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1. 发明申请

WO9700063A3 UROCORTIN PEPTIDES 审中-公开
标题翻译：胭脂虫肽
公开(公告)号：WO9700063A3
公开(公告)日：1997-01-23
申请号：PCT/US9610240
申请日：1996-06-12
申请人： SALK INST FOR BIOLOGICAL STUDI , VALE WYLIE W JR , VAUGHAN JOAN , DONALDSON CYNTHIA J , LEWIS KATHY A , SAWCHENKO PAUL , RIVIER JEAN E F , PERRIN MARILYN H
发明人： VALE WYLIE W JR , VAUGHAN JOAN , DONALDSON CYNTHIA J , LEWIS KATHY A , SAWCHENKO PAUL , RIVIER JEAN E F , PERRIN MARILYN H
IPC分类号： G01N33/50 , A61K38/00 , A61K38/22 , A61P3/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P15/04 , A61P25/22 , A61P25/28 , A61P29/00 , A61P37/02 , A61P43/00 , C07K14/575 , C07K16/26 , C12N15/09 , G01N33/15 , G01N33/53 , A61K
CPC分类号： C07K14/57509 , A61K38/00
摘要： Urocortin (Ucn) is a native mammalian peptide generally related to Urotensin I and Corticotropin Releasing Factor (CRF). Human Ucn has the formula: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (SEQ ID NO:15). Rat-derived Ucn is identical but for 2 substitutions, Asp2 for Asn2 and Pro4 for Ser4. Ucn or analogs thereof or pharmaceutically acceptable salts can be administered to humans and other mammals to achieve substantial elevation of ACTH, β-endorphin, β-lipotropin, other products of the pro-opiomelanocortin gene and corticosterone. They can also be used to lower blood pressure over an extended period of time, as stimulants to elevate mood and to improve memory and learning performance, as well as diagnostically. Shortened fragments may be administered to release endogenous CRF and/or Ucn in the brain and peripherally. Ucn antagonists can be used to block the action of Ucn and/or CRF, as can antibodies to Ucn. Labelled Ucn agonists and antagonists can be used in drug screening assays along with CRF receptors; they may also be used diagnostically along with Ucn antibodies.

2. 发明专利

AU2714088A POTENTIATION OF ERYTHROPOIESIS 未知
公开(公告)号：AU2714088A
公开(公告)日：1989-06-14
申请号：AU2714088
申请日：1988-11-14
申请人： UNIV CALIFORNIA , SALK INST FOR BIOLOGICAL STUDI , SCRIPPS CLINIC AND RES FOUNDATION
发明人： YU JOHN CHENC-PO , YU ALICE LIN-TSING , VAUGHAN JOAN , VALE WYLIE WALKER JR , RIVIER JEAN EDOUARD FREDERIC
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P7/00 , C07K14/435 , C07K14/575 , A61K37/43 , A61K37/24
摘要： A method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells. FRP is found to be an efficacious potentiator of, and inhibin a suppressor of, erythropoietin-induced differentiation. FRP and inhibin are shown to be functional antagonists of each other, and thus represent an effective means for modulating erythropoiesis in a number of disease states which are directly caused by or associated with an abnormal rate of erythropoiesis.

3. 发明专利

AU1016688A GRF ANALOGS V 未知
公开(公告)号：AU1016688A
公开(公告)日：1988-07-14
申请号：AU1016688
申请日：1988-01-11
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： VAUGHAN JOAN , SPIESS JOACHIM , RIVIER JEAN E F , VALE WYLIE W JR
IPC分类号： A23K1/165 , A23K1/18 , A61K38/00 , A61K38/04 , C07K14/00 , C07K14/575 , C07K14/60 , C07K14/61 , C07K7/10 , C07K1/06 , A61K37/43
摘要： The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R1-R2-R3-R4-R5-Phe-R7-R8-R9-Tyr-Arg-R12-R13-Leu-R15-Gln-LeuR18-Ala-Arg -Lys-R22-L eu-R24-R25-R26-R27-R28-R29-R30-R31-Gly-R33-R34-R35-R36-R-37R-38R-39R-4 0R-41-R42- R43-R44-Ser wherein R1 is N-Me Tyr, Tyr, desNH2-Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH2-His, D-His, N-Et His, and N-Ip His; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R4 is Gly or Ala; R5 and R27 are selected from the group consisting of Met, Leu, Val, Nva, Gln, Thr, Ile, Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, Nle, Lys, Phe, Pro, Ser, Tyr and Trp; R7 is Asn or Thr; R8 is Lys, Asn or Ser; R9 is Ala or Ser; R12 is Lys or Arg; R13 is Ala, Val or Ile; R15 is Gly or Ala; R18 is Ser or Tyr; R22 is Tyr or Leu; R24 is His or Gln; R25 is Thr, Asp, or Glu; R26 is Leu or Ile; R28 is Ala, Ser or Asn; R29 is Lys or Arg; R30 is Arg or Gln; R31 is Val or Gln; R33 is Gly or Glu; R34 is Gly, Arg or Ser; R35 is Ser or Asn; R36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R37 is Ile or Glu; R38 is Glu, Gln or Arg; R39 is Asp, Arg or Gly; R40 is Asp, Ser or Ala; R41 is Asn, Arg or Lys; R42 is Glu, Phe, Ala or Val; R43 is Pro, Asn or Arg; R44 is Leu or Ala; provided however that at least one of the following is present: R7 is Asn, R8 is Lys, R13 is Ala, R22 is Tyr and R25 is Thr; and provided further that any or all of the residues after R27 may be deleted. A 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in agriculture.

4. 发明专利

DK14488D0 未知
公开(公告)号：DK14488D0
公开(公告)日：1988-01-13
申请号：DK14488
申请日：1988-01-13
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： VAUGHAN JOAN , SPIESS JOACHIM , RIVIER JEAN EDOUARD FREDERIC , VALE JR WYLIE WALKER
IPC分类号： A23K1/165 , A23K1/18 , A61K38/00 , A61K38/04 , C07K14/00 , C07K14/575 , C07K14/60 , C07K14/61 , C07K7/10
摘要： The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R1-R2-R3-R4-R5-Phe-R7-R8-R9-Tyr-Arg-R12-R13-Leu-R15-Gln-LeuR18-Ala-Arg -Lys-R22-L eu-R24-R25-R26-R27-R28-R29-R30-R31-Gly-R33-R34-R35-R36-R-37R-38R-39R-4 0R-41-R42- R43-R44-Ser wherein R1 is N-Me Tyr, Tyr, desNH2-Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH2-His, D-His, N-Et His, and N-Ip His; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R4 is Gly or Ala; R5 and R27 are selected from the group consisting of Met, Leu, Val, Nva, Gln, Thr, Ile, Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, Nle, Lys, Phe, Pro, Ser, Tyr and Trp; R7 is Asn or Thr; R8 is Lys, Asn or Ser; R9 is Ala or Ser; R12 is Lys or Arg; R13 is Ala, Val or Ile; R15 is Gly or Ala; R18 is Ser or Tyr; R22 is Tyr or Leu; R24 is His or Gln; R25 is Thr, Asp, or Glu; R26 is Leu or Ile; R28 is Ala, Ser or Asn; R29 is Lys or Arg; R30 is Arg or Gln; R31 is Val or Gln; R33 is Gly or Glu; R34 is Gly, Arg or Ser; R35 is Ser or Asn; R36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R37 is Ile or Glu; R38 is Glu, Gln or Arg; R39 is Asp, Arg or Gly; R40 is Asp, Ser or Ala; R41 is Asn, Arg or Lys; R42 is Glu, Phe, Ala or Val; R43 is Pro, Asn or Arg; R44 is Leu or Ala; provided however that at least one of the following is present: R7 is Asn, R8 is Lys, R13 is Ala, R22 is Tyr and R25 is Thr; and provided further that any or all of the residues after R27 may be deleted. A 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in agriculture.

5. 发明专利

DE69028101T2 未知
公开(公告)号：DE69028101T2
公开(公告)日：1997-03-06
申请号：DE69028101
申请日：1990-03-20
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： VAUGHAN JOAN , FISCHER WOLFGANG , RIVIER JEAN , NAHON JEAN-LOUIS MARIE , PRESSE FRANCOISE GENEVIEVE , VALE WYLIE
IPC分类号： C12N15/09 , A61K38/00 , A61K38/04 , A61P35/00 , C07K7/06 , C07K7/08 , C07K7/64 , C07K14/00 , C07K14/575 , C12N15/12 , C12N15/16
摘要： Mammalian melanin-concentrating hormone (MCH) is isolated from rat tissue, purified and characterized. These MCH peptides are useful for treating skin disorders, for suppressing the proliferation of skin tumor cells, such as melanomas in mammals, and for modulating the secretion of ACTH. Generally, peptides are provided which have the following formula: or which are naturally occurring homologs of the peptide with said formula. The peptides which are the naturally occurring MCH homologs of mammalian species other than rat can also be obtained using the materials disclosed, as demonstrated specifically with human MCH, which is found to have the same structure as rat MCH. Also disclosed are the amino acid sequences of, and the nucleotide sequences of the cDNAs which encode, the putative precursors of rat MCH and human MCH. These precursors may also include one or more biologically active peptides N-terminally of the mature MCH's. Among these peptides, which are thought to be formed from the MCH precursors, are the peptide with the sequence H-Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2, which is cross-reactive with antibodies against alpha-MSH and CRF, and the peptide with the sequence H-Gly-XNGE-Phe-Pro-Ala-Glu-Asn-Gly-Val-Gln-Asn-Thr-Glu-Ser-Thr-Gln-Glu-OH, wherein XNGE is Pro-Ala-Val or Ser-Val-Ala, which is cross-reactive with antibodies against GRF.

6. 发明专利

DE3879685T2 未知
公开(公告)号：DE3879685T2
公开(公告)日：1993-07-01
申请号：DE3879685
申请日：1988-11-14
申请人： SALK INST FOR BIOLOGICAL STUDI , SCRIPPS CLINIC RES , UNIV CALIFORNIA
发明人： YU CHENC-PO , YU LIN-TSING , VAUGHAN JOAN , RIVIER EDOUARD , VALE WALKER
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P7/00 , C07K14/435 , C07K14/575 , A61K37/43 , A61K37/24
摘要： A method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells. FRP is found to be an efficacious potentiator of, and inhibin a suppressor of, erythropoietin-induced differentiation. FRP and inhibin are shown to be functional antagonists of each other, and thus represent an effective means for modulating erythropoiesis in a number of disease states which are directly caused by or associated with an abnormal rate of erythropoiesis.

7. 发明专利

AT87213T 未知
公开(公告)号：AT87213T
公开(公告)日：1993-04-15
申请号：AT88910384
申请日：1988-11-14
申请人： SALK INST FOR BIOLOGICAL STUDI , SCRIPPS CLINIC RES , UNIV CALIFORNIA
发明人： YU JOHN CHENC-PO , YU ALICE LIN-TSING , VAUGHAN JOAN , RIVIER JEAN EDOUARD FREDERIC , VALE WYLIE WALKER JR
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P7/00 , C07K14/435 , C07K14/575 , A61K37/43 , A61K37/24
摘要： A method for modulating the rate of erythropoiesis in human hematopoietic progenitor cells. FRP is found to be an efficacious potentiator of, and inhibin a suppressor of, erythropoietin-induced differentiation. FRP and inhibin are shown to be functional antagonists of each other, and thus represent an effective means for modulating erythropoiesis in a number of disease states which are directly caused by or associated with an abnormal rate of erythropoiesis.

8. 发明专利

NZ222951A PEPTIDES RELATED TO TELEOSTEI FISH GROWTH HORMONE RELEASING FACTOR 未知
公开(公告)号：NZ222951A
公开(公告)日：1990-09-26
申请号：NZ22295187
申请日：1987-12-16
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： VAUGHAN JOAN , SPIESS JOACHIM , RIVIER JEAN EDOUARD FREDERIC , VALE WYLIE WALKER
IPC分类号： A23K1/165 , A23K1/18 , A61K38/00 , A61K38/04 , C07K14/00 , C07K14/575 , C07K14/60 , C07K14/61 , C07K7/10 , A61K37/02 , A61K37/43
摘要： The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R1-R2-R3-R4-R5-Phe-R7-R8-R9-Tyr-Arg-R12-R13-Leu-R15-Gln-LeuR18-Ala-Arg -Lys-R22-L eu-R24-R25-R26-R27-R28-R29-R30-R31-Gly-R33-R34-R35-R36-R-37R-38R-39R-4 0R-41-R42- R43-R44-Ser wherein R1 is N-Me Tyr, Tyr, desNH2-Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH2-His, D-His, N-Et His, and N-Ip His; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R4 is Gly or Ala; R5 and R27 are selected from the group consisting of Met, Leu, Val, Nva, Gln, Thr, Ile, Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, Nle, Lys, Phe, Pro, Ser, Tyr and Trp; R7 is Asn or Thr; R8 is Lys, Asn or Ser; R9 is Ala or Ser; R12 is Lys or Arg; R13 is Ala, Val or Ile; R15 is Gly or Ala; R18 is Ser or Tyr; R22 is Tyr or Leu; R24 is His or Gln; R25 is Thr, Asp, or Glu; R26 is Leu or Ile; R28 is Ala, Ser or Asn; R29 is Lys or Arg; R30 is Arg or Gln; R31 is Val or Gln; R33 is Gly or Glu; R34 is Gly, Arg or Ser; R35 is Ser or Asn; R36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R37 is Ile or Glu; R38 is Glu, Gln or Arg; R39 is Asp, Arg or Gly; R40 is Asp, Ser or Ala; R41 is Asn, Arg or Lys; R42 is Glu, Phe, Ala or Val; R43 is Pro, Asn or Arg; R44 is Leu or Ala; provided however that at least one of the following is present: R7 is Asn, R8 is Lys, R13 is Ala, R22 is Tyr and R25 is Thr; and provided further that any or all of the residues after R27 may be deleted. A 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in agriculture.

9. 发明专利

NO875461D0 未知
公开(公告)号：NO875461D0
公开(公告)日：1987-12-29
申请号：NO875461
申请日：1987-12-29
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： VAUGHAN JOAN , SPIESS JOACHIM , RIVIER JEAN EDOUARD FREDERIC , VALE WYLIE WALKER JR
IPC分类号： A23K1/165 , A23K1/18 , A61K38/00 , A61K38/04 , C07K14/00 , C07K14/575 , C07K14/60 , C07K14/61 , C07K
摘要： The invention provides peptides which are potent in stimulating the release of pituitary GH in fish and amphibians which have a substantial portion or all of the following sequence: R1-R2-R3-R4-R5-Phe-R7-R8-R9-Tyr-Arg-R12-R13-Leu-R15-Gln-LeuR18-Ala-Arg -Lys-R22-L eu-R24-R25-R26-R27-R28-R29-R30-R31-Gly-R33-R34-R35-R36-R-37R-38R-39R-4 0R-41-R42- R43-R44-Ser wherein R1 is N-Me Tyr, Tyr, desNH2-Tyr, D-Tyr, N-Et Tyr, N-Ip Tyr, N-Me His, His, desNH2-His, D-His, N-Et His, and N-Ip His; R2 is Ala, D-Ala or D-NMA; R3 is Asp or D-Asp; R4 is Gly or Ala; R5 and R27 are selected from the group consisting of Met, Leu, Val, Nva, Gln, Thr, Ile, Ala, Arg, Asn, Asp, Cys, Glu, Gly, His, Nle, Lys, Phe, Pro, Ser, Tyr and Trp; R7 is Asn or Thr; R8 is Lys, Asn or Ser; R9 is Ala or Ser; R12 is Lys or Arg; R13 is Ala, Val or Ile; R15 is Gly or Ala; R18 is Ser or Tyr; R22 is Tyr or Leu; R24 is His or Gln; R25 is Thr, Asp, or Glu; R26 is Leu or Ile; R28 is Ala, Ser or Asn; R29 is Lys or Arg; R30 is Arg or Gln; R31 is Val or Gln; R33 is Gly or Glu; R34 is Gly, Arg or Ser; R35 is Ser or Asn; R36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R37 is Ile or Glu; R38 is Glu, Gln or Arg; R39 is Asp, Arg or Gly; R40 is Asp, Ser or Ala; R41 is Asn, Arg or Lys; R42 is Glu, Phe, Ala or Val; R43 is Pro, Asn or Arg; R44 is Leu or Ala; provided however that at least one of the following is present: R7 is Asn, R8 is Lys, R13 is Ala, R22 is Tyr and R25 is Thr; and provided further that any or all of the residues after R27 may be deleted. A 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in agriculture.

10. 发明专利

CA2223792A1 UROCORTIN PEPTIDES 未知
公开(公告)号：CA2223792A1
公开(公告)日：1997-01-03
申请号：CA2223792
申请日：1996-06-12
申请人： SALK INST FOR BIOLOGICAL STUDI
发明人： LEWIS KATHY A , DONALDSON CYNTHIA J , VAUGHAN JOAN , RIVIER JEAN E F , PERRIN MARILYN H , SAWCHENKO PAUL , VALE WYLIE W JR
IPC分类号： G01N33/50 , A61K38/00 , A61K38/22 , A61P3/00 , A61P9/02 , A61P9/10 , A61P9/12 , A61P15/04 , A61P25/22 , A61P25/28 , A61P29/00 , A61P37/02 , A61P43/00 , C07K14/575 , C07K16/26 , C12N15/09 , G01N33/15 , G01N33/53 , C12N15/16 , C07H21/00 , C12Q1/68 , G01N33/566 , G01N33/74
摘要： Urocortin (Ucn) is a native mammalian peptide generally related to Urotensin I and Corticotropin Releasing Factor (CRF). Human Ucn has the formula: Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 (SEQ ID NO:15). Rat-derived Ucn is identical but for 2 substitutions, Asp2 for Asn2 and Pro4 for Ser4. Ucn or analogs thereof or pharmaceutically acceptable salts can be administered to humans and other mammals to achieve substantial elevation of ACTH, .beta.-endorphin, .beta.-lipotropin, other products of the pro-opiomelanocortin gene and corticosterone. They can also be used to lower blood pressure over an extended period of time, as stimulants to elevate mood and to improve memory and learning performance, as well as diagnostically. Shortened fragments may be administered to release endogenous CRF and/or Ucn in the brain and peripherally. Ucn antagonists can be used to block the action of Ucn and/or CRF, as can antibodies to Ucn. Labelled Ucn agonists and antagonists can be used in drug screening assays along with CRF receptors; they may also be used diagnostically along with Ucn antibodies.

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