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1. 发明授权

US08536361B2 1,4,6,10-tetra-double bond pentadec-carbon phosphonate, preparation method thereof, and preparation method of lycopene using the same 有权
标题翻译： 1,4,6,10-四 - 双键十五碳酸膦酸酯，其制备方法以及使用其的番茄红素的制备方法
公开(公告)号：US08536361B2
公开(公告)日：2013-09-17
申请号：US13576659
申请日：2011-01-30
申请人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
发明人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
IPC分类号： C07F9/142
CPC分类号： C07F9/4015 , C07C1/34 , C07C11/21
摘要： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
摘要翻译：提供式（4）的1,4,6,10-四 - 双十五碳 - 碳膦酸酯及其制备方法。制备方法包括：使式（2）的假紫罗酮与锍盐反应以制备式（9）的环氧化物，然后使式（9）的环氧化物与溴化镁反应以制备式（C） 3）; 将式（3）的C-14醛缩合成四烷基亚甲基二膦酸盐，得到式（4）的1,4,6,10-四 - 双十五碳酸膦酸酯。此外，还提供了通式（4）的1,4,6,10-四 - 双十五碳碳酸膦酸酯的番茄红素的制备方法。本发明方法路线短，原料易得，成本低。

2. 发明申请

US20120310002A1 1,4,6,10-Tetra-Double Bond Pentadec-Carbon Phosphonate, Preparation Method Thereof, And Preparation Method Of Lycopene Using The Same 有权
标题翻译： 1,4,6,10-四 - 双键十五碳膦酸酯及其制备方法及其使用番茄红素的制备方法
公开(公告)号：US20120310002A1
公开(公告)日：2012-12-06
申请号：US13576659
申请日：2011-01-30
申请人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
发明人： Runpu Shen , Weidong Ye , Shiqing Pi , Xuejun Lao , Luo Liu , Xiaohua Song , Chunlei Wu , Zhigang Wu
IPC分类号： C07C1/34 , C07F9/40
CPC分类号： C07F9/4015 , C07C1/34 , C07C11/21
摘要： 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4), and preparation method thereof are provided. The preparation method comprises: reacting a pseudo ionone of formula (2) with sulfonium salt to prepare a epoxide of formula (9), and then reacting the epoxide of formula (9) with magnesium bromide to prepare a C-14 aldehyde of formula (3); condensing the C-14 aldehyde of formula (3) with tetra-alkyl methylene diphosphonate to obtain 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4). Furthermore, the preparation method of lycopene via 1,4,6,10-tetra-double bond pentadec-carbon phosphonate of formula (4) is also provided. The present method has the advantages of short route, easily obtained raw materials, and low cost.
摘要翻译：提供式（4）的1,4,6,10-四 - 双十五碳 - 碳膦酸酯及其制备方法。制备方法包括：使式（2）的假紫罗酮与锍盐反应以制备式（9）的环氧化物，然后使式（9）的环氧化物与溴化镁反应以制备式（C） 3）; 将式（3）的C-14醛缩合成四烷基亚甲基二膦酸盐，得到式（4）的1,4,6,10-四 - 双十五碳酸膦酸酯。此外，还提供了通式（4）的1,4,6,10-四 - 双十五碳碳酸膦酸酯的番茄红素的制备方法。本发明方法路线短，原料易得，成本低。

3. 发明授权

US08765988B2 Lycopene intermediate 1, 3, 6, 10-tetra-double bond pentadec-carbon phosphonate as well as preparation method and use thereof 有权
标题翻译：番茄红素中间体1,3,6,10-四 - 双十五碳酸膦酸酯及其制备方法和用途
公开(公告)号：US08765988B2
公开(公告)日：2014-07-01
申请号：US13583635
申请日：2011-03-09
申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
发明人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
IPC分类号： C07F9/40
CPC分类号： C07F9/4015
摘要： The invention relates to a novel important lycopene intermediate 3,7,11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2,4,6,10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde from pseudoionone; preparing 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde from the 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde; and subjecting the 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
摘要翻译：本发明涉及新型重要的番茄红素中间体3,7,11-三甲基-1,3,6,10-四烯十二烷基二乙基膦酸酯。目前的番茄红素中间体2,4,6,10-四 - 双十五碳酸膦难以合成。本发明提供了一种新的中间体，其具有以下合成步骤：由假雄酮制备2,6,10-三甲基-3,5,9-十一烷三烯-1-醛; 由2,6,10-三甲基-3,5,9-十一烷三烯-1-醛制备2,6,10-三甲基-2,5,9-十一烷三烯-1-醛; 并使2,6,10-三甲基-2,5,9-十一烷三烯-1-醛和四亚乙基二膦酸四乙酯进行缩合反应，得到目标产物。本发明只能通过四个反应从原料假雄酮生成新的中间体，因此反应易于控制，实现了巨大的工业价值。

4. 发明申请

US20120330048A1 Lycopene Intermediate 1, 3, 6, 10-Tetra-Double Bond Pentadec-Carbon Phosphonate as well as Preparation Method and Use Thereof 有权
标题翻译：番茄红素中间体1,3,6,10-四 - 双键十五碳膦酸酯及其制备方法和用途
公开(公告)号：US20120330048A1
公开(公告)日：2012-12-27
申请号：US13583635
申请日：2011-03-09
申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
发明人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Yibin Wu , Liujiang Hu
IPC分类号： C07F9/40
CPC分类号： C07F9/4015
摘要： The invention relates to a novel important lycopene intermediate 3,7, 11-trimethyl-1,3,6,10-tetraene-dodecyl diethyl phosphonate. A current lycopene intermediate 2,4,6,10-tetra-double bond pentadec-carbon phosphonate is difficult to synthesize. The invention provides a novel intermediate, which has the following synthesis steps of: preparing 2,6,10-trimethyl-3,5,9-undecane triene-1-aldehyde from pseudoionone; preparing 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde from the 2,6,10-trimethyl-3, 5,9-undecane triene-1-aldehyde; and subjecting the 2,6,10-trimethyl-2,5,9-undecane triene-1-aldehyde and tetraethyl methylenediphosphonate to condensation reaction to obtain target product. The invention can generate novel intermediate from raw material pseudoionone only by four reactions, thus the reactions are easy to control and great industrial value are achieved.
摘要翻译：本发明涉及一种新型重要的番茄红素中间体3,7,11-三甲基-1,3,6,10-四烯十二烷基二乙基膦酸酯。目前的番茄红素中间体2,4,6,10-四 - 双十五碳酸膦难以合成。本发明提供了一种新的中间体，其具有以下合成步骤：由假雄酮制备2,6,10-三甲基-3,5,9-十一烷三烯-1-醛; 由2,6,10-三甲基-3,9,9-十一烷三烯-1-醛制备2,6,10-三甲基-2,5,9-十一烷三烯-1-醛; 并使2,6,10-三甲基-2,5,9-十一烷三烯-1-醛和四亚乙基二膦酸四乙酯进行缩合反应，得到目标产物。本发明只能通过四个反应从原料假雄酮生成新的中间体，因此反应易于控制，实现了巨大的工业价值。

5. 发明授权

US08697919B2 1-methoxyl-2, 6, 10-trimethyl-1, 3, 5, 9-undec-tetraene, and preparation method and uses thereof 有权
标题翻译： 1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯及其制备方法和用途
公开(公告)号：US08697919B2
公开(公告)日：2014-04-15
申请号：US13639852
申请日：2011-04-06
申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Xiongsheng Sun , Siping Hu
发明人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Xiongsheng Sun , Siping Hu
IPC分类号： C07C45/42 , C07C41/30 , C07C43/15
CPC分类号： C07C43/16 , C07C41/30 , C07C45/42 , C07C47/21
摘要： The invention discloses an intermediate 1-methoxyl-2,6,10-trimethyl-1,3,5, 9-undec-tetraene, and a preparation method and uses thereof. In the synthesis method for the current lycopene intermediate 2-pos double bond C-14 aldehyde (2,6,10-trimethyl-2,5,9-undecatriene-1-aldehyde), expensive methyl iodide, polluting dimethyl sulphide and dangerous strong base are needed, so that the method is hardly applied to industrial production. The invention provides a new compound 1-methoxyl-2,6,10-trimethyl-1,3,5,9-undec-tetraene, and pure 2-pos double bond C-14 aldehyde can be prepared by hydrolyzing and refining the compound. The synthetic route is simplified and the great suitability for industrial production is achieved.
摘要翻译：本发明公开了中间体1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯及其制备方法和用途。在目前番茄红素中间体2-pos双键C-14醛（2,6,10-三甲基-2,5,9-十一碳三烯-1-醛）的合成方法中，昂贵的甲基碘，污染二甲基硫化物和危险的强需要这种方法，这种方法几乎不适用于工业生产。本发明提供了一种新的化合物1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯，纯的2-位双键C-14醛可以通过水解和精制化合物。合成路线简化，实现了工业生产的良好适应性。

6. 发明申请

US20130046114A1 1-Methoxyl-2, 6, 10-Trimethyl-1, 3, 5, 9-Undec-Tetraene, and Preparation Method and Uses thereof 有权
标题翻译： 1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯及其制备方法和用途
公开(公告)号：US20130046114A1
公开(公告)日：2013-02-21
申请号：US13639852
申请日：2011-04-06
申请人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Xiongsheng Sun , Siping Hu
发明人： Xuejun Lao , Runpu Shen , Weidong Ye , Xiaohua Song , Luo Liu , Chunlei Wu , Xiongsheng Sun , Siping Hu
IPC分类号： C07C41/30 , C07C43/15 , C07C45/42
CPC分类号： C07C43/16 , C07C41/30 , C07C45/42 , C07C47/21
摘要： The invention discloses an intermediate 1-methoxyl-2,6,10-trimethyl-1,3,5,9-undec-tetraene, and a preparation method and uses thereof. In the synthesis method for the current lycopene intermediate 2-pos double bond C-14 aldehyde (2,6,10-trimethyl-2,5,9-undecatriene-1-aldehyde), expensive methyl iodide, polluting dimethyl sulphide and dangerous strong base are needed, so that the method is hardly applied to industrial production. The invention provides a new compound 1-methoxyl-2,6,10-trimethyl-1,3,5,9-undec-tetraene, and pure 2-pos double bond C-14 aldehyde can be prepared by hydrolyzing and refining the compound. The synthetic route is simplified and the great suitability for industrial production is achieved.
摘要翻译：本发明公开了中间体1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯及其制备方法和用途。在目前番茄红素中间体2-pos双键C-14醛（2,6,10-三甲基-2,5,9-十一碳三烯-1-醛）的合成方法中，昂贵的甲基碘，污染二甲基硫化物和危险的强需要这种方法，这种方法几乎不适用于工业生产。本发明提供了一种新的化合物1-甲氧基-2,6,10-三甲基-1,3,5,9-十一四烯，纯的2-位双键C-14醛可以通过水解和精制化合物。合成路线简化，实现了工业生产的良好适应性。

7. 外观设计

USD1046030S1 Pull up exerciser 有权
公开(公告)号：USD1046030S1
公开(公告)日：2024-10-08
申请号：US29869364
申请日：2022-12-29
申请人： Luo Liu
设计人： Luo Liu
摘要： FIG. 1 is a front and top perspective view of a pull up exerciser, showing my new design;
FIG. 2 is a rear and bottom perspective view thereof;
FIG. 3 is a front elevation view thereof;
FIG. 4 is a rear elevation view thereof;
FIG. 5 is a left side elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof;
FIG. 9 is an enlarged perspective view of detail “9” identified in FIG. 1; and,
FIG. 10 is an enlarged perspective view of detail “10” identified in FIG. 1.
The dashed lines in the figures illustrate portions of the pull up exerciser that form no part of the claimed design. The dash dot dash lines in FIGS. 1, 9 and 10 depict the bounds of the enlarged views and form no part of the claimed design.

8. 发明申请

US20130224792A1 Novel 7 alpha-Hydroxysteroid Dehydrogenase Knockout Mutants and Use Therefor 有权
标题翻译：新型7α-羟基甾体脱氢酶敲除突变体及其用途
公开(公告)号：US20130224792A1
公开(公告)日：2013-08-29
申请号：US13699239
申请日：2011-05-27
申请人： Rolf Schmid , Michael Braun , Luo Liu , Arno Aigner , Dirk Weuster-Botz
发明人： Rolf Schmid , Michael Braun , Luo Liu , Arno Aigner , Dirk Weuster-Botz
IPC分类号： C12N9/00 , C12P33/00
CPC分类号： C12N9/0006 , C07K14/245 , C12P33/00 , C12P33/06 , C12Y101/01159
摘要： The invention relates to novel microbial 7α-hydroxysteroid dehydrogenase (7α-HSDH) knockout mutants and to the use thereof for producing other HSDHs having various functionalities, such as 3α-, 7β- or 12α-HSDH, and to the use of thus-produced HSDH enzymes in enzymatic reactions of cholic acid compounds, and in particular for producing ursodeoxycholic acid (UDCS). The invention relates in particular to novel methods for synthesizing UDCS.
摘要翻译：本发明涉及新型微生物7α-羟基类固醇脱氢酶（7α-HSDH）敲除突变体及其用于产生具有各种功能的其它HSDH，例如3α-，7β-或12α-HSDH，以及由此产生的 HSDH酶在胆酸化合物的酶促反应中，特别是用于产生熊去氧胆酸（UDCS）。本发明特别涉及用于合成UDCS的新方法。

9. 发明授权

US09096825B2 7 α-hydroxysteroid dehydrogenase knockout mutants and use therefor 有权
标题翻译： 7α-羟基类固醇脱氢酶敲除突变体并用于此
公开(公告)号：US09096825B2
公开(公告)日：2015-08-04
申请号：US13699239
申请日：2011-05-27
申请人： Rolf Schmid , Michael Braun , Luo Liu , Arno Aigner , Dirk Weuster-Botz
发明人： Rolf Schmid , Michael Braun , Luo Liu , Arno Aigner , Dirk Weuster-Botz
IPC分类号： C12P33/00 , C12N9/04 , C12N1/20 , C12N15/00 , C12N15/87 , C07K14/245 , C12P33/06
CPC分类号： C12N9/0006 , C07K14/245 , C12P33/00 , C12P33/06 , C12Y101/01159
摘要： The invention relates to 12 α-hydroxysteroid dehydrogenases, nucleic acid sequences coding for the same, expression cassettes and vectors, recombinant microorganisms containing the corresponding coding nucleic acid sequences, a method for producing said 12 α-hydroxysteroid dehydrogenases, a method for enzymatic oxidation of 12 α-hydroxysteroids using said enzyme, a method for enzymatic reduction of 12-ketosteroids using said enzyme, a method for qualitative or quantitative determination of 12-ketosteroids and/or 12α-hydroxysteroids using said 12α-hydroxysteroid dehydrogenases and a method for production of ursodesoxycholic acid, comprising the enzyme-catalyzed cholic acid oxidation using said 12 α-hydroxysteroid dehydrogenases.
摘要翻译：本发明涉及12种α-羟基类固醇脱氢酶，编码相同的核酸序列，表达盒和载体，含有相应的编码核酸序列的重组微生物，所述12种α-羟基类固醇脱氢酶的制备方法，使用所述酶的12种α-羟基类固醇，使用所述酶酶促还原12-酮类固醇的方法，使用所述12α-羟基类固醇脱氢酶定性或定量测定12-酮类和/或12α-羟基类固醇的方法及其制备方法熊去氧胆酸，其包含使用所述12α-羟基类固醇脱氢酶的酶催化的胆酸氧化。

10. 发明申请

US20130040341A1 NOVEL 7beta-HYDROXYSTEROID DEHYDROGENASES AND THEIR USE 审中-公开
标题翻译：新型7-脱氢脱氢酶脱氢酶及其用途
公开(公告)号：US20130040341A1
公开(公告)日：2013-02-14
申请号：US13512166
申请日：2010-11-30
申请人： Luo Liu , Rolf Schmid , Arno Aigner
发明人： Luo Liu , Rolf Schmid , Arno Aigner
IPC分类号： C12N9/04 , C12P33/06 , C12P33/02
CPC分类号： C12N9/0006 , C12P33/00 , C12P33/02 , C12P33/06 , C12Y101/01201
摘要： The invention relates to novel 7β-hydroxysteroid dehydrogenases which are obtainable from bacteria of the genus Collinsella, especially of the strain Collinsella aerofaciens, to the sequences encoding said enzymes, to methods for producing said enzymes and to their use in the enzymatic conversion of cholic acid compounds, and especially in the production of ursodeoxycholic acid (UDCS). The invention also relates to novel methods for the synthesis UDCS.
摘要翻译：本发明涉及可从柯氏杆菌属（Collinsella），特别是柯氏杆菌属（Collinsella aerofaciens）细菌获得的新型7＆amp; bgr-羟基类固醇脱氢酶，其编码所述酶的序列，以及用于产生所述酶的方法及其在胆碱酶促转化中的用途酸化合物，特别是在产生熊去氧胆酸（UDCS）中。本发明还涉及用于合成UDCS的新颖方法。

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