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1. 发明申请

US20050281445A1 System and method for locating and accessing a blood vessel 失效
标题翻译：用于定位和访问血管的系统和方法
公开(公告)号：US20050281445A1
公开(公告)日：2005-12-22
申请号：US11022569
申请日：2004-12-22
申请人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
发明人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
IPC分类号： G06K9/00 , G06K9/40 , G06T5/00 , G06T5/10
CPC分类号： A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B5/489 , A61B5/742 , G06T5/004 , G06T5/009 , G06T5/10 , G06T5/20 , G06T2207/10048 , G06T2207/30101
摘要： An imaging system for locating subcutaneous blood vessels and a method for locating subcutaneous blood vessels using the system. The system includes at least one infrared emitter an infrared detector, a computing unit that enhances images and outputs enhanced images in substantially real time, a display device for displaying enhanced images, and a power source. The method includes the steps of preparing a body target area, putting on the headset, powering up the system, locating a target blood vessel, inserting a needle into the target blood vessel, and performing the medical procedure.
摘要翻译：用于定位皮下血管的成像系统和使用该系统定位皮下血管的方法。该系统包括至少一个红外发射器，红外检测器，基本上实时增强图像和输出增强图像的计算单元，用于显示增强图像的显示装置和电源。该方法包括准备身体目标区域，戴上头戴式耳机，上电系统，定位目标血管，将针头插入目标血管，并执行医疗程序的步骤。

2. 发明授权

US07532746B2 System and method for locating and accessing a blood vessel 失效
标题翻译：用于定位和访问血管的系统和方法
公开(公告)号：US07532746B2
公开(公告)日：2009-05-12
申请号：US11022569
申请日：2004-12-22
申请人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
发明人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
IPC分类号： G06K9/00
CPC分类号： A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B5/489 , A61B5/742 , G06T5/004 , G06T5/009 , G06T5/10 , G06T5/20 , G06T2207/10048 , G06T2207/30101
摘要： An imaging system for locating subcutaneous blood vessels and a method for locating subcutaneous blood vessels using the system. The system includes at least one infrared emitter an infrared detector, a computing unit that enhances images and outputs enhanced images in substantially real time, a display device for displaying enhanced images, and a power source. The method includes the steps of preparing a body target area, putting on the headset, powering up the system, locating a target blood vessel, inserting a needle into the target blood vessel, and performing the medical procedure.
摘要翻译：用于定位皮下血管的成像系统和使用该系统定位皮下血管的方法。该系统包括至少一个红外发射器，红外检测器，基本上实时增强图像和输出增强图像的计算单元，用于显示增强图像的显示装置和电源。该方法包括准备身体目标区域，戴上头戴式耳机，上电系统，定位目标血管，将针头插入目标血管，并执行医疗程序的步骤。

3. 发明申请

US20060173351A1 System and method for inserting a needle into a blood vessel 审中-公开
标题翻译：将针插入血管的系统和方法
公开(公告)号：US20060173351A1
公开(公告)日：2006-08-03
申请号：US11028467
申请日：2005-01-03
申请人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
发明人： Ronald Marcotte , Mark Arsenault , Dominic Pelletier , Walter Hebold , Milton Waner , Louis Fink
IPC分类号： A61B6/00
CPC分类号： A61B17/3403 , A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B5/489 , A61B2090/373
摘要： A needle insertion system and method. The insertion system includes an imaging system and a needle. The imaging system includes at least one infrared emitter an infrared detector, a computing unit, a display device, and a power source. The method includes the steps of preparing a body target area, putting on the headset, powering up the system, locating a target blood vessel, picking up the needle, aligning the needle with the target blood vessel, inserting the needle, advancing the needle until a sufficient depth of penetration has been reached, and withdrawing the needle.
摘要翻译：针插入系统和方法。插入系统包括成像系统和针。成像系统包括至少一个红外发射器，红外检测器，计算单元，显示装置和电源。该方法包括以下步骤：准备身体目标区域，戴上头戴式耳机，上电系统，定位目标血管，拾起针头，将针与目标血管对准，插入针头，推进针直到已经达到了足够的穿透深度，并且拔出针头。

4. 发明申请

US20090318891A1 Delivery device, system, and method for delivering substances into blood vessels 审中-公开
标题翻译：用于将物质输送到血管中的输送装置，系统和方法
公开(公告)号：US20090318891A1
公开(公告)日：2009-12-24
申请号：US11398507
申请日：2006-04-05
申请人： Ronald Marcotte , Walter Hebold , Milton Waner , Louis Fink , Mark Cowperthwaite
发明人： Ronald Marcotte , Walter Hebold , Milton Waner , Louis Fink , Mark Cowperthwaite
IPC分类号： A61M5/145 , A61M5/14
CPC分类号： A61M5/427 , A61B5/15003 , A61B5/150748 , A61M5/14228 , A61M5/14232 , A61M5/16827 , A61M5/16836 , A61M5/20 , A61M5/2425 , A61M5/282 , A61M5/283 , A61M5/31596 , A61M2005/1588 , A61M2005/31598
摘要： A delivery device delivery system and a method for delivering substances into blood vessels. The delivery device includes a body having a first end, a second end, and an outer surface. A first substance reservoir is disposed within the body and at least one cannula extends from the first end of the body. The cannula includes a cannula tip having a cannula opening therethrough and a cannula sheathing defining an interior passage in fluid communication with the first substance reservoir. A means is provided for delivering the first substance from the first substance reservoir through one of the at least one cannula, and a means is provided for delivering the second substance through one of the at least one cannula.
摘要翻译：递送装置输送系统和将物质输送到血管中的方法。输送装置包括具有第一端，第二端和外表面的本体。第一物质储存器设置在主体内，并且至少一个套管从主体的第一端延伸。套管包括具有穿过其中的插管开口的插管尖端和限定与第一物质储存器流体连通的内部通道的套管护套。提供了一种用于通过所述至少一个插管中的一个从所述第一物质储存器输送所述第一物质的装置，并且提供用于通过所述至少一个插管之一输送所述第二物质的装置。

5. 发明授权

US07006861B2 Method and apparatus for detecting electro-magnetic reflection from biological tissue 失效
公开(公告)号：US07006861B2
公开(公告)日：2006-02-28
申请号：US09875497
申请日：2001-06-05
申请人： Stephen T. Flock , Louis Fink , Milton Waner
发明人： Stephen T. Flock , Louis Fink , Milton Waner
IPC分类号： A61B1/04 , A61B5/103
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B17/3403 , A61B90/36 , A61B2090/306 , A61B2090/373 , A61B2090/502 , A61M5/427
摘要： A system and method is provided to view an anatomical structure such as a blood vessel in high contrast with its surrounding tissue. The system and method may be used to produce an image of an anatomical structure using reflected electromagnetic radiation singularly scattered from target tissue. The system and method may also provide same-side illumination and detection of reflected electromagnetic radiation in a convenient integral imaging device. The system and method may also provide helmet mounted imaging technology in a single integral helmet which allows the wearer to view an anatomical structure located within a patient such that the image is continuously oriented according to the orientation of the helmet wearer's head. The system and method may also be used in the performance of venipuncture. The system and method may provide for improved contrast between any anatomical structure and its surrounding tissue for use in any imaging system.

6. 发明申请

US20070299425A1 Infrared assisted monitoring of a catheter 审中-公开
标题翻译：红外辅助监测导管
公开(公告)号：US20070299425A1
公开(公告)日：2007-12-27
申请号：US11899274
申请日：2007-09-05
申请人： Milton Waner , Scott Ferguson , Louis Fink , Vladimir Zharov
发明人： Milton Waner , Scott Ferguson , Louis Fink , Vladimir Zharov
IPC分类号： A61M25/095
CPC分类号： A61B5/0059 , A61B5/064 , A61M25/0017 , A61M25/0082 , A61M25/01
摘要： An apparatus for the placement and monitoring of the position of an intraluminal indwelling catheter using an infrared (IR) signal encoded in the catheter and the detection of the IR signal by an IR optical detector. IR emitted from the catheter or IR reflected from the catheter may encode the IR signal into the catheter. The catheter includes a partially opaque flash chamber having a backing with optical properties that contrast with that of blood to allow the detector to image the blood filling the chamber and verify a successful insertion.
摘要翻译：用于使用在导管中编码的红外（IR）信号和通过IR光学检测器检测IR信号来放置和监测管腔内留置导管的位置的装置。从导管发射的IR或从导管反射的IR可以将IR信号编码到导管中。导管包括具有背光的部分不透明的闪光室，其具有与血液相反的光学特性，以允许检测器对填充腔室的血液成像并验证成功插入。

7. 发明授权

US6032070A Method and apparatus for detecting electro-magnetic reflection from biological tissue 失效
标题翻译：用于检测来自生物组织的电磁反射的方法和装置
公开(公告)号：US6032070A
公开(公告)日：2000-02-29
申请号：US483480
申请日：1995-06-07
申请人： Stephen T. Flock , Louis Fink , Milton Waner
发明人： Stephen T. Flock , Louis Fink , Milton Waner
IPC分类号： G01N21/17 , A61B5/00 , A61B5/145 , A61B10/00 , A61B17/34 , A61B19/00 , A61B1/00 , A61B5/103
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B90/36 , A61B17/3403 , A61B2090/306 , A61B2090/373 , A61B2090/502 , A61M5/427
摘要： A system and method is provided to view an anatomical structure such as a blood vessel in high contrast with its surrounding tissue. The system and method may be used to produce an image of an anatomical structure using reflected electromagnetic radiation singularly scattered from target tissue. The system and method may also provide same-side illumination and detection of reflected electromagnetic radiation in a convenient integral imaging device. The system and method may also provide helmet mounted imaging technology in a single integral helmet which allows the wearer to view an anatomical structure located within a patient such that the image is continuously oriented according to the orientation of the helmet wearer's head. The system and method may also be used in the performance of venipuncture. The system and method may provide for improved contrast between any anatomical structure and its surrounding tissue for use in any imaging system.
摘要翻译：提供了一种系统和方法来观察诸如与其周围组织高度对比的血管的解剖结构。系统和方法可以用于使用从目标组织单独散射的反射电磁辐射来产生解剖结构的图像。该系统和方法还可以在方便的整体成像装置中提供相同侧照明和反射电磁辐射的检测。该系统和方法还可以在头盔安装的成像技术中提供头盔安装的成像技术，其允许佩戴者观察位于患者体内的解剖结构，使得图像根据头盔佩戴者的头部的取向连续定向。该系统和方法也可用于静脉穿刺的表现。该系统和方法可提供用于任何成像系统的任何解剖结构及其周围组织之间的改善的对比度。

8. 发明申请

US20050238539A1 Apparatus for automated fresh tissue sectioning 审中-公开
标题翻译：用于自动新鲜组织切片的装置
公开(公告)号：US20050238539A1
公开(公告)日：2005-10-27
申请号：US10816016
申请日：2004-04-01
申请人： Gal Shafirstein , Scott Ferguson , Louis Fink , Paula North , Milton Waner
发明人： Gal Shafirstein , Scott Ferguson , Louis Fink , Paula North , Milton Waner
IPC分类号： B01L3/00 , B23Q15/24 , C12M3/08 , G01N1/04 , G01N1/06
CPC分类号： G01N1/06 , C12M45/07 , G01N2001/045
摘要： An apparatus for sectioning fresh unfixed tissue into very thin layers with preserved tissue architecture, antigenicity, mRNA content, and amenable to 3-D computer reconstruction. An electro-discharge machine (EDM) to accurately slice tissues through electro-dissociation of the tissue without mechanical or thermal damage. The tissue sample is placed on a holder submerged in a cooling bath comprising a liquid such as saline or water to minimize thermal effects and to provide a sink for dissociated ions. A cutting tool is electrically biased with respect to the tissue sample. A computer controlled EDM machine with x-y-z translation stage slices the tissue as defined by a predetermined program. The liquid in the cooling bath may be cooled to minimize tissue heating during cutting. In a preferred embodiment, the cutting tool may use focused RF energy to produce consecutive thin sections of fresh tissue for immunohistochemical and nucleic acids analyses by electro-dissociation without mechanical or thermal damage, ultimately allowing high-resolution volumetric reconstruction of gene and protein expression patterns of large tissue specimens.
摘要翻译：将新鲜未固定组织切片成非常薄的装置，其具有保存的组织结构，抗原性，mRNA含量，并适用于3-D计算机重建。一种放电机（EDM），用于通过组织的电解解来精确地切片组织，而没有机械或热损伤。将组织样品放置在浸没在包含液体如盐水或水的冷却浴中的保持器上以最小化热效应并提供用于离解离子的沉淀。切割工具相对于组织样品被电偏置。具有x-y-z平移台的计算机控制的电火花成型机根据预定的程序限定组织切片。冷却浴中的液体可以被冷却以最小化切割期间的组织加热。在优选实施例中，切割工具可以使用聚焦RF能量来产生新鲜组织的连续薄片，用于免疫组织化学和核酸分析，通过电解解而没有机械或热损伤，最终允许基因和蛋白质表达模式的高分辨率体积重建的大组织标本。

9. 发明授权

US06272374B1 Method and apparatus for detecting electro-magnetic reflection from biological tissue 有权
公开(公告)号：US06272374B1
公开(公告)日：2001-08-07
申请号：US09479755
申请日：2000-01-07
申请人： Stephen T. Flock , Louis Fink , Milton Waner
发明人： Stephen T. Flock , Louis Fink , Milton Waner
IPC分类号： A61B500
CPC分类号： A61B5/489 , A61B5/0059 , A61B5/15003 , A61B5/150748 , A61B17/3403 , A61B90/36 , A61B2090/306 , A61B2090/373 , A61B2090/502 , A61M5/427
摘要： A system and method is provided to view an anatomical structure such as a blood vessel in high contrast with its surrounding tissue. The system and method may be used to produce an image of an anatomical structure using reflected electromagnetic radiation singularly scattered from target tissue. The system and method may also provide same-side illumination and detection of reflected electromagnetic radiation in a convenient integral imaging device. The system and method may also provide helmet mounted imaging technology in a single integral helmet which allows the wearer to view an anatomical structure located within a patient such that the image is continuously oriented according to the orientation of the helmet wearer's head. The system and method may also be used in the performance of venipuncture. The system and method may provide for improved contrast between any anatomical structure and its surrounding tissue for use in any imaging system.

10. 发明申请

US20050220674A1 Tissue electro-sectioning apparatus 审中-公开
标题翻译：组织电切机
公开(公告)号：US20050220674A1
公开(公告)日：2005-10-06
申请号：US11091873
申请日：2005-03-28
申请人： Gal Shafirstein , Scott Ferguson , Louis Fink , Richard Ulrich
发明人： Gal Shafirstein , Scott Ferguson , Louis Fink , Richard Ulrich
IPC分类号： B01L3/00 , B23Q15/24 , C12M3/08 , G01N1/04 , G01N1/06
CPC分类号： G01N1/06 , C12M45/07 , G01N2001/045
摘要： An apparatus for sectioning fresh unfixed tissue into very thin layers with preserved tissue architecture, antigenicity, mRNA content, and amenable to 3-D computer reconstruction without mechanical or thermal damage by employing a sectioning tool having an electrode with an intense focused electrical field at an edge. A computer controlled x-y-z translation stage moves the sectioning tool through the tissue as defined by a predetermined program. The sectioning tool produces consecutive thin sections of fresh tissue for immunohistochemical and nucleic acids analyses without mechanical or thermal damage, ultimately allowing high-resolution volumetric reconstruction of gene and protein expression patterns of large tissue specimens. The geometry of the sectioning tool is selected so as to produce a spatially localized electrical field of sufficient intensity to sever molecular bonds or propagate flaws in tissue without mechanical cutting.
摘要翻译：一种用于将新鲜未固定组织切割成具有保护的组织结构，抗原性，mRNA含量的非常薄的层的装置，并且适用于没有机械或热损伤的3-D计算机重建，通过采用具有电场强度聚焦电场的切片工具边缘。计算机控制的x-y-z平移台通过由预定程序定义的组织移动切片工具。切片工具可生成连续薄片的新鲜组织，用于免疫组织化学和核酸分析，无机械或热损伤，最终允许高分辨率体积重建大组织标本的基因和蛋白质表达模式。选择切片工具的几何形状以产生足够强度的空间局部电场，以切断分子键或传播组织中的缺陷而无需机械切割。

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