专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07111501B2 Devices and methods for separating constituents 有权
标题翻译：用于分离成分的装置和方法
公开(公告)号：US07111501B2
公开(公告)日：2006-09-26
申请号：US10678332
申请日：2003-10-03
申请人： Roy D. Rocklin , Kevin P. Killeen , Hongfeng Yin
发明人： Roy D. Rocklin , Kevin P. Killeen , Hongfeng Yin
IPC分类号： G01N30/00
CPC分类号： G01N30/34 , G01N30/6095 , G01N2030/324 , G01N2030/347 , G01N2030/645
摘要： The subject invention includes constituent separation apparatuses that include a fluid pathway and a pair of spaced-apart electrodes positioned within the pathway for detecting current flow within a mobile phase present in the pathway. Coupled to the pair of spaced-apart electrodes is a mix ratio determinator for determining the mix ratio of the mobile phase from the detected current flow. Also provided are methods that include contacting a mobile phase with an apparatus for separating constituents of a mobile phase, detecting the current flow of the mobile phase when the mobile phase is in contact with the apparatus and determining the mix ratio of the mobile phase from the detected current flow. The mix ratio may be adjusted based on the determined mix ratio. Algorithms for practicing the subject methods are also provided on computer readable mediums. Systems and kits for practicing the subject methods are also provided.
摘要翻译：本发明包括构成分离装置，其包括流体通道和位于通路内的一对间隔开的电极，用于检测存在于通路中的流动相中的电流。耦合到一对间隔开的电极是用于确定流动相与检测到的电流的混合比的混合比率确定器。还提供了包括使流动相与用于分离流动相的组分的装置接触的方法，当流动相与装置接触时检测流动相的当前流量，并确定流动相与装置的混合比检测电流。可以基于所确定的混合比来调节混合比。用于实践主题方法的算法也提供在计算机可读介质上。还提供了用于实践主题方法的系统和套件。

2. 发明授权

US06935192B2 Microfluidic bulk flow determinations based on converting heat tracer measurements 失效
标题翻译：基于转换热示踪剂测量的微流量大流量测定
公开(公告)号：US06935192B2
公开(公告)日：2005-08-30
申请号：US10675037
申请日：2003-09-30
申请人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
发明人： Daniel Sobek , Hongfeng Yin , Roy D. Rocklin , Kevin Killeen
IPC分类号： G01F1/708 , G01P5/06
CPC分类号： G01F1/7084
摘要： The fluid flow rate within a microfluidic passageway of a microfabricated device is determined by measuring the time-of-flight of a heat pulse coupled into the fluid. Since the propagation velocity of the heat trace is generally slower than the mean flow rate of the flow, additional processing provides the appropriate scaling needed to obtain an accurate fluid flow rate measurement. The scaling factor is based on the geometry of the structure and the thermal properties of the fluid and the materials used for the device.
摘要翻译：通过测量耦合到流体中的热脉冲的飞行时间来确定微加工装置的微流体通道内的流体流速。由于热迹线的传播速度通常比流动的平均流速慢，所以额外的处理提供了获得准确的流体流量测量所需的适当的缩放比例。缩放因子基于结构的几何形状和流体和用于该装置的材料的热性质。

3. 发明授权

US07060975B2 Electrospray devices for mass spectrometry 有权
标题翻译：用于质谱的电喷雾装置
公开(公告)号：US07060975B2
公开(公告)日：2006-06-13
申请号：US10982189
申请日：2004-11-05
申请人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/10
CPC分类号： H01J49/165
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion. The hydrophobic coating is electrically nonconductive.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。疏水涂层是不导电的。

4. 发明授权

US07077175B2 Particle packing of microdevice 有权
标题翻译：微型装置的颗粒包装
公开(公告)号：US07077175B2
公开(公告)日：2006-07-18
申请号：US10821543
申请日：2004-04-09
申请人： Hongfeng Yin , Kevin P. Killeen , Reid A. Brennen , Uwe Effelsberg
发明人： Hongfeng Yin , Kevin P. Killeen , Reid A. Brennen , Uwe Effelsberg
IPC分类号： B65B1/04
CPC分类号： G01N30/56 , B01J2219/00466 , G01N2030/565 , G01N2035/00574
摘要： Provided are apparatuses and methods for introducing particles into a microdevice conduit. Also provided are microdevices containing a plurality of particles that occupy at least about 25 volume percent of a microconduit. In some instances, particles may controllably form a particle bridge in a bridging zone within a microdevice.
摘要翻译：提供了将颗粒引入微型设备导管中的装置和方法。还提供了包含占据至少约25体积％微管道的多个颗粒的微器件。在一些情况下，颗粒可以可控制地在微设备内的桥接区域中形成颗粒桥。

5. 发明授权

US08647590B2 Optical detection cell with micro-fluidic chip 有权
标题翻译：具有微流体芯片的光学检测单元
公开(公告)号：US08647590B2
公开(公告)日：2014-02-11
申请号：US11384149
申请日：2006-03-16
申请人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
发明人： Reid A. Brennen , Timothy Beerling , Hongfeng Yin , Kevin P. Killeen
IPC分类号： G01N21/00
CPC分类号： G01N21/05 , B01L3/502707 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N2021/0346
摘要： The present invention relates to an optical detection cell for micro-fluidics. The detection cell provides a first layer, a detection cell layer contacting the first layer, a third layer contacting the detection cell layer, a micro-fluidic chip having a fluidic port and a detection channel defined through the detection cell and being in fluid communication with the fluidic port of the chip, the detection channel serving as a light path for receiving light for detecting a molecule. Methods of detecting molecules and making the detection cell are also disclosed.
摘要翻译：本发明涉及一种用于微流体学的光学检测单元。检测单元提供第一层，接触第一层的检测单元层，接触检测单元层的第三层，具有流体端口的微流体芯片和通过检测单元限定的检测通道，并与芯片的流体端口，检测通道用作用于接收用于检测分子的光的光路。还公开了检测分子和制备检测细胞的方法。

6. 发明授权

US07314599B2 Paek embossing and adhesion for microfluidic devices 失效
标题翻译： Paek压花和微流体装置的粘附
公开(公告)号：US07314599B2
公开(公告)日：2008-01-01
申请号：US10114801
申请日：2002-04-02
申请人： Daniel B. Roitman , Kevin P. Killeen , Karen L. Seaward , Hongfeng Yin , Karla Robotti
发明人： Daniel B. Roitman , Kevin P. Killeen , Karen L. Seaward , Hongfeng Yin , Karla Robotti
IPC分类号： B32B27/04
CPC分类号： B29C66/82661 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/0689 , B01L2200/12 , B01L2300/123 , B01L2400/0622 , B01L2400/0644 , B29C43/56 , B29C59/02 , B29C59/14 , B29C59/142 , B29C65/48 , B29C65/4835 , B29C65/521 , B29C66/001 , B29C66/02 , B29C66/026 , B29C66/1122 , B29C66/53461 , B29C66/536 , B29C66/54 , B29C66/71 , B29C66/73115 , B29C66/73117 , B29C66/73771 , B29C66/73772 , B29C66/73774 , B29C66/73775 , B29C66/73776 , B29C66/73921 , B29C66/73941 , B29C66/7465 , B29C66/91411 , B29C66/91445 , B29C66/919 , B29C66/9192 , B29C66/91941 , B29C66/91943 , B29C2071/022 , B29K2071/00 , B29K2079/08 , B29K2309/08 , B29K2995/0039 , B29K2995/0041 , B29L2031/756 , B81B1/00 , B81C1/00357 , B81C2201/019 , G01N27/44791 , G01N30/60 , G01N30/6052 , G01N30/6095 , Y10T156/1023 , Y10T428/24479
摘要： A fabrication and adhesion method for a polyaryl-ether-ketone (PAEK) device, such as a microfluidic device, is disclosed. At least one glassy uncrystallized PAEK substrate is heated up to near or above the glass transition temperature to allow the substrate to crystallize from the glass state, while embossing the substrate with patterns. Bonding the PAEK substrate to another substrate is accomplished using a solvent-resistant adhesive, such as a polyimide-based adhesive, in combination with an adhesion enhancement treatment. In certain embodiments, the adhesion enhancement treatment is a plasma treatment or a chemical sulfonation treatment.
摘要翻译：公开了一种聚芳醚醚酮（PAEK）器件如微流器件的制造和粘附方法。将至少一个玻璃状未结晶的PAEK基底加热至接近或高于玻璃化转变温度，以允许基底从玻璃态结晶，同时用图案压印基底。使用耐溶剂粘合剂，例如聚酰亚胺基粘合剂，结合粘合增强处理，将PAEK基材粘合到另一基材上。在某些实施方案中，粘附增强处理是等离子体处理或化学磺化处理。

7. 发明授权

US07173240B2 Electrospray devices for mass spectrometry 有权
标题翻译：用于质谱的电喷雾装置
公开(公告)号：US07173240B2
公开(公告)日：2007-02-06
申请号：US11001268
申请日：2004-11-30
申请人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
发明人： Karen L. Seaward , Hongfeng Yin , Kevin P. Killeen , Daniel Sobek , Daniel Roitman
IPC分类号： H01J49/10
CPC分类号： H01J49/167 , G01N30/7266
摘要： An electrospray device for a mass spectrometry system is described. The electrospray device comprises a body portion and a tip portion extending from the body portion. The tip portion comprises a polymeric material. The electrospray device also comprises a hydrophobic coating substantially selectively covering the tip portion.
摘要翻译：描述了用于质谱系统的电喷雾装置。电喷雾装置包括主体部分和从主体部分延伸的尖端部分。尖端部分包括聚合材料。电喷雾装置还包括基本上选择性地覆盖尖端部分的疏水涂层。

8. 发明申请

US20100193702A1 TANDEM IONIZER ION SOURCE FOR MASS SPECTROMETER AND METHOD OF USE 有权
标题翻译：用于质谱仪的串联离子源和使用方法
公开(公告)号：US20100193702A1
公开(公告)日：2010-08-05
申请号：US12363685
申请日：2009-01-30
申请人： Gangqiang Li , Hongfeng Yin
发明人： Gangqiang Li , Hongfeng Yin
IPC分类号： H01J27/02 , H01J49/04 , H01J49/10 , H01J49/14 , H01J27/20
CPC分类号： H01J49/107 , H01J49/165
摘要： An ion source a first ionizer comprising: an electrospray needle comprising a tip; and a conduit disposed annularly about the needle and configured to pass an inert gas in proximity of the tip to nebulize a fluid emerging from the tip, the nebulized fluid comprising analytes and a mobile phase. The ion source comprises a capillary in tandem with the first ionizer and configured to receive the droplets; a heater configured to heat the capillary to a temperature at which mobile phase vaporizes; and a second ionizer in tandem with the capillary and configured to receive the vaporized mobile phase and the analytes. A method is also described.
摘要翻译：离子源，第一离子发生器，包括：电喷针，包括尖端; 以及围绕所述针环设置的导管，其被配置成使所述尖端附近的惰性气体通过，以使从所述尖端出来的流体雾化，所述雾化流体包含分析物和流动相。离子源包括与第一离子发生器串联的毛细管并且构造成接收液滴; 加热器，被配置为将毛细管加热至流动相蒸发的温度; 以及第二离子发生器，其与所述毛细管串联并且被配置为接收蒸发的流动相和所述分析物。还描述了一种方法。

9. 发明申请

US20070260624A1 Incremental update of long-term and short-term user profile scores in a behavioral targeting system 有权
标题翻译：在行为定位系统中增加长期和短期用户配置文件分数
公开(公告)号：US20070260624A1
公开(公告)日：2007-11-08
申请号：US11394358
申请日：2006-03-29
申请人： Christina Chung , Abhinav Gupta , Joshua Koran , Long-Ji Lin , Hongfeng Yin
发明人： Christina Chung , Abhinav Gupta , Joshua Koran , Long-Ji Lin , Hongfeng Yin
IPC分类号： G06F7/00
CPC分类号： G06Q30/02
摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.
摘要翻译：行为定位系统从在线活动确定用户个人资料。该系统包括多个模型，其定义用于确定用户简档分数的参数。事件信息，包括用户的在线活动，在一个实体被接收。要生成用户配置文件分数，选择一个模型。该模型包括近似度，强度和频率尺寸参数。行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。应用来自模型的参数以在类别中生成用户简档分数。行为定位系统具有在在线用户的广告投放中使用的应用。

10. 发明申请

US20070239535A1 Behavioral targeting system that generates user profiles for target objectives 有权
标题翻译：为目标目标生成用户配置文件的行为定位系统
公开(公告)号：US20070239535A1
公开(公告)日：2007-10-11
申请号：US11394332
申请日：2006-03-29
申请人： Joshua Koran , Christina Chung , Long-Ji Lin , Hongfeng Yin
发明人： Joshua Koran , Christina Chung , Long-Ji Lin , Hongfeng Yin
IPC分类号： G06Q30/00
CPC分类号： G06F17/30528 , G06F17/30294 , G06F17/30587 , G06F17/30876 , G06Q30/02 , G06Q30/0224 , G06Q30/0251
摘要： A behavioral targeting system determines user profiles from online activity. The system includes a plurality of models that define parameters for determining a user profile score. Event information, which comprises on-line activity of the user, is received at an entity. To generate a user profile score, a model is selected. The model comprises recency, intensity and frequency dimension parameters. The behavioral targeting system generates a user profile score for a target objective, such as brand advertising or direct response advertising. The parameters from the model are applied to generate the user profile score in a category. The behavioral targeting system has application for use in ad serving to on-line users.
摘要翻译：行为定位系统从在线活动确定用户个人资料。该系统包括多个模型，其定义用于确定用户简档分数的参数。事件信息，包括用户的在线活动，在一个实体被接收。要生成用户配置文件分数，选择一个模型。该模型包括近似度，强度和频率尺寸参数。行为定位系统为目标目标生成用户简档分数，例如品牌广告或直接回应广告。应用来自模型的参数以在类别中生成用户简档分数。行为定位系统具有在在线用户的广告投放中使用的应用。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式