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1. 发明授权

US6114314A Formulations containing hyaluronic acid 失效
标题翻译：含有透明质酸的制剂
公开(公告)号：US6114314A
公开(公告)日：2000-09-05
申请号：US352697
申请日：1994-12-01
申请人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David W. Harper , David Hochman , Don Purschke
发明人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David W. Harper , David Hochman , Don Purschke
IPC分类号： A61K31/70
CPC分类号： A61K9/0014 , A61K31/133 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/44 , A61K31/5415 , A61K47/36 , A61K9/06
摘要： Topically applied transdermally quick penetrating (best targeting the epidermis and subsequently remaining there for a prolonged period of time) systemic independent acting, combinations and formulations which employ, combine, or incorporate a therapeutically effective non-toxic (to the patient) amount of a drug which inhibits prostaglandin synthesis together with an amount of hyaluronic acid and/or salts thereof (for example the sodium salt) and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub units of hyaluronic acid to treat a disease and condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, "liver" spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women and remain in the skin for a prolonged period of time.
摘要翻译：局部应用经皮快速穿透（最佳靶向表皮，随后长时间保留）系统性独立作用，组合和制剂，其使用，组合或并入治疗有效的无毒（至患者）量的药物其与一定量的透明质酸和/或其盐（例如钠盐）和/或透明质酸的同系物，类似物，衍生物，复合物，酯，片段和/或亚单位一起抑制前列腺素合成以治疗疾病皮肤和暴露组织的状况，例如基底细胞癌，癌前期，经常复发的光化性角化病变，真菌病变，“肝”斑点和类似病变（在大部分表皮中发现），鳞状细胞肿瘤，乳腺对皮肤的转移性癌症，皮肤原发性和转移性黑素瘤，生殖器疣宫颈癌和HPV（人乳头状瘤病毒）包括HPV的HPV 子宫颈，牛皮癣（斑块型牛皮癣和指甲银屑病），脚上的玉米和孕妇头部的脱发，并长时间保持在皮肤中。

2. 发明授权

US6103704A Therapeutic methods using hyaluronic acid 失效
标题翻译：使用透明质酸的治疗方法
公开(公告)号：US6103704A
公开(公告)日：2000-08-15
申请号：US18754
申请日：1993-02-17
申请人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David William Harper , David Hochman , Don Purschke
发明人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David William Harper , David Hochman , Don Purschke
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/36 , A61K31/725
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36
摘要： A method of accumulating a drug and a form of hyaluronic acid in the skin and/or exposed tissue of a human includes topically administering a therapeutically effective dosage amount of a formulation which comprises at least 5 mg/cm.sup.2 of the form of hyaluronic acid and a therapeutically effective amount of the drug.
摘要翻译：在人的皮肤和/或暴露组织中积聚药物和形式的透明质酸的方法包括局部施用治疗有效剂量的制剂，其包含至少5mg / cm 2的透明质酸形式和治疗有效量的药物。

3. 发明授权

US5674857A Use of hyaluronic acid to repair ischemia reperfusion damage 失效
标题翻译：使用透明质酸修复缺血再灌注损伤
公开(公告)号：US5674857A
公开(公告)日：1997-10-07
申请号：US200309
申请日：1994-02-23
申请人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein
发明人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein
IPC分类号： A61K31/728 , A61K31/70
CPC分类号： A61K31/728
摘要： A pharmaceutical composition comprising an effective non-toxic amount of hyaluronic acid (HA) and or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments and units of HA in association with a suitable diluent or pharmaceutically acceptable carrier for use in treating ischemia damage in tissue.
摘要翻译：包含有效无毒量的透明质酸（HA）及其盐和/或与适用的稀释剂或药学上可接受的载体结合使用的HA的同系物，类似物，衍生物，复合物，酯，片段和单元的有效无毒量的药物组合物治疗组织缺血损伤。

4. 发明授权

US6017900A Topical composition containing hyaluronic acid and nsaids 失效
标题翻译：含有透明质酸和纳米脂的局部组合物
公开(公告)号：US6017900A
公开(公告)日：2000-01-25
申请号：US466775
申请日：1995-06-06
申请人： Rudolf Edgar Falk , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/10 , A61K47/36 , A61K47/48
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K47/10
摘要： A pharmaceutical composition comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology or trauma of skin or exposed tissue of a human patient in need of treatment suffering from a disease or condition, each such dosage amount comprising a therapeutically effective non-toxic dosage amount of a drug for the treatment of the disease or condition of the skin or exposed tissue at the site of the pathology or trauma and an effective non-toxic dosage amount of hyaluronic acid or salts thereof or homologues, analogues, derivatives, complexes, esters, fragments, or sub-units of hyaluronic acid to transport the drug to the site of the pathology or trauma of the disease or condition.
摘要翻译：一种药物组合物，其包含多种有效的无毒剂量的用于局部施用于需要治疗患有疾病或病症的人类患者的皮肤或暴露组织的病理或创伤部位的组合物，每种这样的剂量包括治疗有效的无毒剂量的用于治疗病理或创伤部位的皮肤或暴露组织的疾病或病症的药物和有效无毒剂量的透明质酸或其盐或同系物，类似物，衍生物，复合物，酯，片段或亚单位，以将药物转运到疾病或病症的病理或创伤的部位。

5. 发明授权

US5962433A Topical composition containing hyaluronic acid and NSAIDS 失效
标题翻译：含有透明质酸和NSAIDS的局部组合物
公开(公告)号：US5962433A
公开(公告)日：1999-10-05
申请号：US466778
申请日：1995-06-06
申请人： Rudolf Edgar Falk , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/10 , A61K47/36 , A61K47/48
CPC分类号： A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K9/0014 , A61K47/10 , A61K47/44
摘要： A pharmaceutical composition is provided comprising a plurality of effective non-toxic dosage amounts of a composition for topical administration to the site of pathology and/or trauma of skin and/or exposed tissue of a human patient in need of treatment suffering from a disease or condition. Each such dosage amount comprises a therapeutically effective non-toxic (to the patient) dosage amount of a drug for the treatment of the disease and/or condition of the skin and/or exposed tissue at the site of the pathology and/or trauma and an effective non-toxic dosage amount of hyaluronic acid and/or salts thereof to transport (to facilitate or cause the transport of) the drug to the site of the pathology and/or trauma of the disease or condition.
摘要翻译：提供了一种药物组合物，其包含多种有效的无毒剂量的组合物，用于局部施用于需要治疗患有疾病的人类患者的皮肤和/或暴露组织的病理学和/或创伤部位，或条件。每个这样的剂量包括用于治疗病理和/或创伤部位的皮肤和/或暴露组织的疾病和/或状况的药物的治疗有效无毒（对患者）剂量，以及有效的无毒剂量的透明质酸和/或其盐将（以促进或导致药物转运到疾病或病症的病理学和/或创伤部位）。

6. 发明授权

US5824658A Topical composition containing hyaluronic acid and NSAIDS 失效
标题翻译：含有透明质酸和NSAIDS的局部组合物
公开(公告)号：US5824658A
公开(公告)日：1998-10-20
申请号：US468329
申请日：1995-08-07
申请人： Rudolf Edgar Falk , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/10 , A61K47/36 , A61K47/48
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K47/10
摘要： A method of treating pain topically, said method comprising administering topically to the skin or exposed tissue of a human, a dosage amount of a pharmaceutical composition, said dosage amount comprising (1) a non-steroidal anti-inflammatory drug (NSAID) in a therapeutically effective amount to treat pain of the skin or exposed tissue and (2) a form of hyaluronic acid selected from the group consisting of hyaluronic acid, its non-toxic salts and combination thereof being between 1% and 3% by weight of the composition, characterized in that said dosage amount of said composition is in a dosage form suitable for topical application to the skin or exposed tissue and in a dosage amount in which component (2) exceeds 10 mg/cm.sup.2 of the skin or exposed tissue to which the dosage amount is to be applied, and is in such form that component (2) is immediately available to transport component (1) percutaneously into the epidermis of the skin or exposed tissue to the site of trauma or pathology of pain to be treated, in the skin or exposed tissue, and wherein the molecular weight of the form of hyaluronic acid is less than 750,000 daltons.
摘要翻译：一种局部治疗疼痛的方法，所述方法包括向皮肤或暴露于人体的组织局部施用剂量的药物组合物，所述剂量包括（1）非甾体抗炎药（NSAID）治疗有效量的治疗皮肤或暴露组织的疼痛和（2）一种形式的透明质酸，其选自透明质酸，其无毒盐及其组合，占组合物重量的1％至3％其特征在于，所述组合物的所述剂量为适于局部施用于皮肤或暴露组织的剂型，并且其中组分（2）超过10mg / cm 2的皮肤或暴露组织的剂量，其中应用剂量，并且为使得组分（2）立即可用于将组分（1）经皮输送到皮肤或暴露组织的表皮至创伤或病理部位的形式在皮肤或暴露组织中待处理的疼痛，并且其中透明质酸形式的分子量小于750000道尔顿。

7. 发明授权

US5847002A Compositions, for inhibition, control and regression of angiogenesis, containing hyaluronic acid and NSAID 失效
标题翻译：用于抑制，控制和消退血管生成的组合物，其含有透明质酸和NSAID
公开(公告)号：US5847002A
公开(公告)日：1998-12-08
申请号：US461123
申请日：1995-06-05
申请人： Derek A. Willoughby , Chandan Alam , Samuel Simon Asculai , Rudolf Edgar Falk , David William Harper
发明人： Derek A. Willoughby , Chandan Alam , Samuel Simon Asculai , Rudolf Edgar Falk , David William Harper
IPC分类号： A61K45/06 , A61K31/195 , A61K31/19 , A61K31/045
CPC分类号： A61K45/06
摘要： The use of: (a) a non-steroidal anti-inflammatory agent, and (b) hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and subunits of hyaluronic acid, in the manufacture of a pharmaceutical composition for inhibiting, controlling and/or regressing angiogenesis in a therapy wherein dosage amounts taken from the composition each comprise: (1) a therapeutically effective amount of component (a); and (2) a therapeutically effective amount of the hyaluronic acid and/or salts thereof and/or homologues, analogues, derivatives, complexes, esters, fragments, and sub-units of hyaluronic acid, the pharmaceutical composition being characterized in that for each dosage amount taken from the pharmaceutical composition, the amount of components (a) and (b) inhibit, control and/or regress angiogenesis.
摘要翻译：使用：（a）非甾体抗炎剂，和（b）透明质酸和/或其盐和/或同系物，类似物，衍生物，复合物，透明质酸的酯，片段和亚单位，在制备用于在治疗中抑制，控制和/或回归血管发生的药物组合物，其中从组合物中取得的剂量各自包括：（1）治疗有效量的组分（a）; 类似物，衍生物，复合物，酯，片段和亚单位的透明质酸的治疗有效量的药物组合物，其特征在于，对于每种剂量取自药物组合物的量，组分（a）和（b）的量抑制，控制和/或退化血管发生。

8. 发明授权

US5792753A Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs 失效
标题翻译：包含透明质酸和前列腺素合成抑制药物的组合物
公开(公告)号：US5792753A
公开(公告)日：1998-08-11
申请号：US18508
申请日：1993-02-17
申请人： Rudolf Edgar Falk , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/36 , A61K31/725
CPC分类号： A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K9/0014 , A61K9/0019
摘要： A topically administrable pharmaceutical composition is disclosed which comprises a therapeutically effective amount of a drug which inhibits prostaglandin synthesis, and an amount of a form of hyaluronic acid sufficient to transport the composition through the skin into the epidermis or dermis where the composition remains until discharged via the lymphatic system, wherein (a) the drug is 1-5% by weight of the composition, and (b) the form of hyaluronic acid is 1-3% by weight of the composition, has a molecular weight greater than about 150,000 daltons and less than 750,000 daltons, and is selected from the group consisting of hyaluronic acid and salts thereof.
摘要翻译：公开了一种局部给药的药物组合物，其包含治疗有效量的抑制前列腺素合成的药物和足以将组合物通过皮肤输送到表皮或真皮中的形式的透明质酸的量，其中组合物保持直至经由淋巴系统，其中（a）药物为组合物的1-5重量％，和（b）透明质酸的形式为组合物的1-3重量％，分子量大于约150,000道尔顿和小于750000道尔顿，并且选自透明质酸及其盐。

9. 发明授权

US5834444A Hyaluronic acid and salts thereof inhibit arterial restenosis 失效
标题翻译：透明质酸及其盐抑制动脉再狭窄
公开(公告)号：US5834444A
公开(公告)日：1998-11-10
申请号：US125398
申请日：1993-09-23
申请人： Rudolf Edgar Falk , Eva Anne Turley , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Eva Anne Turley , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/70 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/10 , A61K47/36 , C08B37/00
CPC分类号： A61K9/0019 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/70 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/10
摘要： A method is provided of preventing arterial restenosis of an animal after the arteries have been traumatized. The method comprises the administration of a therapeutically effective non-toxic amount of hyaluronic acid and/or pharmaceutically acceptable salts thereof to the animal to prevent narrowing of the arteries. The form of hyaluronic acid is selected from hyaluronic acid and pharmaceutically acceptable salts thereof having a molecular weight less than 750,000 daltons.
摘要翻译：提供了一种防止动脉创伤后动脉再狭窄的方法。该方法包括向动物施用治疗有效的无毒量的透明质酸和/或其药学上可接受的盐以防止动脉变窄。透明质酸的形式选自透明质酸及其药学上可接受的盐，其分子量小于750000道尔顿。

10. 发明授权

US5639738A Treatment of basal cell carcinoma and actinic keratosis employing hyaluronic acid and NSAIDs 失效
标题翻译：使用透明质酸和NSAID治疗基底细胞癌和光化性角化病
公开(公告)号：US5639738A
公开(公告)日：1997-06-17
申请号：US838675
申请日：1992-02-21
申请人： Rudolf Edgar Falk , Samuel Simon Asculai
发明人： Rudolf Edgar Falk , Samuel Simon Asculai
IPC分类号： A61K9/00 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/5415 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/00 , A61K47/10 , A61K47/36 , A61K47/44 , A61K47/48
CPC分类号： A61K9/0014 , A61K31/19 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/407 , A61K31/44 , A61K31/455 , A61K31/503 , A61K31/5415 , A61K31/616 , A61K31/715 , A61K31/728 , A61K45/06 , A61K47/36 , A61K47/4823 , A61K47/10 , A61K47/44
摘要： A method of treating a mammal for a condition of the skin or exposed tissue selected from the group consisting of basal cell carcinoma and actinic keratosis is provided. The method consists essentially of topically administering to the site of the condition, more than once per day over a period of days sufficient to treat the condition, a non-toxic effective dosage amount of a composition consisting essentially of(a) a non-steroidal anti-inflammatory drug (NSAID) in an amount sufficient to block prostaglandin synthesis,(b) hyaluronic acid or a pharmaceutically acceptable salt thereof in an amount effective to transport said NSAID into the skin or exposed tissue at the site of the condition. The concentration of the hyaluronic add or salt thereof is between 1-3% by weight of the composition. The molecular weight of the hyaluronic acid or salt thereof is between 150,000 and 750,000 Daltons. A pharmaceutical excipient suitable for topical application is included. The NSAID in the composition may be diclofenac sodium.
摘要翻译：提供了一种治疗哺乳动物皮肤或暴露组织的方法，所述组合选自由基底细胞癌和光化性角化病组成的组。该方法基本上由局部施用于该状况的部位，每天多于足以治疗病症的几天的时间，无毒有效剂量的组合物，其基本上由（a）非甾体化合物抗炎药物（NSAID），其量足以阻断前列腺素合成，（b）透明质酸或其药学上可接受的盐，其量有效地将所述NSAID转运到所述病状部位的皮肤或暴露组织中。透明质酸添加剂或其盐的浓度为组合物重量的1-3％。透明质酸或其盐的分子量为15万至75万道尔顿。包括适用于局部应用的药物赋形剂。组合物中的NSAID可以是双氯芬酸钠。

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