发明申请
WO1987002662A2 HETEROCYCLIC ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
审中-公开
基本信息:
- 专利标题: HETEROCYCLIC ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
- 专利标题(中):梅洛酮及其衍生物的杂环类似物,其生产方法及其作为药物的用途
- 申请号:PCT/EP1986000598 申请日:1986-10-21
- 公开(公告)号:WO1987002662A2 公开(公告)日:1987-05-07
- 发明人: SANDOZ AG , SANDOZ PHARMACEUTICALS CORPORATION , WAREING, James, Richard , DAMON, Robert, Edson
- 申请人: SANDOZ AG , SANDOZ PHARMACEUTICALS CORPORATION
- 专利权人: SANDOZ AG,SANDOZ PHARMACEUTICALS CORPORATION
- 当前专利权人: SANDOZ AG,SANDOZ PHARMACEUTICALS CORPORATION
- 优先权: US791,198 19851025; US816,664 19860107
- 主分类号: C07D207/337
- IPC分类号: C07D207/337
摘要:
Compounds of formula (I), wherein Ra is a group -X-Z, Rb is R2, Rc is R3, Rd is R4 and Y is a group (III), or Ra is R1, Rb is a group -X-Z, Rc is R2, Rd is R3 and Y is O, S or a group (IV); R1, R2, R3 and R4 independently are C1-6alkyl not containing an asymmetric carbon atom, C3-7cycloalkyl or a ring formula (V), or in the case of R3 and R4 additionally hydrogen, or for R3 when Y is O or S formula (VI), whereby R17 is hydrogen or C1-3alkyl and R18 and R19 are independently hydrogen, C1-3alkyl or phenyl; each R5 is independently hydrogen, C1-3alkyl, n-butyl, i-butyl, t-butyl, C1-3alkoxy, n-butoxy, i-butoxy, trifluoromethyl, fluoro, chloro, bromo, phenyl, phenoxy or benzyloxy; each R6 is independently hydrogen, C1-3alkyl, C1-3alkoxy, trifluoromethyl, fluoro, chloro, bromo, phenoxy or benzyloxy, and each R7 is independently hydrogen, C1-2alkyl, C1-2alkoxy, fluoro or chloro, with the proviso that there may only be one each of trifluoromethyl, phenoxy or benzyloxy in each ring A present, X is (CH2)m or (CH2)qCH=CH-(CH2)q, m is 0, 1, 2 or 3 and both q's are 0 or one is 0 and the other is 1, formula (II), wherein R9 is hydrogen or C1-3alkyl, in free acid form, or in the form of an ester or delta-lactone thereof or in salt form as appropriate, which compounds are indicated for use as pharmaceuticals in particular as hypolipoproteinemic and anti-atherosclerotic agents.
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D207/00 | 杂环化合物,含五元环,不与其他环稠合,带1个氮原子作为惟一的环杂原 |
--------C07D207/02 | .只有氧或碳原子直接连在环氮原子上 |
----------C07D207/04 | ..环原子间或环原子与非环原子间无双键 |
------------C07D207/32 | ...只有氢原子,烃基或取代的烃基,直接连在碳原子上 |
--------------C07D207/325 | ....有取代的烃基直接连在环氮原子上 |
----------------C07D207/337 | .....被以3个键连杂原子、其中最多以1个键连卤素的碳原子,例如酯基或腈基取代的基 |