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1. 发明申请

US20070049579A1 Medicament having neovascularization promoting action 审中-公开
标题翻译：具有新血管形成促进作用的药物
公开(公告)号：US20070049579A1
公开(公告)日：2007-03-01
申请号：US11366454
申请日：2006-03-03
申请人： Ryozo Nagai , Ichiro Manabe , Takayuki Shindo , Hiroshi Iwata , Koichi Shudo , Hiroyuki Kagechika
发明人： Ryozo Nagai , Ichiro Manabe , Takayuki Shindo , Hiroshi Iwata , Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A61K31/551
CPC分类号： A61K31/551
摘要： A medicament having a neovascularization promoting action, which comprises a retinoid antagonist such as 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid as an active ingredient and is useful for prophylactic and/or therapeutic treatment of ischemic diseases and wounds.
摘要翻译：具有新血管形成促进作用的药物，其包含类视黄醇拮抗剂，例如4-（5H-7,8,9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2,3- b] [1,4]二氮杂萘-13-基）苯甲酸作为活性成分，可用于预防和/或治疗缺血性疾病和伤口。

2. 发明申请

US20090118264A1 Medicament having neovascularization promoting action 审中-公开
标题翻译：具有新血管形成促进作用的药物
公开(公告)号：US20090118264A1
公开(公告)日：2009-05-07
申请号：US12318248
申请日：2008-12-23
申请人： Ryozo Nagai , Ichiro Manabe , Takayuki Shindo , Hiroshi Iwata , Koichi Shudo , Hiroyuki Kagechika
发明人： Ryozo Nagai , Ichiro Manabe , Takayuki Shindo , Hiroshi Iwata , Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A61K31/551 , A61K31/4164 , A61K31/39 , A61K31/4439 , A61P9/10
CPC分类号： A61K31/551
摘要： Methods of use of medicaments having neovascularization promoting action, which medicaments comprise a retinoid antagonist such as 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1-,4]diazepin-13-yl)benzoic acid as an active ingredient.
摘要翻译：使用具有新血管形成促进作用的药物的方法，该药物包含类视黄醇拮抗剂如4-（5H-7,8,9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2 ，3-b] [1-，4]二氮杂-13-基）苯甲酸作为活性成分。

3. 发明申请

US20090253796A1 METHOD FOR TREATING VASCULAR DISEASE 审中-公开
标题翻译：治疗血管疾病的方法
公开(公告)号：US20090253796A1
公开(公告)日：2009-10-08
申请号：US12412678
申请日：2009-03-27
申请人： Ryozo NAGAI , Takayuki Shindo , Ichiro Manabe , Koichi Shudo , Hiroyuki Kagechika
发明人： Ryozo NAGAI , Takayuki Shindo , Ichiro Manabe , Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A61K31/196 , A61P9/10
CPC分类号： A61K31/27 , A61K31/695 , A61L31/16
摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.
摘要翻译：用于使用血管内支架的经皮腔内冠状动脉成形术之后的血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分类维生素如4- [5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或其盐或4 - [[[3,5- - 双（三甲基甲硅烷基）苯基]羰基]氨基]苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。

4. 发明申请

US20050234130A1 Medicament for therapeutic treatment of vascular disease 审中-公开
标题翻译：用于治疗血管疾病的药物
公开(公告)号：US20050234130A1
公开(公告)日：2005-10-20
申请号：US10511274
申请日：2003-04-22
申请人： Ryozo Nagai , Takayuki Shindo , Ichiro Manabe , Koichi Shudo , Hiroyuki Kagechika
发明人： Ryozo Nagai , Takayuki Shindo , Ichiro Manabe , Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A61K31/27 , A61K31/695 , A61L31/16 , A61P9/00 , A61P9/10 , A61P9/14 , A61P43/00 , A61K31/195 , A61K31/203
CPC分类号： A61K31/27 , A61K31/695 , A61L31/16
摘要： A medicament for prophylactic and/or therapeutic treatment of a vascular disease such as vascular restenosis and/or reocclusion after percutaneous transluminal coronary angioplasty using an intravascular stent, which comprises as an active ingredient a substance selected from the group consisting of retinoids and agents for controlling actions of retinoids such as 4-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or a salt thereof, or 4-[[[(3,5-bis-(trimethylsilyl)phenyl]carbonyl]amino]benzoic acid or a salt thereof, wherein said substance has substantially no antiproliferative action on vascular endothelial cells, but substantially has antiproliferative action on vascular smooth muscle cells.
摘要翻译：用于使用血管内支架的经皮腔内冠状动脉成形术之后的血管疾病如血管再狭窄和/或再闭塞的预防和/或治疗性治疗药物，其包含选自维甲酸类和控制剂的活性成分类维生素如4- [5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或其盐或4 - [[[（3,3- （三甲基甲硅烷基）苯基]羰基]氨基]苯甲酸或其盐，其中所述物质对血管内皮细胞基本上没有抗增殖作用，但对血管平滑肌细胞基本具有抗增殖作用。

5. 发明授权

US08431613B2 Memory fixation accelerator 有权
标题翻译：记忆固定加速器
公开(公告)号：US08431613B2
公开(公告)日：2013-04-30
申请号：US13459959
申请日：2012-04-30
申请人： Koichi Shudo , Hiroyuki Kagechika
发明人： Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A01N37/00 , A01N55/00 , A61K31/185 , A61K31/695
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

6. 发明授权

US08105833B2 Method for forming organ 失效
标题翻译：器官形成方法
公开(公告)号：US08105833B2
公开(公告)日：2012-01-31
申请号：US12535576
申请日：2009-08-04
申请人： Makoto Asashima , Tatsuo Hamazaki , Hiroyuki Kagechika , Koichi Shudo
发明人： Makoto Asashima , Tatsuo Hamazaki , Hiroyuki Kagechika , Koichi Shudo
IPC分类号： C12N5/00 , C12N5/07 , C12N5/071
CPC分类号： C12N5/0062 , C12N2501/385 , C12N2501/999 , C12N2506/00
摘要： A method for forming an organ and/or tissue from undifferentiated cells derived from a vertebrate animal in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid X receptor ligand (e.g., a retinoic acid X receptor agonist or antagonist), and a method for forming a pancreas from undifferentiated cells derived from a vertebrate animal in vitro or a method for forming a tissue having morphology and function of a pancreas from undifferentiated cells derived from a vertebrate in vitro, which comprises the step of culturing the undifferentiated cells derived from a vertebrate animal in the presence of a retinoic acid receptor ligand, together with activin, that does not substantially bind to the retinoic acid receptor subtype γ.
摘要翻译：一种用于从体外衍生自脊椎动物的未分化细胞形成器官和/或组织的方法，其包括在视黄酸X受体配体（例如视黄酸）存在下培养源自脊椎动物的未分化细胞的步骤酸X受体激动剂或拮抗剂）以及从体外衍生自脊椎动物的未分化细胞形成胰腺的方法或用于从体外衍生自脊椎动物的未分化细胞形成具有胰腺形态和功能的组织的方法，其中包括在视黄酸受体配体存在下培养源自脊椎动物的未分化细胞与活化素一起基本上不结合视黄酸受体亚型γ的步骤。

7. 发明申请

US20080021108A1 Memory Fixation Accelerator 有权
标题翻译：内存固定加速器
公开(公告)号：US20080021108A1
公开(公告)日：2008-01-24
申请号：US10598709
申请日：2005-03-09
申请人： Koichi Shudo , Hiroyuki Kagechika
发明人： Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A61K31/192 , A61K31/07 , A61P25/16 , A61P25/28
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthaleny)carbamoyl]benzoic acid or 4- [(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

8. 发明授权

US08198329B2 Memory consolidation promoting agent and method of use 有权
标题翻译：记忆合并促进剂和使用方法
公开(公告)号：US08198329B2
公开(公告)日：2012-06-12
申请号：US10598709
申请日：2005-03-09
申请人： Koichi Shudo , Hiroyuki Kagechika
发明人： Koichi Shudo , Hiroyuki Kagechika
IPC分类号： A01N37/10 , A01N31/04 , A61K31/19 , A61K31/07
CPC分类号： A61K31/192 , A61K31/695
摘要： A medicament for promoting memory consolidation, which comprises, as an active ingredient, a non-natural retinoid, preferably a retinoid having a basic skeleton comprising an aromatic ring bound with an aromatic carboxylic acid or tropolone by means of a bridging group, more preferably 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid or 4-[(3,5-bis-trimethylsilylphenyl)-carboxamido]benzoic acid.
摘要翻译：一种用于促进记忆巩固的药物，其包含作为活性成分的非天然类视黄醇，优选具有基本骨架的类视黄醇，所述基本骨架包含通过桥连基团与芳族羧酸或托洛替林结合的芳环，更优选4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸或4 - [（3,5-双三甲基甲硅烷基苯基） - 甲酰胺基]苯甲酸。

9. 发明申请

US20080255069A1 Medicament for Preventive and/or Therapeutic Treatment of Bowel Disease 审中-公开
标题翻译：肠道疾病预防和/或治疗药物
公开(公告)号：US20080255069A1
公开(公告)日：2008-10-16
申请号：US12065099
申请日：2006-09-07
申请人： Koichi Shudo , Hiroyuki Kagechika , Hiroshi Fukasawa , Tetsuro Matsuishi , Naoko Katsumura , Miwako Ishido
发明人： Koichi Shudo , Hiroyuki Kagechika , Hiroshi Fukasawa , Tetsuro Matsuishi , Naoko Katsumura , Miwako Ishido
IPC分类号： A61K31/695 , A61K31/27
CPC分类号： A61K31/192
摘要： A medicament for preventive and/or therapeutic treatment of a bowel diseases such as inflammatory bowel diseases including Crohn's disease, which comprises as an active ingredient a retinoid such as, for example, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid.
摘要翻译：一种用于预防和/或治疗诸如包括克罗恩病在内的肠疾病的肠疾病的药物，其包含类视黄醇作为活性成分，例如4 - [（5,6,7,8-四氢 - 5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸。

10. 发明授权

US08168677B2 Method for treatment of inflammatory bowel disease 失效
标题翻译：炎症性肠病的治疗方法
公开(公告)号：US08168677B2
公开(公告)日：2012-05-01
申请号：US12559268
申请日：2009-09-14
申请人： Koichi Shudo , Hiroyuki Kagechika , Hiroshi Fukasawa , Tetsuro Matsuishi , Naoko Katsumura , Miwako Ishido
发明人： Koichi Shudo , Hiroyuki Kagechika , Hiroshi Fukasawa , Tetsuro Matsuishi , Naoko Katsumura , Miwako Ishido
IPC分类号： A61K31/192 , A61K31/554 , A61K31/5513 , A61K31/695
CPC分类号： A61K31/192
摘要： Method for therapeutic treatment of inflammatory bowel disease, including Crohn's disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a retinoid as an active ingredient to treat the inflammatory bowel disease, the retinoid being selected from the group consisting of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl) carbamoyl]benzoic acid, 4-[(3,5-bis-trimethylsilylphenyl)carboxamido]benzoic acid, 4-[2,3-(2,5-dimethyl-2,5-hexano)dibenzo[b,f][1,4]thiazepin-11-yl]benzoic acid, and 4-(5H-7,8,9,10-tetrahydro-5,7,7,10,10-pentamethylbenzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid.
摘要翻译：包括克罗恩病在内的治疗性治疗炎症性肠病的方法，包括向有需要的患者施用治疗有效量的包含类视黄醇作为活性成分以治疗炎性肠病的组合物，所述类视色素选自的4 - [（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）氨基甲酰基]苯甲酸，4 - [（3,5-双三甲基甲硅烷基苯基）甲酰氨基]苯甲酸，4- [2,3-（2,5-二甲基-2,5-己烷）二苯并[b，f] [1,4]硫杂吖庚因-11-基]苯甲酸和4-（5H- ，9,10-四氢-5,7,7,10,10-五甲基苯并[e]萘并[2,3-b] [1,4]二氮杂-13-基）苯甲酸。

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