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1. 发明授权

US6114314A Formulations containing hyaluronic acid 失效
标题翻译：含有透明质酸的制剂
公开(公告)号：US6114314A
公开(公告)日：2000-09-05
申请号：US352697
申请日：1994-12-01
申请人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David W. Harper , David Hochman , Don Purschke
发明人： Rudolf Edgar Falk , Samuel Simon Asculai , Ehud Shmuel Klein , David W. Harper , David Hochman , Don Purschke
IPC分类号： A61K31/70
CPC分类号： A61K9/0014 , A61K31/133 , A61K31/192 , A61K31/196 , A61K31/405 , A61K31/44 , A61K31/5415 , A61K47/36 , A61K9/06
摘要： Topically applied transdermally quick penetrating (best targeting the epidermis and subsequently remaining there for a prolonged period of time) systemic independent acting, combinations and formulations which employ, combine, or incorporate a therapeutically effective non-toxic (to the patient) amount of a drug which inhibits prostaglandin synthesis together with an amount of hyaluronic acid and/or salts thereof (for example the sodium salt) and/or homologues, analogues, derivatives, complexes, esters, fragments, and/or sub units of hyaluronic acid to treat a disease and condition of the skin and exposed tissue for example, basal cell carcinoma, the precancerous, often recurrent, actinic keratoses lesions, fungal lesions, "liver" spots and like lesions (found for the most part in the epidermis), squamous cell tumours, metastatic cancer of the breast to the skin, primary and metastatic melanoma in the skin, genital warts cervical cancer, and HPV (Human Papilloma Virus) including HPV of the cervix, psoriasis (both plaque-type psoriasis and nail bed psoriasis), corns on the feet and hair loss on the head of pregnant women and remain in the skin for a prolonged period of time.
摘要翻译：局部应用经皮快速穿透（最佳靶向表皮，随后长时间保留）系统性独立作用，组合和制剂，其使用，组合或并入治疗有效的无毒（至患者）量的药物其与一定量的透明质酸和/或其盐（例如钠盐）和/或透明质酸的同系物，类似物，衍生物，复合物，酯，片段和/或亚单位一起抑制前列腺素合成以治疗疾病皮肤和暴露组织的状况，例如基底细胞癌，癌前期，经常复发的光化性角化病变，真菌病变，“肝”斑点和类似病变（在大部分表皮中发现），鳞状细胞肿瘤，乳腺对皮肤的转移性癌症，皮肤原发性和转移性黑素瘤，生殖器疣宫颈癌和HPV（人乳头状瘤病毒）包括HPV的HPV 子宫颈，牛皮癣（斑块型牛皮癣和指甲银屑病），脚上的玉米和孕妇头部的脱发，并长时间保持在皮肤中。

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