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1. 发明授权

US07063944B1 Human methionine synthase reductase: cloning, and methods for evaluating risk of, preventing, or treating neural tube defects, cardiovascular disease, cancer, and down's syndrome 失效
标题翻译：人甲硫氨酸合成酶还原酶：克隆和评估神经管缺陷，心血管疾病，癌症和衰老综合征的风险，预防或治疗的方法
公开(公告)号：US07063944B1
公开(公告)日：2006-06-20
申请号：US09487841
申请日：2000-01-19
申请人： Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
发明人： Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
IPC分类号： C12Q1/68 , C12Q1/00 , C12P19/34 , C07H21/04
CPC分类号： C12N9/1007
摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.
摘要翻译：本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。本发明还特征在于一种用于检测高半胱氨酸血症的可能性增加的方法，反过来，增加或减少了神经管缺陷，心血管疾病，唐氏综合征或癌症的可能性。本发明还具有用于治疗和/或降低心血管疾病唐氏综合征，癌症或神经管缺陷风险的治疗方法。还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

2. 发明授权

US07045612B2 Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer 失效
标题翻译：人甲硫氨酸合成酶还原酶：克隆，评估神经管缺陷，心血管疾病和癌症风险的方法
公开(公告)号：US07045612B2
公开(公告)日：2006-05-16
申请号：US09371347
申请日：1999-08-10
申请人： Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
发明人： Roy A. Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
IPC分类号： C12N15/53 , C12N9/02 , C12N15/00 , C12N5/00 , C12N1/20 , C12Q1/26 , C12P21/06 , C07H21/04
CPC分类号： C12N9/1007
摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.
摘要翻译：本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。本发明还特征在于一种用于检测增加的高同型半胱氨酸血症的可能性以及神经管缺陷，心血管疾病或癌症的增加或减少的可能性的方法。本发明还具有用于治疗和/或降低心血管疾病，癌症或神经管缺陷风险的治疗方法。还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

3. 发明申请

US20050191701A1 Human methionine synthase reductase: cloning, and methods for evaluating risk of neural tube deffects, cardiovascular disease, cancer and Down's Syndrome 审中-公开
标题翻译：人甲硫氨酸合成酶还原酶：克隆和评估神经管的影响，心血管疾病，癌症和唐氏综合征风险的方法
公开(公告)号：US20050191701A1
公开(公告)日：2005-09-01
申请号：US11119096
申请日：2005-04-29
申请人： Roy Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
发明人： Roy Gravel , Rima Rozen , Daniel Leclerc , Aaron Wilson , David Rosenblatt
IPC分类号： B60J7/10 , C12N9/10 , C12Q1/68
CPC分类号： C12N9/1007
摘要： The invention features a novel gene encoding methionine synthase reductase. The invention also features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects, cardiovascular disease, Down's Syndrome or cancer. The invention also features therapeutic methods for treating and/or reducing the risk of cardiovascular disease, Down's Syndrome, cancer, or neural tube defects. Also provided are the sequences of the human methionine synthase reductase gene and protein and compounds and kits for performing the methods of the invention.
摘要翻译：本发明的特征在于一种编码甲硫氨酸合成酶还原酶的新基因。本发明还特征在于一种用于检测高半胱氨酸血症的可能性增加的方法，反过来，增加或减少了神经管缺陷，心血管疾病，唐氏综合征或癌症的可能性。本发明还具有用于治疗和/或降低心血管疾病唐氏综合征，癌症或神经管缺陷风险的治疗方法。还提供了人甲硫氨酸合酶还原酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

4. 发明授权

US06703197B1 Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer 失效
标题翻译：人甲硫氨酸合酶：克隆，评估神经管缺陷，心血管疾病和癌症风险的方法
公开(公告)号：US06703197B1
公开(公告)日：2004-03-09
申请号：US08980326
申请日：1997-11-26
申请人： Roy A. Gravel , Rima Rozen , Daniel LeClerc , Philippe Goyette , Eric Campeau
发明人： Roy A. Gravel , Rima Rozen , Daniel LeClerc , Philippe Goyette , Eric Campeau
IPC分类号： C07H2102
CPC分类号： C12Q1/6883 , C07H21/02 , C07H21/04 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156
摘要： The invention features a method for detecting an increased likelihood of hyperhomocysteinemia and, in turn, an increased or decreased likelihood of neural tube defects or cardiovascular disease. The invention also features therapeutic methods for reducing the risk of neural tube defects, colon cancers and related cancers. Also provided are the sequences of the human methionine synthase gene and protein and compounds and kits for performing the methods of the invention.
摘要翻译：本发明的特征在于一种用于检测高同型半胱氨酸血症的可能性增加的方法，反过来，神经管缺陷或心血管疾病的可能性增加或降低。本发明还具有降低神经管缺陷，结肠癌和相关癌症风险的治疗方法。还提供了人甲硫氨酸合酶基因和蛋白质的序列，以及用于实施本发明方法的化合物和试剂盒。

5. 发明授权

US06566065B1 Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene 有权
标题翻译：通过检测（MTHFR）基因突变诊断精神分裂症的方法
公开(公告)号：US06566065B1
公开(公告)日：2003-05-20
申请号：US09592595
申请日：2000-06-12
申请人： Rima Rozen
发明人： Rima Rozen
IPC分类号： C12Q168
CPC分类号： C12N9/0028 , A61K38/00 , A61K48/00 , C12N9/0026 , C12Q1/6883 , C12Q2600/156 , C12Y105/0102
摘要： The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.
摘要翻译：本发明的特征在于诊断具有或患有疾病或病症（例如精神病）的受试者的方法。还提供了用于选择特定受试者或一组受试者的优选疗法的方法。

6. 发明申请

US20100003672A1 CDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE AND USES THEREOF 审中-公开
标题翻译：人类甲磺酸降钙素CDNA及其用途
公开(公告)号：US20100003672A1
公开(公告)日：2010-01-07
申请号：US12027128
申请日：2008-02-06
申请人： Rima Rozen
发明人： Rima Rozen
IPC分类号： C12Q1/68
CPC分类号： C12N9/0028 , A61K38/00 , A61K48/00 , C12N9/0026 , C12Q1/6883 , C12Q2600/156 , C12Y105/0102
摘要： The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.
摘要翻译：本发明的特征在于诊断具有或患有疾病或病症（例如精神病）的受试者的方法。还提供了用于选择特定受试者或一组受试者的优选疗法的方法。

7. 发明授权

US07319145B2 Methylenetetrahydrofolate reductase inhibitors and use thereof 失效
标题翻译：亚甲基四氢叶酸还原酶抑制剂及其用途
公开(公告)号：US07319145B2
公开(公告)日：2008-01-15
申请号：US10433392
申请日：2001-12-03
申请人： Rima Rozen , Jaspreet Sekhon
发明人： Rima Rozen , Jaspreet Sekhon
IPC分类号： C07H21/04 , A61K31/70 , C07H21/00
CPC分类号： A61K38/44 , C07K16/40 , C12Y105/0102
摘要： The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors for use in selective inhibition of cancer cell growth in a mammal. These inhibitors can be a small molecule, an antisense oligonucleotide, a ribozyme, a triple helix forming oligonucleotide, an anti-MTHFR antibody or fragment thereof, an MTHFR mutant or a fragment of MTHFR. The present invention further provides nucleic acids encoding an inhibitor of MTHFR, and vectors comprising these nucleic acids. Also encompassed by the present invention are methods of using the MTHFR inhibitors for selective inhibition of cancer cell growth, and pharmaceutical compositions comprising the MTHFR inhibitors.
摘要翻译：本发明提供用于选择性抑制哺乳动物癌细胞生长的亚甲基四氢叶酸还原酶（MTHFR）抑制剂。这些抑制剂可以是小分子，反义寡核苷酸，核酶，形成三螺旋的寡核苷酸，抗MTHFR抗体或其片段，MTHFR突变体或MTHFR的片段。本发明还提供了编码MTHFR抑制剂的核酸和包含这些核酸的载体。本发明还包括使用MTHFR抑制剂选择性抑制癌细胞生长的方法和包含MTHFR抑制剂的药物组合物。

8. 发明授权

US06528259B1 Methods for detecting human methylenetetrahydrofolate reductase allelic variants 有权
标题翻译：检测人亚甲基四氢叶酸还原酶等位变体的方法
公开(公告)号：US06528259B1
公开(公告)日：2003-03-04
申请号：US09660872
申请日：2000-09-13
申请人： Rima Rozen , Philippe Goyette
发明人： Rima Rozen , Philippe Goyette
IPC分类号： C12Q168
CPC分类号： C12N9/0026 , A61K31/495 , A61K38/00 , A61K48/00 , C12N9/0028 , C12Q1/6883 , C12Q2600/156
摘要： Provided herein is a heretofore unknown isolated nucleic acid molecule which encodes human methylenetetrahydrofolate reducatase, along with an amino acid sequence of methylenetetrahydrofolate reductase, and a cDNA probe for human methylenetetrahydrofolate reductase. Also provided are a molecule description of mutations in humans resulting in a phenotype having reduced levels of methylenetetrahydrofolate reductase, and methods of diagnosing methylenetetrahydrofolate reductase deficiency in a human.
摘要翻译：本文提供了迄今为止未知的分离的核酸分子，其编码人亚甲基四氢叶酸还原酶以及亚甲基四氢叶酸还原酶的氨基酸序列和人亚甲基四氢叶酸还原酶的cDNA探针。还提供了人类突变的分子描述，导致具有降低的亚甲基四氢叶酸还原酶水平的表型，以及诊断人中亚甲基四氢叶酸还原酶缺陷的方法。

9. 发明授权

US06218120B1 Methods for detecting human methylene tetrahydrofolate reductase allelic variants 有权
标题翻译：检测人亚甲基四氢叶酸还原酶等位变体的方法
公开(公告)号：US06218120B1
公开(公告)日：2001-04-17
申请号：US09258928
申请日：1999-03-01
申请人： Rima Rozen , Philippe Goyette
发明人： Rima Rozen , Philippe Goyette
IPC分类号： C12Q168
CPC分类号： C12N9/0026 , A61K31/495 , A61K38/00 , A61K48/00 , C12N9/0028 , C12Q1/6883 , C12Q2600/156
摘要： Provided herein is a heretofore unknown isolated nucleic acid molecule which encodes human methylenetetrahydrofolate reducatase, along with an amino acid sequence of methylenetetrahydrofolate reductase, and a cDNA probe for human methylenetetrahydrofolate reductase. Also provided are a molecule description of mutations in humans resulting in a phenotype having reduced levels of methylenetetrahydrofolate reductase, and methods of diagnosing methylenetetrahydrofolate reductase deficiency in a human.
摘要翻译：本文提供了迄今为止未知的分离的核酸分子，其编码人亚甲基四氢叶酸还原酶以及亚甲基四氢叶酸还原酶的氨基酸序列和人亚甲基四氢叶酸还原酶的cDNA探针。还提供了人类突变的分子描述，导致具有降低的亚甲基四氢叶酸还原酶水平的表型，以及诊断人中亚甲基四氢叶酸还原酶缺陷的方法。

10. 发明申请

US20050222063A1 Methylenetetrahydrofolate reductase inhibitors and use thereof 审中-公开
标题翻译：亚甲基四氢叶酸还原酶抑制剂及其用途
公开(公告)号：US20050222063A1
公开(公告)日：2005-10-06
申请号：US10831759
申请日：2004-04-23
申请人： Rima Rozen , Jaspreet Sekhon
发明人： Rima Rozen , Jaspreet Sekhon
IPC分类号： A61K48/00 , C07H21/02 , C12N15/11 , C12N15/113
CPC分类号： C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2320/31 , C12Y105/0102
摘要： The present invention provides methylenetetrahydrofolate reductase (MTHFR) inhibitors, such as antisense oligonucleotides, for use in selective inhibition of cancer cell growth in a mammal. The present invention further provides methods of using the MTHFR inhibitors, alone or in combination with one or more standard chemotherapeutics, for selective inhibition of cancer cell growth.
摘要翻译：本发明提供用于选择性抑制哺乳动物癌细胞生长的亚甲基四氢叶酸还原酶（MTHFR）抑制剂，例如反义寡核苷酸。本发明还提供了单独或与一种或多种标准化学治疗剂组合使用MTHFR抑制剂用于选择性抑制癌细胞生长的方法。

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