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1. 发明申请

WO2006126040A1 BACTERIAL AND BACTERIAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译：细菌和细菌相关的MIRNAS及其用途
公开(公告)号：WO2006126040A1
公开(公告)日：2006-11-30
申请号：PCT/IB2005/002702
申请日：2005-05-25
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir
发明人： BENTWICH, Itzhak , AVNIEL, Amir
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as "Genomic Address Messenger" or "GAM" oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as "Genomic Record" or "GR" polynucleotide. GAM oligonucleotides selectively inhibit translation of known "target" genes, many of which are known to be involved in various bacterial infections. Nucleic acid molecules are provided respectively encoding 21,916 bacterial and 6,100 human GAM precursor oligonucleotides, and 6,056 bacterial and 430 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新的细菌和人类相关寡核苷酸，这里被鉴定为“基因组地址信使”或“GAM”寡核苷酸，以及第二组新的操纵子样细菌和人多核苷酸，这里被鉴定为“基因组记录 “或”GR“多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种细菌感染。分别提供核酸分子，编码21,916个细菌和6,100个人GAM前体寡核苷酸，以及6,056个细菌和430个人GR多核苷酸，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统功能和用途，用于检测GAM寡核苷酸和GR多核苷酸的表达，并用于选择性增强和选择性抑制其各自靶基因的翻译。

2. 发明申请

WO2009125401A3 COMPOSITIONS AND METHODS FOR ENHANCING OIL CONTENT IN PLANTS 审中-公开
公开(公告)号：WO2009125401A3
公开(公告)日：2009-10-15
申请号：PCT/IL2009/000394
申请日：2009-04-07
申请人： ROSETTA GENOMICS LTD. , MAOR, Rudy , SITBON, Einat , AVNIEL, Amir
发明人： MAOR, Rudy , SITBON, Einat , AVNIEL, Amir
IPC分类号： C12N15/82 , C12N15/11
摘要： The present invention provides transgenic plants with altered oil content. The invention further provides nucleic acid sequences and methods for generating such plants.

3. 发明申请

WO2005116250A3 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
公开(公告)号：WO2005116250A3
公开(公告)日：2005-12-08
申请号：PCT/IB2005/002352
申请日：2005-05-26
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir
发明人： BENTWICH, Itzhak , AVNIEL, Amir
IPC分类号： C12Q1/68
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.

4. 发明申请

WO2005111211A3 MICRONAS AND USES THEREOF 审中-公开
公开(公告)号：WO2005111211A3
公开(公告)日：2005-11-24
申请号：PCT/IB2005/002383
申请日：2005-05-14
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

5. 发明申请

WO2006092738A3 MICRORNAS AND RELATED NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2006092738A3
公开(公告)日：2006-09-08
申请号：PCT/IB2006/001400
申请日：2006-02-07
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12N15/11
摘要： Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.

6. 发明公开

EP1784501A2 VIRAL AND VIRUS-ASSOCIATED MIRNAS AND USES THEREOF 有权
标题翻译：微小RNA及其用途
公开(公告)号：EP1784501A2
公开(公告)日：2007-05-16
申请号：EP05766834.5
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

7. 发明公开

EP3040423A2 MICRORNA AND USES THEREOF 无效
标题翻译： MICRORNA及其使用
公开(公告)号：EP3040423A2
公开(公告)日：2016-07-06
申请号：EP15190323.4
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： An isolated nucleic acid molecule which is from 18 to 24 nucleotides in length and comprising at least 12 contiguous nucleotides at least 90% identical to SEQ ID NO: 20613 or the complement thereof, or which is from 18 to 100 nucleotides in length and comprising at least 12 contiguous nucleotides at least 80% identical to the sequence of SEQ ID NO: 6716 or the complement thereof; an isolated nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 20613 or SEQ ID NO: 6716; a probe complementary to SEQ ID NO: 20613 or SEQ ID NO: 6716; and uses thereof.
摘要翻译：分离的核酸分子，其长度为18至24个核苷酸并且包含与SEQ ID NO：20613或其互补序列至少90％相同的至少12个连续核苷酸，或者其长度为18至100个核苷酸并且包含与SEQ ID NO：6716的序列或其互补序列至少80％相同的至少12个连续核苷酸; 包含SEQ ID NO：20613或SEQ ID NO：6716的核苷酸序列或由其组成的分离的核酸分子; 与SEQ ID NO：20613或SEQ ID NO：6716互补的探针; 及其用途。

8. 发明公开

EP3231876A1 NEW MICRORNA AND USES THEREOF 无效
标题翻译：新的MICRORNA及其应用
公开(公告)号：EP3231876A1
公开(公告)日：2017-10-18
申请号：EP17164692.0
申请日：2005-05-14
申请人： Rosetta Genomics Ltd.
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： An isolated nucleic acid of 18 to 24 nucleotides in length selected from a nucleic acid comprising at least 18 contiguous nucleotides of SEQ ID NO: 1; a DNA encoding a nucleic acid comprising at least 18 contiguous nucleotides of SEQ ID NO: 1; or the complement thereof.
摘要翻译：选自包含SEQ ID NO：1的至少18个连续核苷酸的核酸的长度为18至24个核苷酸的分离的核酸; 编码包含SEQ ID NO：1的至少18个连续核苷酸的核酸的DNA; 或其补体。

9. 发明公开

EP1751311A2 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译： VIRALE UND VIRUS-ASSOZIIERTE MIRNAS UND DEREN VERWENDUNG
公开(公告)号：EP1751311A2
公开(公告)日：2007-02-14
申请号：EP05774516.8
申请日：2005-05-26
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir
IPC分类号： C12Q1/68
CPC分类号： C12N7/00 , C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2330/10 , C12N2710/16221 , C12Q1/701
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.
摘要翻译：本文描述了与病毒感染相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定病毒感染调节剂的方法。

10. 发明公开

EP3040423A3 MICRORNA AND USES THEREOF 无效
标题翻译：微RNA及其用途
公开(公告)号：EP3040423A3
公开(公告)日：2016-10-26
申请号：EP15190323.4
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： An isolated nucleic acid molecule which is from 18 to 24 nucleotides in length and comprising at least 12 contiguous nucleotides at least 90% identical to SEQ ID NO: 20613 or the complement thereof, or which is from 18 to 100 nucleotides in length and comprising at least 12 contiguous nucleotides at least 80% identical to the sequence of SEQ ID NO: 6716 or the complement thereof; an isolated nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 20613 or SEQ ID NO: 6716; a probe complementary to SEQ ID NO: 20613 or SEQ ID NO: 6716; and uses thereof.

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