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1. 发明申请

US20100238441A1 DEVICE FOR IMAGING THE INTERIOR OF AN OPTICALLY TURBID MEDIUM AND RECEPTACLE UNIT FOR SUCH A DEVICE 有权
标题翻译：用于成像用于这种装置的光学涡卷介质和插座单元的内部的装置
公开(公告)号：US20100238441A1
公开(公告)日：2010-09-23
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/49 , G01N21/00
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

2. 发明授权

US09488574B2 Device for imaging the interior of an optically turbid medium and receptacle unit for such a device 有权
标题翻译：用于对用于这种装置的光学混浊介质和插座单元的内部进行成像的装置
公开(公告)号：US09488574B2
公开(公告)日：2016-11-08
申请号：US12682939
申请日：2008-10-13
申请人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
发明人： Thomas Koehler , Tim Nielsen , Bernhard Brendel , Andy Ziegler , Ronny Ziegler , Levinus Pieter Bakker , Martinus Bernardus Van Der Mark
IPC分类号： G01N21/47 , A61B5/00 , G01N21/17
CPC分类号： G01N21/4795 , A61B5/0073 , A61B5/0091 , A61B5/4312 , A61B2562/146 , G01N2021/1787 , G01N2201/0826 , G01N2201/0833
摘要： A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.
摘要翻译：提供了用于对光学混浊介质的内部成像的装置（1）。该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

3. 发明授权

US08520921B2 Method for reconstructing a fluorescent image of the interior of a turbid medium and device for imaging the interior of a turbid medium 有权
标题翻译：用于重建浑浊介质内部的荧光图像的方法和用于对浑浊介质的内部进行成像的装置
公开(公告)号：US08520921B2
公开(公告)日：2013-08-27
申请号：US12933887
申请日：2009-03-20
申请人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
IPC分类号： G06K9/00
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6428
摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . , λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
摘要翻译：提供了一种用于重建浑浊介质内部的荧光图像的方法。该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。荧光造影剂能够在照射光时在第一波长范围内发光。该方法还包括：通过随后用来自多个不同源位置的光照射浑浊介质（1）并检测从浑浊介质发出的光，以多个不同波长（兰德，兰布克）进行衰减测量 1）在每个源位置的多个检测位置; 根据衰减测量重建吸收性质（mu（r，λ））作为多个不同波长的混浊介质（1）内部的位置的函数;计算作为内部位置的函数的吸收特性用于波长第一波长范围的混浊介质（1）;通过随后用引起荧光对比剂的光在多个源位置发射第一波长范围内的光来照射浑浊介质来进行荧光测量以及在每个源位置的多个检测位置中检测从荧光对比剂发出的光;以及从所述荧光测量中使用所述荧光测量重建所述浑浊介质（1）内的荧光对比剂的空间分布的荧光图像，使用计算吸收性能。

4. 发明申请

US20110026851A1 METHOD FOR RECONSTRUCTING A FLUORESCENT IMAGE OF THE INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF A TURBID MEDIUM 有权
标题翻译：用于重建涡轮介质内部的荧光图像的方法和用于成像涡轮介质的内部的装置
公开(公告)号：US20110026851A1
公开(公告)日：2011-02-03
申请号：US12933887
申请日：2009-03-20
申请人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Andy Ziegler , Tim Nielsen
IPC分类号： G06K9/40 , G01J1/58
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6428
摘要： A method for reconstructing a fluorescence image of the interior of a turbid medium is provided. The method comprises the step: accommodating a turbid medium (1) to which a fluorescent contrast agent has been administered in a measurement volume (4). The fluorescent contrast agent is capable of emitting light in a first range of wavelengths upon irradiation with light. The method further comprises: performing attenuation measurements at a plurality of different wavelengths (λi, . . . λk) by subsequently irradiating the turbid medium (1) with light from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of detection positions for each source position; reconstructing absorption properties (μa(r, λ)) as a function of the position in the interior of the turbid medium (1) for the plurality of different wavelengths from the attenuation measurements; calculating absorption properties as a function of the position in the interior of the turbid medium (1) for wavelengths of the first range of wavelengths; performing a fluorescence measurement by subsequently irradiating the turbid medium (1) with light causing the fluorescent contrast agent to emit light in the first range of wavelengths from the plurality of source positions and detecting the light emanating from the fluorescent contrast agent in the plurality of detection positions for each source position; and reconstructing a fluorescence image of the spatial distribution of the fluorescent contrast agent in the interior of the turbid medium (1) from the fluorescence measurement using the calculated absorption properties.
摘要翻译：提供了一种用于重建浑浊介质内部的荧光图像的方法。该方法包括以下步骤：在测量体积（4）中容纳已投与荧光造影剂的混浊介质（1）。荧光造影剂能够在照射光时在第一波长范围内发光。该方法还包括：通过随后用来自多个不同源位置的光照射混浊介质（1）并检测从浑浊介质（1）发出的光，在多个不同波长（λ1，...λk）下执行衰减测量）在每个源位置的多个检测位置中; 根据衰减测量，重建作为多个不同波长的混浊介质（1）内部位置的函数的吸收特性（μa（r，λ））; 计算作为第一波长范围波长的混浊介质（1）内部位置的函数的吸收特性; 通过随后用引起荧光对比剂的光在多个源位置的第一波长范围内发射光，并在多个检测中检测从荧光对比剂发出的光，进行荧光测量每个来源职位的职位; 以及使用所计算的吸收特性，从所述荧光测量重建所述浑浊介质（1）内的所述荧光造影剂的空间分布的荧光图像。

5. 发明申请

US20100014084A1 IMAGING OF A TURBID MEDIUM 有权
标题翻译：涡轮介质的成像
公开(公告)号：US20100014084A1
公开(公告)日：2010-01-21
申请号：US12518891
申请日：2007-12-12
申请人： Ronny Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Tim Nielsen
IPC分类号： G01N21/84
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312
摘要： An imaging system for imaging of a turbid medium comprises a radiation source to illuminate an object to be imaged. A detection system detects radiation from the object and includes a separation module which distinguishes radiation components having respective wavelength ranges. An analysis module forms a comparison of respective radiation components. An image dataset is reconstructed on the basis of the comparison of respective radiation components. The comparison e.g. involves (i) the ratio of the levels of the high-wavelength radiation component to the low-wavelength radiation component, or (ii) i the relative difference of the levels of high-wavelength radiation component to the detected radiation, or (iiii) the relative difference of the levels of the high-wavelength radiation component to the low-wavelength radiation component. Good contrast in the reconstructed image is achieved when the comparison is relatively more beneficial to one of the wavelength ranges to the other ones over the relevant range of concentration of contrast agent. Accordingly, in the comparison competition among wavelength ranges is such that the intensity (or photon count) of that one wavelength range dominates so that any contrast in that one wavelength range does not suffer from contrast inversion.
摘要翻译：用于对混浊介质进行成像的成像系统包括用于照射待成像物体的辐射源。检测系统检测来自物体的辐射，并且包括区分具有各个波长范围的辐射分量的分离模块。分析模块形成各个辐射分量的比较。基于各个辐射分量的比较来重建图像数据集。比较例如涉及（i）高波长辐射分量与低波长辐射分量的比例，或（ii）i是高波长辐射分量与检测到的辐射的相对差，或者（iiii）高波长辐射分量与低波长辐射分量的相对差异。当比较在造影剂浓度的相关范围内比较对其中一个波长范围相对更有利时，可以实现重建图像中的良好的对比度。因此，在波长范围内的比较比较中，使得该一个波长范围的强度（或光子计数）成为主导，使得该一个波长范围内的任何对比度都不会遭受对比反转。

6. 发明授权

US07986411B2 Imaging of a turbid medium 有权
标题翻译：浑浊介质成像
公开(公告)号：US07986411B2
公开(公告)日：2011-07-26
申请号：US12518891
申请日：2007-12-12
申请人： Ronny Ziegler , Tim Nielsen
发明人： Ronny Ziegler , Tim Nielsen
IPC分类号： G01N21/00
CPC分类号： G01N21/4795 , A61B5/0091 , A61B5/4312
摘要： An imaging system for imaging of a turbid medium comprises a radiation source to illuminate an object to be imaged. A detection system detects radiation from the object and includes a separation module which separates and distinguishes radiation components having respective wavelength ranges. An analysis module forms a comparison of respective radiation components. An image dataset is reconstructed on the basis of the comparison of respective radiation components. The comparison may involve the ratio of the levels of the high-wavelength radiation component to the low-wavelength radiation component, the relative difference of the levels of high-wavelength radiation component to the detected radiation, and the relative difference of the levels of the high-wavelength radiation component to the low-wavelength radiation component.
摘要翻译：用于对混浊介质进行成像的成像系统包括用于照射待成像物体的辐射源。检测系统检测来自物体的辐射，并且包括分离和区分具有各个波长范围的辐射分量的分离模块。分析模块形成各个辐射分量的比较。基于各个辐射分量的比较来重建图像数据集。该比较可以包括高波长辐射分量与低波长辐射分量的比值，高波长辐射分量的水平与检测到的辐射的相对差异，以及高波长辐射分量到低波长辐射分量。

7. 发明授权

US07672424B2 Image reconstruction with voxel dependent interpolation 有权
标题翻译：用体素依赖插值进行图像重建
公开(公告)号：US07672424B2
公开(公告)日：2010-03-02
申请号：US11575902
申请日：2005-09-22
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Roland Proksa , Dominic J. Heuscher
IPC分类号： A61B6/00
CPC分类号： G06T11/006
摘要： A radiographic imaging apparatus includes a radiation detector (16) and a radiation source (12) which projects a non-parallel beam of radiation into field of view (14). A footprint of each voxel (v) which is projected on the detector (16) is corrected based on the position of the voxel (v) in the field of view (14) in relation to the radiation detector (16) and the radiation source (12). The contributions from substantially parallel redundant projections are further combined based on a fractional distance frac from a center point (82) of the voxel (v) to a center of each of the adjacent redundant projections.
摘要翻译：放射线照相成像装置包括辐射检测器（16）和辐射源（12），其将非平行辐射束投射到视场（14）中。基于在视场（14）中相对于放射线检测器（16）的体素（v）的位置和辐射源（v）来校正投影在检测器（16）上的每个体素（v）的足迹（12）。基于从体素（v）的中心点（82）到每个相邻冗余投影的中心的分数距离压裂进一步组合基本上平行的冗余投影的贡献。

8. 发明申请

US20100030084A1 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
公开(公告)号：US20100030084A1
公开(公告)日：2010-02-04
申请号：US12514589
申请日：2007-11-12
申请人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
发明人： Andy Ziegler , Thomas Koehler , Tim Nielsen , Martinus Bernardus Van Der Mark , Michael Cornelis Van Beek , Levinus Pieter Bakker
IPC分类号： A61B6/00 , G06K9/00
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.

9. 发明授权

US07676018B2 Efficient iterative four-dimensional cardiac cone-beam CT reconstruction 有权
标题翻译：高效迭代四维心脏锥束CT重建
公开(公告)号：US07676018B2
公开(公告)日：2010-03-09
申请号：US12065615
申请日：2006-09-01
申请人： Michael Grass , Andy Ziegler , Tim Nielsen
发明人： Michael Grass , Andy Ziegler , Tim Nielsen
IPC分类号： A61B6/00
CPC分类号： A61B6/032 , A61B6/027 , A61B6/541 , G06T11/006 , G06T2211/412 , G06T2211/424
摘要： The increasing cone angle of current high-end and future CT systems leads to a decrease in image quality if approximate cone-beam reconstruction methods are used. According to an exemplary embodiment of the present invention, an iterative four-dimensional cardiac CT reconstruction is provided, in which phase volumes are selected from the four-dimensional data set, each having the same spatial volume at different phase points. Corresponding voxels inside these phase volumes are then forward projected onto the same projection. After calculation of a different projection, these voxels are updated. This may provide for an efficient implementation of an iterative four-dimensional cardiac cone-beam CT reconstruction.
摘要翻译：目前高端和未来CT系统锥角的增加导致使用近似锥束重建方法时图像质量下降。根据本发明的示例性实施例，提供了一种迭代的四维心脏CT重建，其中从四维数据集中选择相位体积，每个四维数据集在不同相位处具有相同的空间体积。然后将这些相位体积内的相应体素向前投影到相同的投影上。在计算了不同的投影之后，这些体素被更新。这可以提供迭代四维心脏锥束CT重建的有效实施。

10. 发明申请

US20080267480A1 Iterative Image Reconstruction of a Moving Object From Projection Data 审中-公开
标题翻译：投影数据中移动物体的迭代图像重建
公开(公告)号：US20080267480A1
公开(公告)日：2008-10-30
申请号：US12097544
申请日：2006-12-08
申请人： Tim Nielsen , Michael Grass , Andy Ziegler
发明人： Tim Nielsen , Michael Grass , Andy Ziegler
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , G06T2211/412 , G06T2211/424
摘要： Iterative methods for reconstructing an image sequence of a moving object based on projection data usually require a high computationally effort. According to embodiments of the present invention there is provided such a method wherein a first image representing the object at a first phase is used as an initial image for iteratively reconstructing a second image at a second phase. A first gating function is assigned to the first phase, a second gating function is assigned to the second phase. When executing a first iteration for reconstructing the second image only projection data corresponding to a non-overlapping part of the two gating functions are used. For executing further iterations the amount of projection data corresponding to the overlapping part of the two gating functions may be gradually increased. Therefore, for all further but the last iteration the computationally effort is significantly reduced. However, this low computationally expense has no negative impact on the quality of the finally reconstructed second image because the method benefits from the fact that the first image was used as the initial image for iteratively reconstructing the second image.
摘要翻译：基于投影数据重建移动物体的图像序列的迭代方法通常需要较高的计算量。根据本发明的实施例，提供了这样的方法，其中将表示第一阶段的对象的第一图像用作用于在第二阶段迭代重建第二图像的初始图像。第一门控功能被分配给第一阶段，第二门控功能被分配给第二阶段。当执行用于重构第二图像的第一次迭代时，仅使用与两个门控功能的非重叠部分相对应的投影数据。为了执行进一步的迭代，可以逐渐增加对应于两个门控功能的重叠部分的投影数据量。因此，对于所有进一步但最后的迭代，计算量的努力显着降低。然而，这种低的计算费用对最终重建的第二图像的质量没有负面影响，因为该方法受益于第一图像被用作用于迭代重建第二图像的初始图像的事实。

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