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1. 发明申请

WO1996040876A1 METHOD OF EXPANDING HEMATOPOIETIC STEM CELLS, REAGENTS AND BIOREACTORS FOR USE THEREIN 审中-公开
标题翻译：扩增HEMATOPOIETIC干细胞的方法，用于其的试剂和生物反应器
公开(公告)号：WO1996040876A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002464
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , TUCKER, Sean, Newton , CHARY, Srikanth, Ranga , KUO, Suzanne, Chang , SCHWARTZ, Richard, Merrill
IPC分类号： C12N05/08
CPC分类号： C12M25/06 , C12M23/02 , C12M23/04 , C12M23/24 , C12M25/02 , C12M41/32 , C12N5/0647 , C12N2500/02 , C12N2500/90 , C12N2501/125 , C12N2501/22 , C12N2501/23
摘要： The present invention provides methods and bioreactors for expanding stem cells in a population of cells substantially enriched in hematopoietic stem cells and substantially free of stromal cells. The method preferably comprises the steps of inoculating the population of cells in an expansion container in a volume of suitable medium such that the cell density is at least about 5,000 cells/1 mL and at an initial oxygen concentration of less than 8 %; adding an effective amount of at least one cytokine to cause stem cell expansion; culturing the cells under suitable conditions such that the cells condition the medium; increasing the oxygen concentration to about 20 %; exchanging the medium at a rate which allows expansion of the stem cells; and culturing the cells under conditions such that the stem cells are expanded. The present invention also provides a bioreactor constructed to accommodate the operational requirements for stroma-free stem cell expansion.
摘要翻译：本发明提供用于在基本上富含造血干细胞并基本上不含基质细胞的细胞群中扩增干细胞的方法和生物反应器。该方法优选包括以下步骤：将细胞群接种在一定体积的合适培养基中的膨胀容器中，使得细胞密度为至少约5,000个细胞/ 1mL，初始氧浓度小于8％; 加入有效量的至少一种细胞因子以引起干细胞扩张; 在合适的条件下培养细胞，使细胞调节培养基; 将氧浓度提高到约20％; 以允许干细胞扩增的速率交换培养基; 并在使干细胞扩大的条件下培养细胞。本发明还提供了一种生物反应器，其被构造为适应无基质干细胞扩增的操作要求。

2. 发明申请

WO1996039811A1 IMMUNOCOMPROMISED ANIMALS COMPRISING HUMAN SYNOVIAL TISSUE 审中-公开
标题翻译：包含人体征服组织的免疫组织化学动物
公开(公告)号：WO1996039811A1
公开(公告)日：1996-12-19
申请号：PCT/EP1996002457
申请日：1996-06-06
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , KNUDSEN, David, E., B.
IPC分类号： A01K67/027
CPC分类号： A01K67/0271
摘要： Immunocompromised hosts are provided, comprising a functional human synovial sac and articular cartilage. An intact human fetal patella is introduced into the xenogeneic host at a site that permits survival of the tissue, and permits experimental manipulation.Engrafted patella show early differentiation into a columnar matrix and stratification consistent with joint cartilage. The patellar articular surface is closely overlaid with a single layer of large cuboidal to attenuated cells with a central, oval to brick shaped nuclei and clear to pale eosinophilic cytoplasm consistent with synoviocytes. This layer reflects on itself at the margins of the patellar graft and closes, forming a complete envelope over the patellar articular surface. The human articular tissue is useful for investigating the effects of agents such as bacteria and bacterial peptides, cytokines and proteases on synovial function and dysfunction, growing neoplastic synovial sarcoma tissue in a natural environment, studying the hematopoietic interactions that are involved in various inflammatory arthritic diseases, and determining the role of HLA haplotypes in development of joint diseases.
摘要翻译：提供了免疫受损宿主，包括功能性人滑膜和关节软骨。将完整的人胎儿髌骨引入到允许组织存活的位点的异种宿主中，并允许实验操作。移植的髌骨显示早期分化成柱状基质并且与关节软骨一致。髌骨关节表面紧密地覆盖着一层大的长方体细胞，具有中心的，椭圆形到砖状的细胞核，并且与滑膜细胞一致的清澈至浅的嗜酸性细胞质。该层在髌骨移植物的边缘自身反射并闭合，在髌骨关节面上形成完整的包膜。人关节组织可用于研究细菌和细菌肽，细胞因子和蛋白酶等药物对滑膜功能和功能障碍的作用，在自然环境中生长的肿瘤滑膜肉瘤组织，研究各种炎症性关节炎疾病涉及的造血相互作用，并确定HLA单倍体在关节疾病发展中的作用。

3. 发明申请

WO1996027128A2 HIV DETERMINANTS REQUIRED FOR IN VIVO REPLICATION 审中-公开
标题翻译：艾滋病毒检测要求在体内复制
公开(公告)号：WO1996027128A2
公开(公告)日：1996-09-06
申请号：PCT/EP1996000858
申请日：1996-03-02
申请人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
发明人： SANDOZ LTD. , SYSTEMIX, INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SU, Lishan , BONYHADI, Mark , KANESHIMA, Hideto , McCUNE, Joseph, M.
IPC分类号： G01N33/50
CPC分类号： C07K14/005 , A61K48/00 , C12N2740/16122 , C12Q1/18 , G01N33/5005 , G01N33/5088 , G01N33/56988 , G01N2333/16
摘要： A screening method is provided for determining the in vivo infectivity of HIV-1 isolates. Human thymus fragments cultured in vitro or as a xenograft are able to accurately reflect the in vivo infectivity of a particular isolate. The virus may be used directly, or regions of interest may be molecularly cloned into a test vector. Of particular interest is the screening of variant envelope proteins. The screening is useful in the determination of peptides and protein for immunization, and for screening drugs that may block particular determinants.
摘要翻译：提供了一种筛选方法，用于确定HIV-1分离物的体内感染性。在体外培养或作为异种移植物培养的人胸腺能够准确地反映特定分离物的体内感染性。可以直接使用病毒，或者将感兴趣的区域分子克隆到测试载体中。特别感兴趣的是筛选变体包膜蛋白。该筛选可用于测定用于免疫的肽和蛋白质，以及用于筛选可能阻断特定决定簇的药物。

4. 发明申请

WO1997009287A1 UNDERWATER CEMENTITIOUS COMPOSITION 审中-公开
标题翻译：水下成分组成
公开(公告)号：WO1997009287A1
公开(公告)日：1997-03-13
申请号：PCT/EP1996003886
申请日：1996-09-04
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , BURY, Jeffrey, Richard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C04B40/00
CPC分类号： C04B40/0028 , C04B28/02 , C04B2111/00146 , C04B2111/74 , C04B24/226 , C04B24/383
摘要： A method for placing concrete underwater comprising pumping a flowable cementitious mixture comprising cement, water and one of either BNS or a cellulosic polymer to the underwater point of discharge of the cementitious mixture from a delivery tube and adding into the flowable cementitious mixture at the point of discharge, the other of the BNS or a cellulosic polymer resulting in a cementitious mixture having zero flow characteristics.
摘要翻译：一种用于放置水下混凝土的方法，包括将包含水泥，水和BNS或纤维素聚合物之一的可流动的水泥混合物从输送管泵送到水泥混合物的水下排放点，并将其加入到可流动的水泥混合物中排出，另一个BNS或纤维素聚合物，导致具有零流动特性的水泥混合物。

5. 发明申请

WO1997003054A1 BENZO[g]QUINOLINE DERIVATIVES 审中-公开
标题翻译：苯并[g]喹啉衍生物
公开(公告)号：WO1997003054A1
公开(公告)日：1997-01-30
申请号：PCT/EP1996002969
申请日：1996-07-05
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , NEUMANN, Peter , PFAEFFLI, Paul , SEILER, Max, Peter , SWOBODA, Robert
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D221/08
CPC分类号： C07D401/12 , C07D221/08 , C07D265/34 , C07D279/14
摘要： The invention provides compounds of formula (I) wherein X, Y, R1, R2, R3 and R4 are as defined in the description, and a process for preparing them. The compounds of formula (I) are useful as pharmaceuticals.
摘要翻译：本发明提供式（I）化合物，其中X，Y，R 1，R 2，R 3和R 4如说明书中所定义，及其制备方法。式（I）的化合物可用作药物。

6. 发明申请

WO1996003437A1 PTH OR PTHrP ANTAGONISTS 审中-公开
标题翻译： PTH或PTHrP ANTAGONISTS
公开(公告)号：WO1996003437A1
公开(公告)日：1996-02-08
申请号：PCT/EP1995002993
申请日：1995-07-27
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , CARDINAUX, François , FEYEN, Jean, Honoré, M. , GAMSE, Rainer , GOMBERT, Frank, Otto
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07K14/635
CPC分类号： C07K14/635 , A61K38/00
摘要： PTH or PTHrP compounds having potent antagonistic activity at the PTH/PTHrP receptor in which at least one of the amino acid residues naturally occurring in positions 2 and 10 is replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, and optionally at least one of the amino acid residues naturally occurring in positions 3 and 6 is further replaced by tryptophane or another amino acid residue bearing an aromatic or heteroaromatic group on its side chain, having pharmacological activity, e.g. prevention or treatment of conditions which are associated with increased plasma calcium caused by excessive release of PTH or PTHrP.
摘要翻译： PTH或PTHrP化合物在PTH / PTHrP受体中具有有效的拮抗活性，其中天然存在于第2和第10位的氨基酸残基中的至少一个被色氨酸替代，或者其侧链上带有芳族或杂芳族基团的另一个氨基酸残基，并且任选地，位置3和6天然存在的氨基酸残基中的至少一个进一步被其侧链上带有芳香族或杂芳族基团的色氨酸或另一氨基酸残基取代，具有药理活性，例如预防或治疗与过度释放PTH或PTHrP引起的血浆钙升高相关的病症。

7. 发明申请

WO1996000221A1 OPTICAL BRIGHTENING AGENTS 审中-公开
标题翻译：光学加工代理
公开(公告)号：WO1996000221A1
公开(公告)日：1996-01-04
申请号：PCT/EP1995002433
申请日：1995-06-22
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , COWMAN, John, Stuart , FARRAR, John, Martin , GRAHAM, Mark, David , MACKINNON, Neil
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D251/70
CPC分类号： C07D251/68 , C11D3/42 , D06L4/621 , D21H21/30 , Y10T442/2582
摘要： Optical brightening agents for use in textiles, paper, detergents correspond to formula (I) where R, R1 are preferably derived from the amino acids, particularly glutamic and iminodiacetic acids.
摘要翻译：用于纺织品，纸张，洗涤剂的荧光增白剂对应于式（I），其中R，R 1优选衍生自氨基酸，特别是谷氨酸和亚氨基二乙酸。

8. 发明申请

WO1995028362A1 FLUIDITY CONTROL OF CEMENTITIOUS COMPOSITIONS 审中-公开
标题翻译：化学成分的流体控制
公开(公告)号：WO1995028362A1
公开(公告)日：1995-10-26
申请号：PCT/EP1995001360
申请日：1995-04-12
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , DRS, Josef, Franz , OPPLIGER, Max , VALENTI, Salvatore
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C04B24/26
CPC分类号： C04B24/2641 , C04B28/02 , C04B2103/0086 , C04B2103/10 , C04B2103/30 , C04B2111/00155 , C04B14/303 , C04B22/148 , C04B24/003
摘要： The fluidity characteristics of cementitious compositions may be rapidly altered by the addition thereto of an aqueous dispersion of at least one comb polymer which comprises carboxylic moieties. The invention works especially well when the polymer is combined with an accelerator which is at least one of aluminium hydroxide or aluminium hydroxysulphate.
摘要翻译：通过添加至少一种包含羧基部分的梳状聚合物的水性分散体，可以快速改变水泥质组合物的流动性。当聚合物与氢氧化铝或氢氧化铝中的至少一种的促进剂组合时，本发明工作特别好。

9. 发明申请

WO1995015408A1 ALUMINUM ETCHING PROCESS 审中-公开
标题翻译：铝蚀刻工艺
公开(公告)号：WO1995015408A1
公开(公告)日：1995-06-08
申请号：PCT/EP1994003961
申请日：1994-11-29
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , RANIERI, Richard, L. , PATEL, Pinakin
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C23F01/36
CPC分类号： C23F1/36
摘要： Improvements in the etching of aluminum and aluminum alloys is obtained by etching the workpiece in a caustic etching bath in the presence of an anionic surfactant of the sulfate or sulfonate type. Satisfactory results are achieved with reduced amounts of dissolved aluminum.
摘要翻译：通过在硫酸盐或磺酸盐型阴离子表面活性剂的存在下，在苛性碱蚀刻浴中蚀刻工件，可以获得铝和铝合金蚀刻的改进。通过减少溶解的铝量可以获得令人满意的结果。

10. 发明申请

WO1995000126A1 SURFACE-MODIFIED ALBUMIN MICROSPHERES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：表面修饰的铝白蛋白和含有它们的药物组合物
公开(公告)号：WO1995000126A1
公开(公告)日：1995-01-05
申请号：PCT/EP1994002025
申请日：1994-06-21
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , KISSEL, Thomas , MUELLER, Bernhard
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： A61K09/51
CPC分类号： A61K9/5169 , A61K9/167 , Y02A50/409
摘要： Internally cross-linked albumin microspheres their surface being modified by attachment of polyoxy(C1-4)alkylene chains having a terminal ether group, especially such containing pharmacologically active agents, usable for pharmaceutical compositions.
摘要翻译：内部交联的白蛋白微球体，其表面通过连接具有末端醚基团的聚氧化（C 1-4）亚烷基链而被修饰，特别是可用于药物组合物的含有药理学活性剂。

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