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    • 6. 发明授权
    • Solid dispersions or solid dispersion pharmaceutical preparations of phenylalanine derivatives
    • 固体分散体或固体分散体苯丙氨酸衍生物的药物制剂
    • US08518441B2
    • 2013-08-27
    • US11433589
    • 2006-05-15
    • Hiroyuki HiguchiHirokazu HagioKenichi OgawaAkira Yabuki
    • Hiroyuki HiguchiHirokazu HagioKenichi OgawaAkira Yabuki
    • A61K9/22A61K31/517A61K9/20
    • A61K9/14A61K31/517
    • The present invention provides solid dispersions or solid dispersion pharmaceutical preparations containing a water-soluble polymeric substance(s) and a phenylalanine compound of the formula (1) or pharmaceutically acceptable salts thereof, wherein A represents the formula (2) and the like, B represent an alkoxy group and the like, E represents a hydrogen atom and the like, D represents a substituted phenyl group and the like, T, U and V represent a carbonyl group and the like, Arm represents a benzene ring and the like, R1 represents an alkyl group and the like, R2, R3, and R4 may be the same or different from one another and each represent a hydrogen atom, a substituted amino group and the like, and J and J′ represent a hydrogen atom and the like; production methods thereof; and solubilized pharmaceutical preparations containing a solubilizer(s) and the compound (I) or pharmaceutically acceptable salts thereof. According to the solid dispersion pharmaceutical preparations or solubilized pharmaceutical preparations, though they contain the phenylalanine compound of the formula (1) that is a poorly-soluble drug as an active ingredient, the pharmaceutical preparations having high solubility and oral absorbability can be obtained.
    • 本发明提供了含有水溶性聚合物和式(1)的苯丙氨酸化合物或其药学上可接受的盐的固体分散体或固体分散体药物制剂,其中A表示式(2)等,B 表示烷氧基等,E表示氢原子等,D表示取代苯基等,T,U和V表示羰基等,Arm表示苯环等,R 1 表示烷基等,R 2,R 3和R 4可以相同或不同,表示氢原子,取代氨基等,J和J'表示氢原子等 ; 生产方法; 和含有增溶剂和化合物(I)的溶解药物制剂或其药学上可接受的盐。 根据固体分散药物制剂或溶解性药物制剂,虽然它们含有作为有效成分的难溶性药物的式(1)的苯丙氨酸化合物,但是可以获得具有高溶解度和口服吸收性的药物制剂。
    • 8. 发明申请
    • Method and apparatus for creating simplified false-path description on false path, and computer product
    • 用于在虚假路径上创建简化假路径描述的方法和装置,以及计算机产品
    • US20070220457A1
    • 2007-09-20
    • US11521148
    • 2006-09-14
    • Hiroyuki Higuchi
    • Hiroyuki Higuchi
    • G06F17/50
    • G06F17/5031G01R31/31725G01R31/318357G06F2217/84
    • An apparatus for creating a simplified false-path description on a false path among paths in a target circuit extracts, from descriptions on the paths, a target path description on a target path. The apparatus judges whether the target path is a false path based on the target path description. The apparatus identifies, when it is judged that the target path is a false path, a sufficient set of elements from elements included in the target path. The settings for causing every element in the sufficient set to transmit a signal conflict. The apparatus creates the simplified false-path description on the false path by deleting, from the target path description, a description on elements that are not included in the sufficient set.
    • 用于在目标电路中的路径中的伪路径上创建简化的假路径描述的装置从路径的描述中提取目标路径上的目标路径描述。 该装置基于目标路径描述来判断目标路径是否为假路径。 当判断目标路径是假路径时,该装置识别包括在目标路径中的元素的足够的一组元素。 用于使足够的集合中的每个元素发送信号冲突的设置。 该装置通过从目标路径描述中删除不包括在足够集合中的元素的描述来在虚假路径上创建简化的假路径描述。