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1. 发明申请

WO1989010917A2 RENIN INHIBITORS, PROCESS FOR PRODUCING THEM AND USE THEREOF 审中-公开
标题翻译：雷宁抑制剂，生产和使用它们的方法
公开(公告)号：WO1989010917A2
公开(公告)日：1989-11-16
申请号：PCT/EP1989000509
申请日：1989-05-09
申请人： SANDOZ-PATENT-GMBH , SANDOZ AG , WEIDMANN, Beat
发明人： SANDOZ-PATENT-GMBH , SANDOZ AG
IPC分类号： C07C125/65
CPC分类号： C07D295/088 , C07C237/22 , C07C271/22 , C07C327/42 , C07C327/44 , C07C333/04 , C07D213/30 , C07D213/82 , C07F7/081 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0212 , C07K5/0227
摘要： Compound of formula (I), wherein R1, W, R2, Z, A and B have the meaning given in claim 1, process for producing it, and its use as a renin inhibitor in the treatment of hypertension and chronic cardiac insufficiency and in the treatment of diseases of retroviral origin.

2. 发明申请

WO1989006246A1 VINYL MONO- AND COPOLYMERS CONTAINING SIDE-CHAINS 审中-公开
标题翻译：包含侧链的乙烯基单体和共聚物
公开(公告)号：WO1989006246A1
公开(公告)日：1989-07-13
申请号：PCT/EP1989000007
申请日：1989-01-05
申请人： SANDOZ-PATENT-GMBH , SANDOZ AG
发明人： SANDOZ-PATENT-GMBH , SANDOZ AG , DANNER, Bernard
IPC分类号： C08F08/32
CPC分类号： C08F8/44 , C08F8/32 , Y10S526/923
摘要： Water-dilutable vinyl copolymers containing side chains contain groups (gamma) of formula -X-alk-Y-, where alk stands for alkyls with 2 to 6 carbon atoms, hydroxy-substituted alkyls with 3 to 6 carbon atoms, or alkyls with 4 to 6 carbon atoms interrupted by -O-, X stands for a basic amino group or an ammonium group, and Y stands for a basic -NH- group or an acid adduct thereof, one of X or Y also being bonded to a possibly substituted aliphatic or heteroaromatic residual hydrocarbon, the other being bonded to hydrogen or to a possibly substituted aliphatic residual hydrocarbon, in at least one part of the side chains. At least 1 mol % of the comonomer units in the copolymer carry such (gamma)-containing side chains. Said copolymers can be produced by copolymerization of suitable comonomers or by aminoalkylation of suitable starting polymers, and are useful as precipitating or flocculating agents, for example for purifying water or sewage, and in particular in the manufacture of paper.

3. 发明申请

WO1988010261A1 NOVEL THIOPHEN COMPOUNDS AND THEIR PREPARATION 审中-公开
标题翻译：新型噻吩化合物及其制备
公开(公告)号：WO1988010261A1
公开(公告)日：1988-12-29
申请号：PCT/EP1988000525
申请日：1988-06-14
申请人： SANDOZ AG , FÜNFSCHILLING, Peter
发明人： SANDOZ AG
IPC分类号： C07D333/32
CPC分类号： C07D333/36 , C07C45/673 , C07C49/203 , C07D309/22 , C07D333/32
摘要： Processes for the preparation of N-(2,4-dimethylthien-3-yl)-N-(1-methoxyprop-2-yl)-chloroacetamide and of intermediates thereof, and novel intermediates useful for the preparation of N-(2,4-dimethylthien-3-yl)-N-(1-methoxyprop-2-yl)-chloroacetamide.

4. 发明申请

WO1988002023A1 RECOMBINANT LIGNINASE 审中-公开
标题翻译：重组木质素
公开(公告)号：WO1988002023A1
公开(公告)日：1988-03-24
申请号：PCT/EP1987000507
申请日：1987-09-05
申请人： SANDOZ AG
发明人： SANDOZ AG , FARRELL, Roberta, L. , GELEP, Paul , ANILIONIS, Algis , JAVAHERIAN, Kashayar , MAIONE, Theodore, E. , RUSCHE, James, R. , SADOWNICK, Bruce, A. , JACKSON, Jennifer, A.
IPC分类号： C12N15/00
CPC分类号： C12N9/0065
摘要： A recombinant ligninase enzyme is obtained by cloning a DNA sequence of P. chrysosporium encoding a ligninase apoprotein, expressing the recombinant apoprotein in suitable host cells and reconstituting the recombinant ligninase protein with the heme.

5. 发明申请

WO1987002662A2 HETEROCYCLIC ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译：梅洛酮及其衍生物的杂环类似物，其生产方法及其作为药物的用途
公开(公告)号：WO1987002662A2
公开(公告)日：1987-05-07
申请号：PCT/EP1986000598
申请日：1986-10-21
申请人： SANDOZ AG , SANDOZ PHARMACEUTICALS CORPORATION
发明人： SANDOZ AG , SANDOZ PHARMACEUTICALS CORPORATION , WAREING, James, Richard , DAMON, Robert, Edson
IPC分类号： C07D207/337
CPC分类号： C07D207/337 , C07D307/54 , C07D333/24
摘要： Compounds of formula (I), wherein Ra is a group -X-Z, Rb is R2, Rc is R3, Rd is R4 and Y is a group (III), or Ra is R1, Rb is a group -X-Z, Rc is R2, Rd is R3 and Y is O, S or a group (IV); R1, R2, R3 and R4 independently are C1-6alkyl not containing an asymmetric carbon atom, C3-7cycloalkyl or a ring formula (V), or in the case of R3 and R4 additionally hydrogen, or for R3 when Y is O or S formula (VI), whereby R17 is hydrogen or C1-3alkyl and R18 and R19 are independently hydrogen, C1-3alkyl or phenyl; each R5 is independently hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, bromo, phenyl, phenoxy or benzyloxy; each R6 is independently hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, bromo, phenoxy or benzyloxy, and each R7 is independently hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, with the proviso that there may only be one each of trifluoromethyl, phenoxy or benzyloxy in each ring A present, X is (CH2)m or (CH2)qCH=CH-(CH2)q, m is 0, 1, 2 or 3 and both q's are 0 or one is 0 and the other is 1, formula (II), wherein R9 is hydrogen or C1-3alkyl, in free acid form, or in the form of an ester or delta-lactone thereof or in salt form as appropriate, which compounds are indicated for use as pharmaceuticals in particular as hypolipoproteinemic and anti-atherosclerotic agents.

6. 发明申请

WO1986001108A1 NEW PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：新药物组合物
公开(公告)号：WO1986001108A1
公开(公告)日：1986-02-27
申请号：PCT/CH1985000120
申请日：1985-08-06
申请人： SANDOZ AG
发明人： SANDOZ AG , AGIUS, Joseph , MORLEY, John , ROTH, Wolf-Dieter , HAHN, Karl-Heinz
IPC分类号： A61K31/52
CPC分类号： A61K31/52 , A61K31/445 , A61K2300/00
摘要： The composition contains: a) ketotiphene and b) xanthine having an anti-asthmatic activity, particularly theophylline in the form of a stable combination appropriate for the treatment, particularly for the preventive or prophylactic treatment of asthma or for reducing a respiratory tract resistance in particular during the preventive or prophilactic treatment of asthma.

7. 发明申请

WO1985002121A1 IMMUNE RESPONSE TO TUMORS AND VIRUSES INDUCED BY ANTI-IDIOTYPE ANTIBODIES 审中-公开
标题翻译：免疫应答反义抗体诱导的肿瘤和病毒
公开(公告)号：WO1985002121A1
公开(公告)日：1985-05-23
申请号：PCT/EP1984000334
申请日：1984-11-05
申请人： THE WISTAR INSTITUTE , SANDOZ AG
发明人： THE WISTAR INSTITUTE , SANDOZ AG , DeFREITAS, Elaine , HERLYN, Dorothee , KOPROWSKI, Hilary , REAGAN, Kevin , WIKTOR, Tadeusz
IPC分类号： A61K39/395
CPC分类号： C07K16/4216 , A61K38/00 , C07K16/4266
摘要： Anti-idiotype antibodies, their production and their use in inducing immunological response to tumors and viruses.

8. 发明申请

WO1985001048A1 AROMATIC ESTERS OR AMIDES OF CARBOXYLIC ACID AND SULFONIC ACID 审中-公开
标题翻译：芳香酯或羧酸和硫酸的氨基酸
公开(公告)号：WO1985001048A1
公开(公告)日：1985-03-14
申请号：PCT/CH1984000127
申请日：1984-08-14
申请人： SANDOZ AG
发明人： SANDOZ AG , RICHARDSON, Brian, P. , ENGEL, Günter , GIGER, Rudolf, K., A. , VASELLA, Andrea
IPC分类号： C07D401/12
CPC分类号： C07D221/22 , C07D209/36 , C07D221/24 , C07D401/12 , C07D405/12 , C07D451/04 , C07D451/06 , C07D451/12 , C07D451/14 , C07D453/02
摘要： Aromatic esters of amides of carboxylic acid and sulfonic acid having the formula A-B-C-D, wherein A represents groups having the formulas (I), X-Y representing -CH = CH-, -O-C-H2 or N = CH-; Z representing -CH2-, -NR3-, -O- or -S-; R1 and R2 representing hydrogen, halogen, alkyl, alkoxy, hydroxy, amino, alkylamino, dialkylamino, mercapto or alkylthio; R3 representing hydrogen, alkyl, alkenyl, aryl or aralkyl and R4, R5, R6, R7 representing hydrogen, amino, nitro, alkylamino, dialkylamino, halogen, alkoxy, alkyl, alkylanoylamino, pyrrolyl, sulfamoyl or carbamoyl; wherein B represents -CO- or -SO2-; wherein C represents -O- or -NH-; wherein D represents groups having the formulas (II), R8 representing hydrogen, alkyl, alkenyl or aralkyl and n being equal to 2, 3 or 4; acid addition salts thereof or quaternary amonium salts thereof, production process thereof and utilization thereof as analgesics, particularly as antimigraine agents and antiarhythmics.
摘要翻译：具有式A-B-C-D的羧酸和磺酸的酰胺的芳族酯，其中A表示具有式（I）的基团，表示-CH = CH-，-O-C-H 2或N = CH-的X-Y; Z表示-CH 2 - ， - NR 3 - ， - O-或-S-; R 1和R 2代表氢，卤素，烷基，烷氧基，羟基，氨基，烷基氨基，二烷基氨基，巯基或烷硫基; R3代表氢，烷基，烯基，芳基或芳烷基，R4，R5，R6，R7代表氢，氨基，硝基，烷基氨基，二烷基氨基，卤素，烷氧基，烷基，烷酰基氨基，吡咯基，氨磺酰基或氨基甲酰基; 其中B表示-CO-或-SO 2 - ; 其中C表示-O-或-NH-; 其中D表示具有式（II）的基团，R 8表示氢，烷基，烯基或芳烷基，n等于2,3或4; 其酸加成盐或其季铵盐，其制备方法和作为止痛剂的使用，特别是作为抗偏头痛药和抗心律失常药。

9. 发明申请

WO1984000547A1 FLUORALKYLATEDCARBAPENEM DERIVATIVES 审中-公开
标题翻译：氟代甲基丙烯酸衍生物
公开(公告)号：WO1984000547A1
公开(公告)日：1984-02-16
申请号：PCT/EP1983000193
申请日：1983-07-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ AG , SANDOZ-PATENT-GMBH , MAK, Ching, Pong , FLIRI, Hans
IPC分类号： C07D487/04
CPC分类号： C07D477/20 , C07D205/08 , C07D477/10 , C07D499/88 , C07F7/10
摘要： Compounds of formula (I), wherein, R1 represents hydrogen or methyl and R2 represents hydrogen or lower alkyl, lower alkenyl or cycloalkyl each of which may be unsubstituted or mono- or polysubstituted by amino, mono- or di-(lower)-alkylamino, lower acylamino, carboxy, lower alkoxycarbonyl or carbamoyl; a group of formula IIc: (CH2)p-R7, wherein R7 represents phenyl or a 5- or 6-membered saturated or unsaturated heterocycle containing one or more heteroatoms selected from 0, S and/or N and which may be unsubstituted or mono- or polysubstituted by fluoro, chloro, bromo, amino, mono- or di-(lower)-alkylamino, hydroxy, lower alkoxy, mercapto, alkylthio, phenylthio, sulfamoyl, guanidino, nitro, cyano, lower acylamino, carboxyl, alkoxycarbonyl or carbamoyl and p is 0, 1, 2 or 3; or a group of formula (II), (IIa), (IIb), wherein R4, R5 and R6 may be the same or different and each represents hydrogen or lower alkyl or R4 and R6 and/or R5 and one of the CH2 groups may be joined to form a ring as may R5 and R6 in formula II and R4 and R5 in IIa and IIb, which rings may be unsubstituted or mono- or poly-substituted by alkyl, hydroxy, carboxy or di-(lower)-alkylamino, m is 2 or 3, and n is 1, 2 or 3 with the proviso that when R1 is hydrogen and the group containing it has R-configuration, R2 is other than acetylaminoethyl; or protected forms and/or physiologically-hydrolysable and acceptable ester forms thereof; in free acid or salt form or in the form of zwitter-ions. The compounds exhibit chemotherapeutic properties and are particularly indicated for use as anti-bacterially active antibiotics.
摘要翻译：式（I）化合物，其中R 1表示氢或甲基，R 2表示氢或低级烷基，低级烯基或环烷基，其各自可以是未取代的或被氨基，单 - 或二 - （低级） - 烷基氨基，低级酰基氨基，羧基，低级烷氧基羰基或氨基甲酰基; 式IIc的基团：（CH 2）p -R 7，其中R 7表示苯基或含有一个或多个选自O，S和/或N的杂原子的5或6元饱和或不饱和杂环，并且其可以是未取代的或单羟基，低级烷氧基，巯基，烷硫基，苯硫基，氨磺酰基，胍基，硝基，氰基，低级酰氨基，羧基，烷氧基羰基或氨基甲酰基 p为0,1,2或3; 或式（II），（IIa），（IIb）的基团，其中R 4，R 5和R 6可以相同或不同，并且各自表示氢或低级烷基或R 4和R 6和/或R 5和一个CH 2基团可以结合形成环，如式II中的R 5和R 6，以及IIa和IIb中的R 4和R 5，该环可以是未被取代的或被烷基，羟基，羧基或二（低级） - 烷基氨基，m为2或3，n为1,2或3，条件是当R 1为氢且含有R基团时，R 2为乙酰氨基乙基; 或受保护的形式和/或其生理上可水解和可接受的酯形式; 以游离酸或盐的形式或以两性离子的形式存在。该化合物具有化学治疗性质，特别指出用作抗细菌活性抗生素。

10. 发明申请

WO1983004254A1 PIPERAZINE DERIVATIVE COMPOUNDS, PRODUCTION METHOD THEREOF AND DRUGS CONTAINING THEM 审中-公开
标题翻译：哌嗪衍生物，其生产方法和含有它们的药物
公开(公告)号：WO1983004254A1
公开(公告)日：1983-12-08
申请号：PCT/CH1983000067
申请日：1983-05-25
申请人： SANDOZ AG
发明人： SANDOZ AG , NEUMANN, Peter
IPC分类号： C07D471/04
CPC分类号： C07D213/74 , C07D213/75 , C07D405/12 , C07D471/04
摘要： Compounds having the formula I wherein the symbols A, B, Z, R1-R5, X, m and n have the meanings given in claim 1; the invention also encompasses a method for the preparation of said compounds. An other object of the invention relates to compounds having the formula VII wherein the symbols A, B, R1-R5, X', m and n have the meanings given in claim 2; the invention also relates to a method for their preparation. The compounds of formula I and VII are characterized by neuroleptic, hypotensive and bradycardic characteristics.
摘要翻译：具有式I的化合物，其中符号A，B，Z，R 1 -R 5，X，m和n具有权利要求1中给出的含义; 本发明还包括制备所述化合物的方法。本发明的另一个目的涉及具有式VII的化合物，其中符号A，B，R 1 -R 5，X'，m和n具有权利要求2中给出的含义; 本发明还涉及其制备方法。式I和VII的化合物的特征在于精神抑制，降血压和心动过缓的特征。

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