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1. 发明授权

US07094528B2 Magnetic enzyme detection techniques 有权
公开(公告)号：US07094528B2
公开(公告)日：2006-08-22
申请号：US10881316
申请日：2004-06-30
申请人： Xuedong Song , Shu-Ping Yang , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Shu-Ping Yang , Rosann Marie Matthews Kaylor
IPC分类号： C12Q1/00
CPC分类号： G01N33/558 , C12Q1/04 , G01N33/543 , G01N33/54326 , G01N33/58 , G01N33/68
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.

2. 发明授权

US08003399B2 Nitrite detection technique 有权
标题翻译：亚硝酸盐检测技术
公开(公告)号：US08003399B2
公开(公告)日：2011-08-23
申请号：US11217099
申请日：2005-08-31
申请人： Xuedong Song , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/543 , G01N33/558
CPC分类号： G01N33/526 , G01N2800/348 , Y10T436/173076
摘要： A diagnostic test kit for detecting the presence or absence of nitrites within a test sample is provided. The test kit comprises an aromatic primary amine that is capable of reacting with a nitrite to form a diazonium ion. The test kit also comprises a lateral flow device that comprises a chromatographic medium and an absorbent material that receives the test sample after flowing through the chromatographic medium. The chromatographic medium defines a detection zone within which is contained a detection reagent (e.g., nucleophilic aromatic amine) that is capable of reacting with the diazonium ion to form an indicator (e.g., azo compound). The indicator exhibits a color that is different than the color of the detection reagent.
摘要翻译：提供了用于检测测试样品中亚硝酸盐存在或不存在的诊断测试试剂盒。测试试剂盒包括能够与亚硝酸盐反应形成重氮离子的芳族伯胺。测试试剂盒还包括侧流装置，其包括色谱介质和在流过色谱介质之后接收测试样品的吸收材料。色谱介质限定了检测区，其中含有能够与重氮离子反应形成指示剂（例如偶氮化合物）的检测试剂（例如亲核芳族胺）。指示剂显示与检测试剂的颜色不同的颜色。

3. 发明授权

US07939342B2 Diagnostic test kits employing an internal calibration system 有权
标题翻译：使用内部校准系统的诊断测试套件
公开(公告)号：US07939342B2
公开(公告)日：2011-05-10
申请号：US11094498
申请日：2005-03-30
申请人： Xuedong Song , Chibueze Obi Chidebelu-Eze , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Chibueze Obi Chidebelu-Eze , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , Y10T436/10 , Y10T436/105831
摘要： A diagnostic test kit that employs a lateral flow assay device and a plurality of assay reagents for detecting a test analyte within a test sample is disclosed. The assay reagents include detection probes that are capable of producing a detection signal representing the presence or quantity of the test analyte in the test sample. To further enhance detection accuracy, calibration probes are also used that are capable of producing a calibration signal representing the presence or quantity of a calibration analyte. The calibration signal may be utilized to calibrate the detection signal.
摘要翻译：公开了一种使用横向流动测定装置和用于检测测试样品内的测试分析物的多种测定试剂的诊断测试试剂盒。测定试剂包括能够产生表示测试样品中测试分析物的存在或数量的检测信号的检测探针。为了进一步提高检测精度，还可以使用能够产生表示校准分析物的存在或数量的校准信号的校准探针。校准信号可用于校准检测信号。

4. 发明授权

US07670786B2 Membrane-based assay devices 有权
标题翻译：基于膜的测定装置
公开(公告)号：US07670786B2
公开(公告)日：2010-03-02
申请号：US11876018
申请日：2007-10-22
申请人： Xuedong Song , Rosann Marie Matthews Kaylor
发明人： Xuedong Song , Rosann Marie Matthews Kaylor
IPC分类号： G01N33/53
CPC分类号： G01N33/54326 , G01N21/274 , G01N21/6408 , G01N33/525 , G01N33/558 , G01N33/582 , G01N2021/6439 , Y10S435/803 , Y10S435/805 , Y10S435/97 , Y10S436/80 , Y10S436/806 , Y10S436/824 , Y10T436/13
摘要： A membrane-based assay device for detecting the presence or quantity of an analyte residing in a test sample is provided. The device utilizes a self-calibrated magnetic binding assay format (e.g., sandwich, competitive, etc.) that includes detection probes capable of generating a detection signal (e.g., fluorescent non-magnetic particles) and calibration probes capable of generating a calibration signal (e.g., fluorescent magnetic particles). The amount of the analyte within the test sample is proportional (e.g., directly or inversely) to the intensity of the detection signal calibrated by the intensity of the calibration signal. It has been discovered that the fluidics-based device of the present invention provides an accurate, inexpensive, and readily controllable method of determining the presence of an analyte in a test sample.
摘要翻译：提供了一种用于检测驻留在测试样品中的分析物的存在或数量的基于膜的测定装置。该装置使用包括能够产生检测信号的检测探针（例如，荧光非磁性颗粒）和能够产生校准信号的校准探针的自校准磁结合测定格式（例如，夹层，竞争性等）例如荧光磁性颗粒）。测试样品内的分析物的量与由校准信号的强度校准的检测信号的强度成正比（例如，直接或反向）。已经发现，本发明的基于流体的装置提供了确定测试样品中分析物的存在的精确，便宜且易于控制的方法。

5. 发明申请

US20060057661A1 Magnetic enzyme detection techniques 有权
标题翻译：磁性酶检测技术
公开(公告)号：US20060057661A1
公开(公告)日：2006-03-16
申请号：US10881316
申请日：2004-06-30
申请人： Xuedong Song , Shu-Ping Yang , Rosann Kaylor
发明人： Xuedong Song , Shu-Ping Yang , Rosann Kaylor
IPC分类号： C12Q1/68 , C12Q1/26
CPC分类号： G01N33/558 , C12Q1/04 , G01N33/543 , G01N33/54326 , G01N33/58 , G01N33/68
摘要： A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
摘要翻译：提供了用于检测酶或酶抑制剂的存在或数量的诊断测试试剂盒。诊断试剂盒利用反应性配合物来促进酶或酶抑制剂的检测。反应性配合物包括与报告物和磁性物质连接（例如共价键合，物理吸附等）的底物。在一个实施方案中，例如，将肽，蛋白质或糖蛋白底物连接到报告物（例如，染色的胶乳颗粒）和磁性颗粒。在该实施方案中，底物提供蛋白水解酶的切割靶。具体地，当与反应性配合物接触时，蛋白水解酶切割底物并释放报告物和/或磁性颗粒。由释放的记者展示的信号可以用于指示测试样品中酶或酶抑制剂的存在或数量。

6. 发明授权

US09404905B2 Water-based wetness-indicating composition and sensor 有权
标题翻译：水性湿指示组合物和传感器
公开(公告)号：US09404905B2
公开(公告)日：2016-08-02
申请号：US13777846
申请日：2013-02-26
申请人： Ronnie Lee Phillips , Jeffery Richard Seidling , Corey Thomas Cunningham , Xuedong Song
发明人： Ronnie Lee Phillips , Jeffery Richard Seidling , Corey Thomas Cunningham , Xuedong Song
IPC分类号： C09D5/00 , G01N33/18 , C09D11/03 , B05D1/02 , B05D1/18 , B05D1/28 , B05D3/00 , C09D11/037 , C09D11/50
CPC分类号： G01N33/18 , B05D1/02 , B05D1/18 , B05D1/28 , B05D3/007 , C09D11/03 , C09D11/037 , C09D11/50
摘要： A color-appearing ink composition includes a surfactant blend of at least two non-ionic surfactants having hydrophilic-lipophilic balance values greater than 10, or a non-ionic surfactant having a hydrophilic-lipophilic balance value greater than 10 and a charged surfactant. The composition includes one or more water-insoluble leuco dyes, a developer and a desensitizer. The composition may be applied to a substrate to form a sensor.
摘要翻译：显色油墨组合物包括具有大于10的亲水 - 亲油平衡值的至少两种非离子表面活性剂的表面活性剂共混物或亲水亲油平衡值大于10的非离子表面活性剂和带电表面活性剂。该组合物包括一种或多种水不溶性无色染料，显影剂和脱敏剂。组合物可以施加到基底以形成传感器。

7. 发明授权

US09265856B2 Multiple component materials having a color-changing composition 有权
标题翻译：具有变色组合物的多组分材料
公开(公告)号：US09265856B2
公开(公告)日：2016-02-23
申请号：US12825877
申请日：2010-06-29
申请人： Xuedong Song , Thomas M. Ales, III
发明人： Xuedong Song , Thomas M. Ales, III
IPC分类号： G01N21/75 , A61L15/56 , A61F13/42 , C09B7/00 , G01N31/22 , G01N33/566 , G01N21/78 , G01N33/84 , G01N21/81 , G01N21/29 , G01N33/52 , G01N33/543 , G01N21/80 , G01N21/84
CPC分类号： A61L15/56 , A61F13/42 , C09B7/00 , G01N21/29 , G01N21/78 , G01N21/80 , G01N21/81 , G01N21/8483 , G01N31/22 , G01N31/222 , G01N33/525 , G01N33/54386 , G01N33/566 , G01N33/84 , Y10T428/24802 , Y10T428/2481
摘要： The present invention relates to a multiple-component material including a substrate and a printed layer on the substrate. The printed layer includes a color-changing composition to indicate a change in condition, such as a change in pH. The color-changing composition includes a matrix-forming component, a colorant, a surfactant and a pH adjuster. The pH adjuster includes a low molecular weight organic acid and a high molecular weight organic acid.
摘要翻译：本发明涉及一种多组分材料，包括基材和印刷层。印刷层包括变色组合物，以指示条件的变化，例如pH的变化。变色组合物包括基质形成组分，着色剂，表面活性剂和pH调节剂。 pH调节剂包括低分子量有机酸和高分子量有机酸。

8. 发明授权

US09103796B2 Multi-layered devices for analyte detection 有权
标题翻译：用于分析物检测的多层设备
公开(公告)号：US09103796B2
公开(公告)日：2015-08-11
申请号：US11956420
申请日：2007-12-14
申请人： Xuedong Song
发明人： Xuedong Song
IPC分类号： G01N21/78 , G01N33/52 , G01N21/77
CPC分类号： G01N21/78 , C12Q1/44 , G01N33/525 , G01N33/84 , G01N2021/752 , G01N2021/7759
摘要： A multi-layered device for detecting the presence or absence of an analyte within a test sample is described. The device includes a sensing layer and a control layer. The sensing layer is configured to support a reaction so as to exhibit a signal indicative of the presence or absence of the analyte in the test sample. The control layer is in fluid communication with and vertically adjacent to the sensing layer and includes a reagent capable of inhibiting the reaction and/or other unwanted side reactions at the sensing layer after a certain period of time by diffusive movement of the reagent from the control layer to the sensing layer.
摘要翻译：描述了用于检测测试样品中有无分析物的多层装置。该装置包括感测层和控制层。感测层被配置为支持反应以便表现出指示测试样品中分析物的存在或不存在的信号。控制层与感测层流体连通并垂直相邻，并且包括能够在一定时间段之后通过试剂从控制器的扩散运动来抑制反应和/或感测层处的其它不期望的副反应的试剂层到感测层。

9. 发明授权

US08742198B2 Dehydration sensors having polymeric base-buffered inks 有权
标题翻译：具有聚合物基底缓冲油墨的脱水传感器
公开(公告)号：US08742198B2
公开(公告)日：2014-06-03
申请号：US12957542
申请日：2010-12-01
申请人： Ning Wei , Xuedong Song , Ronnie L. Phillips
发明人： Ning Wei , Xuedong Song , Ronnie L. Phillips
IPC分类号： A61F13/15
CPC分类号： G01N21/78 , A61F13/84 , A61F2013/8473 , G01N33/521
摘要： A dehydration sensor having a stable, printable, buffered-ink composition that enables one to miniaturize the detection zone and permits both buffer and indicator dye to be applied in the same area of a detection zone, without need for a conventional, large buffer pad region. The ink composition includes a weak polymeric base as its primary buffering agent.
摘要翻译：一种具有稳定的可印刷缓冲油墨组合物的脱水传感器，其使得能够使检测区域小型化并且允许将缓冲液和指示剂染料施加在检测区域的相同区域中，而不需要常规的大的缓冲垫区域。油墨组合物包括弱聚合物基料作为其主要缓冲剂。

10. 发明申请

US20140066870A1 Color-Changing Composition And Material 有权
标题翻译：变色组合物和材料
公开(公告)号：US20140066870A1
公开(公告)日：2014-03-06
申请号：US13596605
申请日：2012-08-28
申请人： JunMo Gil , Ning Wei , JinHo Ryu , Xuedong Song
发明人： JunMo Gil , Ning Wei , JinHo Ryu , Xuedong Song
IPC分类号： C09D11/02 , A61L15/56
CPC分类号： C09D11/50 , A61F13/42 , A61F2013/422 , C09D11/037
摘要： The present disclosure relates to a color-changing composition and to a substrate having the color-changing compositions disposed thereon. The color-changing composition includes a leuco dye, a color-developer and a desensitizer. The color-changing composition changes from a colorless or largely colorless composition to color upon being wetted with an aqueous liquid. The color-changing composition remains colorless or largely colorless prior to exposure to high relative humidity conditions.
摘要翻译：本公开涉及一种变色组合物和其上设置有变色组合物的基底。变色组合物包括无色染料，显色剂和脱敏剂。颜色变化组合物在用含水液体润湿时从无色或基本无色的组合物变为颜色。变色组合物在暴露于高相对湿度条件之前保持无色或大部分无色。

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