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1. 发明授权

US07098040B2 Self-contained swab-based diagnostic systems 有权
标题翻译：独立的基于拭子的诊断系统
公开(公告)号：US07098040B2
公开(公告)日：2006-08-29
申请号：US10744235
申请日：2003-12-23
申请人： Rosann Marie Matthews Kaylor , RameshBabu Boga , Kaiyuan Yang , David Samuel Cohen , Herb Velazquez , Amanda Lee O'Connor
发明人： Rosann Marie Matthews Kaylor , RameshBabu Boga , Kaiyuan Yang , David Samuel Cohen , Herb Velazquez , Amanda Lee O'Connor
IPC分类号： G01N33/558
CPC分类号： G01N1/02 , C12M33/02 , G01N2001/028 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/81
摘要： A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second end. A swab is disposed at the first end of the stem, the swab being configured to collect a test sample derived from a biological source that is suspected of containing an analyte. The test unit also comprises a fluid chamber configured to contain a fluid, wherein the fluid chamber is in fluid communication with the swab via the flow channel. The test unit also comprises a rupturable seal that inhibits leakage of the fluid from the fluid chamber prior to use, and an assay for detecting the presence or absence of the analyte. The assay is in fluid communication with the swab, the flow channel, and the fluid chamber.
摘要翻译：提供诊断测试单元。测试单元包括具有第一端和第二端的杆，所述杆限定在第一端和第二端之间延伸的至少一个流动通道。拭子设置在茎的第一端，拭子被配置成收集来自怀疑含有分析物的生物来源的测试样品。测试单元还包括被配置为容纳流体的流体室，其中流体室经由流动通道与拭子流体连通。测试单元还包括可破坏的密封，其在使用之前抑制流体从流体室的泄漏，以及用于检测分析物的存在或不存在的测定。测定与拭子，流动通道和流体室流体连通。

2. 发明授权

US07094528B2 Magnetic enzyme detection techniques 有权
公开(公告)号：US07094528B2
公开(公告)日：2006-08-22
申请号：US10881316
申请日：2004-06-30
申请人： Xuedong Song , Shu-Ping Yang , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Shu-Ping Yang , Rosann Marie Matthews Kaylor
IPC分类号： C12Q1/00
CPC分类号： G01N33/558 , C12Q1/04 , G01N33/543 , G01N33/54326 , G01N33/58 , G01N33/68
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.

3. 发明授权

US08003399B2 Nitrite detection technique 有权
标题翻译：亚硝酸盐检测技术
公开(公告)号：US08003399B2
公开(公告)日：2011-08-23
申请号：US11217099
申请日：2005-08-31
申请人： Xuedong Song , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/526 , G01N2800/348 , Y10T436/173076
摘要： A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.
摘要翻译：提供了用于检测测试样品中亚硝酸盐存在或不存在的诊断测试试剂盒。测试试剂盒包括能够与亚硝酸盐反应形成重氮离子的芳族伯胺。测试试剂盒还包括侧流装置，其包括色谱介质和在流过色谱介质之后接收测试样品的吸收材料。色谱介质限定了检测区，其中含有能够与重氮离子反应形成指示剂（例如偶氮化合物）的检测试剂（例如亲核芳族胺）。指示剂显示与检测试剂的颜色不同的颜色。

4. 发明授权

US07939342B2 Diagnostic test kits employing an internal calibration system 有权
标题翻译：使用内部校准系统的诊断测试套件
公开(公告)号：US07939342B2
公开(公告)日：2011-05-10
申请号：US11094498
申请日：2005-03-30
申请人： Xuedong Song , Chibueze Obi Chidebelu-Eze , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Chibueze Obi Chidebelu-Eze , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10T436/10 , Y10T436/105831
摘要： A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.
摘要翻译：公开了一种使用横向流动测定装置和用于检测测试样品内的测试分析物的多种测定试剂的诊断测试试剂盒。测定试剂包括能够产生表示测试样品中测试分析物的存在或数量的检测信号的检测探针。为了进一步提高检测精度，还可以使用能够产生表示校准分析物的存在或数量的校准信号的校准探针。校准信号可用于校准检测信号。

5. 发明申请

US20110097820A1 Swab-Based Diagnostic Systems 审中-公开
标题翻译：基于拭子的诊断系统
公开(公告)号：US20110097820A1
公开(公告)日：2011-04-28
申请号：US12982452
申请日：2010-12-30
申请人： Robert John Lyng , Jeffrey Eldon Fish , Rosann Marie Matthews Kaylor , Naveen Agarwal , Lei Huang , John Albert Shuty
发明人： Robert John Lyng , Jeffrey Eldon Fish , Rosann Marie Matthews Kaylor , Naveen Agarwal , Lei Huang , John Albert Shuty
IPC分类号： G01N33/543 , G01N1/28
CPC分类号： A61B5/14546 , A61B5/150015 , A61B5/150022 , A61B5/150251 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/157 , A61B10/0051 , A61B2010/0009 , Y10T436/25 , Y10T436/25125
摘要： A diagnostic test system for detecting the presence or absence of an analyte within a test sample is provided. For instance, the system may include a swab and a detection unit. The detection unit includes a first component that is capable of receiving the swab, the first component defining an insertion chamber within which a fluid is capable of being retained. The detection unit also includes a second component that defines a detection chamber within which an assay for detecting the presence or absence of the analyte is capable of being contained. The first component is rotatable relative to the second component from an inactive position to an active position. In the inactive position, the fluid remains substantially contained within the insertion chamber. In the active position, the fluid may flow from the insertion chamber to the detection chamber and contact the assay.
摘要翻译：提供了用于检测测试样品中有无分析物的诊断测试系统。例如，系统可以包括拭子和检测单元。检测单元包括能够接收拭子的第一部件，第一部件限定插入室，流体能够保持在该插入室中。检测单元还包括限定检测室的第二组分，其中能够包含用于检测分析物的存在或不存在的测定。第一组件可相对于第二组件从非活动位置旋转到活动位置。在非活动位置，流体基本上保持在插入腔内。在活动位置，流体可以从插入室流到检测室并接触测定。

6. 发明授权

US07863053B2 Swab-based diagnostic systems 有权
标题翻译：基于拭子的诊断系统
公开(公告)号：US07863053B2
公开(公告)日：2011-01-04
申请号：US10744607
申请日：2003-12-23
申请人： Robert John Lyng , Jeffrey Eldon Fish , Rosann Marie Matthews Kaylor , Naveen Agarwal , Lei Huang , John Albert Shuty
发明人： Robert John Lyng , Jeffrey Eldon Fish , Rosann Marie Matthews Kaylor , Naveen Agarwal , Lei Huang , John Albert Shuty
IPC分类号： G01N21/03
CPC分类号： A61B5/14546 , A61B5/150015 , A61B5/150022 , A61B5/150251 , A61B5/150305 , A61B5/150343 , A61B5/150358 , A61B5/157 , A61B10/0051 , A61B2010/0009 , Y10T436/25 , Y10T436/25125
摘要： A diagnostic test system for detecting the presence or absence of an analyte within a test sample is provided. For instance, the system may include a swab and a detection unit. The detection unit includes a first component that is capable of receiving the swab, the first component defining an insertion chamber within which a fluid is capable of being retained. The detection unit also includes a second component that defines a detection chamber within which an assay for detecting the presence or absence of the analyte is capable of being contained. The first component is rotatable relative to the second component from an inactive position to an active position. In the inactive position, the fluid remains substantially contained within the insertion chamber. In the active position, the fluid may flow from the insertion chamber to the detection chamber and contact the assay.
摘要翻译：提供了用于检测测试样品中有无分析物的诊断测试系统。例如，系统可以包括拭子和检测单元。检测单元包括能够接收拭子的第一部件，第一部件限定插入室，流体能够保持在该插入室中。检测单元还包括限定检测室的第二组分，其中可以包含用于检测分析物的存在或不存在的测定。第一组件可相对于第二组件从非活动位置旋转到活动位置。在非活动位置，流体基本上保持在插入腔内。在活动位置，流体可以从插入室流到检测室并接触测定。

7. 发明授权

US07670786B2 Membrane-based assay devices 有权
标题翻译：基于膜的测定装置
公开(公告)号：US07670786B2
公开(公告)日：2010-03-02
申请号：US11876018
申请日：2007-10-22
申请人： Xuedong Song , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

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