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1. 发明申请

US20060195947A1 Ketoreductase polypeptides and related polynucleotides 有权
公开(公告)号：US20060195947A1
公开(公告)日：2006-08-31
申请号：US10916311
申请日：2004-08-11
申请人： S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
发明人： S. Davis , Gjalt Huisman , Stephane Jenne , Anke Krebber , Lisa Newman
IPC分类号： A01H1/00 , C07H21/04 , C12P21/06 , C12N9/02 , C12N5/04
CPC分类号： C12N9/0006
摘要： The present invention is directed to variant polypeptides having enhanced ketoreductase activity and/or thermostability for use in the stereospecific reduction of ketones. In addition, the present invention is directed to polynucleotides that encode the ketoreductase polypeptides, including codon optimized versions of the polynucleotides which provide for enhanced expression in host cells. In another aspect, the present invention is directed to nucleotide constructs, vectors and host cells that are transformed with polynucleotides of the present invention.

2. 发明申请

US20050095619A1 Glucose dehydrogenase polypeptides and related polynucleotides 有权
标题翻译：葡萄糖脱氢酶多肽和相关多核苷酸
公开(公告)号：US20050095619A1
公开(公告)日：2005-05-05
申请号：US10915927
申请日：2004-08-11
申请人： S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
发明人： S. Davis , Stephane Jenne , Anke Krebber , Lisa Newman
IPC分类号： C12N9/04 , C12Q1/68 , C07H21/04 , C12N9/02
CPC分类号： C12N9/0006
摘要： The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleotide that encodes for the GDH polypeptides of the present invention, to nucleic acid sequences comprising the polynucleotides, to expression vectors comprising the polynucleotides operatively linked to a promoter, to host cells transformed to express the GDH polypeptides, and to a method for producing the GDH polypeptides of the present invention.
摘要翻译：本发明涉及相对于骨架野生型葡萄糖脱氢酶多肽具有增强的GDH活性和/或热稳定性的葡萄糖脱氢酶（GDH）多肽。此外，本发明涉及编码本发明的GDH多肽的多核苷酸，包含多核苷酸的核酸序列，包含与启动子有效连接的多核苷酸的表达载体，转化为表达GDH的宿主细胞多肽，以及本发明的GDH多肽的制备方法。

3. 发明申请

US20050272064A1 Halohydrin dehalogenases and related polynucleotides 有权
公开(公告)号：US20050272064A1
公开(公告)日：2005-12-08
申请号：US11067323
申请日：2005-02-23
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
IPC分类号： C07H21/04 , C12N1/21 , C12N9/04 , C12N9/14 , C12N9/88 , C12N15/74 , C12Q1/68
CPC分类号： C12N9/14 , C12N9/88
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

4. 发明申请

US20050153417A1 Halohydrin dehalogenases and related polynucleotides 有权
标题翻译：卤代醇脱卤素酶和相关多核苷酸
公开(公告)号：US20050153417A1
公开(公告)日：2005-07-14
申请号：US10917179
申请日：2004-08-11
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Lisa Newman
IPC分类号： C07H21/04 , C12N1/21 , C12N9/04 , C12N9/14 , C12N9/88 , C12N15/60 , C12N15/74 , C12Q1/68
CPC分类号： C12N9/88 , C12N9/14
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.
摘要翻译：本发明涉及新型卤代醇脱卤素酶多肽和编码它们的多核苷酸。这些多肽可用于制备4-取代-3-丁酸衍生物和连位氰基羟基取代的羧酸酯。本发明还提供相关载体，宿主细胞和方法。

5. 发明申请

US20070161094A1 Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives 有权
标题翻译：用于生产4-取代的3-羟基丁酸衍生物的酶法
公开(公告)号：US20070161094A1
公开(公告)日：2007-07-12
申请号：US11502745
申请日：2006-08-10
申请人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
发明人： S. Davis , John Grate , David Gray , John Gruber , Gjalt Huisman , Steven Ma , Lisa Newman , Roger Sheldon , Li A. Wang
IPC分类号： C12P13/00
CPC分类号： C12P13/002 , C12N9/14 , C12P7/62 , C12P13/02
摘要： The present invention provides methods and compositions for preparing 4-substituted 3-hydroxybutyric acid derivatives by halohydrin dehalogenase-catalyzed conversion of 4-halo-3-hydroxybutyric acid derivatives. The present invention further provides methods and compositions for preparing 4-halo-3-hydroxybutyric acid derivatives by ketoreductase-catalyzed conversion of 4-halo-3-ketobutyric acid derivatives The present invention also provides methods and compositions for preparing vicinal cyano, hydroxyl substituted carboxylic acid esters.
摘要翻译：本发明提供了通过卤代醇脱卤酶催化的4-卤代-3-羟基丁酸衍生物的转化来制备4-取代的3-羟基丁酸衍生物的方法和组合物。本发明还提供了通过酮还原酶催化转化4-卤代-3-酮丁酸衍生物来制备4-卤代-3-羟基丁酸衍生物的方法和组合物。本发明还提供了用于制备邻位氰基，羟基取代的羧酸的方法和组合物酸酯。

6. 发明申请

US20060099700A1 Halohydrin dehalogenases and related polynucleotides 有权
公开(公告)号：US20060099700A1
公开(公告)日：2006-05-11
申请号：US11266747
申请日：2005-11-02
申请人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Emily Mundorff , Lisa Newman
发明人： S. Davis , Richard Fox , Gjalt Huisman , Vesna Gavrilovic , Emily Mundorff , Lisa Newman
IPC分类号： C07H21/04 , C12P21/06 , C12N9/88
CPC分类号： C12N9/14 , C12N9/88
摘要： The present invention relates to novel halohydrin dehalogenase polypeptides and the polynucleotides that encode them. These polypeptides are useful in the production of 4-substituted-3-butyric acid derivatives and vicinal cyano, hydroxyl substituted carboxylic acid esters. The invention also provides related vectors, host cells and methods.

7. 发明申请

US20080015116A1 Integrated Systems and Methods for Diversity Generation and Screening 有权
标题翻译：用于多样性生成和筛选的综合系统和方法
公开(公告)号：US20080015116A1
公开(公告)日：2008-01-17
申请号：US11677505
申请日：2007-02-21
申请人： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
发明人： Steven Bass , S. Davis , Phillip Patten , Matthew Tobin , Jeremy Minshull , Mark Welch , Claus Gustafsson , Brian Carr , Stephane Jenne , Sun Raillard , Andreas Crameri , Willem Stemmer , Robin Emig , Pascal Longschamp , Stanley Goldman , Lorraine Giver , Joseph Affholter
IPC分类号： C40B60/04
CPC分类号： C12N15/1031 , B01J19/0046 , B01J2219/00378 , B01J2219/00585 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/00722 , B82Y30/00 , C12N15/1027 , C40B60/04 , G06F19/18 , Y02A90/22
摘要： Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
摘要翻译：提供了用于多样化生成和筛选的集成系统和方法。该系统使用普通液体和阵列处理组分来提供核酸多样化，转录，翻译，产物筛选和随后的多样化反应。

8. 发明申请

US20060205003A1 Methods, systems, and software for identifying functional biomolecules 有权
标题翻译：用于鉴定功能性生物分子的方法，系统和软件
公开(公告)号：US20060205003A1
公开(公告)日：2006-09-14
申请号：US11429628
申请日：2006-05-05
申请人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
发明人： Claes Gustafsson , Sridhar Govindarajan , Robin Emig , Richard Fox , Ajoy Roy , Jeremy Minshull , S. Davis , Anthony Cox , Phillip Patten , Linda Castle , Daniel Siehl , Rebecca Gorton , Teddy Chen
IPC分类号： C40B40/08 , C40B50/02 , C40B30/02
CPC分类号： G06F19/18 , C40B30/02 , C40B50/02 , G06F19/22 , G06F19/24
摘要： The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
摘要翻译：本发明一般涉及快速有效地搜索生物相关数据空间的方法。更具体地，本发明包括从复杂的生物分子文库或这些文库集合鉴定具有所需性质或最适合于获得这些性质的生物分子的方法。本发明还提供了对序列活性关系建模的方法。由于许多方法是计算机实现的，本发明另外提供用于执行这些方法的数字系统和软件。

9. 发明申请

US20050028457A1 Foundation system for prefabricated houses 有权
标题翻译：预制房屋基础系统
公开(公告)号：US20050028457A1
公开(公告)日：2005-02-10
申请号：US10637806
申请日：2003-08-07
申请人： S. Davis
发明人： S. Davis
IPC分类号： E02D27/01 , E04B1/343 , E02D1/00 , B60R27/00
CPC分类号： E02D27/01 , E04B1/34352 , Y10S52/03 , Y10S52/11
摘要： A prefabricated foundation is provided using a plurality of concrete panels that are cast at a factory location to a predetermined uniform form and size. These panels are of a generally rectangular shape and are positioned end to end forming a wall-like structure around the entire perimeter of a prefabricated structure. The lower surface of the panels are then supported by a plurality of precast posts that correspond in position and number to the joints between the plurality of panels. The joint between two abutting precast panels is sealed to provide a weather tight fit between the exterior and interior of the panels. The upper edge of the precast panels are locked in position keeping them from moving in either an inward or outward manner thereby providing a stable platform upon which a prefabricated structure can be placed.
摘要翻译：使用多个混凝土面板提供预制基础，该混凝土面板在出厂时被铸造成预定的均匀形状和尺寸。这些面板具有大致矩形的形状并且端对端地定位在预制结构的整个周边周围形成壁状结构。然后，面板的下表面由多个预制柱支撑，多个预制柱在位置和数量上对应于多个板之间的接合部。两个邻接的预制板之间的接合是密封的，以在面板的外部和内部之间提供耐气候的配合。预制板的上边缘被锁定在保持它们不向内或向外移动的位置，从而提供稳定的平台，在该平台上可以放置预制结构。

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