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1. 发明授权

US06664422B1 Process for the preparation of strobilurin intermediates 失效
标题翻译：制备嗜球果伞素中间体的方法
公开(公告)号：US06664422B1
公开(公告)日：2003-12-16
申请号：US09857391
申请日：2001-08-13
申请人： Rudolf Waditschatka , René Zurflüh , Edward Kelsall , Hugo Ziegler , Linhua Wang
发明人： Rudolf Waditschatka , René Zurflüh , Edward Kelsall , Hugo Ziegler , Linhua Wang
IPC分类号： C07C24900
CPC分类号： C07C249/08 , C07C45/00 , C07C49/233 , C07C251/48
摘要： The present invention relates to a novel improved process and intermediates for the process of preparing the oxime intermediates of formula (II) wherein R1 is hydrogen, fluoro or chloro, and R2 is methyl, ethyl, methoxy, ethoxy, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro or bromo. The novel process comprises diazotizing an aniline of formula (VI) reacting the resulting diazonium salt with isopropenylacetate of formula (X) and reacting the resulting ketone of formula (XI) with an organic nitrite in the presence of hydrogene chloride, and methylating the resulting ketooxime of formula (VIII) with a methylating agent and reacting the resulting O-methyl ketooxime of formula (IX) with hydroxylamine. The compounds of formula (II) are intermediates for highly active fungicides from the class of the strobilurins.
摘要翻译：本发明涉及制备式（II）的肟中间体的方法和中间体，其中R1是氢，氟或氯，R2是甲基，乙基，甲氧基，乙氧基，三氟甲基，三氟甲氧基，氰基，氟，氯或溴。该新方法包括使式（Ⅵ）的苯胺重氮化，使得到的重氮盐与式（X）的异丙烯基乙酸酯反应，并使所得的式（Ⅺ）酮与有机亚硝酸酯在氯化氢存在下反应，并使所得酮肟甲基化（VIII）与甲基化剂反应，并使所得的式（IX）的O-甲基酮肟与羟胺反应。式（II）化合物是来自嗜球果伞素类的高活性杀真菌剂的中间体。

2. 发明授权

US06420423B1 Pesticides 失效
标题翻译：农药
公开(公告)号：US06420423B1
公开(公告)日：2002-07-16
申请号：US09343662
申请日：1999-06-29
申请人： Saleem Farooq , Stephan Trah , Hugo Ziegler , René Zurflüh , Alfons Pascual , Henry Szczepanski , Roger Graham Hall
发明人： Saleem Farooq , Stephan Trah , Hugo Ziegler , René Zurflüh , Alfons Pascual , Henry Szczepanski , Roger Graham Hall
IPC分类号： A61K3124
CPC分类号： C07D213/53 , A01N37/36 , A01N37/38 , A01N37/50 , A01N43/10 , A01N43/40 , A01N43/54 , A01N43/60 , A01N55/00 , C07C249/12 , C07C251/48 , C07C251/60 , C07C255/54 , C07C323/20 , C07C323/47 , C07C2601/02 , C07C2601/08 , C07D239/26 , C07D241/12 , C07D275/03 , C07D317/64 , C07D333/22 , C07F7/081
摘要： Compounds of the formula: in which n, q, A, X, G, Y, Z, R, R2, R3, R4, R5, R7 and R9 are as defined in claim 1, and, where appropriate, E/Z isomers, E/Z isomer mixtures and/or tautomers thereof, in each case in the free form or in an agrochemically suitable salt form, can be used as agrochemical active compounds and can be prepared in a manner known per se.
摘要翻译：下式的化合物：其中n，q，A，X，G，Y，Z，R，R 2，R 3，R 4，R 5，R 7和R 9如权利要求1中所定义，并且在适当的情况下，E / ，在各种情况下以游离形式或农业化学合适的盐形式的E / Z异构体混合物和/或互变异构体可以用作农业化学活性化合物，并且可以以本身已知的方式制备。

3. 发明授权

US06372787B1 Phenyl-methoxyimino-glyoxylic acid derivatives as pesticides 失效
标题翻译：苯甲氧基亚氨基 - 乙醛酸衍生物作为农药
公开(公告)号：US06372787B1
公开(公告)日：2002-04-16
申请号：US09671421
申请日：2000-09-27
申请人： Hugo Ziegler , René Zurflüh
发明人： Hugo Ziegler , René Zurflüh
IPC分类号： C07C22940
CPC分类号： C07C251/58 , A01N37/50 , C07C251/48 , C07C251/86 , C07C251/88 , C07C2601/02
摘要： Compounds of formula I wherein A is a group OCHR4 or N═CR4; Y is O or NH, R1 is C1-C6-alkyl; R2 is C1-C6-alkyl or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl, CN or halogen, aryl, hetaryl, heterocyclyl, aryloxy, hetaryloxy or heterocyclyloxy, whereby the above-mentioned groups, with the exception of CN and halogen, may be substituted by the same or different substituents; R4 is methyl, ethyl or cyclopropyl; R6 is hydrogen or methyl; have microbicidal, insecticidal and acaricidal activity, and may be used to control plant-pathogenic fungi, acarids and insects in agriculture and in the field of hygiene.
摘要翻译：式I的化合物，其中A是基团OCHR 4或N = CR 4; Y是O或NH，R 1是C 1 -C 6烷基; R 2是被1至5个氟原子取代的C 1 -C 6烷基或C 1 -C 6烷基; R 3是 C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，C 3 -C 6 - 环烷基，C 3 -C 6 - 环烷氧基，C 2 -C 6 - 烯基，C 2 -C 6 - 烯氧基，C 2 -C 6 - C 6 - 烷氧基羰基，CN或卤素，芳基，杂芳基，杂环基，芳氧基，杂芳氧基或杂环氧基，其中除CN和卤素以外的上述基团可以被相同或不同的取代基取代; R4是甲基，乙基或环丙基; R 6为氢或甲基;具有杀菌，杀虫和杀螨活性，可用于控制农业和卫生领域的植物病原真菌，螨虫和昆虫。

4. 发明授权

US06646151B1 Process for the preparation of pesticides 失效
标题翻译：农药制备工艺
公开(公告)号：US06646151B1
公开(公告)日：2003-11-11
申请号：US09670147
申请日：2000-09-26
申请人： Saleem Farooq , Stephan Trah , Hugo Ziegler , René Zurflüh
发明人： Saleem Farooq , Stephan Trah , Hugo Ziegler , René Zurflüh
IPC分类号： C07C24904
CPC分类号： C07C249/12 , C07C251/48 , C07C251/60
摘要： The invention relates to a process for the preparation of compounds of the formula or, if appropriate, a tautomer thereof, in each case in the free form or in salt form, in which A, X, Y, Z, R2, R3, R4, R5, R7, R9 and n are as defined in claim 1 and the C═N double bond marked with E has the E configuration, which comprises a1) reacting either a compound of the formula (II) mentioned above with a compound of the formula (III) mentioned above, in which X1 is a leaving group, or a2) a compound of the formula (IV) mentioned above, if appropriate in the presence of a base, with a compound of the formula (V) mentioned above, or b1) reacting a compound of the formula (VI) mentioned above with a compound of the formula R7—A—X2 (VII), in which X2 is a leaving group, and either further reacting the compound thus obtainable, of the formula (IV), for example according to method a2), or b2) reacting it with hydroxylamine or a salt thereof, if appropriate in the presence of a basic or acid catalyst, and further reacting the compound thus obtainable, of the formula (II), for example according to method a1), or c) reacting a compound of the formula (VIII), mentioned above with a C1-C6alkyl nitrite and further reacting the compound thus obtainable, of the formula (VI), for example according to method b), the E isomers of the compounds of the formulae (II), (IV) and (VI), a process for their preparation and their use for the preparation of compounds of the formula (I).
摘要翻译：本发明涉及一种制备式的化合物的方法，如果合适，其合适的是其互变异构体，其各自为游离形式或盐形式，其中A，X，Y，Z，R 2，R 3，R 4， R5，R7，R9和n如权利要求1中所定义，并且用E标记的C = N双键具有E构型，其包括a）使上述式（II）的化合物与式（II） III），其中X1是离去基团，ora2）如果合适的话，在碱的存在下，上述式（Ⅳ）的化合物与上述式（Ⅴ）的化合物相同，反应1）使上述式（Ⅵ）化合物与式R7-A-X2（Ⅶ）化合物反应，其中X 2为离去基团，并进一步使由此得到的式（Ⅳ）化合物与根据方法a2）的示例，orb2）如果合适，在碱性或酸性催化剂存在下，使其与羟胺或其盐反应，以及进一步使由式（II）得到的化合物，例如按照方法a1）进行反应，或者使上述式（Ⅷ）化合物与亚硝酸C 1 -C 6烷基酯反应，并进一步使由此得到的化合物，式（Ⅵ）化合物的方法，例如根据方法b），式（II），（Ⅳ）和（Ⅵ）化合物的E异构体，其制备方法及其制备方法式（I）。

5. 发明授权

US06313166B1 Phenyl acetic acid derivatives as pesticides 失效
标题翻译：苯乙酸衍生物作为农药
公开(公告)号：US06313166B1
公开(公告)日：2001-11-06
申请号：US09338236
申请日：1999-06-22
申请人： Hugo Ziegler , Stephan Trah , Saleem Farooq , René Zurflüh
发明人： Hugo Ziegler , Stephan Trah , Saleem Farooq , René Zurflüh
IPC分类号： A01N3734
CPC分类号： C07D213/77 , A01N37/36 , A01N37/50 , A01N43/28 , A01N43/30 , A01N43/36 , A01N43/40 , A01N43/46 , A01N43/653 , A01N43/84 , A01N55/00 , C07C251/60 , C07C251/76 , C07C251/80 , C07C255/54 , C07C255/61 , C07C2601/02 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/088 , C07D295/30 , C07D317/18 , C07D317/58 , C07D333/22
摘要： Compounds of the formula I and the isomers thereof, in which either a) X is an N atom and Y is OR11 or N(R12)R13, or b) X is CH and Y is OR11, and in which furthermore: R11 is C1-C4alkyl; R12 and R13, independenty, are hydrogen or C1-C4alkyl; A is an O atom or the group NR4; and wherein R1, R2 and R3 are as defined herein, are pesticidal active ingredients. They can be used for pest control, in particular as microbicides, insecticides and acaricides in agriculture, horticulture and in the hygiene sector.
摘要翻译：其中a）X是N原子，Y是OR 11或N（R 12）R 13，orb）X是CH，Y是OR 11，此外：R 11是C 1 -C 4烷基; R 12和 R 13独立地为氢或C 1 -C 4烷基; A为O原子或NR 4基团; 并且其中R1，R2和R3如本文所定义，是杀虫活性成分。它们可用于害虫防治，特别是农业，园艺和卫生领域的杀微生物剂，杀虫剂和杀螨剂。

6. 发明申请

US20090306061A1 FUNGICIDAL COMBINATIONS COMPRISING A GLYOXALIC ACID METHYL ESTER-O-METHYLOXIME DERIVATIVES 审中-公开
标题翻译：含有羟甲酸甲酯衍生物的灭菌剂组合物
公开(公告)号：US20090306061A1
公开(公告)日：2009-12-10
申请号：US12543731
申请日：2009-08-19
申请人： René Zurflüh , Neil Leadbitter
发明人： René Zurflüh , Neil Leadbitter
IPC分类号： A01N43/88 , A01N43/40 , A01N43/78 , A01N43/64 , A01N37/18
CPC分类号： A01N37/50 , A01N47/24 , A01N47/12 , A01N43/88 , A01N43/653 , A01N43/50 , A01N43/40 , A01N37/52 , A01N37/46 , A01N37/24 , A01N37/20 , A01N2300/00
摘要： A method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of a) 2-[α-{[(α-methyl-3-trifluoromethyl-benzyl)imino]-oxy}-o-tolyl]-glyoxalic acid methyl ester-O methyloxime (I) in association with b) a broad variety of other plant fungicides is particularly effective in combating or preventing diseases of crop plants. These combinations exhibit synergistic fungicidal activity.
摘要翻译：一种在作物植物上对抗植物病原性疾病的方法，其包括向所述植物病原性疾病侵染的作物植物或其基因座施用有效量的a）2- [α - {[（α-甲基-3-三氟甲基 - 苄基）亚氨基] - 氧基} - 对 - 甲苯基] - 乙醛酸甲酯-O甲基肟（I）与b）多种其他植物杀真菌剂在防治或预防作物病害方面特别有效。这些组合表现出协同的杀真菌活性。

7. 发明授权

US06451855B1 Fungicidal combinations comprising glyoxalic acid methyl ester-O-methyloxime derivatives 失效
标题翻译：包含乙醛酸甲酯-O-甲基肟衍生物的杀菌剂组合
公开(公告)号：US06451855B1
公开(公告)日：2002-09-17
申请号：US10059087
申请日：2002-01-28
申请人： René Zurflüh , Neil Leadbitter
发明人： René Zurflüh , Neil Leadbitter
IPC分类号： A01N3712
CPC分类号： A01N37/50 , A01N47/24 , A01N47/12 , A01N43/88 , A01N43/653 , A01N43/50 , A01N43/40 , A01N37/52 , A01N37/46 , A01N37/24 , A01N37/20 , A01N2300/00
摘要： The present invention provides a method of combating phytopathogenic disease on a crop plant which comprises applying to the crop plant and/or its locus an effective amount of a combination of 2-[&agr;-{[(&agr;-methyl-3-trifluoromethyl-benzyl)imino]-oxy}-o-tolyl]-glyoxalic acid methyl ester-O methyloxime (I) and at least one compound selected from a broad variety of other plant fungicides. The combinations exhibit synergistic fungicidal activity and are particularly effective in combating or preventing diseases of crop plants.
摘要翻译：本发明提供了一种在作物植物上对抗植物病原性疾病的方法，其包括向作物植物和/或其基因座施用有效量的2- [α - {[（α-甲基-3-三氟甲基 - 苄基）亚氨基] - 氧基} - 对 - 甲苯基] - 乙醛酸甲酯-O甲基肟（I）和至少一种选自多种其他植物杀真菌剂的化合物。这些组合表现出协同的杀真菌活性，并且特别有效地对抗或预防作物植物的疾病。

8. 发明授权

US06395761B2 Fungicidal combinations comprising glyoxalic acid methyl ester-O-methyloxime derivatives 有权
标题翻译：包含乙醛酸甲酯-O-甲基肟衍生物的杀菌剂组合
公开(公告)号：US06395761B2
公开(公告)日：2002-05-28
申请号：US09728185
申请日：2000-12-02
申请人： René Zurflüh , Neil Leadbitter
发明人： René Zurflüh , Neil Leadbitter
IPC分类号： A01N4340
CPC分类号： A01N37/50 , A01N47/24 , A01N47/12 , A01N43/88 , A01N43/653 , A01N43/50 , A01N43/40 , A01N37/52 , A01N37/46 , A01N37/24 , A01N37/20 , A01N2300/00
摘要： A method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of a) 2-[&agr;-{[(&agr;-methyl-3-trifluoromethyl-benzyl)imino]-oxy}-o-tolyl]-glyoxalic acid methyl ester-O methyloxime (I) in association with b) a broad variety of other plant fungicides is particularly effective in combating or preventing diseases of crop plants. These combinations exhibit synergistic fungicidal activity.
摘要翻译：一种防治作物植物病原性疾病的方法，其特征在于，应用于所述植物病原性疾病侵染的作物植物或其基因座，有效量的a）2 - [（{（α-甲基-3-三氟甲基 - 苄基）亚氨基] - 氧基} - 对 - 甲苯基] - 乙醛酸甲酯-O甲基肟（I）与b）多种其他植物杀真菌剂特别有效地对抗或预防作物的疾病。这些组合表现出协同的杀真菌活性。

9. 发明授权

US06235684B1 Fungicidal combinations comprising phenylacrylic acid derivatives 失效
标题翻译：含有苯基丙烯酸衍生物的杀真菌组合
公开(公告)号：US06235684B1
公开(公告)日：2001-05-22
申请号：US09486519
申请日：2000-02-28
申请人： Gertrude Knauf-Beiter , René Zurflüh , Bettina Gsell
发明人： Gertrude Knauf-Beiter , René Zurflüh , Bettina Gsell
IPC分类号： A01N57100
CPC分类号： A01N37/50 , A01N57/20 , A01N55/00 , A01N47/38 , A01N47/34 , A01N47/24 , A01N47/18 , A01N47/04 , A01N43/88 , A01N43/84 , A01N43/82 , A01N43/78 , A01N43/76 , A01N43/653 , A01N43/56 , A01N43/54 , A01N43/50 , A01N43/42 , A01N43/40 , A01N43/36 , A01N43/30 , A01N43/08 , A01N37/52 , A01N37/46 , A01N37/38 , A01N37/34 , A01N37/24 , A01N37/20 , A01N2300/00
摘要： A method of combating phytopathogenic diseases on crop plants which comprises applying to the crop plants or the locus thereof being infested with said phytopathogenic disease an effective amount of a combination of a) a 2-(5-phenyl-3,6-diaza-2,7-dioxa-octa-3,5-dienyl)phenylacrylamide of formula I wherein R1 is hydrogen, fluoro or chloro, R2 is methyl, ethyl, trifluoromethyl, trifluoromethoxy, cyano, fluoro, chloro or bromo, with the proviso that R2 cannot be fluoro, chloro or bromo, when R1 is hydrogen; in association with b) a broad variety of otherplant fungicides is particularly effective in combating or preventing fungal diseases of crop plants. These combinations exhibit synergistic fungicidal activity.
摘要翻译：一种防治作物植物病原性疾病的方法，其特征在于，向作物植物或其所在的植物病原体侵染地点施用有效量的a）2-（5-苯基-3,6-二氮杂-2， 7-二氧杂 - 八氢-3,5-二烯基）苯基丙烯酰胺，其中R1是氢，氟或氯，R2是甲基，乙基，三氟甲基，三氟甲氧基，氰基，氟，氯或溴，条件是R2不能是氟，氯或溴，当R1是氢时; b）各种各样的其他植物杀真菌剂在对抗或预防作物植物真菌病害方面特别有效。这些组合表现出协同的杀真菌活性。

10. 发明授权

US06211240B1 O-benzyl oxime ether derivatives and their use as pesticides 失效
公开(公告)号：US06211240B1
公开(公告)日：2001-04-03
申请号：US08739388
申请日：1996-10-29
申请人： René Zurflüh
发明人： René Zurflüh
IPC分类号： A01N4342
CPC分类号： C07D295/135 , A01N37/50 , A01N37/52 , C07C255/62 , C07C257/06 , C07C257/14 , C07C259/10 , C07C259/14 , C07C259/20 , C07C271/64 , C07C327/44 , C07C327/58 , C07C2601/02 , C07C2602/08 , C07C2602/10 , C07C2603/18 , C07D295/13 , C07F7/081
摘要： Compounds of the formula I in which Y is hydrogen, C1-C4alkyl, C1-C4alkoxy, OH, CN, NO2, Si(CH3)3, CF3 or halogen, Z is a group a) R1 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4-alkynyl, C3-C6cycloalkyl, phenyl which is unsubstituted or at most trisubstituted by halogen, C1-C4alkyl, C1-C4alkoxy, C1-C4alkylthio, or benzyl which is unsubstituted or at most trisubstituted in the aromatic ring in the same manner; or is cyclopropylmethyl, C1-C4haloalkyl, C2-C5alkoxyalkyl, cyanomethyl, CO—R6, OH, NH2, C1-C4alkylamine or C1-C4alkoxycarbonyl-C1-C2alkyl; X is oxygen, sulfur or NR5; R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, C(O)R6, OH or C1-C4alkoxy, NH2 or C1-C4alkylamine; R5 is hydrogen, C1-C4alkyl, C2-C4alkenyl or C2-C4alkynyl; R6 is hydrogen, C114 C4alkyl, C1-C4haloalkyl, C1-C4alkoxy, C3-C6cycloalkyl, C1-C4alkoxycarbonyl or phenyl which is unsubstituted or at most trisubstituted; and in which R3 and R4 independently of one another are hydrogen, cyano, C1-C4alkyl, halo-C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, cyclopropylmethyl, C1-C4alkoxy, C2-C5alkoxyalkyl, C2-C4alkoxycarbonyl, C1-C4alkylthio, C2-C5-alkylthioalkyl; a ring having not more than 15 ring carbon atoms which can be polymembered and is unsubstituted or at most trisubstituted and has 0-3 hetero atoms N, O or S, it being possible for this ring to be bonded via an aliphatic bridge having not more than 4 carbon atoms and/or via either CO, oxygen or sulfur; or in which R3 and R4 together with the shared carbon atom are a ring or a polymembered ring system having not more than 15 ring carbon atoms which is unsubstituted or at most trisubstituted and has 0-3 hetero atoms N, O or S; are suitable for controlling and preventing attack by microorganisms of plants. They can be used in the form of commercially available formulated compositions.

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