专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4617309A Sulfur-containing indole derivatives 失效
标题翻译：含硫吲哚衍生物
公开(公告)号：US4617309A
公开(公告)日：1986-10-14
申请号：US537621
申请日：1983-09-30
申请人： Henning Bottcher , Rudolf Gottschlich , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
发明人： Henning Bottcher , Rudolf Gottschlich , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/12 , A61P25/00 , A61P25/04 , C07D401/12 , C07D405/14 , C07D491/056
CPC分类号： C07D401/12
摘要： Sulfur-containing indole derivatives of the general formula I ##STR1## wherein Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN by a methylenedioxy group, A is --(CH.sub.2).sub.n --E--C.sub.m H.sub.2m -- or --(CH.sub.2).sub.n --E--C.sub.m-1 H.sub.2m-2 CO--, n is 0 or 1, m is 2, 3 or 4, E is S, SO or SO.sub.2 and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group and wherein the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
摘要翻译：通式I的含硫吲哚衍生物其中Ind是可被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH取代一次或两次的3-吲哚基，（CH2）nE-CmH2m-或 - （CH2）nE-Cm-1H2m-2CO-，n为0或1，m为2，F，Cl，Br，CF3和/或CN为亚烷基二氧基， 3或4，E是S，SO或SO 2，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl， Br，CF 3和/或CN或亚甲二氧基，并且其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统表现出作用。

2. 发明授权

US4870087A Indole containing, 2-thienyl-1,2,3,6-tetrahydropyridyls and their pharmaceutical use 失效
标题翻译：含有2-噻吩基-1,2,3,6-四氢吡啶的吲哚及其药物用途
公开(公告)号：US4870087A
公开(公告)日：1989-09-26
申请号：US588406
申请日：1984-03-12
申请人： Rudolf Gottschlich , Henning Bottcher , Hans-Heinrich Hausberg , Klaus-Otto Minck , Christoph Seyfried
发明人： Rudolf Gottschlich , Henning Bottcher , Hans-Heinrich Hausberg , Klaus-Otto Minck , Christoph Seyfried
IPC分类号： A61K31/4433 , A61K31/445 , A61P25/00 , C07D409/14 , C07D491/04
CPC分类号： C07D409/14 , C07D491/04
摘要： Indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --L--CH.sub.2 CH.sub.2 --, L is --S--, --SO-- or --SO.sub.2 --, and Th is a 2-- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
摘要翻译：其中Ind为可以被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，C 1-4烷基取代一次或两次的3-吲哚基的通式I的吲哚衍生物， Cl，Br，CF 3和/或CN或亚甲二氧基，A是 - （CH 2）4 - 或-CH 2 -L-CH 2 CH 2 - ，L是-S-，-SO-或-SO 2 - ，Th是 2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统具有影响。

3. 发明授权

US4618614A Method of treating psychosis using tetrahydrocarbazole derivatives 失效
标题翻译：使用四氢咔唑衍生物治疗精神病的方法
公开(公告)号：US4618614A
公开(公告)日：1986-10-21
申请号：US818859
申请日：1986-01-15
申请人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056 , A61K31/44 , A61K31/445
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统具有影响。

4. 发明授权

US4547576A Tetrahydrocarbazole derivatives 失效
标题翻译：四氢咔唑衍生物
公开(公告)号：US4547576A
公开(公告)日：1985-10-15
申请号：US568310
申请日：1984-01-04
申请人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl取代一次或两次的苯基， Br，CF 3和/或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中心具有影响神经系统。

5. 发明授权

US4698351A Tetrahydrocarbazole derivatives and pharmaceutical compositions 失效
标题翻译：四氢咔唑衍生物和药物组合物
公开(公告)号：US4698351A
公开(公告)日：1987-10-06
申请号：US899453
申请日：1986-08-22
申请人： Hans-Heinrich Hausberg , Henning Bottch , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottch , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056 , A61K31/44
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl取代一次或两次的苯基， Br，CF 3和/或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中心具有影响神经系统。

6. 发明授权

US5232931A Oxazolidinones 失效
标题翻译：奥沙利铂
公开(公告)号：US5232931A
公开(公告)日：1993-08-03
申请号：US706147
申请日：1991-05-28
申请人： Helmut Prucher , Henning Bottcher , Christoph Seyfried , Anton Haase , Klaus-Otto Minck , Rudolf Gottschlich
发明人： Helmut Prucher , Henning Bottcher , Christoph Seyfried , Anton Haase , Klaus-Otto Minck , Rudolf Gottschlich
IPC分类号： A61K31/445 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D413/14
CPC分类号： C07D413/14
摘要： Novel oxazolidinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Z and n have the meanings defined herein, and their salts have effects on the central nervous system, in particular calming effects.
摘要翻译：其中R1，R2，R3，R4，Z和n具有本文定义的含义的式I的恶唑烷酮及其盐对中枢神经系统具有影响，特别是镇静作用。

7. 发明授权

US4970217A Oxazolidinones 失效
标题翻译：恶唑烷酮
公开(公告)号：US4970217A
公开(公告)日：1990-11-13
申请号：US219634
申请日：1988-07-15
申请人： Helmut Prucher , Henning Bottcher , Rudolf Gottschlich , Klaus-Otto Minck , Anton Haase , Christoph Seyfried
发明人： Helmut Prucher , Henning Bottcher , Rudolf Gottschlich , Klaus-Otto Minck , Anton Haase , Christoph Seyfried
IPC分类号： C07D263/20 , A61K31/44 , A61K31/445 , A61P25/20 , A61P25/24 , A61P25/26 , C07D413/06 , C07D413/14 , C07D471/10
CPC分类号： C07D413/06 , C07D413/14 , C07D471/10
摘要： Novel oxazolidinones of the formula I ##STR1## Z is O or S, R.sup.1 and R.sup.2 are each phenyl or benzyl radicals which are unsubstituted or mono- or disubstituted by alkyl, alkoxy, alkylthio, alkylsulfinyl and/or alkylsulfonyl having each 1-4 C atoms, alkanoyloxy and/or alkanoylamino having each 1-6 C atoms, F, Cl, Br, OH and/or CF.sub.3 or are heteroaryl radicals containing 1-4 heteroatoms and R.sup.3 and R.sup.4 are each H, alkyl or alkoxy having each 1-4 C atoms or are F, Cl, Br, OH or CF.sub.3, and also their salts have effects on the central nervous system, in particular neuroleptic effects.
摘要翻译：式I的新型恶唑烷酮其中R是O或S，R 1和R 2各自是未取代的或被烷基，烷氧基单取代或被二取代的苯基或苄基，具有1-4个C原子的烷硫基，烷基亚磺酰基和/或烷基磺酰基，每个1-6个C原子的烷酰氧基和/或烷酰基氨基，F，Cl，Br，OH和/或CF 3，或者是含1-4个杂原子的杂芳基， R 3和R 4各自为H，具有1-4个C原子的烷基或烷氧基，或者为F，Cl，Br，OH或CF 3，并且它们的盐也对中枢神经系统有影响，特别是精神抑制作用。

8. 发明申请

US20060178426A1 Kappa agonists, especialy for the treatment and/or prophylaxis of irritable bowel syndrome 审中-公开
标题翻译：卡帕激动剂，特别用于治疗和/或预防肠易激综合征
公开(公告)号：US20060178426A1
公开(公告)日：2006-08-10
申请号：US10563975
申请日：2004-06-18
申请人： Wolfgang Stahle , Rudolf Gottschlich , Jurgen Harting , Christoph Seyfried
发明人： Wolfgang Stahle , Rudolf Gottschlich , Jurgen Harting , Christoph Seyfried
IPC分类号： A61K31/4015 , C07D207/46
CPC分类号： C07D207/12
摘要： Compound of the formula (I), in which A, R1, R2, R3, X, Y, m and n have the meaning indicated, are suitable as for the treatment of irritable bowel syndrome.
摘要翻译：式（I）化合物，其中A，R 1，R 2，R 3，X，Y，m和n具有适用于肠易激综合征的治疗。

9. 发明授权

US06756370B1 Piperidine alcohols 失效
标题翻译：哌啶醇
公开(公告)号：US06756370B1
公开(公告)日：2004-06-29
申请号：US10069054
申请日：2002-02-21
申请人： Helmut Prücher , Henning Böttcher , Karl-August Ackermann , Rudolf Gottschlich , Christoph van Amsterdam , Christoph Seyfried , Jürgen Harting , Gerd Bartoszyk , Hartmut Greiner
发明人： Helmut Prücher , Henning Böttcher , Karl-August Ackermann , Rudolf Gottschlich , Christoph van Amsterdam , Christoph Seyfried , Jürgen Harting , Gerd Bartoszyk , Hartmut Greiner
IPC分类号： A61K3154
CPC分类号： C07D401/06 , C07D211/22 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The invention relates to compounds of formula (I), wherein R1, R2 and A have the meanings given in claim 1, are potent 5-HT2A antagonists and are suitable for treating psychoses, schizophrenia, depression, neurological disorders, impaired memory, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Huntington's disease, eating disorders such as bulimia and anorexia nervosa, Pre-Menstrual Syndrome and/or for positively influencing obsessive-compulsive disorders, (OCD).
摘要翻译：本发明涉及式（I）化合物，其中R 1，R 2和A具有权利要求1中给出的含义，它们是有效的5-HT2A拮抗剂，适用于治疗精神病，精神分裂症，抑郁症，神经障碍记忆障碍，帕金森病，肌萎缩性侧索硬化症，阿尔茨海默氏病，亨廷顿疾病，进食障碍如贪食症和神经性厌食症，前月经综合征和/或积极影响强迫症（OCD）。

10. 发明授权

US5977161A Kappa-opiate agonists effective in the treatment of postoperative ileus 失效
标题翻译：卡帕阿片激动剂有效治疗术后肠梗阻
公开(公告)号：US5977161A
公开(公告)日：1999-11-02
申请号：US27228
申请日：1998-02-20
申请人： Andrew Barber , Christoph Seyfried , Gerd Bartoszyk , Rudolf Gottschlich
发明人： Andrew Barber , Christoph Seyfried , Gerd Bartoszyk , Rudolf Gottschlich
IPC分类号： C07D207/08 , A61K31/135 , A61K31/165 , A61K31/40 , A61K31/4015 , A61K31/4025 , A61P1/00 , A61P1/04 , A61P29/00 , A61P43/00 , C07D207/12
CPC分类号： A61K31/4025
摘要： Disclosed herein are pharmaceutical preparations which are suitable for the treatment of postoperative ileus and contain at least one compound of the formula I ##STR1## in which R.sup.1 is Ar, cycloalkyl having 3-7 C atoms or cycloalkylalkyl having 4-8 C atoms,R.sup.2 is Ar, orR.sub.1 and R.sup.2 together are ##STR2## R.sup.3 is H, OH, OA or A, R.sup.4 is A or phenyl which can optionally be mono- or disubstituted by Hal, OH, OA, CF.sub.3, NO.sub.2, NH.sub.2, NHA, NHCOA, NHSO.sub.2 A and/or NA.sub.2,R.sup.5 is OH, CH.sub.2 OH,R.sup.6 and R.sup.7 in each case independently of one another are H, Hal, OH, OA, CF.sub.3, NH.sub.2, NHA, NA.sub.2, NHCOA, NHCONH.sub.2, NO.sub.2 or methylenedioxy, with the oxy groups bonded to adjacent carbons on the ring,A is alkyl having 1-7 C atoms,Ar is a mono- or bicyclic aromatic radical which can optionally contain an N, O or S atom in the ring and can be mono-, di- or trisubstituted by A, Hal, OH, OA, CF.sub.3, NH.sub.2, NHA, NA.sub.2, NHCOA and/or NHCONH.sub.2,D is CH.sub.2, O, S, NH, NA, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --CH.sub.2 NH--, --CH.sub.2 --NA-- or a bondandHal is F, Cl, Br or I.
摘要翻译：本文公开了适用于治疗术后肠梗阻并含有至少一种其中R 1为Ar的式I化合物或具有3-7个C原子的环烷基或具有4-8个C原子的环烷基烷基，R2为Ar，或R 1和R 2一起为R 3为H，OH，OA或A，R 4为A或可任选被Hal，OH，OA，CF 3，NO 2，NH 2，NHA，NHCOA，NHSO 2 A单取代或二取代的苯基和/或 NA2，R5分别为H，Hal，OH，OA，CF3，NH2，NHA，NA2，NHCOA，NHCONH2，NO2或亚甲二氧基的OH，CH2OH，R6和R7彼此独立地键合， A是具有1-7个C原子的烷基，Ar是可以在环中任选含有N，O或S原子的单环或双环芳族基团，并且可以被A，，Hal，OH，OA，CF 3，NH 2，NHA，NA 2，NHCOA和/或NHCONH 2，D是CH 2，O，S，NH，NA，-CH 2 -CH 2 - ， - CH = CH-， - CH 2 NH-， CH2-NA-或键，Hal为F，Cl，Br或I.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式