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1. 发明申请

WO2006126040A1 BACTERIAL AND BACTERIAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
标题翻译：细菌和细菌相关的MIRNAS及其用途
公开(公告)号：WO2006126040A1
公开(公告)日：2006-11-30
申请号：PCT/IB2005/002702
申请日：2005-05-25
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir
发明人： BENTWICH, Itzhak , AVNIEL, Amir
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q2600/158 , C12Q2600/178
摘要： The present invention relates to a first group of novel bacterial and human associated oligonucleotides, here identified as "Genomic Address Messenger" or "GAM" oligonucleotide, and a second group of novel operon-like bacterial and human polynucleotides, here identified as "Genomic Record" or "GR" polynucleotide. GAM oligonucleotides selectively inhibit translation of known "target" genes, many of which are known to be involved in various bacterial infections. Nucleic acid molecules are provided respectively encoding 21,916 bacterial and 6,100 human GAM precursor oligonucleotides, and 6,056 bacterial and 430 human GR polynucleotides, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM oligonucleotides and GR polynucleotides and specific functions and utilities thereof, for detecting expression of GAM oligonucleotides and GR polynucleotides, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及第一组新的细菌和人类相关寡核苷酸，这里被鉴定为“基因组地址信使”或“GAM”寡核苷酸，以及第二组新的操纵子样细菌和人多核苷酸，这里被鉴定为“基因组记录 “或”GR“多核苷酸。 GAM寡核苷酸选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种细菌感染。分别提供核酸分子，编码21,916个细菌和6,100个人GAM前体寡核苷酸，以及6,056个细菌和430个人GR多核苷酸，以及包含核酸分子的载体和探针，以及用于检测GAM寡核苷酸和GR多核苷酸的方法和系统功能和用途，用于检测GAM寡核苷酸和GR多核苷酸的表达，并用于选择性增强和选择性抑制其各自靶基因的翻译。

2. 发明申请

WO2005116250A3 VIRAL AND VIRAL ASSOCIATED MIRNAS AND USES THEREOF 审中-公开
公开(公告)号：WO2005116250A3
公开(公告)日：2005-12-08
申请号：PCT/IB2005/002352
申请日：2005-05-26
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir
发明人： BENTWICH, Itzhak , AVNIEL, Amir
IPC分类号： C12Q1/68
摘要： Described herein are novel polynucleotides associated with viral infections. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of viral infections.

3. 发明申请

WO2004048511A3 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL VIRAL REGULATORY GENES AND USES THEREOF 审中-公开
公开(公告)号：WO2004048511A3
公开(公告)日：2004-06-10
申请号：PCT/IL2003/000998
申请日：2003-11-26
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak
发明人： BENTWICH, Itzhak
IPC分类号： G01N33/48
摘要： The present invention relates to a first group of novel genes, here identified as genomic address messenger or VGAM genes, and a second group of novel operon-like genes, here identified as viral genomic record or VGR genes. VGAM genes selectively inhibit translation of known `target' genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 1560 VGAM genes, and 205 VGR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting VGAM and VGR genes and specific functions and utilities thereof, for detecting expression of VGAM and VGR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.

4. 发明申请

WO2004044123A2 BIOINFORMATICALLY DETECTABLE GROUP OF NOVEL REGULATORY GENES AND USES THEREOF 审中-公开
标题翻译：生物检测的新型法规基因组及其用途
公开(公告)号：WO2004044123A2
公开(公告)日：2004-05-27
申请号：PCT/IL2003/000970
申请日：2003-11-16
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak
发明人： BENTWICH, Itzhak
IPC分类号： C12N
CPC分类号： C12N15/113 , C12N2310/14 , C12N2330/10 , G06F19/16 , G06F19/18
摘要： The present invention relates to a first group of novel genes, here identified as genomic address messenger or GAM genes, and a second group of novel operon-like genes, here identified as genomic record or GR genes. GAM genes selectively inhibit translation of known ‘target’ genes, many of which are known to be involved in various diseases. Nucleic acid molecules are provided respectively encoding 8607 GAM genes, and 1096 GR genes, as are vectors and probes both comprising the nucleic acid molecules, and methods and systems for detecting GAM and GR genes and specific functions and utilities thereof, for detecting expression of GAM and GR genes, and for selectively enhancing and selectively inhibiting translation of the respective target genes thereof.
摘要翻译：本发明涉及这里被鉴定为基因组地址信使或GAM基因的第一组新基因和第二组新的操纵子样基因，这里被鉴定为基因组记录或GR基因。 GAM基因选择性地抑制已知的“靶”基因的翻译，其中许多已知涉及各种疾病。提供分别编码8607个GAM基因和1096个GR基因的核酸分子，以及包含核酸分子的载体和探针以及用于检测GAM和GR基因的方法和系统及其特异功能和用途，用于检测GAM的表达和GR基因，并且用于选择性增强和选择性抑制其各自的靶基因的翻译。

5. 发明申请

WO2005111211A3 MICRONAS AND USES THEREOF 审中-公开
公开(公告)号：WO2005111211A3
公开(公告)日：2005-11-24
申请号：PCT/IB2005/002383
申请日：2005-05-14
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

6. 发明申请

WO2006092738A3 MICRORNAS AND RELATED NUCLEIC ACIDS 审中-公开
公开(公告)号：WO2006092738A3
公开(公告)日：2006-09-08
申请号：PCT/IB2006/001400
申请日：2006-02-07
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12N15/11
摘要： Described herein are novel polynucleotides associated with disease. The polynucleotides are miRNAs, miRNA precursors, and associated nucleic acids. Methods and compositions are described that can be used for diagnosis, prognosis, and treatment of disease. Also described herein are methods that can be used to identify modulators of the disease-associated polynucleotides. Also described herein are methods and compositions for linear amplification and labeling of a targeted nucleic acid. The amplified targeted molecules may be used in hybridization techniques like Luminex and Microarray analysis.

7. 发明申请

WO2006033020A2 METHODS AND APPARATUS FOR THE DETECTION AND VALIDATION OF MICRORNAS 审中-公开
标题翻译： MICRORNAS检测和验证的方法和装置
公开(公告)号：WO2006033020A2
公开(公告)日：2006-03-30
申请号：PCT/IB2005/003493
申请日：2005-04-26
申请人： ROSETTA GENOMICS LTD. , BENTWICH, Itzhak
发明人： BENTWICH, Itzhak
IPC分类号： C07H21/02 , C12N15/11 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12Q1/6809 , C12Q2525/207 , C12Q2525/155 , C12Q2525/143
摘要： The present invention provides methods and apparatus for detecting, sequencing, cloning and otherwise validating nucleic acids, including microRNAs. The methods make use of a plurality of sequence--specific recognition reagents which can also be used for classification of biological samples, and to characterize the expression of certain microRNAs.
摘要翻译：本发明提供用于检测，测序，克隆和以其他方式验证核酸包括微小RNA的方法和装置。该方法利用多个序列特异性识别试剂，也可用于生物样品的分类，并表征某些微小RNA的表达。

8. 发明公开

EP3040423A2 MICRORNA AND USES THEREOF 无效
标题翻译： MICRORNA及其使用
公开(公告)号：EP3040423A2
公开(公告)日：2016-07-06
申请号：EP15190323.4
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/10 , C12N2320/11 , C12N2330/10 , C12Q1/6809 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/178
摘要： An isolated nucleic acid molecule which is from 18 to 24 nucleotides in length and comprising at least 12 contiguous nucleotides at least 90% identical to SEQ ID NO: 20613 or the complement thereof, or which is from 18 to 100 nucleotides in length and comprising at least 12 contiguous nucleotides at least 80% identical to the sequence of SEQ ID NO: 6716 or the complement thereof; an isolated nucleic acid molecule comprising or consisting of the nucleotide sequence of SEQ ID NO: 20613 or SEQ ID NO: 6716; a probe complementary to SEQ ID NO: 20613 or SEQ ID NO: 6716; and uses thereof.
摘要翻译：分离的核酸分子，其长度为18至24个核苷酸并且包含与SEQ ID NO：20613或其互补序列至少90％相同的至少12个连续核苷酸，或者其长度为18至100个核苷酸并且包含与SEQ ID NO：6716的序列或其互补序列至少80％相同的至少12个连续核苷酸; 包含SEQ ID NO：20613或SEQ ID NO：6716的核苷酸序列或由其组成的分离的核酸分子; 与SEQ ID NO：20613或SEQ ID NO：6716互补的探针; 及其用途。

9. 发明公开

EP1784501A2 VIRAL AND VIRUS-ASSOCIATED MIRNAS AND USES THEREOF 有权
标题翻译：微小RNA及其用途
公开(公告)号：EP1784501A2
公开(公告)日：2007-05-16
申请号：EP05766834.5
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.

10. 发明授权

EP1784501B1 VIRAL AND VIRUS ASSOCIATED MicroRNAS AND USES THEREOF 有权
标题翻译： MICRO-RNAS UND DEREN VERWENDUNG
公开(公告)号：EP1784501B1
公开(公告)日：2015-11-18
申请号：EP05766834.5
申请日：2005-05-14
申请人： Rosetta Genomics Ltd
发明人： BENTWICH, Itzhak , AVNIEL, Amir , KAROV, Yael , AHARONOV, Ranit
IPC分类号： C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/531 , C12N2320/10 , C12N2320/11 , C12N2320/30 , C12N2330/10 , C12Q1/6809 , C12Q1/6876 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , Y02A90/26
摘要： Described herein are novel polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and compositions that can be used for diagnosis, prognosis, and treatment of those medical conditions are disclosed. Also described herein are methods that can be used to identify modulators of prostate and lung cancer.
摘要翻译：本文描述的是与前列腺和肺癌相关的新型多核苷酸。多核苷酸是miRNA和miRNA前体。公开了可用于诊断，预后和治疗这些医疗条件的相关方法和组合物。本文还描述了可用于鉴定前列腺和肺癌调节剂的方法。

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