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1. 发明授权

US4617309A Sulfur-containing indole derivatives 失效
标题翻译：含硫吲哚衍生物
公开(公告)号：US4617309A
公开(公告)日：1986-10-14
申请号：US537621
申请日：1983-09-30
申请人： Henning Bottcher , Rudolf Gottschlich , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
发明人： Henning Bottcher , Rudolf Gottschlich , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/12 , A61P25/00 , A61P25/04 , C07D401/12 , C07D405/14 , C07D491/056
CPC分类号： C07D401/12
摘要： Sulfur-containing indole derivatives of the general formula I ##STR1## wherein Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN by a methylenedioxy group, A is --(CH.sub.2).sub.n --E--C.sub.m H.sub.2m -- or --(CH.sub.2).sub.n --E--C.sub.m-1 H.sub.2m-2 CO--, n is 0 or 1, m is 2, 3 or 4, E is S, SO or SO.sub.2 and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group and wherein the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
摘要翻译：通式I的含硫吲哚衍生物其中Ind是可被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH取代一次或两次的3-吲哚基，（CH2）nE-CmH2m-或 - （CH2）nE-Cm-1H2m-2CO-，n为0或1，m为2，F，Cl，Br，CF3和/或CN为亚烷基二氧基， 3或4，E是S，SO或SO 2，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl， Br，CF 3和/或CN或亚甲二氧基，并且其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统表现出作用。

2. 发明授权

US4870087A Indole containing, 2-thienyl-1,2,3,6-tetrahydropyridyls and their pharmaceutical use 失效
标题翻译：含有2-噻吩基-1,2,3,6-四氢吡啶的吲哚及其药物用途
公开(公告)号：US4870087A
公开(公告)日：1989-09-26
申请号：US588406
申请日：1984-03-12
申请人： Rudolf Gottschlich , Henning Bottcher , Hans-Heinrich Hausberg , Klaus-Otto Minck , Christoph Seyfried
发明人： Rudolf Gottschlich , Henning Bottcher , Hans-Heinrich Hausberg , Klaus-Otto Minck , Christoph Seyfried
IPC分类号： A61K31/4433 , A61K31/445 , A61P25/00 , C07D409/14 , C07D491/04
CPC分类号： C07D409/14 , C07D491/04
摘要： Indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, A is --(CH.sub.2).sub.4 -- or --CH.sub.2 --L--CH.sub.2 CH.sub.2 --, L is --S--, --SO-- or --SO.sub.2 --, and Th is a 2-- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts exhibit effects on the central nervous system.
摘要翻译：其中Ind为可以被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，C 1-4烷基取代一次或两次的3-吲哚基的通式I的吲哚衍生物， Cl，Br，CF 3和/或CN或亚甲二氧基，A是 - （CH 2）4 - 或-CH 2 -L-CH 2 CH 2 - ，L是-S-，-SO-或-SO 2 - ，Th是 2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统具有影响。

3. 发明授权

US4618614A Method of treating psychosis using tetrahydrocarbazole derivatives 失效
标题翻译：使用四氢咔唑衍生物治疗精神病的方法
公开(公告)号：US4618614A
公开(公告)日：1986-10-21
申请号：US818859
申请日：1986-01-15
申请人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056 , A61K31/44 , A61K31/445
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中枢神经系统具有影响。

4. 发明授权

US4547576A Tetrahydrocarbazole derivatives 失效
标题翻译：四氢咔唑衍生物
公开(公告)号：US4547576A
公开(公告)日：1985-10-15
申请号：US568310
申请日：1984-01-04
申请人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottcher , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C--C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl取代一次或两次的苯基， Br，CF 3和/或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中心具有影响神经系统。

5. 发明授权

US4824852A Substituted indole compounds which have useful effects on the central nervous system 失效
标题翻译：对中枢神经系统有用的取代吲哚化合物
公开(公告)号：US4824852A
公开(公告)日：1989-04-25
申请号：US153692
申请日：1988-02-08
申请人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
发明人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： A61K31/435 , A61K31/47 , A61P9/12 , A61P25/00 , A61P25/20 , C07D401/06 , C07D401/12 , C07D491/04 , C07D491/048 , C07D495/04 , C07F7/18 , A61K31/44 , C07D231/02
CPC分类号： C07D401/06 , C07D401/12 , C07D491/04 , C07D495/04
摘要： New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 --or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,Z is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,is 2, 3, 4 or 5 andis 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts,have effects on the central nervous system.
摘要翻译：其中Ind是可以被羟甲基，亚甲二氧基，S-烷基，SO-烷基，SO 2 - 烷基，CN或COW基团取代的3-吲哚基，和/或可以被烷基，O-烷基，OH，F，Cl或Br取代一次或两次，是H，OH，O-烷基，NH 2，NH-烷基或N（烷基）2是 - （CH 2）n - -CH 2 -S-CH 2 CH 2 - ， - CH 2 -SO 2 -CH 2 CH 2 - 或-CH 2 -SO 2 -CH 2 CH 2 - ，Z是 - （CH 2）m - ， - CH = CH-，-CHOH-，-CO-，S，SO ，SO 2或O 2为2,3,4或5并且为1,2或3，其中烷基各自具有1-4个C原子，并且它们的盐对中枢神经系统具有影响。

6. 发明授权

US4698351A Tetrahydrocarbazole derivatives and pharmaceutical compositions 失效
标题翻译：四氢咔唑衍生物和药物组合物
公开(公告)号：US4698351A
公开(公告)日：1987-10-06
申请号：US899453
申请日：1986-08-22
申请人： Hans-Heinrich Hausberg , Henning Bottch , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
发明人： Hans-Heinrich Hausberg , Henning Bottch , Rudolf Gottschlich , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04 , C07D491/056 , A61K31/44
CPC分类号： C07D401/06 , C07D405/14 , C07D409/14 , C07D491/04
摘要： Tetrahydrocarbazole derivatives of the general formula I ##STR1## in which Thc is a 1,2,3,4-tetrahydro-3-carbazolyl radical which can be substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, the two radicals Y are each H or together are a C-C bond, one radical Z is Ar and the other radical Z is H, A is --CH.sub.2 -- or --CH.sub.2 CH.sub.2 -- and Ar is a phenyl group which is unsubstituted or substituted once or twice by alkyl, O-alkyl, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, OH, F, Cl, Br, CF.sub.3 and/or CN or by a methylenedioxy group, or is a 2- or 3-thienyl radical, and in which the alkyl groups each have 1-4 C atoms, and their physiologically acceptable acid addition salts have effects on the central nervous system.
摘要翻译：其中Thc是1,2,3,4-四氢-3-咔唑基的四氢咔唑衍生物，其可以被烷基，O-烷基，S-烷基，SO- 烷基，SO 2 - 烷基，OH，F，Cl，Br，CF 3和/或CN或亚甲二氧基，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为 H，A是-CH 2 - 或-CH 2 CH 2 - ，Ar是未被取代或被烷基，O-烷基，S-烷基，SO-烷基，SO 2 - 烷基，OH，F，Cl取代一次或两次的苯基， Br，CF 3和/或CN或亚甲二氧基，或是2-或3-噻吩基，其中烷基各自具有1-4个C原子，并且其生理上可接受的酸加成盐对中心具有影响神经系统。

7. 发明授权

US5256673A Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds 失效
标题翻译：吲哚-3-基-A-四氢吡啶基或哌啶基化合物
公开(公告)号：US5256673A
公开(公告)日：1993-10-26
申请号：US377343
申请日：1989-07-10
申请人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
发明人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： C07D401/06 , C07D401/12 , A61K31/44
CPC分类号： C07D401/06 , C07D401/12
摘要： Indole derivatives of the general formula I ##STR1## wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, Oalkyl, NH.sub.2, NHalkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2,n is 2, 3, 4 or 5,the two radicals Y are each H or together are a C--C bond, one radical Z is Ar,the other radical Z is H andAr is a phenyl group which is unsubstituted or monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group,the alkyl groups each having 1-4 C atoms,wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical,and physiologically acceptable acid addition salts thereof exhibit an action on the central nervous system.
摘要翻译：其中Ind是被羟甲基或COW基团取代的吲哚-3-基，并且可以另外被烷基，O-烷基，OH，F，Cl或Br单取代或二取代的通式I的吲哚衍生物，W是H，OH，O烷基，NH2，NH烷基或N（烷基）2，A是 - （CH2）n-，CH2-S-CH2CH2-，-CH2-SO-CH2CH2或-CH2-SO2-CH2CH2，n 2个，3个，4个或5个，两个基团Y各自为H或一起为CC键，一个基团Z为Ar，另一个基团Z为H，Ar为未被取代或被O取代或二取代的苯基 - 烷基和/或OH或被亚甲二氧基取代，或Ar是2-噻吩基或3-噻吩基，所述烷基各自具有1-4个C原子，但是，当n为2或3时，羟甲基或COW基必须在吲哚-3-基自由基的4-，5-，6-或7-位，其生理上可接受的酸加成盐对中枢神经系统表现出作用。

8. 发明授权

US4740602A Indole derivatives 失效
标题翻译：吲哚衍生物
公开(公告)号：US4740602A
公开(公告)日：1988-04-26
申请号：US878559
申请日：1986-06-26
申请人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
发明人： Henning Bottcher , Hans-Heinrich Hausberg , Christoph Seyfried , Klaus-Otto Minck
IPC分类号： A61K31/435 , A61K31/47 , A61P9/12 , A61P25/00 , A61P25/20 , C07D401/06 , C07D401/12 , C07D491/04 , C07D491/048 , C07D495/04 , C07F7/18
CPC分类号： C07D401/06 , C07D401/12 , C07D491/04 , C07D495/04
摘要： New indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO.sub.2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, O-alkyl, NH.sub.2, NH-alkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, --CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 -- or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2 --,is --(CH.sub.2).sub.m --, --CH.dbd.CH--, --CHOH--, --CO--, S, SO, SO.sub.2 or O,n is 2, 3, 4 or 5 andm is 1, 2 or 3,in which the alkyl groups each have 1-4 C atoms, and their salts, have effects on the central nervous system.
摘要翻译：其中Ind是可以被羟甲基，亚甲二氧基，S-烷基，SO-烷基，SO 2 - 烷基，CN或COW基团取代的3-吲哚基，和/或可以被烷基，O-烷基，OH，F，Cl或Br取代一次或两次，W是H，OH，O-烷基，NH 2，NH-烷基或N（烷基）2，A是 - （CH 2）n - ，-CH 2 -S-CH 2 CH 2 - ， - CH 2 -SO 2 -CH 2 CH 2 - 或-CH 2 -SO 2 -CH 2 CH 2 - 是 - （CH 2）m - ， - CH = CH-，-CHOH-，-CO-， SO，SO 2或O，n为2,3,4或5，m为1,2或3，其中烷基各自具有1-4个C原子，并且其盐对中枢神经系统具有影响。

9. 发明授权

US5232931A Oxazolidinones 失效
标题翻译：奥沙利铂
公开(公告)号：US5232931A
公开(公告)日：1993-08-03
申请号：US706147
申请日：1991-05-28
申请人： Helmut Prucher , Henning Bottcher , Christoph Seyfried , Anton Haase , Klaus-Otto Minck , Rudolf Gottschlich
发明人： Helmut Prucher , Henning Bottcher , Christoph Seyfried , Anton Haase , Klaus-Otto Minck , Rudolf Gottschlich
IPC分类号： A61K31/445 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D413/14
CPC分类号： C07D413/14
摘要： Novel oxazolidinones of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, Z and n have the meanings defined herein, and their salts have effects on the central nervous system, in particular calming effects.
摘要翻译：其中R1，R2，R3，R4，Z和n具有本文定义的含义的式I的恶唑烷酮及其盐对中枢神经系统具有影响，特别是镇静作用。

10. 发明授权

US4970217A Oxazolidinones 失效
标题翻译：恶唑烷酮
公开(公告)号：US4970217A
公开(公告)日：1990-11-13
申请号：US219634
申请日：1988-07-15
申请人： Helmut Prucher , Henning Bottcher , Rudolf Gottschlich , Klaus-Otto Minck , Anton Haase , Christoph Seyfried
发明人： Helmut Prucher , Henning Bottcher , Rudolf Gottschlich , Klaus-Otto Minck , Anton Haase , Christoph Seyfried
IPC分类号： C07D263/20 , A61K31/44 , A61K31/445 , A61P25/20 , A61P25/24 , A61P25/26 , C07D413/06 , C07D413/14 , C07D471/10
CPC分类号： C07D413/06 , C07D413/14 , C07D471/10
摘要： Novel oxazolidinones of the formula I ##STR1## Z is O or S, R.sup.1 and R.sup.2 are each phenyl or benzyl radicals which are unsubstituted or mono- or disubstituted by alkyl, alkoxy, alkylthio, alkylsulfinyl and/or alkylsulfonyl having each 1-4 C atoms, alkanoyloxy and/or alkanoylamino having each 1-6 C atoms, F, Cl, Br, OH and/or CF.sub.3 or are heteroaryl radicals containing 1-4 heteroatoms and R.sup.3 and R.sup.4 are each H, alkyl or alkoxy having each 1-4 C atoms or are F, Cl, Br, OH or CF.sub.3, and also their salts have effects on the central nervous system, in particular neuroleptic effects.
摘要翻译：式I的新型恶唑烷酮其中R是O或S，R 1和R 2各自是未取代的或被烷基，烷氧基单取代或被二取代的苯基或苄基，具有1-4个C原子的烷硫基，烷基亚磺酰基和/或烷基磺酰基，每个1-6个C原子的烷酰氧基和/或烷酰基氨基，F，Cl，Br，OH和/或CF 3，或者是含1-4个杂原子的杂芳基， R 3和R 4各自为H，具有1-4个C原子的烷基或烷氧基，或者为F，Cl，Br，OH或CF 3，并且它们的盐也对中枢神经系统有影响，特别是精神抑制作用。

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