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1. 发明授权

US5296115A Method and apparatus for improved detection of ionic species by capillary electrophoresis 失效
标题翻译：通过毛细管电泳改进离子物质检测的方法和装置
公开(公告)号：US5296115A
公开(公告)日：1994-03-22
申请号：US771336
申请日：1991-10-04
申请人： Roy D. Rocklin , Christopher A. Pohl , John Stillian , Neboisa Avdalovic
发明人： Roy D. Rocklin , Christopher A. Pohl , John Stillian , Neboisa Avdalovic
IPC分类号： G01N27/447 , G01N30/60 , G01N30/96 , G01N27/26
CPC分类号： G01N27/4473 , G01N2030/965
摘要： Apparatus and methods are provided for increasing the sensitivity of detection of ionic species separated by capillary electrophoresis. The apparatus includes capillary electrophoretic separating means, suppressor means and detector means.
摘要翻译：提供了提高通过毛细管电泳分离的离子物质检测灵敏度的装置和方法。该装置包括毛细管电泳分离装置，抑制装置和检测装置。

2. 发明授权

US5472584A Method and apparatus for improved detection of ionic species by capillary electrophoresis 失效
标题翻译：通过毛细管电泳改进离子物质检测的方法和装置
公开(公告)号：US5472584A
公开(公告)日：1995-12-05
申请号：US406764
申请日：1995-03-17
申请人： Roy D. Rocklin , Christopher A. Pohl , John Stillian , Nebojsa Avdalovic
发明人： Roy D. Rocklin , Christopher A. Pohl , John Stillian , Nebojsa Avdalovic
IPC分类号： G01N27/447 , G01N30/60 , G01N30/96 , G01N27/26
CPC分类号： G01N27/4473 , G01N2030/965
摘要： Apparatus and methods are provided for increasing the sensitivity of detection of ionic species separated by capillary electrophoresis. The apparatus includes capillary electrophoretic separating means, suppressor means and detector means.
摘要翻译：提供了提高通过毛细管电泳分离的离子物质检测灵敏度的装置和方法。该装置包括毛细管电泳分离装置，抑制装置和检测装置。

3. 发明授权

US4751189A Method for balancing background conductivity for ion chromatography 失效
标题翻译：用于离子色谱法平衡背景电导率的方法
公开(公告)号：US4751189A
公开(公告)日：1988-06-14
申请号：US838512
申请日：1986-03-11
申请人： Roy D. Rocklin
发明人： Roy D. Rocklin
IPC分类号： G01N30/60 , G01N30/96 , B01D15/08 , G01N30/02
CPC分类号： G01N30/96 , G01N2030/965 , Y10T436/255
摘要： A method of ion chromatography in which the sample passes through a chromatographic column, a suppressor, and a conductivity detector, using a gradient electrolyte eluent. A non-ionic polyhydroxy compound is added with the eluent to the chromatographic column at a concentration inversely related to the concentration of the electrolyte which increases with time. The effluent is passed through a membrane suppressor for the conductivity of the electrolyte. The regenerant stream in the suppressor includes a complexing agent (boric acid) which passes through the membrane into the effluent to form highly ionized complex which counterbalances the increased background conductivity of the electrolyte to stabilize the background conductivity in the conductor.
摘要翻译：使用梯度电解质洗脱液，其中样品通过色谱柱，抑制剂和电导率检测器的离子色谱法。将非离子多羟基化合物与洗脱液一起加入到色谱柱中，浓度与电解质浓度呈负相关，随浓度增加。流出物通过膜抑制器以获得电解质的导电性。抑制剂中的再生剂流包括络合剂（硼酸），其通过膜进入流出物以形成高度电离的络合物，其平衡电解质的增加的背景导电性以稳定导体中的背景导电性。

4. 发明授权

US06935192B2 Microfluidic bulk flow determinations based on converting heat tracer measurements 失效
标题翻译：基于转换热示踪剂测量的微流量大流量测定
公开(公告)号：US06935192B2
公开(公告)日：2005-08-30
申请号：US10675037
申请日：2003-09-30
申请人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
发明人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
IPC分类号： G01F1/708 , G01P5/06
CPC分类号： G01F1/7084
摘要： The fluid flow rate within a microfluidic passageway of a microfabricated device is determined by measuring the time-of-flight of a heat pulse coupled into the fluid. Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure and the thermal properties of the fluid and the materials used for the device.
摘要翻译：通过测量耦合到流体中的热脉冲的飞行时间来确定微加工装置的微流体通道内的流体流速。由于热迹线的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流量测量所需的适当的缩放比例。缩放因子基于结构的几何形状和流体和用于该装置的材料的热性质。

5. 发明授权

US07111501B2 Devices and methods for separating constituents 有权
标题翻译：用于分离成分的装置和方法
公开(公告)号：US07111501B2
公开(公告)日：2006-09-26
申请号：US10678332
申请日：2003-10-03
申请人： Roy D. Rocklin , Kevin P. Killeen , Hongfeng Yin
发明人： Roy D. Rocklin , Kevin P. Killeen , Hongfeng Yin
IPC分类号： G01N30/00
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/324 , G01N2030/347 , G01N2030/645
摘要： The subject invention includes constituent separation apparatuses that include a fluid pathway and a pair of spaced-apart electrodes positioned within the pathway for detecting current flow within a mobile phase present in the pathway. Coupled to the pair of spaced-apart electrodes is a mix ratio determinator for determining the mix ratio of the mobile phase from the detected current flow. Also provided are methods that include contacting a mobile phase with an apparatus for separating constituents of a mobile phase, detecting the current flow of the mobile phase when the mobile phase is in contact with the apparatus and determining the mix ratio of the mobile phase from the detected current flow. The mix ratio may be adjusted based on the determined mix ratio. Algorithms for practicing the subject methods are also provided on computer readable mediums. Systems and kits for practicing the subject methods are also provided.
摘要翻译：本发明包括构成分离装置，其包括流体通道和位于通路内的一对间隔开的电极，用于检测存在于通路中的流动相中的电流。耦合到一对间隔开的电极是用于确定流动相与检测到的电流的混合比的混合比率确定器。还提供了包括使流动相与用于分离流动相的组分的装置接触的方法，当流动相与装置接触时检测流动相的当前流量，并确定流动相与装置的混合比检测电流。可以基于所确定的混合比来调节混合比。用于实践主题方法的算法也提供在计算机可读介质上。还提供了用于实践主题方法的系统和套件。

6. 发明授权

US5441613A Methods and apparatus for real-time monitoring, measurement and control of electroosmotic flow 失效
标题翻译：电渗流实时监测，测量和控制的方法和装置
公开(公告)号：US5441613A
公开(公告)日：1995-08-15
申请号：US161942
申请日：1993-12-03
申请人： Randy M. McCormick , Roy D. Rocklin
发明人： Randy M. McCormick , Roy D. Rocklin
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44752
摘要： In capillary electrophoresis systems, real-time monitoring and measurement of the electroosmotic flow through a separation capillary is accomplished by coupling the outlet of the separation capillary to an electrically-conductive junction. In one embodiment, this junction is an ion-impermeable or an ion-exchange membrane unit that preferentially exchanges ions having a charge opposite to analyte ions of interest. Within a downstream region of the junction, all axial incremental voltage from the electroosmotic voltage source is terminated, which ensures that downstream electrolyte ion movement is passive, due to active flow created upstream when an incremental axial voltage existed. Upstream electrolyte ion flux is proportional to C.sub.1 .multidot.(.mu..sub.e +.mu..sub.eo), where C.sub.1 is the upstream concentration of the electrolyte ion of interest, .mu..sub.e is the electrolyte electrophoretic mobility, and .mu..sub.eo is the electroosmotic mobility. Downstream, the flux is proportional to C.sub.2 .multidot..mu..sub.eo, where C.sub.2 is the downstream concentration of the electrolyte ion of interest. The fluxes are equal, whereupon .mu..sub.eo .apprxeq.C.sub.1 .multidot..mu..sub.e /(C.sub.2 -C.sub.1). Since .mu..sub.e is known, .mu..sub.eo can be determined in real-time by measuring C.sub.2 and C.sub.1. In a second embodiment, the electrically-conductive junction preferably is a grounding capillary that converts plug-like electroosmotic flow to parabolic flow. A parabolic flow characteristic such as streaming potential, streaming current, or pressure differential is measured in real-time to ascertain electroosmotic flow rate. In each embodiment, the realtime measured flow information is feedback-coupled to preferably alter zeta-potential to regulate electrolyte solution flow in the separation capillary.
摘要翻译：在毛细管电泳系统中，通过分离毛细管的电渗流量的实时监测和测量是通过将分离毛细管的出口连接到导电结而实现的。在一个实施方案中，该结是离子不可渗透或离子交换膜单元，其优先交换具有与感兴趣的分析物离子相反的电荷的离子。在接头的下游区域内，来自电渗电压源的所有轴向增量电压被终止，这确保了下游电解质离子运动是被动的，这是由于当存在增量轴向电压时在上游产生的主动流。上游电解质离子通量与C1x（μe +μeo）成比例，其中C1是感兴趣的电解质离子的上游浓度，μe是电解质电泳迁移率，μeo是电渗流动性。在下游，通量与C2x muoo成比例，其中C2是感兴趣的电解质离子的下游浓度。通量相等，于是大约C1×μe /（C2-C1）。由于已知mu e可以通过测量C2和C1来实时确定。在第二实施例中，导电结优选地是将插塞状电渗流转换成抛物线的接地毛细管。实时测量流动电位，流动电流或压差等抛物线流动特征，以确定电渗流速。在每个实施例中，实时测量的流量信息被反馈耦合以优选地改变ζ电位以调节分离毛细管中的电解质溶液流。

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