1999-06-21
申请人： Paul W. Mikus , Jay J. Eum
发明人： Paul W. Mikus , Jay J. Eum
IPC分类号： A61F2/82 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/06 , A61M25/12 , A61M29/00 , A61F11/00
CPC分类号： A61M25/0662 , A61F2/95 , A61F2002/9517 , A61M25/0068 , A61M25/0668 , A61M29/00 , A61M2210/166
摘要： Two embodiments for a stent delivery device are disclosed. In the first embodiment, the stent delivery device comprises an outer sheath and an inner tubular member which distally ends in a tongue having an arcuate cross section. In a second embodiment, the stent delivery device further comprises a housing having a lumen extending longitudinally therethrough, the lumen holding the inner tubular member. A guide pin attached to the outer sheath is slidably disposed within the housing wherein the guide pin may be longitudinally displaced with respect to the lumen. In addition, an endoscope mounting plate may be slidably disposed along the housing. Detents may be used to releasably prevent a proximal displacement of the guide pin within the lumen of the housing as well as to releasably prevent the proximal displacement of the endoscope mounting plate with respect to the housing.
摘要翻译：公开了用于支架输送装置的两个实施例。在第一实施例中，支架输送装置包括外鞘和内管状构件，其以具有弓形横截面的舌头远端终止。在第二实施例中，支架输送装置还包括具有纵向延伸通过其延伸的内腔的壳体，所述内腔保持内管状构件。附接到外护套的引导销可滑动地设置在壳体内，其中引导销可以相对于内腔纵向移位。此外，内窥镜安装板可以沿壳体可滑动地设置。可以使用定位器来可释放地防止引导销在壳体的腔内的近端位移，并且可释放地防止内窥镜安装板相对于壳体的近侧位移。

8. 发明授权

US06694170B1 Computer guided surgery for prostatic nerve sparing 有权
标题翻译：电脑指导手术前列腺神经保护
公开(公告)号：US06694170B1
公开(公告)日：2004-02-17
申请号：US09981336
申请日：2001-10-16
申请人： Paul W. Mikus , Jay Eum , John C. Rewcastle , Jawahar M. Ali
发明人： Paul W. Mikus , Jay Eum , John C. Rewcastle , Jawahar M. Ali
IPC分类号： A61B505
CPC分类号： A61B18/02 , A61B34/10 , A61B2017/00274 , A61B2018/00547 , A61B2090/378 , Y10S128/92
摘要： The computer system is capable of acquiring and displaying images of the prostate of a patient for assisting a surgeon in placing ablative elements in the prostate of the patient. The computer system is programmed with software capable of: 1) determining the dimensions of the prostate; and, 2) determining the dimensions and location of a treatment zone. The treatment zone is determined to include only one neurovascular bundle of the prostate and exclude the other neurovascular bundle of the prostate. The system utilizes the determined dimensions of the prostate and treatment zone for computing the number and location of ablative elements needed to treat the treatment zone while minimizing any adverse effect on the patient's sexual function.
摘要翻译：计算机系统能够获取和显示患者的前列腺的图像，以帮助外科医生将烧伤元件放置在患者的前列腺中。计算机系统用软件编程，能够：1）确定前列腺的尺寸; 以及2）确定治疗区域的尺寸和位置。治疗区被确定为仅包括前列腺的一个神经血管束，并排除前列腺的另一个神经血管束。该系统利用前列腺和治疗区域的确定的尺寸来计算治疗区域所需的烧蚀元件的数量和位置，同时最小化对患者的性功能的任何不利影响。

9. 发明授权

US06702846B2 Urological stent therapy system and method 失效
标题翻译：泌尿支架治疗系统及方法
公开(公告)号：US06702846B2
公开(公告)日：2004-03-09
申请号：US10091112
申请日：2002-02-28
申请人： Paul W. Mikus , William G. Moseley , Jay J. Eum
发明人： Paul W. Mikus , William G. Moseley , Jay J. Eum
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/95 , A61F2002/048 , A61F2002/9505 , A61F2002/9511 , A61F2002/9517 , A61F2250/0039 , A61M27/008
摘要： A stent system and method for use in the prostate gland. The stent is made of a shape memory alloy such as nitinol, and has a low temperature martensite state, with a martensite transition temperature below body temperature, and a high temperature austenite state, with an austenite transition temperature at or above body temperature, and a memorized shape in the high temperature austenite state which is a helical coil of diameter large enough to hold the prostatic urethra open. The stent is used to heat the prostate and is left in the prostatic urethra while the prostate heals. After the prostate is substantially healed, the stent is cooled to its martensite state and is easily removed from the urethra.
摘要翻译：用于前列腺的支架系统和方法。该支架由镍钛诺镍等形状记忆合金制成，具有马氏体转变温度低于体温的低温马氏体状态和奥氏体转变温度在体温以上的高温奥氏体状态，在高温奥氏体状态下记忆形状，其为直径足够大以容纳前列腺尿道打开的螺旋线圈。支架用于加热前列腺，并在前列腺治疗时留在前列腺尿道。在前列腺基本上愈合之后，支架被冷却到其马氏体状态，并且容易地从尿道中移出。

10. 发明授权

US6146378A Placement guide for ablation devices 有权
标题翻译：消融装置放置指南
公开(公告)号：US6146378A
公开(公告)日：2000-11-14
申请号：US272889
申请日：1999-03-19
申请人： Paul W. Mikus , Jay J. Eum
发明人： Paul W. Mikus , Jay J. Eum
IPC分类号： A61B19/00 , A61B1/00 , A61B17/00 , A61B17/32 , A61B17/34 , A61B17/42 , A61B18/02 , A61M25/08 , A61B18/18
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2017/4216 , A61B2018/0212 , A61B2090/034 , A61B2090/0463 , A61B2090/378
摘要： A placement guide for positioning ablation devices within a human body is disclosed. The placement guide comprise an outer catheter and an inner tubular member disposed within a lumen of the outer catheter. When a stop on the inner tubular member engages a seat on the outer catheter, a distal projection of the inner tubular member extends from the distal end of the outer catheter. While monitoring the position of the inner tubular member through an endoscope inserted in its lumen, a clinician positions the distal projection within a human body for optimal ablation. After securing the outer catheter in position, the inner tubular member is withdrawn and replaced with an ablation device which is inserted distally within the outer catheter lumen until a stop on the ablation device engages the seat on the outer catheter wherein a distal projection of the ablation device extends from the distal end of the outer catheter. Because the distal projection of the inner tubular member has a length substantially identical to that of the inner tubular member, the ablation device may be positioned for optimal ablation.
摘要翻译：公开了一种用于将消融装置定位在人体内的放置引导件。放置引导件包括外导管和设置在外导管的内腔内的内管状构件。当内管状构件上的止动件与外导管上的座接合时，内管状构件的远端突出部从外导管的远端延伸。在通过插入其管腔中的内窥镜监测内管状构件的位置的同时，临床医生将远侧突出物定位在人体内以进行最佳消融。在将外导管固定就位之后，内管状构件被取出并且被切除装置替代，该消融装置向远端插入外导管内腔中直到消融装置上的止动件接合外导管上的座，其中消融的远侧突出部装置从外导管的远端延伸。因为内部管状构件的远侧突出部具有与内部管状构件的长度基本相同的长度，所以可以定位消融装置以实现最佳消融。

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