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1. 发明授权

US5424325A Aminoketone derivatives 失效
标题翻译：氨基酮衍生物
公开(公告)号：US5424325A
公开(公告)日：1995-06-13
申请号：US171695
申请日：1993-12-22
申请人： Ryoichi Ando , Naoko Ando , Hirokazu Masuda , Toshiro Sasaki , Yasuhiro Morinaka , Chizuko Takahashi , Yoshikuni Tamao , Akihiro Tobe
发明人： Ryoichi Ando , Naoko Ando , Hirokazu Masuda , Toshiro Sasaki , Yasuhiro Morinaka , Chizuko Takahashi , Yoshikuni Tamao , Akihiro Tobe
IPC分类号： C07D213/32 , C07D213/38 , C07D263/20 , C07D277/26 , C07D307/38 , C07D307/42 , C07D307/46 , C07D307/85 , C07D333/16 , C07D333/18 , C07D333/22 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12 , A61K31/34 , A61K31/425 , C07D213/30
CPC分类号： C07D263/20 , C07D213/32 , C07D213/38 , C07D277/26 , C07D307/38 , C07D307/42 , C07D307/46 , C07D307/85 , C07D333/16 , C07D333/18 , C07D333/22 , C07D405/12 , C07D407/12 , C07D409/12 , C07D417/12
摘要： Aminoketone derivatives according to the present invention strongly inhibit thiol protease such as calpain, papain, cathepsin B, cathepsin H, cathepsin L or the like and have excellent properties concerning absorbance on oral administration, tissue distribution and cell membrane permeability. The aminoketone derivatives cart thus be used as therapeutic agents for treating muscular dystrophy, cataract, cardiac infarction, stroke, Alzheimer's disease, amyotrophy, osteoporosis and hypercalcemia and so on. It may also be used as therapeutic agents for preventing metastasis of cancer. In addition, the present derivatives are also applicable as intermediates for the preparation of ketone derivatives, which have inhibitory activity against thiol protease.
摘要翻译：根据本发明的氨基酮衍生物强烈地抑制硫蛋白酶如钙蛋白酶，木瓜蛋白酶，组织蛋白酶B，组织蛋白酶H，组织蛋白酶L等，并且对于口服给药，组织分布和细胞膜通透性的吸光度具有优异的性质。因此，氨基酮衍生物载体可用作治疗肌营养不良症，白内障，心肌梗塞，中风，阿尔茨海默病，肌萎缩，骨质疏松症和高钙血症等的治疗剂。它也可以用作预防癌转移的治疗剂。此外，本发明的衍生物也可用作制备对硫醇蛋白酶具有抑制活性的酮衍生物的中间体。

2. 发明申请

US20110267902A1 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US20110267902A1
公开(公告)日：2011-11-03
申请号：US13064915
申请日：2011-04-26
申请人： Toshiro Sasaki
发明人： Toshiro Sasaki
IPC分类号： G11C7/00 , G06F1/08
CPC分类号： G06F1/26 , G11C5/145 , G11C16/30 , H01L24/06 , H01L2224/05554
摘要： A semiconductor device includes a drive circuit that outputs a drive signal to drive an external device; a voltage output circuit that outputs a first voltage and a second voltage that is larger than the first voltage; a selector that, when supplying a power supply voltage to the drive circuit, selects the first voltage and, when supplying a power supply voltage to an internal device, selects the second voltage; and a step-up circuit that, when the first voltage selected by the selector is input, boosts the first voltage to a third voltage and outputs the third voltage as the power supply voltage to the drive circuit and, when the second voltage selected by the selector is inputted, boosts the second voltage to a fourth voltage and outputs the fourth voltage as the power supply voltage to the internal device.
摘要翻译：半导体器件包括：驱动电路，其输出用于驱动外部器件的驱动信号; 电压输出电路，其输出大于所述第一电压的第一电压和第二电压; 选择器，当向所述驱动电路供给电源电压时，选择所述第一电压，并且当向所述内部装置供应电源电压时，选择所述第二电压; 以及升压电路，当输入由选择器选择的第一电压时，将第一电压升压到第三电压，并将作为电源电压的第三电压输出到驱动电路，并且当由第二电压选择选择器被输入，将第二电压升压到第四电压，并将第四电压作为电源电压输出到内部装置。

3. 发明申请

US20080076917A1 Intermediates of 2-Substituted Carbapenem Derivatives and Process for Production Thereof 失效
标题翻译： 2-取代的碳青霉烯衍生物的中间体及其制备方法
公开(公告)号：US20080076917A1
公开(公告)日：2008-03-27
申请号：US10538466
申请日：2003-12-15
申请人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
发明人： Toshiro Sasaki , Takashi Ando , Yasuo Yamamoto , Takahiro Imai , Dai Kubota , Katsuhiko Noguchi , Nobuyuki Hori , Eiki Shitara , Kunio Atsumi , Shohei Yasuda
IPC分类号： C07D205/00 , C07D487/00
CPC分类号： C07D513/04 , C07F9/6561 , Y02P20/55
摘要： The present invention relates to compounds represented by formula (1) and a process for producing the same. The use of these compounds can realize the production of carbapenem derivatives having potent antimicrobial activity and a wide antimicrobial spectrum in a safe and cost-effective manner.
摘要翻译：本发明涉及由式（1）表示的化合物及其制备方法。这些化合物的使用可以以安全和成本有效的方式实现具有有效抗微生物活性和广谱抗菌谱的碳青霉烯衍生物的生产。

4. 发明申请

US20070004700A1 2-Thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-噻吩基取代的碳青霉烯衍生物
公开(公告)号：US20070004700A1
公开(公告)日：2007-01-04
申请号：US11401892
申请日：2006-04-12
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Takehiko Sawabe , Nobuyoshi Baba , Hiromi Takata , Hisashi Suzuki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Takehiko Sawabe , Nobuyoshi Baba , Hiromi Takata , Hisashi Suzuki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： A61K31/407 , C07D487/04
CPC分类号： C07D487/04
摘要： [Objective] An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including bata-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis. [Structure] The present invention provides 2-ethenylthio-based carbapenem derivatives represented by the formula (I) or pharmaceutically acceptable salts thereof that are effective, for example, against pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including beta-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis:
摘要翻译： [目的]本发明的目的是提供对于引起目前临床问题的各种抗性细菌有效的化合物，例如包括耐青霉素的肺炎链球菌（PRSP），流感嗜血杆菌，包括不产生氨苄青霉素的bata-内酰胺酶的肺炎球菌流感嗜血杆菌（BLNAR）和莫拉氏菌（布拉汉氏菌）卡他氏菌。 [结构]本发明提供了式（I）表示的2-乙烯基硫代碳青霉烯衍生物或其药学上可接受的盐，其可有效地例如针对包括耐青霉素的肺炎链球菌（PRSP）在内的肺炎球菌，包括β-内酰胺酶的流感嗜血杆菌 - 非生产氨苄青霉素耐药性流感嗜血杆菌（BLNAR）和莫拉氏菌（Branhamella）卡他性：

5. 发明授权

US06708878B2 Service providing method 失效
标题翻译：服务提供方式
公开(公告)号：US06708878B2
公开(公告)日：2004-03-23
申请号：US09987846
申请日：2001-11-16
申请人： Toshihiro Eguchi , Michio Sato , Manabu Miyatake , Hirofumi Nagano , Toshiro Sasaki
发明人： Toshihiro Eguchi , Michio Sato , Manabu Miyatake , Hirofumi Nagano , Toshiro Sasaki
IPC分类号： G06K500
CPC分类号： G07F7/0866 , G06Q20/363 , G07B15/00 , G07B15/02
摘要： When a user accesses an IC card system, the user intentionally registers processing or actions necessary for an IC card to an IC card management system, or the system determines a predetermined state to register the processing to the IC card management system. The IC card management system beforehand delivers the actions to an IC card terminal. Thereafter, when the user inserts the IC card of which the necessary actions have been registered to the IC card management system to the IC card terminal, the IC card terminal executes the actions corresponding to the IC card.
摘要翻译：当用户访问IC卡系统时，用户有意地向IC卡管理系统注册IC卡所需的处理或动作，或者系统确定向IC卡管理系统注册处理的预定状态。 IC卡管理系统预先向IC卡终端传送动作。此后，当用户将IC卡管理系统已经登记了必要动作的IC卡插入IC卡终端时，IC卡终端执行与IC卡对应的动作。

6. 发明授权

US5599815A Antipsychotic benzoisothiazolyl piperazine derivatives 失效
标题翻译：抗精神病药苯并异噻唑基哌嗪衍生物
公开(公告)号：US5599815A
公开(公告)日：1997-02-04
申请号：US318857
申请日：1994-12-20
申请人： Yoshimasa Fukuda , Toshiro Sasaki , Yuuko Nakatani , Yasuyuki Ichimaru , Taiichiro Imanishi
发明人： Yoshimasa Fukuda , Toshiro Sasaki , Yuuko Nakatani , Yasuyuki Ichimaru , Taiichiro Imanishi
IPC分类号： C07D417/12 , C07D417/14 , A61K31/495 , A61K31/50 , A61K31/55
CPC分类号： C07D417/12
摘要： Compounds represented by the formula (I) and pharmacologically acceptable salts thereof: ##STR1## These compounds have little extrapyramidal effect and thus are effective as an anti-psychotic agent having few side effects.
摘要翻译： PCT No.PCT / JP94 / 00159 Sec。 371日期1994年12月20日第 102（e）1994年12月20日日期PCT 1994年2月3日PCT PCT。公开号WO94 / 18197 （I）化合物及其药理学上可接受的盐：（I）这些化合物具有很小的锥体束外效应，因此作为具有很少副作用的抗精神病药是有效的。

7. 发明授权

US4680718A Method and apparatus of determining an attitude of a satellite 失效
标题翻译：确定卫星姿态的方法和装置
公开(公告)号：US4680718A
公开(公告)日：1987-07-14
申请号：US669428
申请日：1984-11-08
申请人： Toshiro Sasaki , Michitaka Kosaka , Satoshi Mohri , Katsumi Kawano , Shoji Miyamoto
发明人： Toshiro Sasaki , Michitaka Kosaka , Satoshi Mohri , Katsumi Kawano , Shoji Miyamoto
IPC分类号： G01C21/24 , B64G1/36 , G01S3/78 , G01S3/782 , G01S3/785 , G01S3/786 , G01S5/16 , G01V8/10 , G06F7/56
CPC分类号： G01S5/163 , G01S3/782 , G01S3/7867
摘要： There is an attitude control method and system for a satellite. This system comprises a star catalogue of the universe, a star sensor and means for calculating features on the surface of the star sensor from a signal detected by the star sensor. The calculated features are compared with a table of which the star catalogue was reconstituted so as to easily search the features, thereby determining the attitude of the satellite.
摘要翻译：卫星有一种姿态控制方法和系统。该系统包括宇宙的星形目录，星形传感器和用于通过星形传感器检测到的信号来计算星形传感器表面上的特征的装置。将计算出的特征与重新组合星形目录的表进行比较，以便容易地搜索特征，从而确定卫星的姿态。

8. 发明授权

US08773938B2 Semiconductor device 有权
标题翻译：半导体器件
公开(公告)号：US08773938B2
公开(公告)日：2014-07-08
申请号：US13064915
申请日：2011-04-26
申请人： Toshiro Sasaki
发明人： Toshiro Sasaki
IPC分类号： G11C5/14
CPC分类号： G06F1/26 , G11C5/145 , G11C16/30 , H01L24/06 , H01L2224/05554
摘要： A semiconductor device includes a drive circuit that outputs a drive signal to drive an external device; a voltage output circuit that outputs a first voltage and a second voltage that is larger than the first voltage; a selector that, when supplying a power supply voltage to the drive circuit, selects the first voltage and, when supplying a power supply voltage to an internal device, selects the second voltage; and a step-up circuit that, when the first voltage selected by the selector is input, boosts the first voltage to a third voltage and outputs the third voltage as the power supply voltage to the drive circuit and, when the second voltage selected by the selector is inputted, boosts the second voltage to a fourth voltage and outputs the fourth voltage as the power supply voltage to the internal device.
摘要翻译：半导体器件包括：驱动电路，其输出用于驱动外部器件的驱动信号; 电压输出电路，其输出大于所述第一电压的第一电压和第二电压; 选择器，当向所述驱动电路供给电源电压时，选择所述第一电压，并且当向所述内部装置供应电源电压时，选择所述第二电压; 以及升压电路，当输入由选择器选择的第一电压时，将第一电压升压到第三电压，并将作为电源电压的第三电压输出到驱动电路，并且当由第二电压选择选择器被输入，将第二电压升压到第四电压，并将第四电压作为电源电压输出到内部装置。

9. 发明授权

US08344154B2 2-thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-硫代乙烯基取代的碳青霉烯衍生物
公开(公告)号：US08344154B2
公开(公告)日：2013-01-01
申请号：US12656606
申请日：2010-02-04
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： C07D277/24 , C07D277/26
CPC分类号： C07D487/04
摘要： 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including β-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.
摘要翻译：提供式（I）的2-乙烯基硫代碳代青霉烯衍生物或其药学上可接受的盐。根据本发明的化合物具有有效的抗微生物活性和抗肺炎球菌的广谱抗菌谱，包括耐青霉素肺炎链球菌（PRSP），流感嗜血杆菌，包括β-内酰胺酶阴性，氨苄青霉素抗性流感嗜血杆菌（BLNAR）和莫拉氏菌）卡他氏菌

10. 发明申请

US20100145063A1 2- thioethenyl substituted carbapenem derivatives 失效
标题翻译： 2-硫代乙烯基取代的碳青霉烯衍生物
公开(公告)号：US20100145063A1
公开(公告)日：2010-06-10
申请号：US12656606
申请日：2010-02-04
申请人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
发明人： Takahisa Maruyama , Yuko Kano , Takashi Ando , Toshiro Sasaki , Kazuhiro Aihara , Toshiki Fujita
IPC分类号： C07D277/34 , C07D417/02
CPC分类号： C07D487/04
摘要： 2-Ethenylthio-type carbapenem derivatives of formula (I) or pharmaceutically acceptable salts thereof are provided. The compounds according to the present invention have potent antimicrobial activity and a wide antimicrobial spectrum against pneumococci including penicillin resistant Streptococcus pneumoniae (PRSP), Haemophilus influenzae including β-lactamase-negative, ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.
摘要翻译：提供式（I）的2-乙烯基硫代碳代青霉烯衍生物或其药学上可接受的盐。根据本发明的化合物具有有效的抗微生物活性和抗肺炎球菌的广谱抗菌谱，包括耐青霉素肺炎链球菌（PRSP），流感嗜血杆菌，包括β-内酰胺酶阴性，氨苄青霉素抗性流感嗜血杆菌（BLNAR）和莫拉氏菌）卡他氏菌

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